PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25481740-6	2015	Restoration of normal c-Cbl function also allows more effective harnessing of estrogen receptor-alpha (ERalpha)-independent activities of tamoxifen to activate the RFC pathway and target ERalpha-negative cancer cells.	Tamoxifen	138-147	Cbl proto-oncogene	Homo sapiens	22-27	
28100467-4	2017	Using a newly engineered tamoxifen-inducible Cbl and Cbl-b deletion model with a dual fluorescent reporter (Cblflox/flox; Cbl-bflox/flox; Rosa26-CreERT; mT/mG), we show that Cbl/Cbl-b DKO in mammary organoids leads to hyperactivation of AKT-mTOR signaling with depletion of MaSCs.	Tamoxifen	25-34	Cbl proto-oncogene	Homo sapiens	45-48	
21175263-0	2011	Ubiquitin ligase c-Cbl is involved in tamoxifen-induced apoptosis of MCF-7 cells by downregulating the survival signals.	Tamoxifen	38-47	Cbl proto-oncogene	Homo sapiens	17-22	
23606532-0	2013	Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells.	Tamoxifen	96-105	Cbl proto-oncogene	Homo sapiens	24-29	
21175263-13	2011	Over-expression of c-Cbl significantly enhanced the apoptosis-inducing effects of TAM, while 70Z/Cbl suppressed the apoptosis-inducing effects of TAM.	Tamoxifen	82-85	Cbl proto-oncogene	Homo sapiens	19-24	
21175263-16	2011	CONCLUSIONS: This study demonstrates that c-Src, ERK, and AKT played a protective role during TAM-induced apoptosis, and that c-Cbl sensitized MCF-7 cells to TAM by modulating the expression of c-Src, and TAM-induced ERK and AKT activity.	Tamoxifen	158-161	Cbl proto-oncogene	Homo sapiens	126-131	
21175263-16	2011	CONCLUSIONS: This study demonstrates that c-Src, ERK, and AKT played a protective role during TAM-induced apoptosis, and that c-Cbl sensitized MCF-7 cells to TAM by modulating the expression of c-Src, and TAM-induced ERK and AKT activity.	Tamoxifen	158-161	Cbl proto-oncogene	Homo sapiens	126-131	
21175263-13	2011	Over-expression of c-Cbl significantly enhanced the apoptosis-inducing effects of TAM, while 70Z/Cbl suppressed the apoptosis-inducing effects of TAM.	Tamoxifen	82-85	Cbl proto-oncogene	Homo sapiens	21-24	
21175263-14	2011	Further investigation revealed that, overexpression of c-Cbl significantly downregulated the c-Src protein levels and TAM-induced AKT activity.	Tamoxifen	118-121	Cbl proto-oncogene	Homo sapiens	55-60	
21175263-15	2011	But 70Z/Cbl significantly upregulated TAM-induced ERK and AKT activity.	Tamoxifen	38-41	Cbl proto-oncogene	Homo sapiens	8-11	
29720121-0	2018	C-Cbl reverses HER2-mediated tamoxifen resistance in human breast cancer cells.	Tamoxifen	29-38	Cbl proto-oncogene	Homo sapiens	0-5	
29720121-15	2018	In addition, c-Cbl could reverse tamoxifen resistance in BT474 cells, but the ubiquitin ligase mutant had no effect.	Tamoxifen	33-42	Cbl proto-oncogene	Homo sapiens	13-18	
29720121-18	2018	CONCLUSIONS: Our results suggested that c-Cbl can reverse tamoxifen resistance in HER2-overexpressing breast cancer cells by inhibiting the formation of the ER-c-Src-HER2 complex.	Tamoxifen	58-67	Cbl proto-oncogene	Homo sapiens	40-45