PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27197229-4	2016	Specific inhibition of HOXB7 is particularly relevant in cancers still lacking effective therapies, such as tamoxifen-resistant breast cancer and melanoma.	Tamoxifen	108-117	homeobox B7	Homo sapiens	23-28	
26334046-0	2015	Targeting a Novel ER/HOXB7 Signaling Loop in Tamoxifen-Resistant Breast Cancer.	Tamoxifen	45-54	homeobox B7	Homo sapiens	21-26	
26334046-4	2015	Jin and colleagues describe a novel ER/HOXB7 signaling loop in tamoxifen-resistant breast cancer models.	Tamoxifen	63-72	homeobox B7	Homo sapiens	39-44	
25542862-9	2015	TGFbeta2 mediated HOXB7-induced activation of macrophages, suggesting that TAMs may contribute to HOXB7-promoted tumor metastasis.	Tamoxifen	75-79	homeobox B7	Homo sapiens	18-23	
25542862-9	2015	TGFbeta2 mediated HOXB7-induced activation of macrophages, suggesting that TAMs may contribute to HOXB7-promoted tumor metastasis.	Tamoxifen	75-79	homeobox B7	Homo sapiens	98-103	
21690342-0	2012	The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway.	Tamoxifen	59-68	homeobox B7	Homo sapiens	4-9	
21690342-3	2012	In this report, we provide evidence that HOXB7 overexpression renders MCF-7 cells resistant to tamoxifen via cross-talk between receptor tyrosine kinases and ERalpha signaling.	Tamoxifen	95-104	homeobox B7	Homo sapiens	41-46	
21690342-5	2012	Extended treatment of MCF-7 cells with tamoxifen resulted in progressively increasing levels of HOXB7 expression, along with EGFR and EGFR ligands.	Tamoxifen	39-48	homeobox B7	Homo sapiens	96-101	
21690342-7	2012	Finally, higher expression levels of HOXB7 in the tumor significantly correlated with poorer disease-free survival in ERalpha-positive patients with breast cancer on adjuvant tamoxifen monotherapy.	Tamoxifen	175-184	homeobox B7	Homo sapiens	37-42	
21690342-9	2012	Functional antagonism of HOXB7 could circumvent tamoxifen resistance.	Tamoxifen	48-57	homeobox B7	Homo sapiens	25-30	
26697525-1	2015	HOXB7 is a homeodomain containing transcription factor which plays a pivotal role in tamoxifen resistant breast cancer.	Tamoxifen	85-94	homeobox B7	Homo sapiens	0-5	
26697525-2	2015	Our work has shown that overexpression of HOXB7 renders cells tamoxifen resistant by mobilizing a number of receptor tyrosine kinase pathways.	Tamoxifen	62-71	homeobox B7	Homo sapiens	42-47	
26697525-3	2015	EGFR expression is upregulated by direct binding of HOXB7 to the EGFR promoter, while HOXB7 functions as a cofactor with ERalpha to cause overexpression of multiple ER-target genes, including HER2, in tamoxifen resistant breast cancer cells.	Tamoxifen	201-210	homeobox B7	Homo sapiens	86-91	
26180042-7	2015	SIGNIFICANCE: HOXB7 acts as an ERalpha cofactor regulating a myriad of ER target genes, including HER2, in tamoxifen-resistant breast cancer.	Tamoxifen	107-116	homeobox B7	Homo sapiens	14-19