PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23129443-7	2012	The target of AMM has been proved to be the DNA gyrase B subunit and its binding mode to DNA gyrase is different from those of novobiocin and coumermycin, the known DNA gyrase inhibitors.	Novobiocin	127-137	DNA topoisomerase II alpha	Homo sapiens	44-54	
28019639-1	2017	BACKGROUND: The aminocoumarin antibiotic, novobiocin, is a natural product that inhibits DNA gyrase, a bacterial enzyme involved in cell division.	Novobiocin	42-52	DNA topoisomerase II alpha	Homo sapiens	89-99	
23859777-1	2013	Recent studies have shown that novobiocin (NB), a member of the coumermycin (CA) family of antibiotics with demonstrated DNA gyrase inhibitory activity, inhibits Heat shock protein 90 (HSP90) by binding weakly to a putative ATP-binding site within its C-terminus.	Novobiocin	31-41	DNA topoisomerase II alpha	Homo sapiens	121-131	
18093089-0	2008	Transferred NOE and saturation transfer difference NMR studies of novobiocin binding to EnvZ suggest binding mode similar to DNA gyrase.	Novobiocin	66-76	DNA topoisomerase II alpha	Homo sapiens	125-135	
19374378-1	2009	Complexes of the antibiotics novobiocin and clorobiocin with DNA gyrase are illustrative of the importance of bound water to binding thermodynamics.	Novobiocin	29-39	DNA topoisomerase II alpha	Homo sapiens	61-71	
21904660-1	2010	Structural modifications to the coumarin core and benzamide side chain of novobiocin have successfully transformed the natural product from a selective DNA gyrase inhibitor into a potent inhibitor of the Hsp90 C-terminus.	Novobiocin	74-84	DNA topoisomerase II alpha	Homo sapiens	152-162	
18093089-4	2008	DNA Gyrase B has several well-characterized potent inhibitors, including novobiocin and clorobiocin which have detailed structures in complex.	Novobiocin	73-83	DNA topoisomerase II alpha	Homo sapiens	0-10	
17132020-0	2006	Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90.	Novobiocin	0-10	DNA topoisomerase II alpha	Homo sapiens	26-36	
17132020-1	2006	Novobiocin is a member of the coumermycin family of antibiotics and is a well-established inhibitor of DNA gyrase.	Novobiocin	0-10	DNA topoisomerase II alpha	Homo sapiens	103-113	
11894947-2	1983	Using both cores and DNA-protein complexes as templates, it was also demonstrated that novobiocin, an inhibitor of DNA gyrase, inhibited in vitro DNA replication by preventing formation of the initiation complex.	Novobiocin	87-97	DNA topoisomerase II alpha	Homo sapiens	115-125	
16868863-3	2006	This is exemplified in this review for the biosynthetic gene clusters of the aminocoumarin antibiotics novobiocin, clorobiocin and coumermycin A (1), which are potent inhibitors of DNA gyrase.	Novobiocin	103-113	DNA topoisomerase II alpha	Homo sapiens	181-191	
16166072-3	2005	The capacity of these DNA tracts to undergo deletions-expansions was explored with three genetic-biochemical approaches including first, the utilization of topoisomerase I and/or DNA gyrase mutants, second, the specific inhibition of DNA gyrase by novobiocin, and third, the genetic removal of the HU protein, thus lowering the negative supercoil density (-sigma).	Novobiocin	248-258	DNA topoisomerase II alpha	Homo sapiens	234-244	
1846146-0	1991	Mutations in DNA gyrase result in novobiocin resistance in halophilic archaebacteria.	Novobiocin	34-44	DNA topoisomerase II alpha	Homo sapiens	13-23	
1330339-3	1992	The resulting ideas were tested through the rational design and synthesis of original phospholipid structures linked to novobiocin subsequently used in the production of two-dimensional crystals of DNA gyrase (B subunit), a prokaryotic type II DNA topoisomerase.	Novobiocin	120-130	DNA topoisomerase II alpha	Homo sapiens	198-208	
6253912-1	1980	The DNA gyrase inhibitor novobiocin specifically inhibits the transcription of ribosomal RNA in vivo while protein synthesis and the mRNA transcription are only partly affected.	Novobiocin	25-35	DNA topoisomerase II alpha	Homo sapiens	4-14	
29746111-4	2018	Polymyxin has been shown to synergize with many antibiotics including novobiocin, which inhibits DNA gyrase, by facilitating transport of these antibiotics across the outer membrane.	Novobiocin	70-80	DNA topoisomerase II alpha	Homo sapiens	97-107	
227861-3	1979	Coumermycin, novobiocin, nalidixic acid, and oxolinic acid are known to be inhibitors of Escherichia coli gyrase, to inhibit E. coli DNA replication, to abolish colicin E1 replication, and to depress the supercoiling of phage lambda DNA, the last two via inhibition of the DNA gyrase.	Novobiocin	13-23	DNA topoisomerase II alpha	Homo sapiens	273-283	
226966-1	1979	We have used the antibiotics coumermycin A1, novobiocin, and oxolinic acid, which are specific inhibitors of DNA gyrase, to study the coupled transcription and translation of several bacterial and plasmid genes in a DNA-directed cell-free system.	Novobiocin	45-55	DNA topoisomerase II alpha	Homo sapiens	109-119	
29746111-5	2018	Recently, we have shown that novobiocin not only inhibits DNA gyrase but also binds and stimulates LptB, the ATPase that powers LPS transport.	Novobiocin	29-39	DNA topoisomerase II alpha	Homo sapiens	58-68	
29746111-10	2018	We also report other novobiocin analogs that inhibit DNA gyrase better than or equal to novobiocin, but bind better to LptB and therefore have even greater LptB stimulatory activity.	Novobiocin	21-31	DNA topoisomerase II alpha	Homo sapiens	53-63