PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18847196-1 2008 To approach the daunting problem of multidrug resistant bacterial pathogens, a multidisciplinary chemical proteomic strategy was applied and functionalized beta-lactones were identified as potent, cell permeable inhibitors for specific and selective targeting of the key virulence regulator complex ClpP in S. aureus and methicillin resistant S. aureus (MRSA) strains. Methicillin 321-332 caseinolytic mitochondrial matrix peptidase proteolytic subunit Homo sapiens 299-303