PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17472573-5 2007 Secretion in response to thrombin, a protease-activated receptor-1 agonist peptide, histamine, forskolin and adrenaline (epinephrine) was inhibited. Epinephrine 109-119 coagulation factor II, thrombin Homo sapiens 25-33 20460337-9 2011 Although the lack of response to epinephrine and aspirin treatment displayed similarities in aggregations using epinephrine, ADP, collagen, and thrombin, they differed in aggregations using AA and for ATP secretion. Epinephrine 33-44 coagulation factor II, thrombin Homo sapiens 144-152 21388249-5 2011 Thrombin-induced alpha-granule secretion, measured by the release of fibrinogen in gel-filtered platelets, was also potentiated by adrenaline at thrombin concentrations above 0.05 U/ml. Epinephrine 131-141 coagulation factor II, thrombin Homo sapiens 0-8 21388249-5 2011 Thrombin-induced alpha-granule secretion, measured by the release of fibrinogen in gel-filtered platelets, was also potentiated by adrenaline at thrombin concentrations above 0.05 U/ml. Epinephrine 131-141 coagulation factor II, thrombin Homo sapiens 145-153 21388249-6 2011 In contrast, adrenaline had little effect on thrombin-induced secretion of beta-acetyl-hexosaminidase and potentiated very little liberation of arachidonate at high thrombin concentrations. Epinephrine 13-23 coagulation factor II, thrombin Homo sapiens 165-173 21388249-7 2011 When autocrine stimulation was inhibited by the removal of secreted ADP by creatine phosphate/creatine phosphate kinase and specific blocking of the thromboxane A(2) and fibrinogen receptors, the potentiation of thrombin-induced ADP + ATP secretion by adrenaline was reduced and this reduction was mostly due to the blocking of the thromboxane A(2) receptor. Epinephrine 252-262 coagulation factor II, thrombin Homo sapiens 212-220 21388249-8 2011 Protein tyrosine phosphorylation by both thrombin and collagen was reduced by adrenaline, and inhibitors of autocrine stimulation counteracted this reduction. Epinephrine 78-88 coagulation factor II, thrombin Homo sapiens 41-49 18480058-3 2008 The results show that epinephrine acted via alpha(2A)-adrenergic receptors to provoke aggregation, secretion, and Ca(2+) mobilization in aspirin-treated platelets pre-stimulated with subthreshold concentrations of thrombin. Epinephrine 22-33 coagulation factor II, thrombin Homo sapiens 214-222 17472573-5 2007 Secretion in response to thrombin, a protease-activated receptor-1 agonist peptide, histamine, forskolin and adrenaline (epinephrine) was inhibited. Epinephrine 121-132 coagulation factor II, thrombin Homo sapiens 25-33 15886804-8 2005 Furthermore, epinephrine, acting via inhibitory Gz-coupled alpha(2A)-adrenoceptors, bypasses the inhibitory effect of AR-C69931MX on thrombin-induced p27 and p31 tyrosine phosphorylation. Epinephrine 13-24 coagulation factor II, thrombin Homo sapiens 133-141 17365862-0 2007 Epinephrine induces intracellular Ca2+ mobilization in thrombin-desensitized platelets: a role for GPIb-IX-V. Epinephrine 0-11 coagulation factor II, thrombin Homo sapiens 55-63 17365862-1 2007 In this work we have investigated the ability of epinephrine to trigger the release of intracellular Ca2+ in thrombin-desensitized platelets. Epinephrine 49-60 coagulation factor II, thrombin Homo sapiens 109-117 17365862-3 2007 Although epinephrine alone had no effect on intracellular Ca2+ mobilization, its addition to thrombin-desensitized platelets was associated to a rapid and evident secondary release of intracellular Ca2+. Epinephrine 9-20 coagulation factor II, thrombin Homo sapiens 93-101 16420577-7 2006 Dose-response curves for peptide agonists specific for the two platelet thrombin receptors, protease-activated receptor 1 (PAR1) and PAR4, show a relative responsiveness that mirrors that of human platelets, and sub-maximal ADP responses are augmented by epinephrine. Epinephrine 255-266 coagulation factor II, thrombin Homo sapiens 72-80 17365862-6 2007 Addition of hirudin to thrombin-desensitized platelets prevented epinephrine-promoted secondary release of Ca2+, indicating that thrombin, rather than epinephrine itself, is actually responsible for this event as a consequence of thrombin receptors resensitization. Epinephrine 65-76 coagulation factor II, thrombin Homo sapiens 23-31 17365862-6 2007 Addition of hirudin to thrombin-desensitized platelets prevented epinephrine-promoted secondary release of Ca2+, indicating that thrombin, rather than epinephrine itself, is actually responsible for this event as a consequence of thrombin receptors resensitization. Epinephrine 65-76 coagulation factor II, thrombin Homo sapiens 129-137 17365862-6 2007 Addition of hirudin to thrombin-desensitized platelets prevented epinephrine-promoted secondary release of Ca2+, indicating that thrombin, rather than epinephrine itself, is actually responsible for this event as a consequence of thrombin receptors resensitization. Epinephrine 65-76 coagulation factor II, thrombin Homo sapiens 129-137 17365862-8 2007 Moreover, we found that thrombin was still able to induce a reduced, but evident release of Ca2+ from internal stores in PAR1- and PAR4-desensitized platelets, which could be followed by a secondary Ca2+ release upon subsequent addition of epinephrine. Epinephrine 240-251 coagulation factor II, thrombin Homo sapiens 24-32 17365862-10 2007 These results demonstrate a direct role of thrombin binding to GPIb-IX-V in the mobilization of Ca2+ from intracellular stores, and reveal that epinephrine can restore this process in desensitized platelets, thus prolonging the effect of thrombin stimulation. Epinephrine 144-155 coagulation factor II, thrombin Homo sapiens 238-246 12429357-3 2002 The functional status of alpha(2A)-adrenergic receptor-coupled G(i2) and thrombin receptor-coupled G proteins (G(i2)+G(q)) was determined by the increase in high-affinity GTPase activity in response to epinephrine and thrombin, respectively, in platelet membranes from 18 patients with mood disorders (15 unipolar and three bipolar subtype), 13 schizophrenic patients, four neurotic patients and 29 healthy control subjects. Epinephrine 202-213 coagulation factor II, thrombin Homo sapiens 73-81 15213852-8 2004 In addition, 2-methylthio-ADP as well as epinephrine provoke ERK2 activation at a thrombin concentration that alone has no detectable effect (0.05 U/ml). Epinephrine 41-52 coagulation factor II, thrombin Homo sapiens 82-90 11086166-4 2000 It is concluded that adrenaline can replace secreted ADP to potentiate PtdIns(3,4)P(2) production in thrombin-stimulated but not in SFRLLN-stimulated platelets, thus demonstrating a qualitative difference between platelet stimulation by thrombin and the thrombin receptor activating peptide SFRLLN. Epinephrine 21-31 coagulation factor II, thrombin Homo sapiens 101-109 11086166-4 2000 It is concluded that adrenaline can replace secreted ADP to potentiate PtdIns(3,4)P(2) production in thrombin-stimulated but not in SFRLLN-stimulated platelets, thus demonstrating a qualitative difference between platelet stimulation by thrombin and the thrombin receptor activating peptide SFRLLN. Epinephrine 21-31 coagulation factor II, thrombin Homo sapiens 237-245 11086166-0 2000 Adrenaline potentiates PI 3-kinase in platelets stimulated with thrombin and SFRLLN: role of secreted ADP. Epinephrine 0-10 coagulation factor II, thrombin Homo sapiens 64-72 11086166-4 2000 It is concluded that adrenaline can replace secreted ADP to potentiate PtdIns(3,4)P(2) production in thrombin-stimulated but not in SFRLLN-stimulated platelets, thus demonstrating a qualitative difference between platelet stimulation by thrombin and the thrombin receptor activating peptide SFRLLN. Epinephrine 21-31 coagulation factor II, thrombin Homo sapiens 237-245 11086166-1 2000 Adrenaline significantly potentiated late thrombin- and SFRLLN-induced PtdIns(3,4)P(2) production. Epinephrine 0-10 coagulation factor II, thrombin Homo sapiens 42-50 11086166-2 2000 Furthermore, the potentiating effect of adrenaline on thrombin-induced PtdIns(3, 4)P(2) production was independent on secreted ADP, whereas, the effect of adrenaline on SFRLLN-induced PtdIns(3,4)P(2) production was completely dependent of secreted ADP. Epinephrine 40-50 coagulation factor II, thrombin Homo sapiens 54-62 9268194-5 1997 Stimulation of platelets with thrombin, ADP or epinephrine causes a partial translocation of dynein from the soluble fraction to the particulate fraction with thrombin being the most efficient agent at promoting this shift. Epinephrine 47-58 coagulation factor II, thrombin Homo sapiens 159-167 10369791-2 1999 We compared the effects of mental stress, dynamic exercise and adrenaline infusion on platelet sensitivity to thrombin using flow-cytometric analysis of platelet fibrinogen binding in whole blood, and platelet aggregability using filtragometry ex vivo, in healthy volunteers. Epinephrine 63-73 coagulation factor II, thrombin Homo sapiens 110-118 10369791-5 1999 Adrenaline infusion enhanced thrombin-induced platelet fibrinogen binding and platelet aggregability (P<0.05), and elevated thrombin-antithrombin complexes (P<0.05), whereas F1+2 and fibrinopeptide A levels were not significantly affected. Epinephrine 0-10 coagulation factor II, thrombin Homo sapiens 29-37 10369791-5 1999 Adrenaline infusion enhanced thrombin-induced platelet fibrinogen binding and platelet aggregability (P<0.05), and elevated thrombin-antithrombin complexes (P<0.05), whereas F1+2 and fibrinopeptide A levels were not significantly affected. Epinephrine 0-10 coagulation factor II, thrombin Homo sapiens 127-135 9461228-8 1998 Finally, subthreshold concentrations of epinephrine also potentiated thrombin-induced platelet aggregation, and blockade of chloride transport diminished this synergistic action of epinephrine on thrombin-stimulated platelet aggregation. Epinephrine 40-51 coagulation factor II, thrombin Homo sapiens 69-77 9461228-8 1998 Finally, subthreshold concentrations of epinephrine also potentiated thrombin-induced platelet aggregation, and blockade of chloride transport diminished this synergistic action of epinephrine on thrombin-stimulated platelet aggregation. Epinephrine 40-51 coagulation factor II, thrombin Homo sapiens 196-204 9461228-8 1998 Finally, subthreshold concentrations of epinephrine also potentiated thrombin-induced platelet aggregation, and blockade of chloride transport diminished this synergistic action of epinephrine on thrombin-stimulated platelet aggregation. Epinephrine 181-192 coagulation factor II, thrombin Homo sapiens 196-204 10952808-3 2000 In one study, a combination of the injection of adrenaline and a high dose of thrombin was superior to using adrenaline alone. Epinephrine 109-119 coagulation factor II, thrombin Homo sapiens 78-86 10405323-4 1999 Thrombin, a thrombin receptor agonist peptide, a thromboxane A(2) analogue, collagen, crosslinking the glycoprotein VI, ADP, and epinephrine, but not phorbol 12, 13-dibutyrate activated p38. Epinephrine 129-140 coagulation factor II, thrombin Homo sapiens 0-8 10405323-4 1999 Thrombin, a thrombin receptor agonist peptide, a thromboxane A(2) analogue, collagen, crosslinking the glycoprotein VI, ADP, and epinephrine, but not phorbol 12, 13-dibutyrate activated p38. Epinephrine 129-140 coagulation factor II, thrombin Homo sapiens 12-20 10233893-4 1999 Activation of human platelets with thrombin, a stable thromboxane A2 analog STA2, epinephrine, and serotonin resulted in an increase in MBS phosphorylation, and the agonist-induced MBS phosphorylation was prevented by pretreatment with the respective receptor antagonist. Epinephrine 82-93 coagulation factor II, thrombin Homo sapiens 35-43 10461011-4 1998 First, in platelets that were stimulated to spread over fibrin or fibrinogen surfaces with adrenaline, addition of thrombin and CaCl(2) caused a potent Ca(2+) signal that in about 30% of the cells was accompanied by exposure of PS. Epinephrine 91-101 coagulation factor II, thrombin Homo sapiens 115-123 10461011-6 1998 Second, in platelet-fibrinogen microaggregates that were preformed in the presence of adrenaline, thrombin/CaCl(2) induced PS exposure and bleb formation of about 35% of the cells. Epinephrine 86-96 coagulation factor II, thrombin Homo sapiens 98-106 10461011-8 1998 These results indicate that, in the absence of coagulating plasma, thrombin is a moderate inducer of the procoagulant response of platelets, once integrin alpha(IIb)beta(3)-mediated interactions are stimulated (by adrenaline) and CaCl(2) is present. Epinephrine 214-224 coagulation factor II, thrombin Homo sapiens 67-75 9241755-7 1997 Epinephrine (together with IBMX) caused a small, dose-dependent increase in vWf release, maximal at 10(-6) M (+50%), and also potentiated the response to thrombin. Epinephrine 0-11 coagulation factor II, thrombin Homo sapiens 154-162 9089407-0 1997 Tyrosine phosphorylation and Syk activation are involved in thrombin-induced aggregation of epinephrine-potentiated platelets. Epinephrine 92-103 coagulation factor II, thrombin Homo sapiens 60-68 9089407-4 1997 Although epinephrine alone (4 microM) slightly induced protein-tyrosine phosphorylation and Syk activation, the presence of epinephrine caused a shift to the left in the dose-dependence of thrombin (0.01-0.5 U/ml)-induced tyrosine phosphorylation and Syk activation, as well as platelet aggregation. Epinephrine 124-135 coagulation factor II, thrombin Homo sapiens 189-197 7792747-1 1995 In a suspension of thrombin degranulated platelets (TDP), ADP and epinephrine can induce platelet aggregation, whereas the synthetic agonist of the thromboxane/endoperoxide receptor U46619 causes only shape change. Epinephrine 66-77 coagulation factor II, thrombin Homo sapiens 19-27 8329564-4 1993 The platelet electrophoretic mobility decreases from -2 (mu-cm)/(V-s) to -0.5 (mu-cm)/(V-s) when the platelet is activated with either 1 microM ADP, 10 microM epinephrine or 0.5 NIH U/ml alpha-thrombin. Epinephrine 159-170 coagulation factor II, thrombin Homo sapiens 193-201 7903535-10 1993 These results indicate that epinephrine stimulates high-affinity GTPase activity of G proteins (putatively Gi2), which are also coupled with thrombin receptors, in a Mg(2+)-dependent and stereospecific manner, via alpha 2A-adrenergic receptor activation in human platelet membrane preparations. Epinephrine 28-39 coagulation factor II, thrombin Homo sapiens 141-149 8259557-6 1993 (3) The response of CP/CPK-treated thrombin- or platelet-activating factor (PAF)-stimulated platelets was markedly increased by a subsequent addition of adrenaline. Epinephrine 153-163 coagulation factor II, thrombin Homo sapiens 35-43 8259557-7 1993 When hirudin or BN 50726 was added just prior to adrenaline to terminate the activation by thrombin or PAF, respectively, the stimulating effect of adrenaline was also abolished. Epinephrine 148-158 coagulation factor II, thrombin Homo sapiens 91-99 1902217-7 1991 Cell stimulation by thrombin, ADP plus epinephrine or phorbol-ester caused up to a 2-fold increase in RET between chromophore-labeled, platelet-bound B1B5, SSA6, and A2A9 (p less than or equal to 0.05), suggesting a change in the separation or orientation of these epitopes within the GP IIb-IIIa complex. Epinephrine 39-50 coagulation factor II, thrombin Homo sapiens 20-28 1311555-6 1992 (2) Inhibition of adenylate cyclase by thrombin, adrenaline or collagen fibres could be abolished in the presence of guanosine 5"-[beta-thio]diphosphate; half-maximal inhibition was obtained at about 100 microM for the inhibitory action of thrombin, and at about 500 microM for that of either adrenaline or collagen. Epinephrine 49-59 coagulation factor II, thrombin Homo sapiens 240-248 1311555-6 1992 (2) Inhibition of adenylate cyclase by thrombin, adrenaline or collagen fibres could be abolished in the presence of guanosine 5"-[beta-thio]diphosphate; half-maximal inhibition was obtained at about 100 microM for the inhibitory action of thrombin, and at about 500 microM for that of either adrenaline or collagen. Epinephrine 293-303 coagulation factor II, thrombin Homo sapiens 39-47 1631566-10 1992 The thrombin-inhibiting activity of these antibodies could partially be reversed by pretreating antibody-coated platelets with epinephrine immediately followed by stimulation with thrombin. Epinephrine 127-138 coagulation factor II, thrombin Homo sapiens 4-12 2035681-1 1991 In the presence of extracellular Ca2+, epinephrine induces a rise in cytoplasmic Ca2+ ([Ca2+]i) that is associated with fibrinogen binding to the platelet surface, platelet aggregation, and enhancement of the thrombin-stimulated [Ca2+]i rise and protein phosphorylation. Epinephrine 39-50 coagulation factor II, thrombin Homo sapiens 209-217 2831879-2 1988 Unlike thrombin, however, epinephrine is incapable of directly activating phospholipase C, but is well known to potentiate the effects of thrombin on this enzyme and other subsequent steps of platelet activation. Epinephrine 26-37 coagulation factor II, thrombin Homo sapiens 138-146 2159285-4 1990 In the presence of ethanol, thrombin and other agonists (platelet-activating factor, adrenaline and ADP, as well as fetal-calf serum) stimulated the appearance of phosphatidylethanol, an indicator of phospholipase D activity. Epinephrine 85-95 coagulation factor II, thrombin Homo sapiens 28-36 2845924-5 1988 The thrombin-induced hydrolysis of inositol phospholipids by phospholipase C, which was measured as the formation of [32P]PA, was potentiated by adrenaline, as was the increase in the levels of [32P]PIP2 and [32P]PIP. Epinephrine 145-155 coagulation factor II, thrombin Homo sapiens 4-12 2845924-6 1988 The presence of adrenaline caused a shift to the left for the thrombin-induced changes in the phosphoinositide metabolism, without affecting the maximal levels of 32P-labelled compounds obtained. Epinephrine 16-26 coagulation factor II, thrombin Homo sapiens 62-70 2845924-7 1988 A similar shift by adrenaline in the dose-response relationship was previously demonstrated for thrombin-induced aggregation and dense-granule secretion. Epinephrine 19-29 coagulation factor II, thrombin Homo sapiens 96-104 2845924-8 1988 Also, the narrow range of concentrations of thrombin over which adrenaline potentiates thrombin-induced platelet responses is the same for changes in phosphoinositide metabolism and physiological responses (aggregation and dense-granule secretion). Epinephrine 64-74 coagulation factor II, thrombin Homo sapiens 44-52 2845924-8 1988 Also, the narrow range of concentrations of thrombin over which adrenaline potentiates thrombin-induced platelet responses is the same for changes in phosphoinositide metabolism and physiological responses (aggregation and dense-granule secretion). Epinephrine 64-74 coagulation factor II, thrombin Homo sapiens 87-95 2845924-9 1988 Our observations clearly indicate that adrenaline directly or indirectly influences thrombin-induced changes in phosphoinositide metabolism. Epinephrine 39-49 coagulation factor II, thrombin Homo sapiens 84-92 3132162-12 1988 When alpha-thrombin stimulation of platelets was preceded by epinephrine, there was a potentiation of phospholipase C activation, Ca2+ mobilization and aggregation. Epinephrine 61-72 coagulation factor II, thrombin Homo sapiens 11-19 3388294-1 1988 In a medium containing 1 mM extracellular Ca2+ (Ca2+o), the prior addition of 0.5 microM adrenaline to quin 2-loaded human platelets increased both the rate and amplitude of the rise in cytosolic free Ca2+ (Ca2+i) in response to sub-threshold concentrations of thrombin and PAF and these effects were not prevented by blocking either fibrinogen binding and aggregation or cyclo-oxygenase. Epinephrine 89-99 coagulation factor II, thrombin Homo sapiens 261-269 2830284-4 1988 Epinephrine added following thrombin desensitization restored both the ability of thrombin to release Ca2+ stores and stimulate inositol phospholipid hydrolysis. Epinephrine 0-11 coagulation factor II, thrombin Homo sapiens 28-36 2830284-4 1988 Epinephrine added following thrombin desensitization restored both the ability of thrombin to release Ca2+ stores and stimulate inositol phospholipid hydrolysis. Epinephrine 0-11 coagulation factor II, thrombin Homo sapiens 82-90 2830284-6 1988 Pretreatment of platelets with phorbol dibutyrate at concentrations which specifically activate protein kinase C increased the rate of desensitization of the thrombin-induced release of Ca2+ stores and abolished the ability of epinephrine to restore the thrombin response. Epinephrine 227-238 coagulation factor II, thrombin Homo sapiens 158-166 2830284-6 1988 Pretreatment of platelets with phorbol dibutyrate at concentrations which specifically activate protein kinase C increased the rate of desensitization of the thrombin-induced release of Ca2+ stores and abolished the ability of epinephrine to restore the thrombin response. Epinephrine 227-238 coagulation factor II, thrombin Homo sapiens 254-262 2830284-9 1988 This protein is involved in thrombin stimulation of phospholipase C but is not directly stimulatory since epinephrine alone does not activate this enzyme. Epinephrine 106-117 coagulation factor II, thrombin Homo sapiens 28-36 2137716-10 1990 Because epinephrine increases fibrinogen binding to thrombin-stimulated platelets to a greater extent than ADP, but does not stabilize the aggregates, it is unlikely that the additional fibrinogen binding sites induced by ADP have a major role in inhibiting deaggregation by the combination of inhibitors. Epinephrine 8-19 coagulation factor II, thrombin Homo sapiens 52-60 2190817-4 1990 However, when added after the thrombin-induced response, epinephrine could evoke a considerable release of Ca2+ from cellular stores. Epinephrine 57-68 coagulation factor II, thrombin Homo sapiens 30-38 2190817-5 1990 This appeared to be due to epinephrine recoupling thrombin receptors to phospholipase C. In support of this, epinephrine was able to induce the formation of inositol triphosphate when added after the response to thrombin had also become desensitized. Epinephrine 27-38 coagulation factor II, thrombin Homo sapiens 50-58 2190817-5 1990 This appeared to be due to epinephrine recoupling thrombin receptors to phospholipase C. In support of this, epinephrine was able to induce the formation of inositol triphosphate when added after the response to thrombin had also become desensitized. Epinephrine 109-120 coagulation factor II, thrombin Homo sapiens 50-58 2190817-5 1990 This appeared to be due to epinephrine recoupling thrombin receptors to phospholipase C. In support of this, epinephrine was able to induce the formation of inositol triphosphate when added after the response to thrombin had also become desensitized. Epinephrine 109-120 coagulation factor II, thrombin Homo sapiens 212-220 2546796-0 1989 Potentiation by adrenaline of thrombin-induced elevation of pHi is not essential for synergistic activation of human platelets. Epinephrine 16-26 coagulation factor II, thrombin Homo sapiens 30-38 2546796-2 1989 Adrenaline markedly enhanced the thrombin-induced increase in cytoplasmic pH (pHi) in BCECF-loaded platelets. Epinephrine 0-10 coagulation factor II, thrombin Homo sapiens 33-41 2546796-4 1989 The potentiation by adrenaline of thrombin-induced PLC activation measured as [32P]PA formation and final platelet responses was, however, not blocked by EIPA, even at low concentrations of thrombin. Epinephrine 20-30 coagulation factor II, thrombin Homo sapiens 34-42 2546796-5 1989 These results indicate that the enhancement by adrenaline of thrombin-induced cytoplasmic alkalinization may be a secondary effect which is not essential for the potentiation by adrenaline of platelet activation by thrombin. Epinephrine 47-57 coagulation factor II, thrombin Homo sapiens 61-69 2845924-0 1988 Synergism between thrombin and adrenaline (epinephrine) in human platelets. Epinephrine 43-54 coagulation factor II, thrombin Homo sapiens 18-26 2845924-4 1988 Adrenaline alone (3.5-4.0 microM) did not cause a change in any parameter (phosphoinositide metabolism, aggregation and dense-granule secretion), but markedly enhanced the thrombin-induced responses over a narrow range of thrombin concentrations (0.03-0.08 units/ml). Epinephrine 0-10 coagulation factor II, thrombin Homo sapiens 172-180 2845924-4 1988 Adrenaline alone (3.5-4.0 microM) did not cause a change in any parameter (phosphoinositide metabolism, aggregation and dense-granule secretion), but markedly enhanced the thrombin-induced responses over a narrow range of thrombin concentrations (0.03-0.08 units/ml). Epinephrine 0-10 coagulation factor II, thrombin Homo sapiens 222-230 2831879-6 1988 The response to thrombin desensitized over a period of minutes, and after this had occurred, epinephrine was able to activate phospholipase C and induce the release of intracellular Ca2+. Epinephrine 93-104 coagulation factor II, thrombin Homo sapiens 16-24 2831879-7 1988 This showed that epinephrine was able to recouple thrombin receptors to phospholipase C, and this appeared to be mediated by the same mechanism which is involved in potentiation by epinephrine of thrombin-stimulation of phospholipase C. These effects of epinephrine were not altered by inhibition of the Na+/H+ antiporter with ethylisopropylamiloride or by use of the Na+/H+ ionophore, monensin. Epinephrine 17-28 coagulation factor II, thrombin Homo sapiens 50-58 2831879-7 1988 This showed that epinephrine was able to recouple thrombin receptors to phospholipase C, and this appeared to be mediated by the same mechanism which is involved in potentiation by epinephrine of thrombin-stimulation of phospholipase C. These effects of epinephrine were not altered by inhibition of the Na+/H+ antiporter with ethylisopropylamiloride or by use of the Na+/H+ ionophore, monensin. Epinephrine 17-28 coagulation factor II, thrombin Homo sapiens 196-204 2831879-7 1988 This showed that epinephrine was able to recouple thrombin receptors to phospholipase C, and this appeared to be mediated by the same mechanism which is involved in potentiation by epinephrine of thrombin-stimulation of phospholipase C. These effects of epinephrine were not altered by inhibition of the Na+/H+ antiporter with ethylisopropylamiloride or by use of the Na+/H+ ionophore, monensin. Epinephrine 181-192 coagulation factor II, thrombin Homo sapiens 196-204 2831879-7 1988 This showed that epinephrine was able to recouple thrombin receptors to phospholipase C, and this appeared to be mediated by the same mechanism which is involved in potentiation by epinephrine of thrombin-stimulation of phospholipase C. These effects of epinephrine were not altered by inhibition of the Na+/H+ antiporter with ethylisopropylamiloride or by use of the Na+/H+ ionophore, monensin. Epinephrine 181-192 coagulation factor II, thrombin Homo sapiens 196-204 2831879-8 1988 We conclude that epinephrine potentiates thrombin-induced responses by a mechanism which is unrelated to its effects on the Na+/H+ antiporter, and this is not a requirement for thrombin-induced phospholipase C activation. Epinephrine 17-28 coagulation factor II, thrombin Homo sapiens 41-49 3617010-2 1987 In the presence of 1mM external calcium, epinephrine augmented the increase in cytoplasmic free calcium in response to collagen or thrombin, and this was inhibited by yohimbine. Epinephrine 41-52 coagulation factor II, thrombin Homo sapiens 131-139 3004519-1 1985 Epinephrine at concentrations varying between 3.3 and 12.5 nM had no effect on blood platelets when added alone, but augmented the in vitro platelet response to collagen and thrombin. Epinephrine 0-11 coagulation factor II, thrombin Homo sapiens 174-182 3490977-8 1986 Adrenaline, when added prior to non-saturating concentrations of U46619, thrombin, vasopressin or ADP, significantly enhances the increase in cytosolic [Ca2+] induced by these agonists in platelets suspended in media containing less than 0.1 microM or 1 mM Ca2+. Epinephrine 0-10 coagulation factor II, thrombin Homo sapiens 73-81 3083525-1 1986 The effects of low concentrations of epinephrine on the aggregation of macaque and human platelets by arachidonic acid (AA), collagen, and thrombin were studied. Epinephrine 37-48 coagulation factor II, thrombin Homo sapiens 139-147 3083525-4 1986 When near-threshold concentrations of collagen or thrombin were present in the medium, low concentrations of epinephrine (0.05 to 0.50 microM) potentiated the aggregation of macaque and human citrated platelets and macaque heparinized platelets. Epinephrine 109-120 coagulation factor II, thrombin Homo sapiens 50-58 2948506-3 1986 Both alpha and gamma thrombin induced platelet aggregation which was potentiated in each case by epinephrine. Epinephrine 97-108 coagulation factor II, thrombin Homo sapiens 21-29 2948506-5 1986 The gamma thrombin-induced phosphorylation was slightly enhanced by epinephrine. Epinephrine 68-79 coagulation factor II, thrombin Homo sapiens 10-18 2948506-6 1986 In contrast, only alpha thrombin was capable of inducing significant arachidonic acid release and the small release induced by gamma thrombin was reduced by epinephrine. Epinephrine 157-168 coagulation factor II, thrombin Homo sapiens 133-141 3490977-10 1986 Enhancement by adrenaline of Ca2+ influx induced by U46619, thrombin and ADP has been shown by using Mn2+ as probe. Epinephrine 15-25 coagulation factor II, thrombin Homo sapiens 60-68 3490977-11 1986 Adrenaline also enhances the extent of [3H]5HT secretion induced by U46619, thrombin and vasopressin but fails to increase that induced by ADP in this aspirin-treated preparation. Epinephrine 0-10 coagulation factor II, thrombin Homo sapiens 76-84 3698518-4 1986 As observed with aggregation, 0.3 unit of thrombin/ml produced a more marked effect on release than ADP, noradrenaline and adrenaline being increased by 570% and 169% respectively. Epinephrine 108-118 coagulation factor II, thrombin Homo sapiens 42-50 4089798-3 1985 Both aggregation and secretion induced with 0.03-0.3 U/ml of thrombin were markedly potentiated by epinephrine (0.5-4 microM), which alone was without effect. Epinephrine 99-110 coagulation factor II, thrombin Homo sapiens 61-69 6615246-5 1983 Very low density lipoprotein and low density lipoprotein increased thrombin-induced platelet aggregation and [14C] serotonin release induced by epinephrine, ADP, and thrombin. Epinephrine 144-155 coagulation factor II, thrombin Homo sapiens 67-75 2414575-4 1985 The higher sensitivity to adrenaline for thrombin-induced calcium increases in platelets of hypertensive patients indicates potentiation of calcium influx (and mobilization from intracellular stores) by adrenaline, a mechanism that is mediated by alpha 2-adrenoceptors. Epinephrine 26-36 coagulation factor II, thrombin Homo sapiens 41-49 2414575-4 1985 The higher sensitivity to adrenaline for thrombin-induced calcium increases in platelets of hypertensive patients indicates potentiation of calcium influx (and mobilization from intracellular stores) by adrenaline, a mechanism that is mediated by alpha 2-adrenoceptors. Epinephrine 203-213 coagulation factor II, thrombin Homo sapiens 41-49 3889486-1 1985 Sensitivity to adrenaline-antagonism of the inhibitory effect of PGI2 on thrombin-induced increase in [Ca2+]i was measured in platelets from normotensive and untreated hypertensive subjects. Epinephrine 15-25 coagulation factor II, thrombin Homo sapiens 73-81 6439269-9 1984 Since the synergistic effect of Paf-acether and adrenaline was maintained when thrombin-degranulated platelets were used, and aspirin remained ineffective against it, it is clear that the augmented platelet responsiveness is not accounted for by the platelet release reaction. Epinephrine 48-58 coagulation factor II, thrombin Homo sapiens 79-87 6612681-6 1983 Indomethacin (1 microgram/ml), a cyclooxygenase inhibitor, remarkably inhibited epinephrine plus ADP induced serotonin release, 40K-dalton protein phosphorylation and DG production although this agent had little effect on the same reactions induced by thrombin. Epinephrine 80-91 coagulation factor II, thrombin Homo sapiens 252-260 4089798-4 1985 Addition of epinephrine before stimulation with thrombin resulted in a marked decrease in the concentration of thrombin required for half-maximal aggregation, without affecting the maximal aggregation response. Epinephrine 12-23 coagulation factor II, thrombin Homo sapiens 111-119 6326566-2 1984 Recently epinephrine was reported to induce maximal aggregation of aspirin-treated platelets when combined with ADP or thrombin, and to increase fibrinogen binding of non-aspirin treated platelets stimulated with low doses of ADP. Epinephrine 9-20 coagulation factor II, thrombin Homo sapiens 119-127 6326566-4 1984 When fresh platelets were stimulated with epinephrine (5 microM) together with either ADP (10 microM) or thrombin (150 mU/ml), fibrinogen binding increased by 180% compared to binding observed in response to ADP or thrombin alone. Epinephrine 42-53 coagulation factor II, thrombin Homo sapiens 215-223 6326566-6 1984 While both ADP and epinephrine potentiated the aggregation and fibrinogen binding of stored platelets in response to high doses of thrombin (150 mU/ml), maximal aggregation was achieved only with thrombin (150 mU/ml) and epinephrine (5 microM) in combination. Epinephrine 19-30 coagulation factor II, thrombin Homo sapiens 131-139 6329175-3 1984 Responses to epinephrine (via alpha-2 adrenoreceptors) and ADP were independent of extracellular Ca2+, but required maintained occupancy of thrombin receptors and intact cAMP-phosphodiesterase activity. Epinephrine 13-24 coagulation factor II, thrombin Homo sapiens 140-148 6753559-6 1982 Also, adrenaline evoked a milder (p less than 0.01) potentiation of aggregation by thrombin of the washed platelet suspensions in the sulfinpyrazone versus the placebo group. Epinephrine 6-16 coagulation factor II, thrombin Homo sapiens 83-91 6813995-2 1982 Aggregation to collagen, calcium ionophore A23187 and thrombin (low doses) were often markedly inhibited by ethanol, adrenaline and ADP responses were little affected, and aggregation to exogenous arachidonic acid was actually potentiated by ethanol. Epinephrine 117-127 coagulation factor II, thrombin Homo sapiens 54-62 6251492-9 1980 However, epinephrine addition to refractory platelets restored in large measure their sensitivity to aggregation by arachidonate, thrombin, ADP and A23187. Epinephrine 9-20 coagulation factor II, thrombin Homo sapiens 130-138 7280120-5 1981 Results of the study demonstrate that aspirin-treated SPD platelets, which cannot form thromboxane or undergo the release reaction on stimulation by arachidonate, can still undergo irreversible aggregation in response to thrombin and ADP if treated first with epinephrine. Epinephrine 260-271 coagulation factor II, thrombin Homo sapiens 221-229 6251499-6 1980 Epinephrine reverses the refractory state and potentiates the response of dissociated cells to the action of thrombin, arachidonate and ionophore A23187. Epinephrine 0-11 coagulation factor II, thrombin Homo sapiens 109-117 7403340-2 1980 Concentrations of ADP, thrombin and arachidonate that caused reversible stimulation of aspirin platelets produced irreversible aggregation when the aspirin samples had been pretreated with epinephrine. Epinephrine 189-200 coagulation factor II, thrombin Homo sapiens 23-31 4675006-23 1972 We conclude that ADP and adrenaline, like thrombin and collagen, cause extrusion of non-metabolic granula-located platelet adenine nucleotides. Epinephrine 25-35 coagulation factor II, thrombin Homo sapiens 42-50 578021-2 1977 Epinephrine, known to potentiate and elicit aggregation of human platelets, was shown to inhibit thrombin-induced aggregation of rat platelets, delaying the onset of aggregation from 2 to 12 times. Epinephrine 0-11 coagulation factor II, thrombin Homo sapiens 97-105 9149-4 1976 During the early phases of thrombin-and ADP-induced platelet aggregation a marked activation of the guanylate cyclase occurs whereas aggregation induced by arachidonic acid or epinephrine results in a rapid diminution of this activity. Epinephrine 176-187 coagulation factor II, thrombin Homo sapiens 27-35 747039-0 1978 Inhibition of adrenaline-potentiated thrombin-induced reaction of human blood platelets by dihydroergotoxine. Epinephrine 14-24 coagulation factor II, thrombin Homo sapiens 37-45 747039-1 1978 The potentiating effect of adrenaline on thrombin-induced aggregation and release reaction of human blood platelets has been studied in vitro. Epinephrine 27-37 coagulation factor II, thrombin Homo sapiens 41-49 5649642-5 1968 Acid phosphatase, beta-glucuronidase and adenylate kinase were released to a small extent during second phase aggregation by ADP or adrenaline; thrombin and collagen particles caused significantly greater release of beta-glucuronidase than of either acid phosphatase or of adenylate kinase.4. Epinephrine 132-142 coagulation factor II, thrombin Homo sapiens 144-152 5485150-15 1970 Thrombin caused the release from platelets of intact adrenaline but not of the metabolite.10. Epinephrine 53-63 coagulation factor II, thrombin Homo sapiens 0-8 32526790-11 2020 Thrombin generation was faster with small, but accelerated by PS exposure and epinephrine-coactivated large platelets. Epinephrine 78-89 coagulation factor II, thrombin Homo sapiens 0-8 14869513-2 1951 Plasma and serum prothrombin before and after intramuscular injection of adrenaline]. Epinephrine 73-83 coagulation factor II, thrombin Homo sapiens 17-28 33457164-7 2021 The antiplatelet activity of serine protease was demonstrated by inhibition of agonists induced platelet aggregation; it was in the order of Epinephrine > Adenosine tri phosphate. Epinephrine 141-152 coagulation factor II, thrombin Homo sapiens 29-44 28817667-4 2017 We found that thrombin, Trap-6, arachidonic acid, collagen, A23187, epinephrine and ADP significantly increased glycolytic flux (3-38 times vs. non-activated platelets) whereas ristocetin was ineffective. Epinephrine 68-79 coagulation factor II, thrombin Homo sapiens 14-22