PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15249727-9 2004 Coadministration of propranolol and epinephrine augmented the propranolol-induced changes of splenocyte apoptosis and IL-6 release and was associated with the highest mortality of septic mice. Epinephrine 36-47 interleukin 6 Mus musculus 118-122 25205821-7 2014 Interestingly, IL-6 augments glucagon secretion from both sites only in the presence of an accompanying stressor (such as epinephrine). Epinephrine 122-133 interleukin 6 Mus musculus 15-19 24121404-4 2014 Prolonged systemic exposure of epinephrine resulted in persistent PMN trafficking to the wound site via an IL-6-mediated mechanism, and this in turn impaired wound repair. Epinephrine 31-42 interleukin 6 Mus musculus 107-111 24121404-5 2014 Further, we demonstrate that beta2-adrenergic receptor-dependent activation of proinflammatory macrophages is critical for epinephrine-mediated IL-6 production. Epinephrine 123-134 interleukin 6 Mus musculus 144-148 24052031-3 2013 Furthermore, epinephrine increases IL-6 secretion from skeletal muscle, suggesting that IL-6 could play a role in mediating the lipolytic effects of catecholamines. Epinephrine 13-24 interleukin 6 Mus musculus 35-39 24052031-3 2013 Furthermore, epinephrine increases IL-6 secretion from skeletal muscle, suggesting that IL-6 could play a role in mediating the lipolytic effects of catecholamines. Epinephrine 13-24 interleukin 6 Mus musculus 88-92 24052031-4 2013 The purpose of this study was to determine whether IL-6 stimulates skeletal muscle lipolysis in a fiber type dependent manner and is required for epinephrine-stimulated lipolysis in murine skeletal muscle. Epinephrine 146-157 interleukin 6 Mus musculus 51-55 22290536-8 2013 In addition, enhanced IL-6 promoter activity can be similarly induced by ET-1 and catecholamines (epinephrine and norepinephrine). Epinephrine 98-109 interleukin 6 Mus musculus 22-26 22290536-11 2013 Furthermore, injection of mice with epinephrine and ET-1 induced a tremendously synergistic increase in serum IL-6 levels. Epinephrine 36-47 interleukin 6 Mus musculus 110-114 17974982-10 2007 These studies show IL-6-independent activation of STAT3 by norepinephrine and epinephrine, proceeding through the beta1/beta2-adrenergic receptors and protein kinase A, resulting in increased matrix metalloproteinase production, invasion, and in vivo tumor growth, which can be ameliorated by the down-regulation of STAT3. Epinephrine 62-73 interleukin 6 Mus musculus 19-23 14722032-0 2004 Epinephrine stimulates IL-6 expression in skeletal muscle and C2C12 myoblasts: role of c-Jun NH2-terminal kinase and histone deacetylase activity. Epinephrine 0-11 interleukin 6 Mus musculus 23-27 14722032-6 2004 Epinephrine had a similar effect in C2C12 muscle cells, where the hormone increased IL-6 protein and mRNA in a dose- and time-dependent manner. Epinephrine 0-11 interleukin 6 Mus musculus 84-88 14722032-7 2004 Epinephrine-stimulated IL-6 expression was attenuated by the alpha-adrenergic receptor antagonist phentolamine and completely blocked by either the beta1/2-adrenergic receptor antagonist propranalol or the beta2-antagonist ICI-118551. Epinephrine 0-11 interleukin 6 Mus musculus 23-27 14722032-8 2004 The transcriptional inhibitor DRB and the synthetic glucocorticoid dexamethasone also blocked epinephrine-induced IL-6. Epinephrine 94-105 interleukin 6 Mus musculus 114-118 14722032-9 2004 SP-600125 (a JNK inhibitor) and SB-202190 (a p38 MAP kinase inhibitor) completely blocked epinephrine-induced IL-6 synthesis. Epinephrine 90-101 interleukin 6 Mus musculus 110-114 14722032-11 2004 Trichostatin A (a histone deacetylase inhibitor) blocked both endotoxin- and epinephrine-induced IL-6 expression. Epinephrine 77-88 interleukin 6 Mus musculus 97-101 14722032-12 2004 These data suggest that epinephrine induces IL-6 synthesis in skeletal muscle in vivo and myocytes in vitro. Epinephrine 24-35 interleukin 6 Mus musculus 44-48 11373471-7 2001 MEASUREMENTS AND MAIN RESULTS: Epinephrine and norepinephrine increased the production of IL-6 but not of IL-1alpha in normal abdominal skin, and these increases were reversed by a beta-blocker (propranolol hydrochloride) but not an alpha-blocker (phentolamine mesylate). Epinephrine 31-42 interleukin 6 Mus musculus 90-94 10780996-33 2000 These results suggest that NOS activity in the brain tonically down-regulates peripheral IL-6 by inhibiting adrenaline release from the adrenal medulla. Epinephrine 108-118 interleukin 6 Mus musculus 89-93 11239501-5 2001 Epinephrine (1 microM) also increased interleukin (IL)-6, IL-11, and cyclooxygenase (COX)-II mRNA levels, as well as increased prostaglandin E(2) (PGE(2)) accumulation in the culture medium. Epinephrine 0-11 interleukin 6 Mus musculus 38-56 10478575-0 1999 Adrenaline influences the release of interleukin-6 from murine pituicytes: role of beta2-adrenoceptors. Epinephrine 0-10 interleukin 6 Mus musculus 37-50 10478575-1 1999 In this study, we examined the effect of adrenaline and interleukin-1beta on interleukin-6 secretion from cultured murine neurohypophyseal cells. Epinephrine 41-51 interleukin 6 Mus musculus 77-90 10478575-6 1999 Incubation with adrenaline (10(-6) M) or interleukin-1beta (11 pM) induced maximal secretion of interleukin-6, resulting in a 2.2-fold and 19.8-fold increase, respectively (P<0.01). Epinephrine 16-26 interleukin 6 Mus musculus 96-109 10216531-9 1999 Epinephrine-tolerant animals had higher levels of TNF-alpha, IL-6, and IL-12 than the controls did. Epinephrine 0-11 interleukin 6 Mus musculus 61-65 10216531-10 1999 CONCLUSION: Epinephrine tolerance primes for an exaggerated release of TNF-alpha, IL-6, and IL-12 in response to lipopolysaccharide challenge, suggesting anti-inflammatory and immunosuppressive effects by epinephrine. Epinephrine 12-23 interleukin 6 Mus musculus 82-86 26895752-7 2016 Moreover, epinephrine induced a selective mobilization of IL-6-sensitive NK cells, and IL-6-blocking antibodies blunted training-induced tumor suppression, intratumoral NK cell infiltration, and NK cell activation. Epinephrine 10-21 interleukin 6 Mus musculus 58-62 29192066-0 2017 Epinephrine stimulates CXCL1 IL-1alpha, IL-6 secretion in isolated mouse limb muscle. Epinephrine 0-11 interleukin 6 Mus musculus 40-44 32388084-6 2020 In an acute mouse model of atherosclerosis, ALE suppressed TNF-alpha-induced monocyte infiltration of the vascular endothelium and the expression of genes encoding inflammatory cytokines including IL-1beta, IL-6, TNF-alpha, and MCP-1 in the mouse aorta. Epinephrine 44-47 interleukin 6 Mus musculus 207-211 26872389-3 2016 IL-6 regulation was tested in C2C12 myotubes and in soleus during treatment with epinephrine (EPI) or LPS. Epinephrine 81-92 interleukin 6 Mus musculus 0-4