PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24155262-3 2014 Epinephrine is synthesized from norepinephrine by the enzyme phenylethanolamine N-methyltransferase (PNMT) and works as an endogenous adrenoceptor ligand secreted peripherally by the adrenal medulla. Epinephrine 0-11 phenylethanolamine-N-methyltransferase Mus musculus 61-99 28084430-1 2017 In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enzyme responsible for conversion of noradrenaline to adrenaline. Epinephrine 223-233 phenylethanolamine-N-methyltransferase Mus musculus 109-147 28084430-1 2017 In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enzyme responsible for conversion of noradrenaline to adrenaline. Epinephrine 223-233 phenylethanolamine-N-methyltransferase Mus musculus 149-153 26909542-1 2016 Mice lacking the endogenous beta2-adrenoceptor (beta2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model, and chronic administration of beta2AR agonists to PNMT-KO mice restores the phenotype. Epinephrine 65-76 phenylethanolamine-N-methyltransferase Mus musculus 78-116 26909542-1 2016 Mice lacking the endogenous beta2-adrenoceptor (beta2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model, and chronic administration of beta2AR agonists to PNMT-KO mice restores the phenotype. Epinephrine 65-76 phenylethanolamine-N-methyltransferase Mus musculus 118-122 26909542-1 2016 Mice lacking the endogenous beta2-adrenoceptor (beta2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model, and chronic administration of beta2AR agonists to PNMT-KO mice restores the phenotype. Epinephrine 65-76 phenylethanolamine-N-methyltransferase Mus musculus 305-309 25161169-7 2014 Epinephrine is absent in Pnmt-KO mice. Epinephrine 0-11 phenylethanolamine-N-methyltransferase Mus musculus 25-29 24155262-3 2014 Epinephrine is synthesized from norepinephrine by the enzyme phenylethanolamine N-methyltransferase (PNMT) and works as an endogenous adrenoceptor ligand secreted peripherally by the adrenal medulla. Epinephrine 0-11 phenylethanolamine-N-methyltransferase Mus musculus 101-105 16685530-7 2006 These cells appear more mature than the scattered intracortical chromaffin progenitors and express the adrenaline synthesizing enzyme PNMT with a delay of 1 day in comparison with wildtype littermates. Epinephrine 103-113 phenylethanolamine-N-methyltransferase Mus musculus 134-138 22706789-3 2013 Specifically, we generated a reporter mouse strain in which a nuclear-localized enhanced green fluorescent protein gene (nEGFP) was inserted into exon 1 of the gene encoding Phenylethanolamine n-methyltransferase (Pnmt), the enzyme responsible for production of adrenaline from noradrenaline. Epinephrine 262-272 phenylethanolamine-N-methyltransferase Mus musculus 174-212 22706789-3 2013 Specifically, we generated a reporter mouse strain in which a nuclear-localized enhanced green fluorescent protein gene (nEGFP) was inserted into exon 1 of the gene encoding Phenylethanolamine n-methyltransferase (Pnmt), the enzyme responsible for production of adrenaline from noradrenaline. Epinephrine 262-272 phenylethanolamine-N-methyltransferase Mus musculus 214-218 20351116-7 2010 At 4 weeks post-MI, plasma levels of both norepinephrine and epinephrine were reduced in PNMT-driven GRK2 KO, compared with control mice, suggesting markedly reduced post-MI sympathetic activation. Epinephrine 45-56 phenylethanolamine-N-methyltransferase Mus musculus 89-93 19503019-2 2010 Adrenal glucocorticoid stimulates phenylethanolamine N-methyltransferase (PNMT) to convert norepinephrine to epinephrine in the adrenal medulla. Epinephrine 94-105 phenylethanolamine-N-methyltransferase Mus musculus 34-72 19503019-2 2010 Adrenal glucocorticoid stimulates phenylethanolamine N-methyltransferase (PNMT) to convert norepinephrine to epinephrine in the adrenal medulla. Epinephrine 94-105 phenylethanolamine-N-methyltransferase Mus musculus 74-78 17853069-3 2008 Also, in the adrenal glands basal levels of tyrosine hydroxylase protein, the rate-limiting enzyme for catecholamine biosynthesis, and of phenylethanolamine N-methyltransferase, which converts norepinephrine to epinephrine, were significantly reduced in nNOS KO mice. Epinephrine 196-207 phenylethanolamine-N-methyltransferase Mus musculus 138-176 19120124-2 2008 To identify when and where catecholamine-synthesizing cells are found in the embryonic heart, we developed a novel mouse genetic model by "knocking-in" the Cre-recombinase gene to the locus encoding for the epinephrine biosynthetic enzyme, phenylethanolamine n-methyltransferase. Epinephrine 207-218 phenylethanolamine-N-methyltransferase Mus musculus 240-278 19120125-1 2008 Phenylethanolamine N-methyltransferase (PNMT) catalyzes synthesis of epinephrine (E) and is present in the brain, heart, and adrenal. Epinephrine 69-80 phenylethanolamine-N-methyltransferase Mus musculus 0-38 19120125-1 2008 Phenylethanolamine N-methyltransferase (PNMT) catalyzes synthesis of epinephrine (E) and is present in the brain, heart, and adrenal. Epinephrine 69-80 phenylethanolamine-N-methyltransferase Mus musculus 40-44 17698731-0 2007 Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse. Epinephrine 0-11 phenylethanolamine-N-methyltransferase Mus musculus 77-115 17698731-3 2007 METHODS AND RESULTS: An epinephrine-deficient mouse model was generated in which the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase was knocked out (KO). Epinephrine 24-35 phenylethanolamine-N-methyltransferase Mus musculus 117-155 17196587-2 2007 Although the two lineages are closely related, only adrenergic chromaffin cells express phenylethanolamine N-methyltransferase (PNMT), the enzyme that synthesizes epinephrine, while neurons and noradrenergic chromaffin cells are PNMT-negative. Epinephrine 163-174 phenylethanolamine-N-methyltransferase Mus musculus 88-126 17196587-2 2007 Although the two lineages are closely related, only adrenergic chromaffin cells express phenylethanolamine N-methyltransferase (PNMT), the enzyme that synthesizes epinephrine, while neurons and noradrenergic chromaffin cells are PNMT-negative. Epinephrine 163-174 phenylethanolamine-N-methyltransferase Mus musculus 128-132 15369781-3 2004 In contrast, transcripts of phenylethanolamine-N-methyltransferase, the enzyme catalyzing the conversion of norepinephrine into epinephrine, were not detected in aortae in either mouse strain. Epinephrine 111-122 phenylethanolamine-N-methyltransferase Mus musculus 28-66 16643958-2 2006 Phenylethanolamine-N-methyltransferase, the enzyme catalyzing the conversion of norepinephrine into epinephrine, was not detected in either Mk -/- and WT (+/+) mouse aorta. Epinephrine 83-94 phenylethanolamine-N-methyltransferase Mus musculus 0-38 15824970-1 2005 PNMT (phenylethanolamine-N-methyl-transferase) is the enzyme that catalyzes the formation of epinephrine from norepinephrine. Epinephrine 93-104 phenylethanolamine-N-methyltransferase Mus musculus 0-4 15824970-1 2005 PNMT (phenylethanolamine-N-methyl-transferase) is the enzyme that catalyzes the formation of epinephrine from norepinephrine. Epinephrine 93-104 phenylethanolamine-N-methyltransferase Mus musculus 6-45 10357937-7 1999 However, GR mutant mice lack the adrenaline-synthesizing enzyme PNMT and secretogranin II. Epinephrine 33-43 phenylethanolamine-N-methyltransferase Mus musculus 64-68 12746566-3 2003 The expression of phenylethanolamine-N-methyltransferase (PNMT), the enzyme responsible for production of epinephrine from norepinephrine, is common to both mouse and human pheochromocytomas. Epinephrine 106-117 phenylethanolamine-N-methyltransferase Mus musculus 18-56 12746566-3 2003 The expression of phenylethanolamine-N-methyltransferase (PNMT), the enzyme responsible for production of epinephrine from norepinephrine, is common to both mouse and human pheochromocytomas. Epinephrine 106-117 phenylethanolamine-N-methyltransferase Mus musculus 58-62 12591599-6 2003 However, adrenaline levels and numbers of chromaffin cells immunoreactive for the adrenaline synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) are reduced by about 30% in c-Ret-deficient mice arguing for a direct or indirect role of c-Ret in the regulation of PNMT. Epinephrine 82-92 phenylethanolamine-N-methyltransferase Mus musculus 113-151 12591599-6 2003 However, adrenaline levels and numbers of chromaffin cells immunoreactive for the adrenaline synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) are reduced by about 30% in c-Ret-deficient mice arguing for a direct or indirect role of c-Ret in the regulation of PNMT. Epinephrine 82-92 phenylethanolamine-N-methyltransferase Mus musculus 153-157 12591599-6 2003 However, adrenaline levels and numbers of chromaffin cells immunoreactive for the adrenaline synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) are reduced by about 30% in c-Ret-deficient mice arguing for a direct or indirect role of c-Ret in the regulation of PNMT. Epinephrine 82-92 phenylethanolamine-N-methyltransferase Mus musculus 276-280 12096893-2 2002 In this study, surprisingly high levels of the epinephrine synthesizing enzyme phenylethanolamine N-methyl transferase (PNMT) were detected in the thymus of young mice. Epinephrine 47-58 phenylethanolamine-N-methyltransferase Mus musculus 79-118 12096893-2 2002 In this study, surprisingly high levels of the epinephrine synthesizing enzyme phenylethanolamine N-methyl transferase (PNMT) were detected in the thymus of young mice. Epinephrine 47-58 phenylethanolamine-N-methyltransferase Mus musculus 120-124 11089558-0 2000 Increased body fat mass and suppression of circulating leptin levels in response to hypersecretion of epinephrine in phenylethanolamine-N-methyltransferase (PNMT)-overexpressing mice. Epinephrine 102-113 phenylethanolamine-N-methyltransferase Mus musculus 117-155 11089558-0 2000 Increased body fat mass and suppression of circulating leptin levels in response to hypersecretion of epinephrine in phenylethanolamine-N-methyltransferase (PNMT)-overexpressing mice. Epinephrine 102-113 phenylethanolamine-N-methyltransferase Mus musculus 157-161 11089558-3 2000 A 100-fold overexpression of PNMT and subsequent elevation of epinephrine levels resulted in a marked suppression of circulating leptin levels in the transgenic animals (1.14 +/- 0.05 vs. 2.17 +/- 0.35 ng/ml; P < 0.01), which correlated negatively with plasma epinephrine (r = -0.82; P < 0.05), thus providing evidence for an inhibitory action of epinephrine on leptin production in vivo. Epinephrine 263-274 phenylethanolamine-N-methyltransferase Mus musculus 29-33 11089558-3 2000 A 100-fold overexpression of PNMT and subsequent elevation of epinephrine levels resulted in a marked suppression of circulating leptin levels in the transgenic animals (1.14 +/- 0.05 vs. 2.17 +/- 0.35 ng/ml; P < 0.01), which correlated negatively with plasma epinephrine (r = -0.82; P < 0.05), thus providing evidence for an inhibitory action of epinephrine on leptin production in vivo. Epinephrine 263-274 phenylethanolamine-N-methyltransferase Mus musculus 29-33 11089558-7 2000 In summary, sustained primary overproduction of epinephrine resulted in suppression of plasma leptin levels and increased lipid storage in the PNMT transgenic mice. Epinephrine 48-59 phenylethanolamine-N-methyltransferase Mus musculus 143-147 7616202-2 1995 We previously generated transgenic mice expressing phenylethanolamine N-methyltransferase (PNMT) under the control of a human dopamine beta-hydroxylase gene promoter to switch catecholamine specificity from the norepinephrine phenotype to the epinephrine phenotype. Epinephrine 214-225 phenylethanolamine-N-methyltransferase Mus musculus 51-89 7616202-2 1995 We previously generated transgenic mice expressing phenylethanolamine N-methyltransferase (PNMT) under the control of a human dopamine beta-hydroxylase gene promoter to switch catecholamine specificity from the norepinephrine phenotype to the epinephrine phenotype. Epinephrine 214-225 phenylethanolamine-N-methyltransferase Mus musculus 91-95 7616202-4 1995 In the transgenic target tissues, a high-level expression of PNMT led to a dramatic increase in the epinephrine levels, whereas the norepinephrine levels were decreased to 48.6-87.9% of the nontransgenic control levels. Epinephrine 100-111 phenylethanolamine-N-methyltransferase Mus musculus 61-65 1542654-1 1992 Epinephrine-producing cells are characterized by the presence of phenylethanolamine N-methyltransferase (PNMT), which catalyzes the formation of epinephrine from norepinephrine. Epinephrine 0-11 phenylethanolamine-N-methyltransferase Mus musculus 65-103 8000434-1 1994 We cloned and sequenced the mouse phenylethanolamine N-methyltransferase (PNMT) gene which encodes the enzyme that catalyses the conversion of norepinephrine to epinephrine. Epinephrine 146-157 phenylethanolamine-N-methyltransferase Mus musculus 34-72 8000434-1 1994 We cloned and sequenced the mouse phenylethanolamine N-methyltransferase (PNMT) gene which encodes the enzyme that catalyses the conversion of norepinephrine to epinephrine. Epinephrine 146-157 phenylethanolamine-N-methyltransferase Mus musculus 74-78 1320721-1 1992 Phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) catalyzes the conversion of norepinephrine to epinephrine, the last step of catecholamine biosynthesis. Epinephrine 90-101 phenylethanolamine-N-methyltransferase Mus musculus 0-38 1320721-1 1992 Phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) catalyzes the conversion of norepinephrine to epinephrine, the last step of catecholamine biosynthesis. Epinephrine 90-101 phenylethanolamine-N-methyltransferase Mus musculus 40-44 1542654-5 1992 These results indicate that the additional PNMT expression in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggest that norepinephrine-producing cells normally possess the basic machinery required for the synthesis of epinephrine except for PNMT. Epinephrine 65-76 phenylethanolamine-N-methyltransferase Mus musculus 43-47 1542654-5 1992 These results indicate that the additional PNMT expression in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggest that norepinephrine-producing cells normally possess the basic machinery required for the synthesis of epinephrine except for PNMT. Epinephrine 65-76 phenylethanolamine-N-methyltransferase Mus musculus 285-289 1542654-5 1992 These results indicate that the additional PNMT expression in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggest that norepinephrine-producing cells normally possess the basic machinery required for the synthesis of epinephrine except for PNMT. Epinephrine 124-135 phenylethanolamine-N-methyltransferase Mus musculus 43-47 1542654-6 1992 Thus it appears that the only major difference between norepinephrine- and epinephrine-producing cells is the expression of PNMT. Epinephrine 58-69 phenylethanolamine-N-methyltransferase Mus musculus 124-128 1542654-1 1992 Epinephrine-producing cells are characterized by the presence of phenylethanolamine N-methyltransferase (PNMT), which catalyzes the formation of epinephrine from norepinephrine. Epinephrine 0-11 phenylethanolamine-N-methyltransferase Mus musculus 105-109 1542654-1 1992 Epinephrine-producing cells are characterized by the presence of phenylethanolamine N-methyltransferase (PNMT), which catalyzes the formation of epinephrine from norepinephrine. Epinephrine 145-156 phenylethanolamine-N-methyltransferase Mus musculus 65-103 1542654-1 1992 Epinephrine-producing cells are characterized by the presence of phenylethanolamine N-methyltransferase (PNMT), which catalyzes the formation of epinephrine from norepinephrine. Epinephrine 145-156 phenylethanolamine-N-methyltransferase Mus musculus 105-109 3004732-3 1986 Immunocytochemical staining for phenylethanolamine-N-methyltransferase revealed that both epinephrine and non-epinephrine cells concentrate 1,25-dihydroxyvitamin D3 in their nuclei. Epinephrine 90-101 phenylethanolamine-N-methyltransferase Mus musculus 32-70 3540039-6 1986 Perikarya immunoreactive to the adrenaline-synthesizing enzyme PNMT were localized to a more restricted region of the VLM that extended from approximately the rostral aspect of the caudal third of the inferior olivary complex (level of the obex) to the caudal pole of the facial nucleus. Epinephrine 32-42 phenylethanolamine-N-methyltransferase Mus musculus 63-67 34480587-2 2021 Here, we reveal that deficiency of HIF (hypoxia inducible factors) prolyl hydroxylase domain protein-2 (PHD2) in the adrenal medulla of mice results in HIF2alpha-mediated reduction in phenylethanolamine N-methyltransferase (PNMT) expression, and consequent reduction in epinephrine synthesis. Epinephrine 270-281 phenylethanolamine-N-methyltransferase Mus musculus 184-222 34480587-2 2021 Here, we reveal that deficiency of HIF (hypoxia inducible factors) prolyl hydroxylase domain protein-2 (PHD2) in the adrenal medulla of mice results in HIF2alpha-mediated reduction in phenylethanolamine N-methyltransferase (PNMT) expression, and consequent reduction in epinephrine synthesis. Epinephrine 270-281 phenylethanolamine-N-methyltransferase Mus musculus 224-228 33692790-4 2021 Our results show that phenylethanol N-methyltransferase (PNMT), a rate-limiting enzyme of epinephrine synthesis, is specifically expressed in vitro in differentiated TH17 cells and in tissue-resident TH17 cells. Epinephrine 90-101 phenylethanolamine-N-methyltransferase Mus musculus 22-55 6108152-8 1980 Furthermore, in intact animals, chronic administration of SKF 64139, an inhibitor of adrenal PNMT which depletes circulating epinephrine levels, also reduced ganglionic TH activity to the same level as that after adrenalectomy. Epinephrine 125-136 phenylethanolamine-N-methyltransferase Mus musculus 93-97 33692790-4 2021 Our results show that phenylethanol N-methyltransferase (PNMT), a rate-limiting enzyme of epinephrine synthesis, is specifically expressed in vitro in differentiated TH17 cells and in tissue-resident TH17 cells. Epinephrine 90-101 phenylethanolamine-N-methyltransferase Mus musculus 57-61 33192300-4 2020 Some Pnmt-KO mice were administered with EPI or vehicle. Epinephrine 41-44 phenylethanolamine-N-methyltransferase Mus musculus 5-9 33192300-9 2020 After PTSD induction, Pnmt-KO mice administered with EPI showed an increase in freezing compared with the vehicle. Epinephrine 53-56 phenylethanolamine-N-methyltransferase Mus musculus 22-26 33192300-12 2020 Peripheral administration of EPI restored contextual traumatic memories in Pnmt-KO mice, which suggests a causal role for EPI. Epinephrine 29-32 phenylethanolamine-N-methyltransferase Mus musculus 75-79 29306449-1 2018 Adrenaline-deficient phenylethanolamine-N-methyltransferase-knockout mice (Pnmt-KO) have concentric heart remodeling and though their resting blood pressure is normal, it becomes higher during acute exercise. Epinephrine 0-10 phenylethanolamine-N-methyltransferase Mus musculus 21-59 29306449-1 2018 Adrenaline-deficient phenylethanolamine-N-methyltransferase-knockout mice (Pnmt-KO) have concentric heart remodeling and though their resting blood pressure is normal, it becomes higher during acute exercise. Epinephrine 0-10 phenylethanolamine-N-methyltransferase Mus musculus 75-79