PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11520900-4	2001	Both RGS1 and RGS16 reduced the potency of the alpha2A-adrenoreceptor agonist adrenaline by some 10-fold.	Epinephrine	78-88	adrenoceptor alpha 2A	Homo sapiens	47-69	
24723553-2	2014	The 6.3-kb variant of alpha2A-AR gene is associated with increased epinephrine-induced platelet aggregation in healthy volunteers.	Epinephrine	67-78	adrenoceptor alpha 2A	Homo sapiens	22-32	
12649300-5	2003	The capacity of the dexefaroxan analogs to antagonize the (-)-epinephrine-mediated [35S]GTP gamma S binding response at a G alpha oCys351Ile protein was inversely correlated with their magnitude of intrinsic activity and unrelated to their ligand binding affinity for the alpha 2A AR.	Epinephrine	58-73	adrenoceptor alpha 2A	Homo sapiens	272-283	
12642394-0	2003	Desensitization of alpha 2A-adrenoceptor signalling by modest levels of adrenaline is facilitated by beta 2-adrenoceptor-dependent GRK3 up-regulation.	Epinephrine	72-82	adrenoceptor alpha 2A	Homo sapiens	19-40	
24723553-11	2014	CONCLUSIONS: The 6.3-kb alpha2A-AR variant is associated with increased platelet reactivity to epinephrine and has an additive effect along with CYP2C19*2 loss-of-function allele on P2Y12-mediated platelet responses in patients with stable angina on dual antiplatelet therapy.	Epinephrine	95-106	adrenoceptor alpha 2A	Homo sapiens	24-34	
16854373-1	2006	alpha2A adrenergic receptor (ADRA2A) on platelets interacts with epinephrine, which has a key role in regulating platelet functions.	Epinephrine	65-76	adrenoceptor alpha 2A	Homo sapiens	0-27	
16854373-1	2006	alpha2A adrenergic receptor (ADRA2A) on platelets interacts with epinephrine, which has a key role in regulating platelet functions.	Epinephrine	65-76	adrenoceptor alpha 2A	Homo sapiens	29-35	
7903535-10	1993	These results indicate that epinephrine stimulates high-affinity GTPase activity of G proteins (putatively Gi2), which are also coupled with thrombin receptors, in a Mg(2+)-dependent and stereospecific manner, via alpha 2A-adrenergic receptor activation in human platelet membrane preparations.	Epinephrine	28-39	adrenoceptor alpha 2A	Homo sapiens	214-242	
11306720-0	2001	Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine.	Epinephrine	81-92	adrenoceptor alpha 2A	Homo sapiens	41-63	
10640303-4	2000	The basal [(35)S]GTPgammaS binding response displayed a constitutive alpha(2A)-AR activity that amounted to 21% of the maximal receptor activation as obtained with 10 microM (-)-adrenaline.	Epinephrine	174-188	adrenoceptor alpha 2A	Homo sapiens	69-81	
10622745-1	1999	The quantitative effects of an Asp79Asn mutation in the porcine alpha2A-adrenoceptor on adrenaline-mediated stimulation of the alpha subunit of individual members of the Gi family of G proteins were assessed by measuring GTP turnover number for fusion proteins between the wild type or mutated receptor and pertussis toxin-resistant forms of each of Gi1, Gi2 and Gi3.	Epinephrine	88-98	adrenoceptor alpha 2A	Homo sapiens	64-84	
9313925-2	1997	In this study we have compared the abilities of the enantiomers of the structural isomers of the phenolamines, octopamine and synephrine, and the catecholamines, noradrenaline and adrenaline, to couple selectively a human cloned alpha 2A-adrenoceptor, stably expressed in a Chinese hamster ovary (CHO) cell line, to G-protein linked second messenger pathways mediating an increase and a decrease in cyclic AMP production.	Epinephrine	165-175	adrenoceptor alpha 2A	Homo sapiens	229-250	
7530955-5	1995	HEL membranes also bound [3H]idazoxan in the presence of adrenaline to block alpha 2-adrenoceptors.	Epinephrine	57-67	adrenoceptor alpha 2A	Homo sapiens	77-98	
8075868-7	1994	Cross-desensitization experiments with neuropeptide Y, adrenaline and moxonidine demonstrated the presence of homologous (both receptors) and heterologous desensitization (neuropeptide Y receptors only), and that the alpha 2A-adrenoceptor desensitization was not specific for phenylethylamine (adrenaline) or imidazoline agonists (moxonidine).	Epinephrine	294-304	adrenoceptor alpha 2A	Homo sapiens	217-238	
7910371-10	1994	Overall, the rank order of efficacy of these agonists to elicit stimulation of adenylyl cyclase activity by alpha 2C10 was epinephrine = norepinephrine = UK-14304 > BHT-933 > BHT-920 > oxymetazoline.	Epinephrine	123-134	adrenoceptor alpha 2A	Homo sapiens	108-118	
9843377-2	1998	In transfected CHO cells expressing the human alpha2AAR, a 40.1 +/- 3.3% downregulation of Galphai2 protein occurred after 24 h of exposure of the cells to epinephrine, which was not accompanied by a decrease in Galphai2 mRNA.	Epinephrine	156-167	adrenoceptor alpha 2A	Homo sapiens	46-55	
9645466-3	1998	The alpha2A-adrenoceptor-wild type Gi1alpha fusion protein produced substantially higher maximal stimulation of GTPase activity in response to adrenaline than that containing Gly351 Gi1alpha.	Epinephrine	143-153	adrenoceptor alpha 2A	Homo sapiens	4-24	
7908287-4	1994	When Chinese hamster ovary cells stably expressing each of the three receptor genes were incubated with epinephrine for 20 min, a marked decrease in sensitivity to subsequent agonist-mediated inhibition of adenylyl cyclase was observed for the alpha 2-C10 and alpha 2-C2 receptors but not for the alpha 2-C4 receptors.	Epinephrine	104-115	adrenoceptor alpha 2A	Homo sapiens	244-255	
7908287-5	1994	When similar incubations were performed with 32Pi-labeled cells and the receptors were immunoprecipitated with specific antibodies, alpha 2-C10 and alpha 2-C2 receptors were found to undergo an approximately 3-fold increase in receptor phosphorylation after epinephrine exposure.	Epinephrine	258-269	adrenoceptor alpha 2A	Homo sapiens	132-143	
1334095-5	1992	After 30 min of agonist exposure, alpha 2C10 and alpha 2C2 displayed desensitization characterized by rightward shifts in the curves for epinephrine-mediated inhibition of adenylyl cyclase (EC50 = alpha 2C10, 0.24 +/- 0.02 microM increasing to 1.1 +/- 0.1 microM; alpha 2C2, 1.3 +/- 0.3 increasing to 2.6 +/- 0.3 microM).	Epinephrine	137-148	adrenoceptor alpha 2A	Homo sapiens	34-44	
1311318-3	1992	After cells were exposed to epinephrine for 30 min, the ability of the wild type alpha 2AAR to mediate inhibition of forskolin-stimulated adenylyl cyclase was depressed by approximately 78%.	Epinephrine	28-39	adrenoceptor alpha 2A	Homo sapiens	81-91	
35245122-1	2022	The alpha2A adrenergic receptor (alpha2AAR) is a G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor that mediates important physiological functions in response to the endogenous neurotransmitters norepinephrine and epinephrine, as well as numerous chemically distinct drugs.	Epinephrine	243-254	adrenoceptor alpha 2A	Homo sapiens	4-31	
35245122-1	2022	The alpha2A adrenergic receptor (alpha2AAR) is a G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor that mediates important physiological functions in response to the endogenous neurotransmitters norepinephrine and epinephrine, as well as numerous chemically distinct drugs.	Epinephrine	243-254	adrenoceptor alpha 2A	Homo sapiens	33-42