PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16426068-0	2006	A two model receptor system of the alpha1D adrenergic receptor to describe interactions with epinephrine and BMY7378.	Epinephrine	93-104	adrenoceptor alpha 1D	Homo sapiens	35-62	
17114981-0	2006	Simultaneous blockade of alpha1- and beta-actions of epinephrine during cardiopulmonary resuscitation.	Epinephrine	53-64	adrenoceptor alpha 1D	Homo sapiens	25-41	
17114981-1	2006	OBJECTIVE: Experimental and clinical studies have implicated that alpha1- and beta-adrenergic effects of epinephrine significantly increased the severity of postresuscitation myocardial dysfunction by increasing myocardial oxygen consumption during ventricular fibrillation.	Epinephrine	105-116	adrenoceptor alpha 1D	Homo sapiens	66-72	
17114981-2	2006	This prompted experimental studies to investigate the effect of simultaneous blockade of alpha1- and beta-actions of epinephrine during cardiopulmonary resuscitation.	Epinephrine	117-128	adrenoceptor alpha 1D	Homo sapiens	89-105	
17114981-4	2006	RESULTS: Improved postresuscitation myocardial dysfunction was observed in epinephrine-treated animals after its alpha1- and beta-actions were blocked, which were associated with less postresuscitation arrhythmia, lower blood lactate level, better neurologic recovery, and longer duration of survival.	Epinephrine	75-86	adrenoceptor alpha 1D	Homo sapiens	113-129	
17114981-5	2006	CONCLUSIONS: After simultaneous alpha1- and beta-adrenergic blockade, epinephrine administered during cardiopulmonary resuscitation yielded improved postresuscitation myocardial functions and significantly better postresuscitation outcomes.	Epinephrine	70-81	adrenoceptor alpha 1D	Homo sapiens	32-48	
30419287-1	2019	The human alpha1D-adrenergic receptor is a seven transmembrane-domain protein that mediates many of the physiological actions of adrenaline and noradrenaline and participates in the development of hypertension and benign prostatic hyperplasia.	Epinephrine	129-139	adrenoceptor alpha 1D	Homo sapiens	10-37	
1980236-2	1990	The alpha receptor is divided into two types, alpha 1 and alpha 2, based on response to epinephrine and norepinephrine.	Epinephrine	88-99	adrenoceptor alpha 1D	Homo sapiens	46-65	
10443582-1	1999	Alpha1-adrenoceptors are one of three subfamilies of receptors (alpha1, alpha2, beta) mediating responses to adrenaline and noradrenaline.	Epinephrine	109-119	adrenoceptor alpha 1D	Homo sapiens	0-6	
10443582-1	1999	Alpha1-adrenoceptors are one of three subfamilies of receptors (alpha1, alpha2, beta) mediating responses to adrenaline and noradrenaline.	Epinephrine	109-119	adrenoceptor alpha 1D	Homo sapiens	64-70	
1347200-6	1992	The effects of l-epinephrine were not blocked by the beta-adrenergic antagonist dl-propranolol but were mimicked by the alpha 1-adrenergic agonist methoxamine.	Epinephrine	15-28	adrenoceptor alpha 1D	Homo sapiens	120-127	
1347200-7	1992	Prazosin, an alpha 1-adrenergic antagonist, and pertussis toxin (PTX) blocked the effects of l-epinephrine and methoxamine.	Epinephrine	93-106	adrenoceptor alpha 1D	Homo sapiens	13-20	
2899848-8	1988	Results of this study support the hypothesis that epinephrine and/or norepinephrine regulate the release of ACTH and vasopressin via alpha-1- and alpha-2-adrenergic receptors associated with CRF- and VP-containing somata within the PVN.	Epinephrine	50-61	adrenoceptor alpha 1D	Homo sapiens	133-141	
2154750-1	1990	The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine.	Epinephrine	224-235	adrenoceptor alpha 1D	Homo sapiens	41-77	
6147403-7	1984	The results suggest that prolonged reductions in endogenous brain epinephrine formation produce unique effects on brain norepinephrine function; these effects are regionally distinctive and are qualitatively different from the effects seen with chronic alpha-1 or alpha-2 adrenergic receptor blockade.	Epinephrine	66-77	adrenoceptor alpha 1D	Homo sapiens	253-260	
6476551-7	1984	Norepinephrine and epinephrine demonstrate activity at alpha 1, alpha 2, beta 1, and beta 2 receptor sites.	Epinephrine	3-14	adrenoceptor alpha 1D	Homo sapiens	55-91	
6142395-7	1984	On the other hand, prazosine (alpha 1-type antagonist) blocked the stimulatory effect of epinephrine and norepinephrine on AC system.	Epinephrine	89-100	adrenoceptor alpha 1D	Homo sapiens	30-37	
6121823-2	1982	Yohimbine, an alpha-2 adrenoceptor antagonist, markedly reduced epinephrine-stimulated 3H-glycerol uptake into phosphatidylinositol; while prazosin, an alpha-1 antagonist, was without effect.	Epinephrine	64-75	adrenoceptor alpha 1D	Homo sapiens	152-159