PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2572679-4 1989 The results suggest that the induced increase of adrenal TH activity, as mediated by certain drugs, results in an elevation of the plasma epinephrine level and that the adrenal dopamine content is a better indicator of the catecholamine-synthesizing capacity of the adrenal medulla than are the other catecholamines. Epinephrine 138-149 tyrosine hydroxylase Rattus norvegicus 57-59 25957836-5 2015 However, how TH is regulated by epinephrine is still unknown. Epinephrine 32-43 tyrosine hydroxylase Rattus norvegicus 13-15 6115746-6 1981 From these data, it appears that after 2 postnatal weeks, further developmental rise of TH activity in the sympathetic ganglion is an epinephrine-dependent process. Epinephrine 134-145 tyrosine hydroxylase Rattus norvegicus 88-90 20213-4 1977 While in the hypothyroid animals at 4 degrees C the concentration of adrenal catecholamines was less, the epinephrine to norepinephrine ratio was higher than at 23 degrees C. Very high TH activity with a decline in catecholamine concentration suggests that the capacity of TH had been exceeded. Epinephrine 106-117 tyrosine hydroxylase Rattus norvegicus 185-187 12423-4 1976 Principally, TH was present in neuron systems with a distribution similar to known dopamine, noradrenaline and adrenaline systems. Epinephrine 96-106 tyrosine hydroxylase Rattus norvegicus 13-15 29246838-12 2018 When the chromaffin cells were treated with nicotine in the presence of the insecticide, nicotine-elevated adrenaline production was enhanced due to facilitation of nicotine-increased TH and PNMT protein expression, and simultaneous enhancement of nicotine-elevated adrenaline secretion also took place. Epinephrine 107-117 tyrosine hydroxylase Rattus norvegicus 184-186 25957836-6 2015 In the present study, we found that epinephrine increased the expression of TH in a dose- and time-dependent manner in PC12 cells, which was inhibited by propranolol (beta-adrenergic receptor inhibitor), but not by phenoxybenzamine (alpha-adrenergic receptor inhibitor). Epinephrine 36-47 tyrosine hydroxylase Rattus norvegicus 76-78 25713330-1 2015 Acute metabolic stress such as insulin-induced hypoglycemia triggers a counterregulatory response during which the release of catecholamines (epinephrine), the activation of tyrosine hydroxylase (TH) enzyme and subsequent compensatory catecholamine biosynthesis occur in the adrenal medulla. Epinephrine 142-153 tyrosine hydroxylase Rattus norvegicus 174-194 16396986-2 2006 The blunted epinephrine responses are associated with reduced adrenomedullary tyrosine hydroxylase (TH) mRNA levels. Epinephrine 12-23 tyrosine hydroxylase Rattus norvegicus 78-98 18976638-3 2009 Emerging evidence indicates that brain noradrenergic systems contribute to the symptoms of mood disorders and may involve regulation of tyrosine hydroxylase (TH) expression, the rate-limiting enzyme in the biosynthesis of dopamine, norepinephrine and epinephrine. Epinephrine 235-246 tyrosine hydroxylase Rattus norvegicus 136-156 16396986-2 2006 The blunted epinephrine responses are associated with reduced adrenomedullary tyrosine hydroxylase (TH) mRNA levels. Epinephrine 12-23 tyrosine hydroxylase Rattus norvegicus 100-102 1671583-1 1991 The enzyme tyrosine hydroxylase catalyzes the first step in the biosynthesis of dopamine, norepinephrine, and epinephrine. Epinephrine 93-104 tyrosine hydroxylase Rattus norvegicus 11-31 10064798-2 1999 Immunolabelling for tyrosine hydroxylase (TH), dopamine beta-hydroxylase and phenylethanolamine-N-methyl transferase (PNMT) occurred in all SIF cells of the PCG, thus demonstrating the presence of all the enzymes required for adrenaline biosynthesis. Epinephrine 226-236 tyrosine hydroxylase Rattus norvegicus 20-40 7878073-9 1994 TH mRNA and TH activity in the adrenal glands were increased in the 3 cold-treated groups and these measures were correlated directly and significantly with plasma norepinephrine and epinephrine concentrations. Epinephrine 167-178 tyrosine hydroxylase Rattus norvegicus 0-2 15620421-9 2005 The PrRP immunopositive cells were double positive for tyrosine hydroxylase (TH) and for phenylethanolamine N-methyltransferase (PNMT), which indicates that PrRP may be produced in a part of the adrenaline cells in the adrenal gland. Epinephrine 195-205 tyrosine hydroxylase Rattus norvegicus 55-75 15494609-13 2005 Furthermore, impaired epinephrine counterregulation in diabetes is associated with reduced adrenal TH mRNA, whereas the additional epinephrine defect after recurrent hypoglycemia is associated with decreases in both TH and PNMT mRNA. Epinephrine 22-33 tyrosine hydroxylase Rattus norvegicus 99-101 7990274-4 1994 These results suggested that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA, which increases epinephrine and norepinephrine levels in the adrenal medulla. Epinephrine 145-156 tyrosine hydroxylase Rattus norvegicus 92-94 7990274-4 1994 These results suggested that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA, which increases epinephrine and norepinephrine levels in the adrenal medulla. Epinephrine 145-156 tyrosine hydroxylase Rattus norvegicus 120-122