PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18976638-3	2009	Emerging evidence indicates that brain noradrenergic systems contribute to the symptoms of mood disorders and may involve regulation of tyrosine hydroxylase (TH) expression, the rate-limiting enzyme in the biosynthesis of dopamine, norepinephrine and epinephrine.	Epinephrine	235-246	tyrosine hydroxylase	Rattus norvegicus	136-156	
15620421-9	2005	The PrRP immunopositive cells were double positive for tyrosine hydroxylase (TH) and for phenylethanolamine N-methyltransferase (PNMT), which indicates that PrRP may be produced in a part of the adrenaline cells in the adrenal gland.	Epinephrine	195-205	tyrosine hydroxylase	Rattus norvegicus	55-75	
16396986-2	2006	The blunted epinephrine responses are associated with reduced adrenomedullary tyrosine hydroxylase (TH) mRNA levels.	Epinephrine	12-23	tyrosine hydroxylase	Rattus norvegicus	78-98	
16396986-2	2006	The blunted epinephrine responses are associated with reduced adrenomedullary tyrosine hydroxylase (TH) mRNA levels.	Epinephrine	12-23	tyrosine hydroxylase	Rattus norvegicus	100-102	
15494609-13	2005	Furthermore, impaired epinephrine counterregulation in diabetes is associated with reduced adrenal TH mRNA, whereas the additional epinephrine defect after recurrent hypoglycemia is associated with decreases in both TH and PNMT mRNA.	Epinephrine	22-33	tyrosine hydroxylase	Rattus norvegicus	99-101	
10064798-2	1999	Immunolabelling for tyrosine hydroxylase (TH), dopamine beta-hydroxylase and phenylethanolamine-N-methyl transferase (PNMT) occurred in all SIF cells of the PCG, thus demonstrating the presence of all the enzymes required for adrenaline biosynthesis.	Epinephrine	226-236	tyrosine hydroxylase	Rattus norvegicus	20-40	
7878073-9	1994	TH mRNA and TH activity in the adrenal glands were increased in the 3 cold-treated groups and these measures were correlated directly and significantly with plasma norepinephrine and epinephrine concentrations.	Epinephrine	167-178	tyrosine hydroxylase	Rattus norvegicus	0-2	
6115746-6	1981	From these data, it appears that after 2 postnatal weeks, further developmental rise of TH activity in the sympathetic ganglion is an epinephrine-dependent process.	Epinephrine	134-145	tyrosine hydroxylase	Rattus norvegicus	88-90	
7990274-4	1994	These results suggested that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA, which increases epinephrine and norepinephrine levels in the adrenal medulla.	Epinephrine	145-156	tyrosine hydroxylase	Rattus norvegicus	92-94	
7990274-4	1994	These results suggested that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA, which increases epinephrine and norepinephrine levels in the adrenal medulla.	Epinephrine	145-156	tyrosine hydroxylase	Rattus norvegicus	120-122	
1671583-1	1991	The enzyme tyrosine hydroxylase catalyzes the first step in the biosynthesis of dopamine, norepinephrine, and epinephrine.	Epinephrine	93-104	tyrosine hydroxylase	Rattus norvegicus	11-31	
2572679-4	1989	The results suggest that the induced increase of adrenal TH activity, as mediated by certain drugs, results in an elevation of the plasma epinephrine level and that the adrenal dopamine content is a better indicator of the catecholamine-synthesizing capacity of the adrenal medulla than are the other catecholamines.	Epinephrine	138-149	tyrosine hydroxylase	Rattus norvegicus	57-59	
12423-4	1976	Principally, TH was present in neuron systems with a distribution similar to known dopamine, noradrenaline and adrenaline systems.	Epinephrine	96-106	tyrosine hydroxylase	Rattus norvegicus	13-15	
20213-4	1977	While in the hypothyroid animals at 4 degrees C the concentration of adrenal catecholamines was less, the epinephrine to norepinephrine ratio was higher than at 23 degrees C. Very high TH activity with a decline in catecholamine concentration suggests that the capacity of TH had been exceeded.	Epinephrine	106-117	tyrosine hydroxylase	Rattus norvegicus	185-187	
25957836-5	2015	However, how TH is regulated by epinephrine is still unknown.	Epinephrine	32-43	tyrosine hydroxylase	Rattus norvegicus	13-15	
29246838-12	2018	When the chromaffin cells were treated with nicotine in the presence of the insecticide, nicotine-elevated adrenaline production was enhanced due to facilitation of nicotine-increased TH and PNMT protein expression, and simultaneous enhancement of nicotine-elevated adrenaline secretion also took place.	Epinephrine	107-117	tyrosine hydroxylase	Rattus norvegicus	184-186	
25957836-6	2015	In the present study, we found that epinephrine increased the expression of TH in a dose- and time-dependent manner in PC12 cells, which was inhibited by propranolol (beta-adrenergic receptor inhibitor), but not by phenoxybenzamine (alpha-adrenergic receptor inhibitor).	Epinephrine	36-47	tyrosine hydroxylase	Rattus norvegicus	76-78	
25713330-1	2015	Acute metabolic stress such as insulin-induced hypoglycemia triggers a counterregulatory response during which the release of catecholamines (epinephrine), the activation of tyrosine hydroxylase (TH) enzyme and subsequent compensatory catecholamine biosynthesis occur in the adrenal medulla.	Epinephrine	142-153	tyrosine hydroxylase	Rattus norvegicus	174-194