PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
202259-5	1977	In contrast with the process of electron transfer to cytochrome c, the rate of reduction of cytochrome P-450 and the rate of oxidation of adrenaline in liver microsomal fraction are correlated.	Epinephrine	138-148	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	92-108	
11805199-3	2002	Thus, in the present report, we provide evidence that measurement of adrenochrome cannot be used as an index of reactive oxygen species generated during CYP-mediated metabolism of xenobiotics because adrenochrome and its precursor, epinephrine, interact with the CYP enzyme system as substrates and inhibitors.	Epinephrine	232-243	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	153-156	
11805199-3	2002	Thus, in the present report, we provide evidence that measurement of adrenochrome cannot be used as an index of reactive oxygen species generated during CYP-mediated metabolism of xenobiotics because adrenochrome and its precursor, epinephrine, interact with the CYP enzyme system as substrates and inhibitors.	Epinephrine	232-243	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	263-266	
198028-4	1977	In contrast to the process of electron transfer on cytochrome c, there is a direct correlation between the rate of cytochrome P-450 reduction and the rate of adrenaline oxidation in liver microsomes.	Epinephrine	158-168	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	115-131	
21401511-7	2011	Moreover, the influence of the peripheral nervous system involving several neurotransmitters (acetylcholine, noradrenaline, adrenaline, dopamine, serotonin) on liver function may also be important for the physiological regulation of hepatic CYP activity.	Epinephrine	112-122	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	241-244	
11805199-1	2002	The adrenochrome reaction (oxidation of epinephrine to adrenochrome) has been widely employed as a standard assay for reactive oxygen species, produced under a variety of conditions, including those produced during cytochrome P450 (CYP)-mediated oxidation of substrates such as cyclosporine.	Epinephrine	40-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	215-230	
11805199-1	2002	The adrenochrome reaction (oxidation of epinephrine to adrenochrome) has been widely employed as a standard assay for reactive oxygen species, produced under a variety of conditions, including those produced during cytochrome P450 (CYP)-mediated oxidation of substrates such as cyclosporine.	Epinephrine	40-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	232-235