PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24799686-11 2014 In the intervention group, plasma levels of the anti-inflammatory cytokine IL-10 increased more rapidly after endotoxin administration, correlated strongly with preceding epinephrine levels, and were higher. Epinephrine 171-182 interleukin 10 Homo sapiens 75-80 28212885-3 2017 Human macrophages exposed to epinephrine and TNFalpha, or macrophages generated in 6day cultures in the presence of epinephrine, expressed high levels of COX-2, IDO and IL-10, and strongly suppressed both the proliferation and IFNgamma production of CD8+ T cells. Epinephrine 29-40 interleukin 10 Homo sapiens 169-174 25243125-6 2014 Our results showed that epinephrine pretreatment (10 ng/mL) significantly promoted immune responses from LPS stimulated macrophages, including phagocytic rate, phagocytic index, TNFalpha/IL-1beta/IL-10 secretion, and CD14 expression (P < 0.05). Epinephrine 24-35 interleukin 10 Homo sapiens 196-201 18641310-5 2008 Thus, low vs high epinephrine excretors had a 2- to 5-fold higher TNF-alpha and IL-12 production but 2-fold lower IL-10 production induced by LPS ex vivo. Epinephrine 18-29 interleukin 10 Homo sapiens 114-119 18641310-8 2008 In human monocytes, epinephrine and the beta(2) adrenoreceptor agonist fenoterol potently inhibited LPS-induced TNF-alpha and IL-12, but stimulated IL-10 production. Epinephrine 20-31 interleukin 10 Homo sapiens 148-153 16889669-6 2006 Catecholamines inhibited the synthesis of IFN-gamma, TNF-alpha, and IL-10 at a concentration of 10(-5) M. In addition, IFN-gamma release was suppressed by 10(-7) M epinephrine. Epinephrine 164-175 interleukin 10 Homo sapiens 68-73 17427275-7 2007 RESULTS: Plasma concentrations of epinephrine or dopamine prolong increased significantly 3 days after SAH, involved in elevation of plasma IL-10. Epinephrine 34-45 interleukin 10 Homo sapiens 140-145 16719987-6 2006 Acetylcholine and epinephrine contribute with IL-10 and other mediators to the anti-inflammatory compensatory response initiated to dampen the inflammatory process. Epinephrine 18-29 interleukin 10 Homo sapiens 46-51 10588509-6 1999 In blood of healthy volunteers, epinephrine reduced the LPS-stimulated synthesis of TNFalpha by 62.5% (P< 0.0001), of IL-6 by 39% (P< 0.0001), and of IL-1beta by 40% (P= 0.015), and increased the LPS-stimulated IL-10 production by 77.8% (P < 0.0001). Epinephrine 32-43 interleukin 10 Homo sapiens 217-222 15923319-6 2005 Gene expression of TNF-alpha, IL-6, and IL-10 was markedly enhanced by epinephrine in EMCV-inoculated mice. Epinephrine 71-82 interleukin 10 Homo sapiens 40-45 16463884-7 2005 Finally, we examined the impact of epinephrine infusion on blood IL-10 levels. Epinephrine 35-46 interleukin 10 Homo sapiens 65-70 16463884-10 2005 Furthermore, epinephrine infusion directly induced systemic release of IL-10. Epinephrine 13-24 interleukin 10 Homo sapiens 71-76 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Epinephrine 26-37 interleukin 10 Homo sapiens 233-238 11216955-11 2001 The TNF-alpha/IL-10 ratio correlated well with plasma epinephrine levels (r = 0.677, p = 0.025), and the level of sTNF-R2 was closely related to LV size. Epinephrine 54-65 interleukin 10 Homo sapiens 14-19 8855809-6 1996 Further, hydrocortisone reversed the increase in IL-10 concentrations by epinephrine in LPS-stimulated whole blood. Epinephrine 73-84 interleukin 10 Homo sapiens 49-54 9717082-9 1998 Finally, the combination of adrenaline and exogenous IL-10 led to a more pronounced suppression of TNF synthesis after LPS stimulation compared to suppression by IL-10 or adrenaline alone. Epinephrine 171-181 interleukin 10 Homo sapiens 53-58 9717082-10 1998 The present results suggest the role of protein kinase A activation for adrenaline-induced IL-10 synthesis in human mononuclear cells. Epinephrine 72-82 interleukin 10 Homo sapiens 91-96 9717082-11 1998 Additionally, based on the kinetic analysis and further experiments described in the literature, endogenous IL-10 could contribute to the adrenaline-induced suppression of TNF synthesis after prolonged incubation. Epinephrine 138-148 interleukin 10 Homo sapiens 108-113 9717082-0 1998 Adrenaline enhances LPS-induced IL-10 synthesis: evidence for protein kinase A-mediated pathway. Epinephrine 0-10 interleukin 10 Homo sapiens 32-37 9717082-4 1998 In this in vitro model adrenaline enhanced the LPS-induced synthesis of IL-10 with parallel suppression of TNF synthesis. Epinephrine 23-33 interleukin 10 Homo sapiens 72-77 9717082-7 1998 Simultaneous addition of adrenaline and (Rp)-cAMPS led to a reversal of IL-10 synthesis to values induced by LPS stimulation alone. Epinephrine 25-35 interleukin 10 Homo sapiens 72-77 9435641-0 1997 Epinephrine inhibits endotoxin-induced IL-1 beta production: roles of tumor necrosis factor-alpha and IL-10. Epinephrine 0-11 interleukin 10 Homo sapiens 102-107 9169777-4 1997 Epinephrine-induced upregulation of IL-10 production masked an even more pronounced stimulating effect of this hormone on IL-8 synthesis, as indicated by the finding that the extent of IL-8 upregulation was greater in the presence of anti-IL-10 than in the absence of anti-IL-10. Epinephrine 0-11 interleukin 10 Homo sapiens 36-41 9169777-4 1997 Epinephrine-induced upregulation of IL-10 production masked an even more pronounced stimulating effect of this hormone on IL-8 synthesis, as indicated by the finding that the extent of IL-8 upregulation was greater in the presence of anti-IL-10 than in the absence of anti-IL-10. Epinephrine 0-11 interleukin 10 Homo sapiens 239-244 9169777-4 1997 Epinephrine-induced upregulation of IL-10 production masked an even more pronounced stimulating effect of this hormone on IL-8 synthesis, as indicated by the finding that the extent of IL-8 upregulation was greater in the presence of anti-IL-10 than in the absence of anti-IL-10. Epinephrine 0-11 interleukin 10 Homo sapiens 239-244 8902882-5 1996 Norepinephrine and epinephrine also suppressed IL-12 production in a dose-dependent fashion and at physiological concentrations; both catecholamines, however, dose-dependently increased the production of IL-10. Epinephrine 3-14 interleukin 10 Homo sapiens 204-209 8609227-4 1996 In separate in vitro experiments in whole blood, epinephrine increased LPS-induced IL-10 release by a combined effect on alpha and beta adrenergic receptors. Epinephrine 49-60 interleukin 10 Homo sapiens 83-88 8609227-5 1996 Further, in LPS-stimulated blood, the increase on IL-10 levels caused by epinephrine only marginally contributed to concurrent inhibition of TNF production. Epinephrine 73-84 interleukin 10 Homo sapiens 50-55