PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9300318-12 1997 These results suggest that treatment of patients with primary hypertension with the beta 1-adrenoceptor blocker atenolol inhibits the adrenomedullary secretion of epinephrine, but it does not affect the biochemical indices of sympathoneural activity. Epinephrine 163-174 adrenoceptor beta 1 Homo sapiens 84-103 1685558-14 1991 Consistent with this finding, around 80% of the adenylyl cyclase stimulation by both (-)-noradrenaline and (-)-adrenaline was mediated through beta 1AR, around 20% through beta 2AR. Epinephrine 107-121 adrenoceptor beta 1 Homo sapiens 143-151 8738299-1 1996 We have reported that chronic treatment of patients with beta 1-adrenoceptor blockers sensitises isolated atrial preparations to adrenaline, noradrenaline and 5-Ht. Epinephrine 129-139 adrenoceptor beta 1 Homo sapiens 57-76 8114953-4 1993 beta 2-adrenoceptors were activated by (-)-adrenaline during beta 1-adrenoceptor blockade with 300 nmol/l CGP 20712A. Epinephrine 39-53 adrenoceptor beta 1 Homo sapiens 61-80 8102599-5 1993 Responses to (-)-epinephrine were antagonized to a variable degree by the blockers, suggesting heterogeneous contribution of beta 1AR and beta 2AR among cells. Epinephrine 13-28 adrenoceptor beta 1 Homo sapiens 125-133 8102599-8 1993 These observations suggest that both beta 1AR and beta 2AR contribute to the increase in contraction amplitude with (-)-epinephrine in this group of myocytes. Epinephrine 116-131 adrenoceptor beta 1 Homo sapiens 37-45 1282602-0 1992 Differential effect of selective beta 1 and nonselective beta-adrenoceptor blockade on epinephrine and atropine response in normal humans. Epinephrine 87-98 adrenoceptor beta 1 Homo sapiens 33-74 1685558-7 1991 In the sinoatrial pacemaker (-)-adrenaline caused positive chronotropic effects through both beta 1AR and beta 2AR while (-)-noradrenaline does so predominantly through beta 1AR. Epinephrine 28-42 adrenoceptor beta 1 Homo sapiens 93-101 1685558-8 1991 During beta 1AR blockade (-)-adrenaline did cause the same maximum effects through beta 2AR as (-)-noradrenaline did through beta 1AR. Epinephrine 25-39 adrenoceptor beta 1 Homo sapiens 7-15 1685558-8 1991 During beta 1AR blockade (-)-adrenaline did cause the same maximum effects through beta 2AR as (-)-noradrenaline did through beta 1AR. Epinephrine 25-39 adrenoceptor beta 1 Homo sapiens 125-133 1685558-10 1991 In left atria (-)-adrenaline caused positive inotropic effects predominantly through beta 1AR. Epinephrine 14-28 adrenoceptor beta 1 Homo sapiens 85-93 1685558-11 1991 CGP 20,712 A also uncovered a beta 2AR component at high (-)-adrenaline concentrations comprising one third of the maximum beta 1AR-mediated response. Epinephrine 61-71 adrenoceptor beta 1 Homo sapiens 123-131 1685558-17 1991 The positive inotropic effects of (-)-adrenaline were quite variable with regard to beta 1AR and beta 2AR in right ventricular papillary muscles. Epinephrine 34-48 adrenoceptor beta 1 Homo sapiens 84-92 1685558-22 1991 One muscle only exhibited beta 1AR-mediated effects of (-)-adrenaline whereas in the other muscle maximal effects could be elicited through beta 2AR. Epinephrine 55-69 adrenoceptor beta 1 Homo sapiens 26-34 2829863-0 1987 Adrenaline and noradrenaline increase contractile force of human ventricle through both beta 1- and beta 2-adrenoceptors. Epinephrine 0-10 adrenoceptor beta 1 Homo sapiens 88-120 1652275-1 1991 Heart rate and force can be increased by noradrenaline and adrenaline through an interaction with both beta 1-adrenoceptors (beta 1AR) and beta 2-adrenoceptors (beta 2 AR). Epinephrine 44-54 adrenoceptor beta 1 Homo sapiens 103-123 1652275-1 1991 Heart rate and force can be increased by noradrenaline and adrenaline through an interaction with both beta 1-adrenoceptors (beta 1AR) and beta 2-adrenoceptors (beta 2 AR). Epinephrine 44-54 adrenoceptor beta 1 Homo sapiens 125-133 6127782-4 1982 Plasma adrenaline levels increased significantly during selective beta-1-adrenoceptor blockade. Epinephrine 7-17 adrenoceptor beta 1 Homo sapiens 66-85 2876904-3 1986 Further pretraining injections of a variety of adrenoceptor antagonists, including selective alpha 1-, alpha 2-, beta 1- and/or beta 2-adrenoceptor antagonists, attenuated the retention enhancing effects of posttraining epinephrine. Epinephrine 220-231 adrenoceptor beta 1 Homo sapiens 93-147 232027-13 1979 If adrenaline infusion can be considered as a model for acute stress, our results seem to favour a selective beta 1-adrenoreceptor blocking agent over a non-selective one, even when the blocker is combined with a diuretic or a vasodilator. Epinephrine 3-13 adrenoceptor beta 1 Homo sapiens 109-130 33093660-3 2021 To understand the structural basis for this physiologically important selectivity, we solved the crystal structures of the human beta1AR bound to an antagonist carazolol and different agonists including norepinephrine, epinephrine and BI-167107. Epinephrine 206-217 adrenoceptor beta 1 Homo sapiens 129-136 33093660-2 2021 While the hormone epinephrine binds beta1AR and beta2AR with similar affinity, the smaller neurotransmitter norepinephrine is approximately tenfold selective for the beta1AR. Epinephrine 18-29 adrenoceptor beta 1 Homo sapiens 36-43 33372534-4 2021 In vitro evidence showed a direct interaction in ADRB1 and GRK2 and genetic depletion of GRK2 blocks epinephrine-induced upregulation of hypertrophic and fibrotic genes in cardiomyocytes. Epinephrine 101-112 adrenoceptor beta 1 Homo sapiens 49-54 33481407-17 2021 Our studies suggest that both beta1- and beta2-adrenergic receptor mediate the stabilizing effects of epinephrine and norepinephrine on the endothelial barrier. Epinephrine 102-113 adrenoceptor beta 1 Homo sapiens 30-66 33372534-8 2021 Paroxetine treatment also blocks epinephrine-induced upregulation of hypertrophic and fibrotic genes as well as ADRB1 internalization in cardiomyocytes. Epinephrine 33-44 adrenoceptor beta 1 Homo sapiens 112-117 27830686-9 2016 In glial and neuronal cells the adrenaline-evoked cAMP effect was mediated mainly by the beta1-adrenoceptor, whereas in tumor cells the effect was probably mediated by all three beta-subtype specific drugs. Epinephrine 32-42 adrenoceptor beta 1 Homo sapiens 89-107 24663151-1 2014 The beta1-adrenoceptor (beta1AR) is a G protein-coupled receptor (GPCR) that is activated by the endogenous agonists adrenaline and noradrenaline. Epinephrine 117-127 adrenoceptor beta 1 Homo sapiens 4-22 24663151-1 2014 The beta1-adrenoceptor (beta1AR) is a G protein-coupled receptor (GPCR) that is activated by the endogenous agonists adrenaline and noradrenaline. Epinephrine 117-127 adrenoceptor beta 1 Homo sapiens 24-31 17541557-4 2007 For this purpose, we assessed in 82 patients, who were preoperatively chronically treated with metoprolol, after CABG surgery with CPB, the dose and duration of adrenaline-induced inotropic support in relation to the Arg389Gly-beta(1)AR genotype. Epinephrine 161-171 adrenoceptor beta 1 Homo sapiens 227-236 22013013-12 2011 Indeed, the B1AR antagonist increased rather than decreased epinephrine release (P < 0.05). Epinephrine 60-71 adrenoceptor beta 1 Homo sapiens 12-16 21561432-8 2011 Dobutamine, a member of this group, had 70% of the adrenaline (epinephrine) effect on arrestin via beta1-AR, but acted as a competitive antagonist of adrenaline via beta2-AR. Epinephrine 51-61 adrenoceptor beta 1 Homo sapiens 99-107 21561432-8 2011 Dobutamine, a member of this group, had 70% of the adrenaline (epinephrine) effect on arrestin via beta1-AR, but acted as a competitive antagonist of adrenaline via beta2-AR. Epinephrine 63-74 adrenoceptor beta 1 Homo sapiens 99-107 15523499-1 2005 The beta-adrenergic receptors (beta-AR) are G protein-coupled receptors activated by epinephrine and norepinephrine and are involved in a variety of their physiological functions. Epinephrine 85-96 adrenoceptor beta 1 Homo sapiens 31-38 15908512-7 2005 In the presence of alphaAR blockade, concentration-response curves for isoproterenol, norepinephrine, and epinephrine suggested that a beta1AR was involved in this response, and the rank order of potency was isoproterenol > norepinephrine = epinephrine. Epinephrine 89-100 adrenoceptor beta 1 Homo sapiens 135-142 15908512-7 2005 In the presence of alphaAR blockade, concentration-response curves for isoproterenol, norepinephrine, and epinephrine suggested that a beta1AR was involved in this response, and the rank order of potency was isoproterenol > norepinephrine = epinephrine. Epinephrine 106-117 adrenoceptor beta 1 Homo sapiens 135-142 11163531-9 2001 These observations suggest that epinephrine via beta(1)-adrenoceptor activation causes superoxide anion generation, and the superoxide subsequently upregulates the endogenous antioxidant species SOD. Epinephrine 32-43 adrenoceptor beta 1 Homo sapiens 48-68 12351677-7 2002 We find that the predicted structure of beta1-adrenergic receptor leads to a binding site for epinephrine that agrees well with the mutation experiments. Epinephrine 94-105 adrenoceptor beta 1 Homo sapiens 40-65 9884381-10 1999 CONCLUSIONS: Norepinephrine and epinephrine hasten human ventricular relaxation and promote phosphorylation of implicated proteins through both beta1- and beta2-adrenergic receptors, thereby potentially improving diastolic function. Epinephrine 16-27 adrenoceptor beta 1 Homo sapiens 144-181