PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33526157-3 2021 The minor allele of various FADS single nucleotide polymorphisms (SNPs) have been associated with increased maternal concentrations of the precursors linoleic acid (LA) and alpha-linolenic acid (ALA), and lower concentrations of arachidonic acid (AA) and docosahexaenoic acid (DHA). Docosahexaenoic Acids 255-275 stearoyl-CoA desaturase Homo sapiens 28-32 33509958-6 2021 This gene-nutrient interaction on incident asthma was replicated in BAMSE.In children with a common FADS variant, higher intake of EPA and DHA from fish in childhood was strongly associated with a lower risk of incident asthma up to mid-adolescence. Docosahexaenoic Acids 139-142 stearoyl-CoA desaturase Homo sapiens 100-104 33526157-3 2021 The minor allele of various FADS single nucleotide polymorphisms (SNPs) have been associated with increased maternal concentrations of the precursors linoleic acid (LA) and alpha-linolenic acid (ALA), and lower concentrations of arachidonic acid (AA) and docosahexaenoic acid (DHA). Docosahexaenoic Acids 277-280 stearoyl-CoA desaturase Homo sapiens 28-32 21570480-9 2011 In the presence of SC or IAB fat, the combination of PA with either DHA or LA decreased SCD1 and increased AMPKalpha2 mRNA. Docosahexaenoic Acids 68-71 stearoyl-CoA desaturase Homo sapiens 88-92 30871048-1 2019 Polymorphisms in the fatty acid desaturase (FADS) genes influence the arachidonic (AA) and docosahexaenoic (DHA) acid concentrations (crucial in early life). Docosahexaenoic Acids 108-117 stearoyl-CoA desaturase Homo sapiens 21-42 30871048-1 2019 Polymorphisms in the fatty acid desaturase (FADS) genes influence the arachidonic (AA) and docosahexaenoic (DHA) acid concentrations (crucial in early life). Docosahexaenoic Acids 108-117 stearoyl-CoA desaturase Homo sapiens 44-48 25660172-2 2015 The effects of cod liver oil supplementation on SCD activity, as estimated by the palmitoleate/palmitate ratio, depended on the docosahexaenoic acid (DHA) contents at baseline. Docosahexaenoic Acids 128-148 stearoyl-CoA desaturase Homo sapiens 48-51 25660172-2 2015 The effects of cod liver oil supplementation on SCD activity, as estimated by the palmitoleate/palmitate ratio, depended on the docosahexaenoic acid (DHA) contents at baseline. Docosahexaenoic Acids 150-153 stearoyl-CoA desaturase Homo sapiens 48-51 25660172-3 2015 Baseline DHA contents were negatively correlated with baseline SCD activity. Docosahexaenoic Acids 9-12 stearoyl-CoA desaturase Homo sapiens 63-66 25660172-4 2015 After the treatment, baseline DHA contents were found to be significantly associated with the reduction of SCD activity. Docosahexaenoic Acids 30-33 stearoyl-CoA desaturase Homo sapiens 107-110 25264165-6 2014 Polyunsaturated docosahexaenoic acid (DHA, C22:6), eicosapentaenoic acid (EPA, C20:5) and arachidonic acid (AA, C20:4) were able to reduce SREBP-1 binding to SCD1 promoter, while saturated stearic acid (SA, C18:0) did not give any effect. Docosahexaenoic Acids 38-41 stearoyl-CoA desaturase Homo sapiens 158-162 31943072-2 2020 The fatty acid desaturase (FADS) genes also influence PUFA status, with the FADS genes controlling how much product (eg, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid) is metabolized from the precursor molecules linoleic acid and alpha-linolenic acid. Docosahexaenoic Acids 166-186 stearoyl-CoA desaturase Homo sapiens 4-25 31943072-2 2020 The fatty acid desaturase (FADS) genes also influence PUFA status, with the FADS genes controlling how much product (eg, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid) is metabolized from the precursor molecules linoleic acid and alpha-linolenic acid. Docosahexaenoic Acids 166-186 stearoyl-CoA desaturase Homo sapiens 27-31 31943072-2 2020 The fatty acid desaturase (FADS) genes also influence PUFA status, with the FADS genes controlling how much product (eg, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid) is metabolized from the precursor molecules linoleic acid and alpha-linolenic acid. Docosahexaenoic Acids 166-186 stearoyl-CoA desaturase Homo sapiens 76-80 31050749-3 2019 OBJECTIVE: The aim of this study was to explore the associations between plasma concentrations of total, LDL, and HDL cholesterol and TGs in infants and 2 single nucleotide polymorphisms (SNPs) in the fatty acid desaturase genes (FADS) oppositely associated with docosahexaenoic acid (rs1535 and rs174448) and potential effect modification by a functional peroxisome proliferator-activated receptor-gamma2 gene variant (PPARG2 Pro12Ala). Docosahexaenoic Acids 263-283 stearoyl-CoA desaturase Homo sapiens 201-222 28515069-2 2017 One study suggested that single-nucleotide polymorphisms (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on erythrocyte LCPUFAs at 9 mo.Objective: To explore whether SNPs in FADS and elongase (ELOVL) genes were associated with school performance in a sex-specific manner, we performed a Mendelian randomization study using data from the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study with 765 Danish schoolchildren 8-11 y old.Design: Associations between selected FADS1/2 SNPs (rs1535, rs174448, and rs174468) and ELOVL5 rs2397142, whole-blood fatty acid composition, and performance in the d2 Test of Attention and a reading test were analyzed in multiple regression models including all SNPs, SNP-sex interactions, and covariates related to testing conditions.Results:FADS, rs1535 minor allele carriage associated with lower whole-blood arachidonic acid (P <= 0.002), and minor alleles of rs174448 tended to associate with lower docosahexaenoic acid (DHA) (P = 0.052). Docosahexaenoic Acids 1059-1079 stearoyl-CoA desaturase Homo sapiens 91-112 28515069-2 2017 One study suggested that single-nucleotide polymorphisms (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on erythrocyte LCPUFAs at 9 mo.Objective: To explore whether SNPs in FADS and elongase (ELOVL) genes were associated with school performance in a sex-specific manner, we performed a Mendelian randomization study using data from the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study with 765 Danish schoolchildren 8-11 y old.Design: Associations between selected FADS1/2 SNPs (rs1535, rs174448, and rs174468) and ELOVL5 rs2397142, whole-blood fatty acid composition, and performance in the d2 Test of Attention and a reading test were analyzed in multiple regression models including all SNPs, SNP-sex interactions, and covariates related to testing conditions.Results:FADS, rs1535 minor allele carriage associated with lower whole-blood arachidonic acid (P <= 0.002), and minor alleles of rs174448 tended to associate with lower docosahexaenoic acid (DHA) (P = 0.052). Docosahexaenoic Acids 1059-1079 stearoyl-CoA desaturase Homo sapiens 114-118 28515069-2 2017 One study suggested that single-nucleotide polymorphisms (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on erythrocyte LCPUFAs at 9 mo.Objective: To explore whether SNPs in FADS and elongase (ELOVL) genes were associated with school performance in a sex-specific manner, we performed a Mendelian randomization study using data from the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study with 765 Danish schoolchildren 8-11 y old.Design: Associations between selected FADS1/2 SNPs (rs1535, rs174448, and rs174468) and ELOVL5 rs2397142, whole-blood fatty acid composition, and performance in the d2 Test of Attention and a reading test were analyzed in multiple regression models including all SNPs, SNP-sex interactions, and covariates related to testing conditions.Results:FADS, rs1535 minor allele carriage associated with lower whole-blood arachidonic acid (P <= 0.002), and minor alleles of rs174448 tended to associate with lower docosahexaenoic acid (DHA) (P = 0.052). Docosahexaenoic Acids 1081-1084 stearoyl-CoA desaturase Homo sapiens 91-112 28515069-2 2017 One study suggested that single-nucleotide polymorphisms (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on erythrocyte LCPUFAs at 9 mo.Objective: To explore whether SNPs in FADS and elongase (ELOVL) genes were associated with school performance in a sex-specific manner, we performed a Mendelian randomization study using data from the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study with 765 Danish schoolchildren 8-11 y old.Design: Associations between selected FADS1/2 SNPs (rs1535, rs174448, and rs174468) and ELOVL5 rs2397142, whole-blood fatty acid composition, and performance in the d2 Test of Attention and a reading test were analyzed in multiple regression models including all SNPs, SNP-sex interactions, and covariates related to testing conditions.Results:FADS, rs1535 minor allele carriage associated with lower whole-blood arachidonic acid (P <= 0.002), and minor alleles of rs174448 tended to associate with lower docosahexaenoic acid (DHA) (P = 0.052). Docosahexaenoic Acids 1081-1084 stearoyl-CoA desaturase Homo sapiens 114-118 24075244-0 2013 Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets. Docosahexaenoic Acids 29-49 stearoyl-CoA desaturase Homo sapiens 88-92 24075244-1 2013 Molecular regulation of fatty acid desaturase (Fads) gene expression by dietary arachidonic acid (ARA) and docosahexaenoic acid (DHA) during early post-natal period, when the demand for long chain polyunsaturated fatty acids (LC-PUFA) is very high, has not been well defined. Docosahexaenoic Acids 107-127 stearoyl-CoA desaturase Homo sapiens 47-51 24075244-1 2013 Molecular regulation of fatty acid desaturase (Fads) gene expression by dietary arachidonic acid (ARA) and docosahexaenoic acid (DHA) during early post-natal period, when the demand for long chain polyunsaturated fatty acids (LC-PUFA) is very high, has not been well defined. Docosahexaenoic Acids 129-132 stearoyl-CoA desaturase Homo sapiens 47-51 21388747-2 2011 Docosahexaenoic acid (DHA) reduces, whereas insulin augments, nuclear abundance of sterol-regulatory-element-binding-protein-1 (SREBP-1), which promotes DNL, stearoyl-CoA-desaturase (SCD, also Delta9-desaturase), fatty acid-(FA)-elongation (Elovl) and FA-desaturation (FADS). Docosahexaenoic Acids 0-20 stearoyl-CoA desaturase Homo sapiens 158-181 21388747-2 2011 Docosahexaenoic acid (DHA) reduces, whereas insulin augments, nuclear abundance of sterol-regulatory-element-binding-protein-1 (SREBP-1), which promotes DNL, stearoyl-CoA-desaturase (SCD, also Delta9-desaturase), fatty acid-(FA)-elongation (Elovl) and FA-desaturation (FADS). Docosahexaenoic Acids 0-20 stearoyl-CoA desaturase Homo sapiens 183-186 21388747-2 2011 Docosahexaenoic acid (DHA) reduces, whereas insulin augments, nuclear abundance of sterol-regulatory-element-binding-protein-1 (SREBP-1), which promotes DNL, stearoyl-CoA-desaturase (SCD, also Delta9-desaturase), fatty acid-(FA)-elongation (Elovl) and FA-desaturation (FADS). Docosahexaenoic Acids 0-20 stearoyl-CoA desaturase Homo sapiens 193-210 21388747-2 2011 Docosahexaenoic acid (DHA) reduces, whereas insulin augments, nuclear abundance of sterol-regulatory-element-binding-protein-1 (SREBP-1), which promotes DNL, stearoyl-CoA-desaturase (SCD, also Delta9-desaturase), fatty acid-(FA)-elongation (Elovl) and FA-desaturation (FADS). Docosahexaenoic Acids 22-25 stearoyl-CoA desaturase Homo sapiens 158-181 21388747-2 2011 Docosahexaenoic acid (DHA) reduces, whereas insulin augments, nuclear abundance of sterol-regulatory-element-binding-protein-1 (SREBP-1), which promotes DNL, stearoyl-CoA-desaturase (SCD, also Delta9-desaturase), fatty acid-(FA)-elongation (Elovl) and FA-desaturation (FADS). Docosahexaenoic Acids 22-25 stearoyl-CoA desaturase Homo sapiens 183-186 21388747-2 2011 Docosahexaenoic acid (DHA) reduces, whereas insulin augments, nuclear abundance of sterol-regulatory-element-binding-protein-1 (SREBP-1), which promotes DNL, stearoyl-CoA-desaturase (SCD, also Delta9-desaturase), fatty acid-(FA)-elongation (Elovl) and FA-desaturation (FADS). Docosahexaenoic Acids 22-25 stearoyl-CoA desaturase Homo sapiens 193-210 21388747-15 2011 This concurs with suppression of both SCD- and Elovl-6 activities by DHA, through its influence on SREBP. Docosahexaenoic Acids 69-72 stearoyl-CoA desaturase Homo sapiens 38-41 21366865-4 2011 New data have become available to show that FADS single nucleotide polymorphisms (SNPs) also modulate docosahexaenoic acid status in pregnancy as well as LC-PUFA levels in children and in human milk. Docosahexaenoic Acids 102-122 stearoyl-CoA desaturase Homo sapiens 44-48 21307609-8 2011 In addition, DHA content had significant negative relationships with SCD indices (SCD16; r=-0.373, p=0.0357 and SCD18; r=-0.580, p=0.0005), which correlated positively with BMI(r=0.439, p=0.0120, r=0.353, p=0.0473, respectively), but had no association with D5D or D6D. Docosahexaenoic Acids 13-16 stearoyl-CoA desaturase Homo sapiens 69-72 21307609-10 2011 Reduced DHA content was associated with increased SCD index, and might contribute to the development of metabolic syndrome. Docosahexaenoic Acids 8-11 stearoyl-CoA desaturase Homo sapiens 50-53 34201625-5 2021 Here, we discuss the role of a FADS gene-by-dietary PUFA interaction model that takes into consideration dietary exposure, including the intake of LA and ALA, n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in determining the efficacy of n-3 PUFA supplementation. Docosahexaenoic Acids 202-222 stearoyl-CoA desaturase Homo sapiens 31-35 34201625-5 2021 Here, we discuss the role of a FADS gene-by-dietary PUFA interaction model that takes into consideration dietary exposure, including the intake of LA and ALA, n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in determining the efficacy of n-3 PUFA supplementation. Docosahexaenoic Acids 224-227 stearoyl-CoA desaturase Homo sapiens 31-35 18181169-6 2008 DHA also downregulated stearoyl-CoA desaturase (SCD) and sterol regulatory element binding protein (SREBP-1) expression, while vitamin E did not affect these products. Docosahexaenoic Acids 0-3 stearoyl-CoA desaturase Homo sapiens 23-46 18181169-6 2008 DHA also downregulated stearoyl-CoA desaturase (SCD) and sterol regulatory element binding protein (SREBP-1) expression, while vitamin E did not affect these products. Docosahexaenoic Acids 0-3 stearoyl-CoA desaturase Homo sapiens 48-51