PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32581844-8	2020	EPA, DPA, and DHA co-treatment maintained cell viability, prevented PAL-induced apoptosis and attenuated PAL-induced increases in BiP, whereas only DPA prevented increases in CHOP.	Docosahexaenoic Acids	14-17	DNA damage inducible transcript 3	Homo sapiens	175-179	
31337142-5	2019	Oxaliplatin and DHA also increased the expression of Sestrin 2 (SESN2) and endoplasmic reticulum (ER) stress related C/EBP homologous protein (CHOP).	Docosahexaenoic Acids	16-19	DNA damage inducible transcript 3	Homo sapiens	117-141	
31337142-5	2019	Oxaliplatin and DHA also increased the expression of Sestrin 2 (SESN2) and endoplasmic reticulum (ER) stress related C/EBP homologous protein (CHOP).	Docosahexaenoic Acids	16-19	DNA damage inducible transcript 3	Homo sapiens	143-147	
31337142-6	2019	Additionally, treatment with Oxaliplatin and DHA enhanced the binding of CHOP to the promotor region of SESN2, increasing SESN2 expression.	Docosahexaenoic Acids	45-48	DNA damage inducible transcript 3	Homo sapiens	73-77	
30764601-8	2019	Indeed, the knockdown of C/EBP homologous protein (CHOP), a transcription factor that functions under ER stress conditions, markedly reduced DHA-mediated apoptosis, indicating that CHOP plays an essential role in the anti-cancer activity of DHA.	Docosahexaenoic Acids	141-144	DNA damage inducible transcript 3	Homo sapiens	25-49	
30764601-8	2019	Indeed, the knockdown of C/EBP homologous protein (CHOP), a transcription factor that functions under ER stress conditions, markedly reduced DHA-mediated apoptosis, indicating that CHOP plays an essential role in the anti-cancer activity of DHA.	Docosahexaenoic Acids	141-144	DNA damage inducible transcript 3	Homo sapiens	51-55	
30764601-8	2019	Indeed, the knockdown of C/EBP homologous protein (CHOP), a transcription factor that functions under ER stress conditions, markedly reduced DHA-mediated apoptosis, indicating that CHOP plays an essential role in the anti-cancer activity of DHA.	Docosahexaenoic Acids	141-144	DNA damage inducible transcript 3	Homo sapiens	181-185	
30764601-8	2019	Indeed, the knockdown of C/EBP homologous protein (CHOP), a transcription factor that functions under ER stress conditions, markedly reduced DHA-mediated apoptosis, indicating that CHOP plays an essential role in the anti-cancer activity of DHA.	Docosahexaenoic Acids	241-244	DNA damage inducible transcript 3	Homo sapiens	25-49	
30764601-8	2019	Indeed, the knockdown of C/EBP homologous protein (CHOP), a transcription factor that functions under ER stress conditions, markedly reduced DHA-mediated apoptosis, indicating that CHOP plays an essential role in the anti-cancer activity of DHA.	Docosahexaenoic Acids	241-244	DNA damage inducible transcript 3	Homo sapiens	51-55	
30764601-8	2019	Indeed, the knockdown of C/EBP homologous protein (CHOP), a transcription factor that functions under ER stress conditions, markedly reduced DHA-mediated apoptosis, indicating that CHOP plays an essential role in the anti-cancer activity of DHA.	Docosahexaenoic Acids	241-244	DNA damage inducible transcript 3	Homo sapiens	181-185	
22707267-4	2012	Chemical inhibitors of caspase-8 and -9 and small interfering RNAs (siRNAs) show DHA to induce ERS/CHOP/DR5-mediated caspase-8 and -9 dependent apoptosis.	Docosahexaenoic Acids	81-84	DNA damage inducible transcript 3	Homo sapiens	99-103	
22707267-7	2012	CONCLUSION: Data, for the first time, demonstrate that DHA induces apoptosis in TNBC cells via activation of ERS/CHOP/DR5-mediated caspase-8 and -9 dependent pro-apoptotic events, and that different forms of vitamin E exhibit distinct effects on DHA-induced apoptosis; namely, inhibition by alphaT and enhancement by gammaT3.	Docosahexaenoic Acids	55-58	DNA damage inducible transcript 3	Homo sapiens	113-117