PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22253709-6 2012 Thus, ratios of docosahexaenoic acid (DHA) to alpha linolenic acid (ALA) and the activity of fatty acid desaturase 2 (FADS2) involved in the conversion of ALA to DHA were positively associated with openness factor scores. Docosahexaenoic Acids 162-165 fatty acid desaturase 2 Homo sapiens 93-116 33530084-7 2021 In addition, genetic variants in FADS1, FADS2, ELOV-2, and ELOV-5 lead to a more efficient biosynthesis of long-chain polyunsaturated fatty acids (PUFAs), e.g., of linoleic acid (LA) to arachidonic acid (ARA), and (alpha-linolenic acid) (ALA) to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), leading to higher ARA levels. Docosahexaenoic Acids 278-298 fatty acid desaturase 2 Homo sapiens 40-45 33530084-7 2021 In addition, genetic variants in FADS1, FADS2, ELOV-2, and ELOV-5 lead to a more efficient biosynthesis of long-chain polyunsaturated fatty acids (PUFAs), e.g., of linoleic acid (LA) to arachidonic acid (ARA), and (alpha-linolenic acid) (ALA) to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), leading to higher ARA levels. Docosahexaenoic Acids 300-303 fatty acid desaturase 2 Homo sapiens 40-45 29750879-0 2018 DHA upregulates FADS2 expression in primary cortical astrocytes exposed to vitamin A. Docosahexaenoic Acids 0-3 fatty acid desaturase 2 Homo sapiens 16-21 29750879-4 2018 The study examines whether challenge of astrocytes with VA, prior 24-h treatment with palmitic acid (PA), alpha-linolenic acid (ALA) or docosahexaenoic acid (DHA) has the effect on the FADS2 expression. Docosahexaenoic Acids 136-156 fatty acid desaturase 2 Homo sapiens 185-190 29750879-4 2018 The study examines whether challenge of astrocytes with VA, prior 24-h treatment with palmitic acid (PA), alpha-linolenic acid (ALA) or docosahexaenoic acid (DHA) has the effect on the FADS2 expression. Docosahexaenoic Acids 158-161 fatty acid desaturase 2 Homo sapiens 185-190 29750879-6 2018 However, in VA-primed astrocytes, PA doubled the FADS2 mRNA levels, while DHA increased fads2 gene expression, oppositely to non-primed cells. Docosahexaenoic Acids 74-77 fatty acid desaturase 2 Homo sapiens 88-93 29750879-9 2018 These findings indicate that in the presence of vitamin A, DHA upregulates fads2 gene expression in astrocytes. Docosahexaenoic Acids 59-62 fatty acid desaturase 2 Homo sapiens 75-80 26092623-5 2015 Similarly, decreased FADS1 gene expression was paralleled by lowered arachidonic acid (20:4 n-6) and eicosapentaenoic acid (20:5 n-3) contents, while the down-regulation of FADS2 expression was accompanied by a diminished docosahexaenoic acid (22:6 n-3) content. Docosahexaenoic Acids 222-242 fatty acid desaturase 2 Homo sapiens 173-178 25573539-3 2015 Using complimentary cell, rodent and human studies we investigated the impact of anthocyanins and anthocyanin-rich foods/extracts on plasma and tissue EPA and DHA levels and on the expression of fatty acid desaturase 2 (FADS2), which represents the rate limiting enzymes in EPA and DHA synthesis. Docosahexaenoic Acids 282-285 fatty acid desaturase 2 Homo sapiens 195-218 24075244-2 2013 The objective of the current study was to determine regulation of liver Fads1, Fads2 and Fads3 classical (CS) and alternative transcripts (AT) expression by dietary ARA and DHA, within the physiological range present in human breast milk, in suckling piglets. Docosahexaenoic Acids 173-176 fatty acid desaturase 2 Homo sapiens 79-84 24075244-7 2013 Fads2 expression was down-regulated significantly in diets with 1:1 ratio of ARA:DHA, compared to MR. Fads2 AT1 expression was highly correlated to Fads2 expression. Docosahexaenoic Acids 81-84 fatty acid desaturase 2 Homo sapiens 0-5 24075244-7 2013 Fads2 expression was down-regulated significantly in diets with 1:1 ratio of ARA:DHA, compared to MR. Fads2 AT1 expression was highly correlated to Fads2 expression. Docosahexaenoic Acids 81-84 fatty acid desaturase 2 Homo sapiens 102-107 24075244-7 2013 Fads2 expression was down-regulated significantly in diets with 1:1 ratio of ARA:DHA, compared to MR. Fads2 AT1 expression was highly correlated to Fads2 expression. Docosahexaenoic Acids 81-84 fatty acid desaturase 2 Homo sapiens 102-107 24075244-9 2013 Thus, the present study provides evidence that the proportion of dietary ARA:DHA is a significant determinant of Fads2 expression and LC-PUFA metabolism during the early postnatal period. Docosahexaenoic Acids 77-80 fatty acid desaturase 2 Homo sapiens 113-118 32489952-0 2019 Docosahexaenoic Acid (DHA) Inhibits FADS2 Expression in Astrocytes but Increases Survival of Neurons Co-cultured with DHA-enriched Astrocytes. Docosahexaenoic Acids 0-20 fatty acid desaturase 2 Homo sapiens 36-41 32489952-0 2019 Docosahexaenoic Acid (DHA) Inhibits FADS2 Expression in Astrocytes but Increases Survival of Neurons Co-cultured with DHA-enriched Astrocytes. Docosahexaenoic Acids 22-25 fatty acid desaturase 2 Homo sapiens 36-41 32489952-2 2019 Astrocytes that provide structural, functional, and metabolic support for neurons, express 6- desaturase encoded by FADS2 gene that can be, next to the plasma DHA pool, additional source of DHA in the brain. Docosahexaenoic Acids 160-163 fatty acid desaturase 2 Homo sapiens 117-122 32489952-2 2019 Astrocytes that provide structural, functional, and metabolic support for neurons, express 6- desaturase encoded by FADS2 gene that can be, next to the plasma DHA pool, additional source of DHA in the brain. Docosahexaenoic Acids 191-194 fatty acid desaturase 2 Homo sapiens 117-122 32489952-8 2019 Although FADS2 mRNA was down-regulated by DHA, its level in astrocytic membranes significantly increased (P <0.01). Docosahexaenoic Acids 42-45 fatty acid desaturase 2 Homo sapiens 9-14 30368227-3 2019 Humans carrying genetic variants in the FADS2 gene have reduced levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as oxylipins, in blood, erythrocytes and white adipose tissue (WAT). Docosahexaenoic Acids 106-126 fatty acid desaturase 2 Homo sapiens 40-45 30368227-3 2019 Humans carrying genetic variants in the FADS2 gene have reduced levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as oxylipins, in blood, erythrocytes and white adipose tissue (WAT). Docosahexaenoic Acids 128-131 fatty acid desaturase 2 Homo sapiens 40-45 28186827-6 2017 EPA and DHA are also produced endogenously to a limited extent through a pathway regulated by fatty acid desaturase 1 and 2 (FADS1 and FADS2) genes. Docosahexaenoic Acids 8-11 fatty acid desaturase 2 Homo sapiens 135-140 26895389-8 2016 An index of delta-6 desaturase activity increased 30% and positively correlated with the rate of change of DHA concentration between 18 and 29 d post-LH surge (R2 adjusted = 41%; P = .0002). Docosahexaenoic Acids 107-110 fatty acid desaturase 2 Homo sapiens 12-30 26805387-12 2016 Cell culture and metabolic flux experiments, showing enhanced expression of desaturases (FADS2) and beta-oxidation enzymes after H2O2 challenge suggest that DHA production can be an initial response to oxidative stress, driven by TDP-43 aggregation and drebrin loss. Docosahexaenoic Acids 157-160 fatty acid desaturase 2 Homo sapiens 89-94 26065859-3 2015 We demonstrate here that the FADS2 gene product can directly Delta4-desaturate 22:5n-3 22:6n-3 (DHA) and 22:4n-6 22:5n-6. Docosahexaenoic Acids 96-99 fatty acid desaturase 2 Homo sapiens 29-34 24842322-2 2014 Two desaturase steps (Delta6, encoded by FADS2 and Delta5, encoded by FADS1) are rate limiting in the conversion of dietary essential 18 carbon PUFAs (18C-PUFAs) such as LA (18:2, n-6) to AA and alpha-linolenic acid (ALA, 18:3, n-3) to EPA and DHA. Docosahexaenoic Acids 244-247 fatty acid desaturase 2 Homo sapiens 41-46 24284026-3 2014 METHODS AND RESULTS: Compositional analysis of phospholipids from hearts explanted from patients with dilated cardiomyopathy revealed elevated polyunsaturated fatty acid product/precursor ratios reflective of D6D hyperactivity, manifesting primarily as lower levels of linoleic acid with reciprocally higher levels of arachidonic and docosahexaenoic acids. Docosahexaenoic Acids 334-355 fatty acid desaturase 2 Homo sapiens 209-212 22253709-6 2012 Thus, ratios of docosahexaenoic acid (DHA) to alpha linolenic acid (ALA) and the activity of fatty acid desaturase 2 (FADS2) involved in the conversion of ALA to DHA were positively associated with openness factor scores. Docosahexaenoic Acids 162-165 fatty acid desaturase 2 Homo sapiens 118-123 20395685-1 2009 AIMS: The FADS1/FADS2 gene cluster encodes Delta-5 and Delta-6 desaturase, rate-limiting enzymes in metabolism of linoleic (LA) to arachidonic (ARA) and alpha-linolenic to eicosapentaenoic and docosahexaenoic acid (DHA). Docosahexaenoic Acids 193-213 fatty acid desaturase 2 Homo sapiens 16-21 21307609-8 2011 In addition, DHA content had significant negative relationships with SCD indices (SCD16; r=-0.373, p=0.0357 and SCD18; r=-0.580, p=0.0005), which correlated positively with BMI(r=0.439, p=0.0120, r=0.353, p=0.0473, respectively), but had no association with D5D or D6D. Docosahexaenoic Acids 13-16 fatty acid desaturase 2 Homo sapiens 265-268 20335541-0 2010 FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk. Docosahexaenoic Acids 77-97 fatty acid desaturase 2 Homo sapiens 6-11 19144731-2 2009 The Delta(6)-desaturase enzyme converts ALA into EPA and DHA, and genetic variation in the Delta(6)-desaturase gene (FADS2) may affect this conversion. Docosahexaenoic Acids 57-60 fatty acid desaturase 2 Homo sapiens 4-23 19144731-2 2009 The Delta(6)-desaturase enzyme converts ALA into EPA and DHA, and genetic variation in the Delta(6)-desaturase gene (FADS2) may affect this conversion. Docosahexaenoic Acids 57-60 fatty acid desaturase 2 Homo sapiens 91-110 19144731-2 2009 The Delta(6)-desaturase enzyme converts ALA into EPA and DHA, and genetic variation in the Delta(6)-desaturase gene (FADS2) may affect this conversion. Docosahexaenoic Acids 57-60 fatty acid desaturase 2 Homo sapiens 117-122 21388747-18 2011 Maternal postpartum decreases in FADS2-, and apparent increases in FADS1-activity, together with increases in LA, AA, and 22:5omega3, but decrease in DHA, confirm that FADS2 is rate limiting in EFA-desaturation. Docosahexaenoic Acids 150-153 fatty acid desaturase 2 Homo sapiens 168-173 20413162-8 2010 Erythrocyte DHA composition was inversely correlated with indices of delta-9 desaturase activity (18:1/18:0), and associated elevations in oleic acid (18:1n-9) composition, and delta-6 desaturase activity (20:3/18:2). Docosahexaenoic Acids 12-15 fatty acid desaturase 2 Homo sapiens 177-195 20395685-1 2009 AIMS: The FADS1/FADS2 gene cluster encodes Delta-5 and Delta-6 desaturase, rate-limiting enzymes in metabolism of linoleic (LA) to arachidonic (ARA) and alpha-linolenic to eicosapentaenoic and docosahexaenoic acid (DHA). Docosahexaenoic Acids 193-213 fatty acid desaturase 2 Homo sapiens 43-73 20395685-1 2009 AIMS: The FADS1/FADS2 gene cluster encodes Delta-5 and Delta-6 desaturase, rate-limiting enzymes in metabolism of linoleic (LA) to arachidonic (ARA) and alpha-linolenic to eicosapentaenoic and docosahexaenoic acid (DHA). Docosahexaenoic Acids 215-218 fatty acid desaturase 2 Homo sapiens 16-21 20395685-1 2009 AIMS: The FADS1/FADS2 gene cluster encodes Delta-5 and Delta-6 desaturase, rate-limiting enzymes in metabolism of linoleic (LA) to arachidonic (ARA) and alpha-linolenic to eicosapentaenoic and docosahexaenoic acid (DHA). Docosahexaenoic Acids 215-218 fatty acid desaturase 2 Homo sapiens 43-73 9888202-0 1998 Loss of delta6-desaturase activity leads to impaired docosahexaenoic acid synthesis in Y-79 retinoblastoma cells. Docosahexaenoic Acids 53-73 fatty acid desaturase 2 Homo sapiens 8-25 17409318-0 2007 Competition between 24:5n-3 and ALA for Delta 6 desaturase may limit the accumulation of DHA in HepG2 cell membranes. Docosahexaenoic Acids 89-92 fatty acid desaturase 2 Homo sapiens 40-58 17409318-1 2007 The use of Delta 6 desaturase (D6D) twice in the conversion of alpha-linolenic acid (ALA; 18:3n-3) to docosahexaenoic acid (DHA; 22:6n-3) suggests that this enzyme may play a key regulatory role in the synthesis and accumulation of DHA from ALA. Docosahexaenoic Acids 102-122 fatty acid desaturase 2 Homo sapiens 11-29 17409318-1 2007 The use of Delta 6 desaturase (D6D) twice in the conversion of alpha-linolenic acid (ALA; 18:3n-3) to docosahexaenoic acid (DHA; 22:6n-3) suggests that this enzyme may play a key regulatory role in the synthesis and accumulation of DHA from ALA. Docosahexaenoic Acids 102-122 fatty acid desaturase 2 Homo sapiens 31-34 17409318-1 2007 The use of Delta 6 desaturase (D6D) twice in the conversion of alpha-linolenic acid (ALA; 18:3n-3) to docosahexaenoic acid (DHA; 22:6n-3) suggests that this enzyme may play a key regulatory role in the synthesis and accumulation of DHA from ALA. Docosahexaenoic Acids 124-127 fatty acid desaturase 2 Homo sapiens 11-29 17409318-1 2007 The use of Delta 6 desaturase (D6D) twice in the conversion of alpha-linolenic acid (ALA; 18:3n-3) to docosahexaenoic acid (DHA; 22:6n-3) suggests that this enzyme may play a key regulatory role in the synthesis and accumulation of DHA from ALA. Docosahexaenoic Acids 124-127 fatty acid desaturase 2 Homo sapiens 31-34 17409318-1 2007 The use of Delta 6 desaturase (D6D) twice in the conversion of alpha-linolenic acid (ALA; 18:3n-3) to docosahexaenoic acid (DHA; 22:6n-3) suggests that this enzyme may play a key regulatory role in the synthesis and accumulation of DHA from ALA. Docosahexaenoic Acids 232-235 fatty acid desaturase 2 Homo sapiens 11-29 17409318-1 2007 The use of Delta 6 desaturase (D6D) twice in the conversion of alpha-linolenic acid (ALA; 18:3n-3) to docosahexaenoic acid (DHA; 22:6n-3) suggests that this enzyme may play a key regulatory role in the synthesis and accumulation of DHA from ALA. Docosahexaenoic Acids 232-235 fatty acid desaturase 2 Homo sapiens 31-34 17409318-4 2007 The accumulation of the post-D6D products of 22:5n-3, 24:6n-3 and DHA, in cell phospholipids was saturated at concentrations of >18 microM ALA. Docosahexaenoic Acids 66-69 fatty acid desaturase 2 Homo sapiens 29-32 17409318-6 2007 The parallel pattern of accumulation of 24:6n-3 and DHA in response to increasing concentrations of ALA suggests that the competition between 24:5n-3 and ALA for D6D may contribute to the limited accumulation of DHA in cell membranes. Docosahexaenoic Acids 52-55 fatty acid desaturase 2 Homo sapiens 162-165 17409318-6 2007 The parallel pattern of accumulation of 24:6n-3 and DHA in response to increasing concentrations of ALA suggests that the competition between 24:5n-3 and ALA for D6D may contribute to the limited accumulation of DHA in cell membranes. Docosahexaenoic Acids 212-215 fatty acid desaturase 2 Homo sapiens 162-165 12440976-2 2002 Delta-6 Desaturase (D6D) and Delta-5 desaturase (D5D) are the key enzymes for the synthesis of highly unsaturated fatty acids (HUFAs), such as arachidonic acid (20:4, n -6) and docosahexaenoic acid (22:6, n -3), that are incorporated in phospholipids (PLs) and perform essential physiological functions. Docosahexaenoic Acids 177-197 fatty acid desaturase 2 Homo sapiens 0-18 12440976-2 2002 Delta-6 Desaturase (D6D) and Delta-5 desaturase (D5D) are the key enzymes for the synthesis of highly unsaturated fatty acids (HUFAs), such as arachidonic acid (20:4, n -6) and docosahexaenoic acid (22:6, n -3), that are incorporated in phospholipids (PLs) and perform essential physiological functions. Docosahexaenoic Acids 177-197 fatty acid desaturase 2 Homo sapiens 20-23 9888202-1 1998 We have studied the synthesis of docosahexaenoic acid (22:6 n-3) from linolenic acid (18:3 n-3) and eicosapentaenoic acid (20:5 n-3) in Y-79 human retinoblastoma cells and in a derived cell line, Y-79a, which has lost delta6-desaturase activity. Docosahexaenoic Acids 33-53 fatty acid desaturase 2 Homo sapiens 218-235 8664338-0 1996 Biosynthesis of docosahexaenoic acid in human cells: evidence that two different delta 6-desaturase activities may exist. Docosahexaenoic Acids 16-36 fatty acid desaturase 2 Homo sapiens 81-99 34543890-0 2021 Maternal FADS2 single nucleotide polymorphism modified the impact of prenatal docosahexaenoic acid (DHA) supplementation on child neurodevelopment at 5 years: Follow-up of a randomized clinical trial. Docosahexaenoic Acids 78-98 fatty acid desaturase 2 Homo sapiens 9-14 34543890-0 2021 Maternal FADS2 single nucleotide polymorphism modified the impact of prenatal docosahexaenoic acid (DHA) supplementation on child neurodevelopment at 5 years: Follow-up of a randomized clinical trial. Docosahexaenoic Acids 100-103 fatty acid desaturase 2 Homo sapiens 9-14 34543890-1 2021 BACKGROUND: Variability in the FADS2 gene, which codifies the Delta-6 Desaturases and modulates the conversion of essential n-3 and n-6 fatty acids into long-chain polyunsaturated fatty acids, might modify the impact of prenatal supplementation with n-3 docosahexaenoic acid (DHA) on neurodevelopment. Docosahexaenoic Acids 276-279 fatty acid desaturase 2 Homo sapiens 31-36 34543890-2 2021 OBJECTIVE: To assess if maternal FADS2 single nucleotide polymorphisms (SNPs) modified the effect of prenatal DHA on offspring development at 5 years. Docosahexaenoic Acids 110-113 fatty acid desaturase 2 Homo sapiens 33-38 34543890-10 2021 CONCLUSIONS: Maternal FADS2 SNP rs174602 modified the effect of prenatal DHA on cognitive development at 5 years. Docosahexaenoic Acids 73-76 fatty acid desaturase 2 Homo sapiens 22-27 34428959-4 2021 Our previous work revealed that, relative to marine fishes, several freshwater fishes evolved higher copy numbers of the fatty acid desaturase2 (Fads2) gene, which encodes essential enzymes for DHA biosynthesis, likely compensating for the limited availability of DHA in freshwater. Docosahexaenoic Acids 194-197 fatty acid desaturase 2 Homo sapiens 121-143 34428959-4 2021 Our previous work revealed that, relative to marine fishes, several freshwater fishes evolved higher copy numbers of the fatty acid desaturase2 (Fads2) gene, which encodes essential enzymes for DHA biosynthesis, likely compensating for the limited availability of DHA in freshwater. Docosahexaenoic Acids 194-197 fatty acid desaturase 2 Homo sapiens 145-150