PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15548707-7	2004	Using recombinant human enzymes, oxidation of ellipticine to 9-hydroxyellipticine and 7-hydroxyellipticine by CYP1A1/2 and to 13-hydroxyellipticine and N(2)-oxide by CYP3A4 was corroborated.	13-hydroxyellipticine	126-147	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	166-172	
15548707-8	2004	Homologue modeling and docking of ellipticine to the CYP3A4 active center was used to explain the predominance of ellipticine oxidation by CYP3A4 to 13-hydroxyellipticine and N(2)-oxide.	13-hydroxyellipticine	149-170	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	53-59	
15548707-8	2004	Homologue modeling and docking of ellipticine to the CYP3A4 active center was used to explain the predominance of ellipticine oxidation by CYP3A4 to 13-hydroxyellipticine and N(2)-oxide.	13-hydroxyellipticine	149-170	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	139-145	
22917556-4	2012	13-Hydroxyellipticine, the metabolite forming the major ellipticine-DNA adduct, was generated mainly by CYP3A4 and 1A1, followed by CYP2D6>2C19>1B1>1A2>2E1 and >2C9.	13-hydroxyellipticine	0-21	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	104-118	
22917556-9	2012	CYP3A4 and 1A1 in the presence of cytochrome b(5) are mainly responsible for bioactivation of ellipticine to DNA adduct 1 (formed by ellipticine-13-ylium from 13-hydroxyellipticine), while 12-hydroxyellipticine generated during the CYP2C19-mediated ellipticine oxidation is the predominant metabolite forming ellipticine-12-ylium that generates ellipticine-DNA adduct 2.	13-hydroxyellipticine	159-180	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-14