PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19208203-1	2009	BACKGROUND: Cytochrome P450 1B1 (CYP1B1) is active in the metabolism of estrogens to reactive catechols and of different procarcinogens.	Catechols	94-103	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	12-31	
19208203-1	2009	BACKGROUND: Cytochrome P450 1B1 (CYP1B1) is active in the metabolism of estrogens to reactive catechols and of different procarcinogens.	Catechols	94-103	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	33-39	
16985022-6	2006	Using experimentally derived rate constants for genetic variants of CYP1A1, CYP1B1, and COMT, we used the model to simulate the kinetic effect of enzyme polymorphisms on the pathway and identified those haplotypes generating the largest amounts of catechols and quinones.	Catechols	248-257	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	76-82	
28985473-3	2017	In the estrogen chemical carcinogenesis pathway, P450 1B1 metabolizes estrogens to 4-hydroxylated catechols, which are oxidized to genotoxic quinones that initiate and promote breast cancer.	Catechols	98-107	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	49-57	
19250193-6	2009	Using rate constants of genetic variants of CYP1A1, CYP1B1, and COMT, the model further allowed examination of the kinetic impact of enzyme polymorphisms on the entire metabolic pathway, including the identification of those haplotypes producing the largest amounts of catechols and quinones.	Catechols	269-278	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	52-58	
19138946-4	2008	CYP1B1 favors quinone formation by catalyzing estrogen 4-hydroxylation, whereas NAD(P)H quinone oxidoreductase 1 (NQO1) catalyzes the protective reduction of quinones to catechols.	Catechols	170-179	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-6	
12844487-1	2003	Cytochrome P450 1B1 (CYP1B1) is active in the metabolism of estrogens to reactive catechols and of different procarcinogens.	Catechols	82-91	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-19	
12844487-1	2003	Cytochrome P450 1B1 (CYP1B1) is active in the metabolism of estrogens to reactive catechols and of different procarcinogens.	Catechols	82-91	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	21-27