PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21559393-0	2011	Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells.	sagopilone	85-95	tumor protein p53	Homo sapiens	37-41	
21559393-0	2011	Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells.	sagopilone	97-103	tumor protein p53	Homo sapiens	37-41	
21559393-11	2011	In contrast, treatment of A549 cells with a low concentration of sagopilone revealed an upregulation of direct transcriptional target genes of TP53, like CDKN1A, MDM2, GADD45A, FAS.	sagopilone	65-75	tumor protein p53	Homo sapiens	143-147	
21559393-12	2011	Knockdown of TP53, which inhibited the transcriptional induction of TP53 target genes, led to a significant increase in apoptosis induction in A549 cells when treated with a low concentration of sagopilone.	sagopilone	195-205	tumor protein p53	Homo sapiens	13-17	
21559393-12	2011	Knockdown of TP53, which inhibited the transcriptional induction of TP53 target genes, led to a significant increase in apoptosis induction in A549 cells when treated with a low concentration of sagopilone.	sagopilone	195-205	tumor protein p53	Homo sapiens	68-72	
21559393-13	2011	The results indicate that activation of TP53 and its downstream effectors like CDKN1A by low concentrations of sagopilone is responsible for the relative apoptosis resistance of A549 cells and might represent a mechanism of resistance to sagopilone.	sagopilone	111-121	tumor protein p53	Homo sapiens	40-44	
21559393-13	2011	The results indicate that activation of TP53 and its downstream effectors like CDKN1A by low concentrations of sagopilone is responsible for the relative apoptosis resistance of A549 cells and might represent a mechanism of resistance to sagopilone.	sagopilone	238-248	tumor protein p53	Homo sapiens	40-44	
20179216-7	2010	Moreover, tumors with high expression of genes involved in cell adhesion/angiogenesis as well as of wild-type TP53 were more likely to be resistant to Sagopilone therapy.	sagopilone	151-161	tumor protein p53	Homo sapiens	110-114