PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27955654-11 2016 SAG is an E3 ligase that promotes ubiquitylation and degradation of PHLPP1 and DEPTOR, leading to activation of the PI3K/AKT/mTOR axis, whereas SAG knockdown caused their accumulation. sagopilone 0-3 mechanistic target of rapamycin kinase Homo sapiens 125-129 24430184-5 2014 Using cultured lung cancer cells, we showed that SAG knockdown suppressed growth and survival, inactivated both NF-kappaB and mTOR pathways, and resulted in accumulation of tumor suppressor substrates, including p21, p27, NOXA, and BIM. sagopilone 49-52 mechanistic target of rapamycin kinase Homo sapiens 126-130