PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17004712-0 2006 Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction. biarylpyrazole 0-14 cannabinoid receptor 1 Homo sapiens 51-54 17004712-1 2006 The biarylpyrazole, N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716; 1) has been shown to act as an inverse agonist/antagonist at the cannabinoid CB1 receptor. biarylpyrazole 4-18 cannabinoid receptor 1 Homo sapiens 204-207 17004712-5 2006 (1) These results suggested a relationship between biarylpyrazole interaction with K3.28(192) at CB1 and inverse agonism, but these results were for a single pair of compounds (1 and 2). biarylpyrazole 51-65 cannabinoid receptor 1 Homo sapiens 97-100 18954042-2 2008 In the present study, biarylpyrazole analogues based on a pyrazole core coupled with 1,3,4-oxadiazole were synthesized and tested for CB1 receptor binding affinity. biarylpyrazole 22-36 cannabinoid receptor 1 Homo sapiens 134-137