PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30223923-9 2018 Further studies revealed that TFA significantly inhibited iNOS and COX-2 protein levels, the phosphorylations of p38 and JNK in MAPKs pathway and IKKalpha/beta, IkappaBalpha and the expression of nuclear NF-kappaB p65 in NF-kappaB pathway in LPS-stimulated RAW 264.7 cells. Trifluoroacetic Acid 30-33 mitogen-activated protein kinase 8 Mus musculus 121-124 33091854-8 2021 Further study demonstrated that TFA repressed the phosphorylation, nuclear translocation and transcriptional activity of NFkappaB, and inhibited the activation of AKT and JNK signaling in BV-2 cells induced by LPS. Trifluoroacetic Acid 32-35 mitogen-activated protein kinase 8 Mus musculus 171-174 33091854-9 2021 The agonists of AKT and JNK, anisomycin and SC79, could partly abolish the inhibitory effect of TFA on the production of inflammatory mediators in BV-2 cells induced by LPS. Trifluoroacetic Acid 96-99 mitogen-activated protein kinase 8 Mus musculus 24-27 33091854-10 2021 CONCLUSIONS: Taken together, our results clarified that TFA inhibited microglia-mediated inflammation in EAE mice probably through deactivating JNK/AKT/NFkappaB signaling pathways. Trifluoroacetic Acid 56-59 mitogen-activated protein kinase 8 Mus musculus 144-147