PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22504157-7	2012	CES1 levels significantly correlated with hydrolysis of the CES1 substrates, clopidogrel (5 muM) and oxybutynin (10 muM), whereas CES2 levels correlated strongly with hydrolysis of the CES2 substrate, irinotecan (1 muM), indicating that quantified protein levels are highly reliable.	oxybutynin	101-111	carboxylesterase 1	Homo sapiens	0-4	
22293119-4	2012	A correlation analysis using a set of individual HLMs, in which both CESs acted independently showed that the hydrolysis rate of oxybutynin, correlated significantly with a CES1 marker reaction, clopidogrel hydrolysis, but not with a CES2 marker reaction, irinotecan (CPT-11) hydrolysis.	oxybutynin	129-139	carboxylesterase 1	Homo sapiens	173-177	
22293119-6	2012	These results strongly suggest that CES1, rather than CES2, is the principal enzyme responsible for the hydrolysis of oxybutynin in human liver.	oxybutynin	118-128	carboxylesterase 1	Homo sapiens	36-40	
18383336-1	2008	Esterified drugs such as imidapril, derapril, and oxybutynin hydrolyzed by carboxylesterase 1 (CES1) are extensively used in clinical practice.	oxybutynin	50-60	carboxylesterase 1	Homo sapiens	75-93	
18383336-1	2008	Esterified drugs such as imidapril, derapril, and oxybutynin hydrolyzed by carboxylesterase 1 (CES1) are extensively used in clinical practice.	oxybutynin	50-60	carboxylesterase 1	Homo sapiens	95-99