PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19905875-2	2010	The inactivation kinetics of CYP3A4 by diazepam dissolved in acetonitrile and methanol were almost equal with k(inact)/K(I) values, 0.095 and 0.15 min(-1) mM(-1) for HLM and 1.1 and 1.4 min(-1) mM(-1) for rCYP3A4, respectively.	acetonitrile	61-73	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	29-35	
23682612-5	2013	In this study, we investigated the effects of methanol, ethanol, acetonitrile and dimethyl sulfoxide (1% to 4%) on the assessment of km, Vmax and Clint for the metabolism of midazolam via CYP3A4 to 1-hydroxymidazolam and the metabolism of caffeine to paraxanthine via CYP1A2 using expressed enzymes in vitro.	acetonitrile	65-77	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	188-194	
19451401-6	2009	The comparatively higher inhibitory effects of DMSO relative to that for acetonitrile and methanol on LIPA metabolism were consistent with its known CYP3A4 inhibitory effects reported by others.	acetonitrile	73-85	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	149-155	
11159803-5	2001	At 2% DMSO, the activities for the four isoforms were approximately 40% (CYP2C9), 23% (CYP2C19), and 11% (CYP2E1) of that observed for 0.1% acetonitrile and 45% (CYP3A4) of that observed for 1% acetonitrile.	acetonitrile	140-152	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	162-168	
9929510-9	1999	At 1%, acetonitrile decreased activities of CYP1A1 and CYP2B6 by 40 to 60%, and inhibited CYP2A6, CYP3A4, CYP2C19, and CYP2D6 activity by 10 to 20%.	acetonitrile	7-19	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	98-104