PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1626806-1 1992 In a rat model of pulmonary hypertension induced by monocrotaline, medial hypertrophy of the pulmonary arteries is associated with enhanced production (synthesis) of insoluble elastin relative to accumulation and an increased number of elastin fragments, features suggestive of an elastolytic process. Monocrotaline 52-65 elastin Rattus norvegicus 176-183 1626806-1 1992 In a rat model of pulmonary hypertension induced by monocrotaline, medial hypertrophy of the pulmonary arteries is associated with enhanced production (synthesis) of insoluble elastin relative to accumulation and an increased number of elastin fragments, features suggestive of an elastolytic process. Monocrotaline 52-65 elastin Rattus norvegicus 236-243 2495195-1 1989 In rats injected with the toxin monocrotaline, altered synthesis and distribution of pulmonary artery elastin suggest that increased elastase activity may be important in the development of vascular changes and progressive pulmonary hypertension. Monocrotaline 32-45 elastin Rattus norvegicus 102-109 3123799-0 1988 Altered elastin and collagen synthesis associated with progressive pulmonary hypertension induced by monocrotaline. Monocrotaline 101-114 elastin Rattus norvegicus 8-15 3123799-2 1988 Changes in elastin and collagen synthesis in the pulmonary artery wall, assessed both biochemically and ultrastructurally, were related to the development of progressive pulmonary hypertension induced by the toxin monocrotaline. Monocrotaline 214-227 elastin Rattus norvegicus 11-18 3123799-8 1988 Eight days after monocrotaline injection, there was pulmonary artery endothelial swelling and a significant decrease in the number of myoendothelial junctions (p less than 0.05) associated with a decreased proportion of amorphous elastin in the media (p less than 0.01). Monocrotaline 17-30 elastin Rattus norvegicus 230-237 3123799-9 1988 Sixteen days after monocrotaline injection, a decrease in the proportion of elastin in the media was still evident (p less than 0.01) despite an apparent increase in insoluble elastin synthesis. Monocrotaline 19-32 elastin Rattus norvegicus 76-83