PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22217203-1	2012	Human leukotriene C4 synthase (hLTC4S) is an integral membrane protein that catalyzes the committed step in the biosynthesis of cysteinyl-leukotrienes, i.e., formation of leukotriene C4 (LTC4).	Leukotriene C4	6-20	leukotriene C4 synthase	Homo sapiens	31-37	
24366866-1	2014	Leukotriene (LT) C4 synthase (LTC4S) catalyzes the conjugation of the fatty acid LTA4 with the tripeptide GSH to produce LTC4, the parent compound of the cysteinyl leukotrienes, important mediators of asthma.	Leukotriene C4	30-34	leukotriene C4 synthase	Homo sapiens	0-28	
20525128-7	2008	Leukotriene C4 (LTC4) synthase is the enzyme responsible for the production of leukotriene C4, the chief cysteinyl leukotriene responsible for AEA.	Leukotriene C4	79-93	leukotriene C4 synthase	Homo sapiens	0-30	
17632546-3	2007	This intermediate is conjugated with glutathione (GSH) to produce leukotriene C4 (LTC4) in a reaction catalysed by LTC4 synthase: this reaction is the key step in cysteinyl leukotriene formation.	Leukotriene C4	66-80	leukotriene C4 synthase	Homo sapiens	115-128	
12816731-1	2003	The increased bronchial production of leukotriene C4 (LTC4) in asthma is assumed to derive from infiltrating eosinophils expressing LTC4-synthase (LTC4S).	Leukotriene C4	38-52	leukotriene C4 synthase	Homo sapiens	132-145	
12816731-1	2003	The increased bronchial production of leukotriene C4 (LTC4) in asthma is assumed to derive from infiltrating eosinophils expressing LTC4-synthase (LTC4S).	Leukotriene C4	38-52	leukotriene C4 synthase	Homo sapiens	147-152	
12589355-9	2003	Subjects were genotyped for leukotriene C(4) (LTC(4)) synthase C-to-A promoter polymorphism.	Leukotriene C4	28-41	leukotriene C4 synthase	Homo sapiens	46-62	
12023288-1	2002	Leukotriene C(4) (LTC(4)) synthase conjugates LTA(4) with GSH to form LTC(4).	Leukotriene C4	0-13	leukotriene C4 synthase	Homo sapiens	18-34	
1517222-2	1992	The specific activity of LTC4 synthase in differentiated cells (399.0 +/- 84.1 pmol of LTC4 formed.min-1.mg-1) was markedly higher (10-fold; p less than 0.001) than in undifferentiated U937 cells (39.9 +/- 16.7 pmol of LTC4 formed.min-1.mg-1) or freshly isolated blood monocytes (21.5 +/- 4.8 pmol of LTC4 formed.min-1.mg-1).	Leukotriene C4	87-91	leukotriene C4 synthase	Homo sapiens	25-38	
8425605-1	1993	Human leukotriene C4 synthase specific activity in the human monocytic leukemia cell line THP-1 (0.302 +/- 0.062 nmol LTC4 formed.min-1 x mg-1) was 7.6-fold higher than in U937 cells (0.040 +/- 0.017 nmol LTC4 formed.min-1 x mg-1) and comparable to dimethylsulfoxide-differentiated U937 cells (0.399 +/- 0.084 nmol LTC4 formed.min-1 x mg-1).	Leukotriene C4	118-122	leukotriene C4 synthase	Homo sapiens	6-29	
8425605-1	1993	Human leukotriene C4 synthase specific activity in the human monocytic leukemia cell line THP-1 (0.302 +/- 0.062 nmol LTC4 formed.min-1 x mg-1) was 7.6-fold higher than in U937 cells (0.040 +/- 0.017 nmol LTC4 formed.min-1 x mg-1) and comparable to dimethylsulfoxide-differentiated U937 cells (0.399 +/- 0.084 nmol LTC4 formed.min-1 x mg-1).	Leukotriene C4	205-209	leukotriene C4 synthase	Homo sapiens	6-29	
1517222-2	1992	The specific activity of LTC4 synthase in differentiated cells (399.0 +/- 84.1 pmol of LTC4 formed.min-1.mg-1) was markedly higher (10-fold; p less than 0.001) than in undifferentiated U937 cells (39.9 +/- 16.7 pmol of LTC4 formed.min-1.mg-1) or freshly isolated blood monocytes (21.5 +/- 4.8 pmol of LTC4 formed.min-1.mg-1).	Leukotriene C4	87-91	leukotriene C4 synthase	Homo sapiens	25-38