PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17632546-3 2007 This intermediate is conjugated with glutathione (GSH) to produce leukotriene C4 (LTC4) in a reaction catalysed by LTC4 synthase: this reaction is the key step in cysteinyl leukotriene formation. Leukotriene C4 66-80 leukotriene C4 synthase Homo sapiens 115-128 22217203-1 2012 Human leukotriene C4 synthase (hLTC4S) is an integral membrane protein that catalyzes the committed step in the biosynthesis of cysteinyl-leukotrienes, i.e., formation of leukotriene C4 (LTC4). Leukotriene C4 6-20 leukotriene C4 synthase Homo sapiens 31-37 20525128-7 2008 Leukotriene C4 (LTC4) synthase is the enzyme responsible for the production of leukotriene C4, the chief cysteinyl leukotriene responsible for AEA. Leukotriene C4 79-93 leukotriene C4 synthase Homo sapiens 0-30 12023288-1 2002 Leukotriene C(4) (LTC(4)) synthase conjugates LTA(4) with GSH to form LTC(4). Leukotriene C4 0-13 leukotriene C4 synthase Homo sapiens 18-34 8425605-1 1993 Human leukotriene C4 synthase specific activity in the human monocytic leukemia cell line THP-1 (0.302 +/- 0.062 nmol LTC4 formed.min-1 x mg-1) was 7.6-fold higher than in U937 cells (0.040 +/- 0.017 nmol LTC4 formed.min-1 x mg-1) and comparable to dimethylsulfoxide-differentiated U937 cells (0.399 +/- 0.084 nmol LTC4 formed.min-1 x mg-1). Leukotriene C4 118-122 leukotriene C4 synthase Homo sapiens 6-29 8425605-1 1993 Human leukotriene C4 synthase specific activity in the human monocytic leukemia cell line THP-1 (0.302 +/- 0.062 nmol LTC4 formed.min-1 x mg-1) was 7.6-fold higher than in U937 cells (0.040 +/- 0.017 nmol LTC4 formed.min-1 x mg-1) and comparable to dimethylsulfoxide-differentiated U937 cells (0.399 +/- 0.084 nmol LTC4 formed.min-1 x mg-1). Leukotriene C4 205-209 leukotriene C4 synthase Homo sapiens 6-29 1517222-2 1992 The specific activity of LTC4 synthase in differentiated cells (399.0 +/- 84.1 pmol of LTC4 formed.min-1.mg-1) was markedly higher (10-fold; p less than 0.001) than in undifferentiated U937 cells (39.9 +/- 16.7 pmol of LTC4 formed.min-1.mg-1) or freshly isolated blood monocytes (21.5 +/- 4.8 pmol of LTC4 formed.min-1.mg-1). Leukotriene C4 87-91 leukotriene C4 synthase Homo sapiens 25-38 1517222-2 1992 The specific activity of LTC4 synthase in differentiated cells (399.0 +/- 84.1 pmol of LTC4 formed.min-1.mg-1) was markedly higher (10-fold; p less than 0.001) than in undifferentiated U937 cells (39.9 +/- 16.7 pmol of LTC4 formed.min-1.mg-1) or freshly isolated blood monocytes (21.5 +/- 4.8 pmol of LTC4 formed.min-1.mg-1). Leukotriene C4 87-91 leukotriene C4 synthase Homo sapiens 25-38 24366866-1 2014 Leukotriene (LT) C4 synthase (LTC4S) catalyzes the conjugation of the fatty acid LTA4 with the tripeptide GSH to produce LTC4, the parent compound of the cysteinyl leukotrienes, important mediators of asthma. Leukotriene C4 30-34 leukotriene C4 synthase Homo sapiens 0-28 12816731-1 2003 The increased bronchial production of leukotriene C4 (LTC4) in asthma is assumed to derive from infiltrating eosinophils expressing LTC4-synthase (LTC4S). Leukotriene C4 38-52 leukotriene C4 synthase Homo sapiens 132-145 12816731-1 2003 The increased bronchial production of leukotriene C4 (LTC4) in asthma is assumed to derive from infiltrating eosinophils expressing LTC4-synthase (LTC4S). Leukotriene C4 38-52 leukotriene C4 synthase Homo sapiens 147-152 12589355-9 2003 Subjects were genotyped for leukotriene C(4) (LTC(4)) synthase C-to-A promoter polymorphism. Leukotriene C4 28-41 leukotriene C4 synthase Homo sapiens 46-62