PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17478601-1	2007	The exporter ABCC2 (cMOAT, MRP2) is a membrane-bound protein on the apical side of enterocytes and hepatic biliary vessels that transports leukotriene C(4), glutathione, some conjugated bile salts, drugs, xenobiotics, and phytonutrients.	Leukotriene C4	139-152	ATP binding cassette subfamily C member 2	Homo sapiens	13-18	
11901101-7	2002	Moderate inhibition of etoposide efflux by leukotriene C4 (LTC4) was observed in MDCKII-cMOAT cells.	Leukotriene C4	43-57	ATP binding cassette subfamily C member 2	Homo sapiens	88-93	
16847695-2	2007	This localization supports the function of ABCC2 in the terminal excretion and detoxification of endogenous and xenobiotic organic anions, particularly in the unidirectional efflux of substances conjugated with glutathione, glucuronate, or sulfate, as exemplified by leukotriene C(4), bilirubin glucuronosides, and some steroid sulfates.	Leukotriene C4	267-280	ATP binding cassette subfamily C member 2	Homo sapiens	43-48	
15648254-3	2004	This work characterizes effects of Pluronic P85 on ATPase activities of Pgp, MRP1, and MRP2 drug efflux transport proteins and interaction of these proteins with their substrates, vinblastine, and leucotriene C4.	Leukotriene C4	197-211	ATP binding cassette subfamily C member 2	Homo sapiens	87-91	
10760098-7	2000	The high-affinity substrate leukotriene C4 and the inhibitor of MRP-mediated transport, MK571, inhibited MRP2-mediated transport of PAH (100 nmol/L) with IC50 values of 3.3 and 4.0 micromol/L, respectively.	Leukotriene C4	28-42	ATP binding cassette subfamily C member 2	Homo sapiens	105-109	
10727523-3	2000	Both MRP1 and MRP2 actively transported leukotriene C(4) and N-ethylmaleimide glutathione (NEM-GS), although the relative affinity of MRP2 for these substrates was found to be significantly lower than that of MRP1.	Leukotriene C4	40-53	ATP binding cassette subfamily C member 2	Homo sapiens	14-18	
10727523-3	2000	Both MRP1 and MRP2 actively transported leukotriene C(4) and N-ethylmaleimide glutathione (NEM-GS), although the relative affinity of MRP2 for these substrates was found to be significantly lower than that of MRP1.	Leukotriene C4	40-53	ATP binding cassette subfamily C member 2	Homo sapiens	134-138	
10491184-5	1999	Isolated membrane vesicles from the MRP2-(His)6-expressing cells were active in ATP-dependent transport of the glutathione S-conjugate leukotriene C4 and were photoaffinity-labelled with 8-azido-[alpha-32P]ATP.	Leukotriene C4	135-149	ATP binding cassette subfamily C member 2	Homo sapiens	36-40	
11076395-5	2000	Prototypic endogenous substrates of high affinity for recombinant human MRP2 include bisglucuronosyl bilirubin, monoglucuronosyl bilirubin, and the glutathione S-conjugate leukotriene C4.	Leukotriene C4	172-186	ATP binding cassette subfamily C member 2	Homo sapiens	72-76	
10456333-0	1999	Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2).	Leukotriene C4	44-58	ATP binding cassette subfamily C member 2	Homo sapiens	125-130	
10456333-0	1999	Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2).	Leukotriene C4	44-58	ATP binding cassette subfamily C member 2	Homo sapiens	131-135	
10421658-7	1999	Leukotriene C(4) and 17beta-glucuronosyl estradiol, which are both known high-affinity substrates for human MRP2, inhibited [(3)H]MGB transport with IC(50) values of 2.3 and 30 micromol/L, respectively.	Leukotriene C4	0-13	ATP binding cassette subfamily C member 2	Homo sapiens	108-112	
10470375-5	1999	The K(m) of leukotriene C4 for MRP2 is 10-fold higher than for MRP1, and the K(m) of 17 beta-glucuronosyl estradiol is 4.8-fold higher for MRP2 than for recombinant human MRP1.	Leukotriene C4	12-26	ATP binding cassette subfamily C member 2	Homo sapiens	31-35	
10220572-7	1999	The Km value of human MRP2 was 1.0 +/- 0.1 microM for leukotriene C4 and 7.2 +/- 0.7 microM for 17beta-glucuronosyl estradiol; the Km values of human MRP1 were 0.1 +/- 0.02 microM for leukotriene C4 and 1.5 +/- 0.3 microM for 17beta-glucoronosyl estradiol.	Leukotriene C4	54-68	ATP binding cassette subfamily C member 2	Homo sapiens	22-26	
10470375-5	1999	The K(m) of leukotriene C4 for MRP2 is 10-fold higher than for MRP1, and the K(m) of 17 beta-glucuronosyl estradiol is 4.8-fold higher for MRP2 than for recombinant human MRP1.	Leukotriene C4	12-26	ATP binding cassette subfamily C member 2	Homo sapiens	139-143	
21968553-1	2011	Several studies have shown that the multidrug resistant protein MRP2 mediates the transport of chemotherapeutic drugs and normal cell metabolites, including Leukotriene C (LTC(4)); however direct binding of the LTC(4) to MRP2 has not been demonstrated.	Leukotriene C4	157-170	ATP binding cassette subfamily C member 2	Homo sapiens	64-68	
21968553-1	2011	Several studies have shown that the multidrug resistant protein MRP2 mediates the transport of chemotherapeutic drugs and normal cell metabolites, including Leukotriene C (LTC(4)); however direct binding of the LTC(4) to MRP2 has not been demonstrated.	Leukotriene C4	157-170	ATP binding cassette subfamily C member 2	Homo sapiens	221-225	
19566819-5	2010	Multidrug resistance-associated protein 1 can be distinguished from MRP2 and MRP3 by its higher affinity for leukotriene C(4).	Leukotriene C4	109-122	ATP binding cassette subfamily C member 2	Homo sapiens	68-72