PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10420360-2 1999 Transmembrane bicarbonate transport has also been associated with the recently characterised membrane-anchored isoform of carbonic anhydrase (CA IV) in various tissues. Bicarbonates 14-25 carbonic anhydrase 4 Homo sapiens 142-147 10420360-10 1999 CONCLUSION: The localisation of CA IV to the cell surface of fresh and cultured corneal endothelium suggests the presence of a membrane-bound ion exchange mechanism which may be important for HCO3- transport and corneal hydration. Bicarbonates 192-196 carbonic anhydrase 4 Homo sapiens 32-37 9523771-2 1997 They may be broadly recognized according to the efficiency with which they catalyze the reversible interconversion of CO2 and HCO3-, and they differ in physicochemical properties, in sensitivity to various inhibitors and in their subcellular localization; cytoplasmic (CA I, CA II, CA III, and CA VII), cell-surface membrane (CA IV), and mitochondrial (CA V) and secretory (CA VI) isoenzymes have been described. Bicarbonates 126-130 carbonic anhydrase 4 Homo sapiens 326-331 33596759-10 2021 These results indicate that CA IV participates in the regulation of bicarbonate/carbon dioxide fluxes in the ductal system of the human parotid gland. Bicarbonates 68-79 carbonic anhydrase 4 Homo sapiens 28-33 9054574-4 1997 Furthermore, CA IV is more active in HCO3- dehydration than is CA II as illustrated by the nearly 3-fold increase in kcat/K(M) to 3 x 10(7) M(-1) s(-1). Bicarbonates 37-41 carbonic anhydrase 4 Homo sapiens 13-18 9054574-8 1997 Additional positive charges in the active site of CA IV stabilize anions as indicated by a decreased pKa for the Zn-bound water compared to CA II (6.2 vs 6.9), as well as lower inhibition constants for a variety of anions, including halides, sulfate, formate, acetate, and bicarbonate. Bicarbonates 273-284 carbonic anhydrase 4 Homo sapiens 50-55 9054574-12 1997 The increased bicarbonate activity and altered pH profile are consistent with the proposed physiological role of CA IV in renal bicarbonate reabsorption. Bicarbonates 14-25 carbonic anhydrase 4 Homo sapiens 113-118 9054574-12 1997 The increased bicarbonate activity and altered pH profile are consistent with the proposed physiological role of CA IV in renal bicarbonate reabsorption. Bicarbonates 128-139 carbonic anhydrase 4 Homo sapiens 113-118 8903383-9 1996 The results show that CA IV is expressed in abundance in the human gallbladder epithelium, where it may participate together with cytoplasmic CA II and ion transporters in acidification of the gallbladder bile via bicarbonate reabsorption. Bicarbonates 214-225 carbonic anhydrase 4 Homo sapiens 22-27 19011010-15 2009 AE2, CAII, and CAIV are enriched in the NPE layer of the ciliary body, and their coordinated function may contribute to AH secretion by effecting bicarbonate transport into the eye. Bicarbonates 146-157 carbonic anhydrase 4 Homo sapiens 15-19 32922550-1 2020 Background: Carbonic anhydrase 4 (CA4) maintains homeostasis of carbon dioxide and bicarbonate. Bicarbonates 83-94 carbonic anhydrase 4 Homo sapiens 12-32 32922550-1 2020 Background: Carbonic anhydrase 4 (CA4) maintains homeostasis of carbon dioxide and bicarbonate. Bicarbonates 83-94 carbonic anhydrase 4 Homo sapiens 34-37 24146379-5 2014 The 35-kDa human CA IV is a "high activity" isozyme in CO2 hydration activity, like CA II, and has higher activity than other isozymes in catalyzing the dehydration of HCO3 (-). Bicarbonates 168-172 carbonic anhydrase 4 Homo sapiens 17-22 24146379-6 2014 Human CA IV is also unique in that it contains no oligosaccharide chains, where all other mammalian CA IVs are glycoproteins with one to several oligosaccharide side chains.Although CA IV has been shown to be active in mediating CO2 and HCO3 (-) transport in many important tissues like kidney and lung, and in isolated cells from brain and muscle, the gene for CA IV appears not to be essential. Bicarbonates 237-241 carbonic anhydrase 4 Homo sapiens 6-11 11994299-3 2002 To determine whether cell surface-anchored carbonic anhydrase IV (CAIV) interacts with AE proteins to accelerate the bicarbonate transport rate, AE1-mediated bicarbonate transport was monitored in transfected HEK293 cells. Bicarbonates 117-128 carbonic anhydrase 4 Homo sapiens 43-64 17409381-9 2007 The expression in Capan-1 cells of a 35-kDa CA IV anchored in the apical plasma membrane through a hydrophobic segment, as is the case in the healthy human pancreas, should make the study of its role in pancreatic HCO(3)(-) secretion easier. Bicarbonates 214-220 carbonic anhydrase 4 Homo sapiens 44-49 17652713-6 2007 Functional consequences of CA4 mutations on the NBC1-mediated bicarbonate transport were studied by measuring bicarbonate fluxes in HEK293 cells cotransfected with NBC1 and CA4 mutant cDNAs. Bicarbonates 62-73 carbonic anhydrase 4 Homo sapiens 27-30 17652713-6 2007 Functional consequences of CA4 mutations on the NBC1-mediated bicarbonate transport were studied by measuring bicarbonate fluxes in HEK293 cells cotransfected with NBC1 and CA4 mutant cDNAs. Bicarbonates 110-121 carbonic anhydrase 4 Homo sapiens 27-30 17164835-13 2007 For example, CAII on the cytoplasmic face and CAIV on the extracellular surface provide the "push" and "pull" for bicarbonate transport by supplying and dissipating substrate respectively. Bicarbonates 114-125 carbonic anhydrase 4 Homo sapiens 46-50 15956032-2 2005 Previously, we demonstrated that in pancreatic duct CFPAC-1 cells, which express DeltaF508 CFTR (cystic fibrosis transmembrane conductance regulator), the intracellular trafficking of carbonic anhydrase IV (CA IV), a membrane protein involved in HCO(3)(-) secretion, was impaired. Bicarbonates 246-252 carbonic anhydrase 4 Homo sapiens 184-205 15956032-2 2005 Previously, we demonstrated that in pancreatic duct CFPAC-1 cells, which express DeltaF508 CFTR (cystic fibrosis transmembrane conductance regulator), the intracellular trafficking of carbonic anhydrase IV (CA IV), a membrane protein involved in HCO(3)(-) secretion, was impaired. Bicarbonates 246-252 carbonic anhydrase 4 Homo sapiens 207-212 15563508-4 2005 Here, we show that a functional complex of carbonic anhydrase 4 (CA4) and Na+/bicarbonate co-transporter 1 (NBC1) is specifically expressed in the choriocapillaris and that missense mutations in CA4 linked to autosomal dominant rod-cone dystrophy disrupt NBC1-mediated HCO3- transport. Bicarbonates 269-273 carbonic anhydrase 4 Homo sapiens 43-63 15563508-4 2005 Here, we show that a functional complex of carbonic anhydrase 4 (CA4) and Na+/bicarbonate co-transporter 1 (NBC1) is specifically expressed in the choriocapillaris and that missense mutations in CA4 linked to autosomal dominant rod-cone dystrophy disrupt NBC1-mediated HCO3- transport. Bicarbonates 269-273 carbonic anhydrase 4 Homo sapiens 65-68 15563508-4 2005 Here, we show that a functional complex of carbonic anhydrase 4 (CA4) and Na+/bicarbonate co-transporter 1 (NBC1) is specifically expressed in the choriocapillaris and that missense mutations in CA4 linked to autosomal dominant rod-cone dystrophy disrupt NBC1-mediated HCO3- transport. Bicarbonates 269-273 carbonic anhydrase 4 Homo sapiens 195-198 15499994-11 2004 In summary, bicarbonate transporters directly interact with the CAII and CAIV carbonic anhydrases to increase the transmembrane bicarbonate flux. Bicarbonates 12-23 carbonic anhydrase 4 Homo sapiens 73-77 14567693-3 2003 Carbonic anhydrase IV (CAIV), which is also present in these tissues, is glycosylphosphatidyl inositol-anchored to the outer surface of the plasma membrane where it catalyzes the hydration-dehydration of CO(2)/HCO(3)(-). Bicarbonates 210-216 carbonic anhydrase 4 Homo sapiens 0-21 14567693-3 2003 Carbonic anhydrase IV (CAIV), which is also present in these tissues, is glycosylphosphatidyl inositol-anchored to the outer surface of the plasma membrane where it catalyzes the hydration-dehydration of CO(2)/HCO(3)(-). Bicarbonates 210-216 carbonic anhydrase 4 Homo sapiens 23-27 14611844-3 2003 Inhibition data of the cytosolic isozymes CA I and CA II as well as the membrane-bound isozyme CA IV with a large number of anionic species such as halides, pseudohalides, bicarbonate, nitrate, hydrosulfide, arsenate, sulfamate, and sulfamidate and so on, are also provided for comparison. Bicarbonates 172-183 carbonic anhydrase 4 Homo sapiens 95-100 12234015-1 2002 Human pancreatic duct cells secrete HCO3- ions mediated by a Cl-/HCO3- exchanger and a HCO3- channel that may be a carbonic anhydrase IV (CA IV) in a channel-like conformation. Bicarbonates 36-40 carbonic anhydrase 4 Homo sapiens 115-136 12234015-1 2002 Human pancreatic duct cells secrete HCO3- ions mediated by a Cl-/HCO3- exchanger and a HCO3- channel that may be a carbonic anhydrase IV (CA IV) in a channel-like conformation. Bicarbonates 36-40 carbonic anhydrase 4 Homo sapiens 138-143 12234015-12 2002 On the basis of these observations, we propose that the absence of CA IV in apical plasma membranes due to the impairment in targeting in cells expressing a deltaAF508 CFTR largely contributes to the disruption in HCO3- secretion in CF epithelia. Bicarbonates 214-218 carbonic anhydrase 4 Homo sapiens 67-72 11994299-3 2002 To determine whether cell surface-anchored carbonic anhydrase IV (CAIV) interacts with AE proteins to accelerate the bicarbonate transport rate, AE1-mediated bicarbonate transport was monitored in transfected HEK293 cells. Bicarbonates 117-128 carbonic anhydrase 4 Homo sapiens 66-70 11994299-9 2002 We conclude that AE1 and CAIV interact on extracellular loop 4 of AE1, forming the extracellular component of a bicarbonate transport metabolon, which accelerates the rate of AE-mediated bicarbonate transport. Bicarbonates 112-123 carbonic anhydrase 4 Homo sapiens 25-29 11994299-9 2002 We conclude that AE1 and CAIV interact on extracellular loop 4 of AE1, forming the extracellular component of a bicarbonate transport metabolon, which accelerates the rate of AE-mediated bicarbonate transport. Bicarbonates 187-198 carbonic anhydrase 4 Homo sapiens 25-29