PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12609767-1 2003 Secretin is released from upper small intestinal mucosa to drive pancreatic secretion of fluid and bicarbonate and inhibit gastric acid secretion. Bicarbonates 99-110 secretin Rattus norvegicus 0-8 25019073-11 2014 Also, secretin increased the expression of proteins (SR and CFTR) that are key in the regulating ductal secretion and enhanced secretin-stimulated cAMP levels and bile and bicarbonate secretion. Bicarbonates 172-183 secretin Rattus norvegicus 127-135 25019073-2 2014 Enhanced biliary proliferation [for example after bile duct ligation (BDL) and partial hepatectomy] is associated with increased expression of secretin receptor (SR), cystic fibrosis transmembrane conductance regulator (CFTR) and Cl(-)/HCO3 (-) anion exchanger 2 and secretin-stimulated ductal secretion, whereas loss/damage of bile ducts [for example after acute carbon tetrachloride (CCl4) administration] is associated with reduced secretin-stimulated ductal secretory activity. Bicarbonates 236-240 secretin Rattus norvegicus 143-151 25019073-11 2014 Also, secretin increased the expression of proteins (SR and CFTR) that are key in the regulating ductal secretion and enhanced secretin-stimulated cAMP levels and bile and bicarbonate secretion. Bicarbonates 172-183 secretin Rattus norvegicus 6-14 16440368-0 2006 Bicarbonate-rich choleresis induced by secretin in normal rat is taurocholate-dependent and involves AE2 anion exchanger. Bicarbonates 0-11 secretin Rattus norvegicus 39-47 16440368-2 2006 Secretin stimulates ductular cystic fibrosis transmembrane conductance regulator (CFTR)-dependent Cl- efflux and subsequent biliary HCO3- secretion, possibly via Cl-/HCO3- anion exchange (AE). Bicarbonates 132-136 secretin Rattus norvegicus 0-8 16440368-2 2006 Secretin stimulates ductular cystic fibrosis transmembrane conductance regulator (CFTR)-dependent Cl- efflux and subsequent biliary HCO3- secretion, possibly via Cl-/HCO3- anion exchange (AE). Bicarbonates 166-170 secretin Rattus norvegicus 0-8 16440368-6 2006 Secretin increased bile flow and biliary excretion of HCO3- and Cl-. Bicarbonates 54-59 secretin Rattus norvegicus 0-8 16440368-8 2006 Whereas secretin effects were all blocked by intrabiliary NPPB, DIDS only inhibited secretin-induced increases in bile flow and HCO3- excretion but not the increased Cl- excretion, revealing a role of biliary Cl-/HCO3- exchange in secretin-induced, bicarbonate-rich choleresis in normal rats. Bicarbonates 128-132 secretin Rattus norvegicus 84-92 16440368-8 2006 Whereas secretin effects were all blocked by intrabiliary NPPB, DIDS only inhibited secretin-induced increases in bile flow and HCO3- excretion but not the increased Cl- excretion, revealing a role of biliary Cl-/HCO3- exchange in secretin-induced, bicarbonate-rich choleresis in normal rats. Bicarbonates 128-132 secretin Rattus norvegicus 84-92 16440368-10 2006 AE2 gene silencing caused a marked inhibition of unstimulated and secretin-stimulated Cl-/HCO3- exchange. Bicarbonates 90-94 secretin Rattus norvegicus 66-74 16440368-11 2006 In conclusion, maintenance of the bile acid pool is crucial for secretin to induce bicarbonate-rich choleresis in the normal rat and that this occurs via a chloride-bicarbonate exchange process consistent with AE2 function. Bicarbonates 83-94 secretin Rattus norvegicus 64-72 14749298-5 2004 It is further shown that secretin and pituitary adenylate cyclase-activating polypeptide (PACAP) function via totally different mechanisms: 1) PACAP works only from the apical side of the epithelium to stimulate chloride and not bicarbonate secretion, while secretin acts on the apical and basolateral sides to stimulate chloride and bicarbonate secretion. Bicarbonates 229-240 secretin Rattus norvegicus 25-33 14749298-5 2004 It is further shown that secretin and pituitary adenylate cyclase-activating polypeptide (PACAP) function via totally different mechanisms: 1) PACAP works only from the apical side of the epithelium to stimulate chloride and not bicarbonate secretion, while secretin acts on the apical and basolateral sides to stimulate chloride and bicarbonate secretion. Bicarbonates 334-345 secretin Rattus norvegicus 25-33 7631787-5 1995 In vivo, somatostatin infusion caused a dose-dependent bicarbonate-poor decrease (57% maximal decrease below baseline; P < 0.05) in bile flow in BDL but not in sham-operated rats; in contrast, secretin caused a dose-dependent bicarbonate-rich choleresis (228% maximal increase above baseline; P < 0.05) in BDL but not in sham-operated rats. Bicarbonates 55-66 secretin Rattus norvegicus 196-204 11316259-0 2001 Secretin stimulates HCO3(-) and acetate efflux but not Na+/HCO3(-) uptake in rat pancreatic ducts. Bicarbonates 20-24 secretin Rattus norvegicus 0-8 11316259-10 2001 Secretin (1 nM) and carbachol (1 microM) stimulated HCO3(-) efflux, which can account for the observed HCO3(-) concentrations in rat pancreatic juice. Bicarbonates 52-56 secretin Rattus norvegicus 0-8 11316259-10 2001 Secretin (1 nM) and carbachol (1 microM) stimulated HCO3(-) efflux, which can account for the observed HCO3(-) concentrations in rat pancreatic juice. Bicarbonates 103-107 secretin Rattus norvegicus 0-8 10755466-10 2000 Intravenous injection of a rabbit anti-secretin serum, which rendered plasma secretin almost undetectable in rat plasma, also abolished Fr 3-stimulated pancreatic secretion of fluid and bicarbonate secretion. Bicarbonates 186-197 secretin Rattus norvegicus 39-47 11882418-4 2002 Secretin prevented the decrease in bile flow and enhanced biliary excretions of bile acids and bicarbonate, but serum levels of TCDCA or TDCA at the end of the study showed no significant changes in the secretin group as compared with controls. Bicarbonates 95-106 secretin Rattus norvegicus 0-8 8571208-0 1996 Intracerebroventricular secretin enhances pancreatic volume and bicarbonate response in rats. Bicarbonates 64-75 secretin Rattus norvegicus 24-32 8571208-2 1996 The hypothesis that intracerebroventricular secretin enhances pancreatic volume and bicarbonate output at doses that have no effect when given intravenously was tested. Bicarbonates 84-95 secretin Rattus norvegicus 44-52 8571208-5 1996 RESULTS: Increasing doses of intracerebroventricular secretin (0.005, 0.05, and 0.5 microgram/1.0 microliter) induced a significant dose-related increase in bicarbonate output (2.95, 3.32, and 4.02 microEq/30 min, respectively) above basal (2.62 microEq/30 min) compared with control or intracerebroventricular saline treated animals. Bicarbonates 157-168 secretin Rattus norvegicus 53-61 8571208-8 1996 CONCLUSIONS: These observations indicate that intracerebroventricular secretin stimulates pancreatic volume and bicarbonate output and suggest that central secretin may play a role in the regulation of exocrine pancreatic secretion. Bicarbonates 112-123 secretin Rattus norvegicus 70-78 7958697-1 1994 BACKGROUND/AIMS: Secretin has been shown to mediate feedback control of pancreatic secretion of fluid and bicarbonate in rats, guinea pigs, and dogs. Bicarbonates 106-117 secretin Rattus norvegicus 17-25 7930475-1 1994 Secretin is known to stimulate the flow of bicarbonate-rich bile from the bile-duct epithelium, but has no effect on hepatocytes. Bicarbonates 43-54 secretin Rattus norvegicus 0-8 7930475-5 1994 In contrast, the simultaneous infusion of secretin significantly increased bile flow and the biliary excretion of bile acids and bicarbonate. Bicarbonates 129-140 secretin Rattus norvegicus 42-50 2061329-2 1991 Secretin is a 27-amino acid gastrointestinal hormone that stimulates the secretion of bicarbonate-rich pancreatic fluid. Bicarbonates 86-97 secretin Rattus norvegicus 0-8 1329554-8 1992 In vivo, both secretin and SG-secretin stimulated a bicarbonate-rich fluid in rats with bile ductular cell hyperplasia and in normal guinea pigs, which was demonstrated to originate at the distal biliary epithelium. Bicarbonates 52-63 secretin Rattus norvegicus 14-22 1329554-8 1992 In vivo, both secretin and SG-secretin stimulated a bicarbonate-rich fluid in rats with bile ductular cell hyperplasia and in normal guinea pigs, which was demonstrated to originate at the distal biliary epithelium. Bicarbonates 52-63 secretin Rattus norvegicus 30-38 1624081-6 1992 The bile flow and biliary bicarbonate excretion rate were significantly increased after secretin infusion in the CC fistula rats when compared with the control rats, but no stimulation by secretin was observed in the ligated rats. Bicarbonates 26-37 secretin Rattus norvegicus 88-96 1550548-1 1992 Secretin is a 27-amino acid gastrointestinal hormone that stimulates the secretion of bicarbonate-rich pancreatic fluid. Bicarbonates 86-97 secretin Rattus norvegicus 0-8 2315322-1 1990 Secretin is a 27-amino acid gastrointestinal hormone that stimulates the secretion of bicarbonate-rich pancreatic fluid. Bicarbonates 86-97 secretin Rattus norvegicus 0-8 1646711-1 1991 Secretin is a 27 amino acid peptide which stimulates the secretion of bicarbonate, enzymes and potassium ion from the pancreas. Bicarbonates 70-81 secretin Rattus norvegicus 0-8 2351243-11 1990 Secretin, at the dose of 3 clinical units/100 g, induced an increase of approximately 75 percent in bile flow, and 70 percent in biliary bicarbonate concentration in cirrhotics. Bicarbonates 137-148 secretin Rattus norvegicus 0-8 2448343-5 1988 Secretin choleresis was associated with an increase in bicarbonate biliary concentration and with a decline in [14C]mannitol bile-to-plasma ratio, although solute biliary clearance significantly increased. Bicarbonates 55-66 secretin Rattus norvegicus 0-8 2480464-3 1989 Simultaneous infusion of CCK-8 with secretin in a dose of 0.03 CU/kg-hr produced statistically greater pancreatic secretion of volume, bicarbonate, amylase and trypsin outputs than that by CCK-8 alone, and than the sum by secretin alone and CCK-8 alone in each dose. Bicarbonates 135-146 secretin Rattus norvegicus 36-44 2483390-3 1989 The pancreatic bicarbonate output was closely correlated to plasma secretin concentrations (r = 0.631, p less than 0.001). Bicarbonates 15-26 secretin Rattus norvegicus 67-75 2483390-5 1989 These findings suggest strongly that the increase in pancreatic secretion of fluid and bicarbonate output was mainly due to increased endogenous secretin release resulting from plaunotol administration. Bicarbonates 87-98 secretin Rattus norvegicus 145-153 2925061-3 1989 This increase in secretin coincided with a steady but significant increase in pancreatic secretion of volume and bicarbonate. Bicarbonates 113-124 secretin Rattus norvegicus 17-25 2762274-4 1989 Plasma secretin concentration caused dose-dependent elevation (p less than 0.001) by oleic acid, which correlated very well with bicarbonate output in response to oleic acid (p less than 0.001). Bicarbonates 129-140 secretin Rattus norvegicus 7-15 6548570-6 1984 The two higher doses of secretin and only the 96 nmol/kg dose of PHI significantly increased bicarbonate output. Bicarbonates 93-104 secretin Rattus norvegicus 24-32 3337239-4 1988 Injection of the peptide secretagogues cholecystokinin or secretin resulted in a relatively fast (within 4 min) activation or induction of high chloride permeabilities through both chloride conductance and chloride/hydroxide (or chloride/bicarbonate) exchange pathways. Bicarbonates 238-249 secretin Rattus norvegicus 58-66 3024200-9 1986 Variation in culture time up to 52 h had no effect on fluid secretion, and the response to secretin was dependent on the presence of bicarbonate ions in the perifusion fluid. Bicarbonates 133-144 secretin Rattus norvegicus 91-99 3966629-4 1985 Our results show that in aged rats, the basal pancreatic secretion volume and protein and bicarbonate outputs were significantly reduced, and the pancreatic secretion volume and protein and bicarbonate responses to graded doses of secretin or cholecystokinin-8 were significantly reduced. Bicarbonates 190-201 secretin Rattus norvegicus 231-239 6548570-0 1984 Secretin, VIP, and PHI stimulate rat proximal duodenal surface epithelial bicarbonate secretion in vivo. Bicarbonates 74-85 secretin Rattus norvegicus 0-8 6548570-2 1984 Since those hormones with structural homology may have similar effects, the purpose of the present study was to examine the effect of graded doses (6, 24, and 96 nmol/kg) of pure porcine secretin, VIP, and PHI on bicarbonate secretion by the proximal duodenum containing Brunner"s glands. Bicarbonates 213-224 secretin Rattus norvegicus 187-195 6548570-8 1984 It is concluded that secretin and VIP stimulate proximal duodenal bicarbonate secretion and are more potent than PHI. Bicarbonates 66-77 secretin Rattus norvegicus 21-29 908483-3 1977 The duct cells responded to increasing doses of secretin by producing more juice with increasing outputs of bicarbonate, sodium, potassium, and chloride. Bicarbonates 108-119 secretin Rattus norvegicus 48-56 6698442-4 1984 Bicarbonate secretion was related to plasma secretin concentration, and a marked stimulatory effect of secretin was found in very low, probably physiological, plasma concentrations. Bicarbonates 0-11 secretin Rattus norvegicus 44-52 6698442-5 1984 Maximal bicarbonate output was obtained at a plasma concentration of secretin about 20 pmol/l. Bicarbonates 8-19 secretin Rattus norvegicus 69-77 6698442-8 1984 It is concluded that secretin in very low plasma concentrations stimulates secretion of bicarbonate, protein and mucus from Brunner"s glands in the rat, while glucagon has no effect, and it is suggested that secretin may be involved in the physiological regulation of Brunner"s gland secretion. Bicarbonates 88-99 secretin Rattus norvegicus 21-29 6832701-7 1983 These results suggest that the terminal ileum, through release of secretin, might play a role in regulating the pancreatic secretion of water and bicarbonate in response to changes in intraluminal fluids in the distal intestine in the rat. Bicarbonates 146-157 secretin Rattus norvegicus 66-74 574944-12 1979 Secretin and urecholine showed similar protein responses during return of pancreatic juice but after diversion, they stimulated water and bicarbonate secretion only. Bicarbonates 138-149 secretin Rattus norvegicus 0-8 422007-4 1979 After subtracting basal values and normalizing for body weight, the treated group means were statistically significantly greater than those of the control for: maximal bicarbonate output (1.81 times control) to secretin; and maximal outputs to cholecystokinin of volume (2.46 times control), bicarbonate (2.69 times control), and protein (2.28 times control). Bicarbonates 168-179 secretin Rattus norvegicus 211-219 422007-7 1979 We conclude that chronic treatment with secretin plus caerulein exerts a trophic effect on the pancreas associated with increased maximal protein output to cholecystokinin and increased maximal bicarbonate output to secretin. Bicarbonates 194-205 secretin Rattus norvegicus 40-48 908483-4 1977 Bicarbonate concentration increased with the lowest dose of secretin up to values of 64 mEq per liter and did not further increase with higher doses of secretin and increasing secretory rates. Bicarbonates 0-11 secretin Rattus norvegicus 60-68 192137-14 1977 Under the influence of secretin, and to a lesser degree other intestinal hormones, the ducts or ductules can secrete additional fluid in which HCO3- is concentrated with respect to plasma. Bicarbonates 143-147 secretin Rattus norvegicus 23-31 6065757-0 1967 Effect of secretin on bicarbonate secretion in fluid perfusing the rat ileum. Bicarbonates 22-33 secretin Rattus norvegicus 10-18 845824-0 1977 Differentiation between the calcium-dependent effects of cholecystokinin-pancreaozymin and the bicarbonate-dependent effects of secretin in exocrine secretion of the rat pancreas. Bicarbonates 95-106 secretin Rattus norvegicus 128-136