PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29779931-5 2018 Loss of SLC4A7 resulted in increased cytoplasmic acidification during phagocytosis, suggesting that SLC4A7-mediated, bicarbonate-driven maintenance of cytoplasmic pH is necessary for phagosome acidification. Bicarbonates 117-128 solute carrier family 4 member 7 Homo sapiens 8-14 32776463-7 2021 In FD, the mRNA expression of SLC4A7 and SLC4A4, which transport bicarbonate into cells at the basolateral surface, and the apical anion exchanger SLC26A3 were reduced (false discovery rate <0.05), the serotonin receptor HTR4 was increased, and the serotonin transporter SLC6A4 was decreased. Bicarbonates 65-76 solute carrier family 4 member 7 Homo sapiens 30-36 29779931-5 2018 Loss of SLC4A7 resulted in increased cytoplasmic acidification during phagocytosis, suggesting that SLC4A7-mediated, bicarbonate-driven maintenance of cytoplasmic pH is necessary for phagosome acidification. Bicarbonates 117-128 solute carrier family 4 member 7 Homo sapiens 100-106 22082831-10 2012 We reason that the loss of sodium-sparing bicarbonate reabsorption by SLC4A5 initiates a regulatory cascade consisting of compensatory bicarbonate reabsorption via other sodium-bicarbonate transporters (e.g. SLC4A7) at the expense of an increased sodium uptake. Bicarbonates 42-53 solute carrier family 4 member 7 Homo sapiens 208-214 25123669-1 2014 Bicarbonate transporter (BCT) plays a crucial role in maintaining pH homeostasis of tumor cells by import of HCO3(-). Bicarbonates 109-113 solute carrier family 4 member 7 Homo sapiens 0-23 25123669-1 2014 Bicarbonate transporter (BCT) plays a crucial role in maintaining pH homeostasis of tumor cells by import of HCO3(-). Bicarbonates 109-113 solute carrier family 4 member 7 Homo sapiens 25-28 25123669-3 2014 Therefore, blocking BCT-mediated HCO3(-) transport is envisaged as a promising anticancer therapeutic approach. Bicarbonates 33-37 solute carrier family 4 member 7 Homo sapiens 20-23 24005470-1 2013 The NBCn1 Na(+)/HCO3(-) cotransporter catalyzes the electroneutral movement of 1 Na(+):1 HCO3(-) into kidney cells. Bicarbonates 16-20 solute carrier family 4 member 7 Homo sapiens 4-9 24005470-8 2013 We conclude that HEK cells expressed the NBCn1 Na(+)/HCO3(-) cotransporter as the only HCO3(-)-dependent mechanism responsible for cellular alkaline loading. Bicarbonates 53-57 solute carrier family 4 member 7 Homo sapiens 41-46 24005470-9 2013 NBCn1, which expresses in different kidney cell types, was upregulated by 24-h high-Pco2 exposure of HEK cells, and this upregulation was accompanied by increased NBCn1-mediated HCO3(-) transport. Bicarbonates 178-182 solute carrier family 4 member 7 Homo sapiens 0-5 24005470-9 2013 NBCn1, which expresses in different kidney cell types, was upregulated by 24-h high-Pco2 exposure of HEK cells, and this upregulation was accompanied by increased NBCn1-mediated HCO3(-) transport. Bicarbonates 178-182 solute carrier family 4 member 7 Homo sapiens 163-168 28936625-6 2017 The reproducibility of the mean absolute change from baseline to peak in HCO3- was good in SBC2 (r = 0.68) and excellent in SBC3 (r = 0.78). Bicarbonates 73-77 solute carrier family 4 member 7 Homo sapiens 91-95 22907202-2 2013 To determine whether NBCn1, by transporting HCO(3)(-) into cells, may dispose of acid produced during high metabolic activity, we studied the expression of NBCn1 and the functional impact of Na(+),HCO(3)(-)-cotransport in human breast cancer. Bicarbonates 44-50 solute carrier family 4 member 7 Homo sapiens 21-26 22082831-10 2012 We reason that the loss of sodium-sparing bicarbonate reabsorption by SLC4A5 initiates a regulatory cascade consisting of compensatory bicarbonate reabsorption via other sodium-bicarbonate transporters (e.g. SLC4A7) at the expense of an increased sodium uptake. Bicarbonates 135-146 solute carrier family 4 member 7 Homo sapiens 208-214 23183381-1 2012 BACKGROUND/AIMS: The sodium/bicarbonate transporter NBCn1 plays an essential role in intracellular pH regulation and transepithelial HCO(3)(-) movement in the body. Bicarbonates 133-139 solute carrier family 4 member 7 Homo sapiens 52-57 14736710-1 2004 Human NBC3 is an electroneutral Na(+)/HCO(3)(-) cotransporter expressed in heart, skeletal muscle, and kidney in which it plays an important role in HCO(3)(-) metabolism. Bicarbonates 38-44 solute carrier family 4 member 7 Homo sapiens 6-10 14736710-10 2004 These results demonstrate that NBC3 and CAII interact to maximize the HCO(3)(-) transport rate. Bicarbonates 70-76 solute carrier family 4 member 7 Homo sapiens 31-35 10362779-14 1999 On the basis of the widespread distribution of NBC-3, we propose that this isoform is likely involved in cell pH regulation by transporting HCO-3 from blood to the cell. Bicarbonates 140-145 solute carrier family 4 member 7 Homo sapiens 47-52 10362779-15 1999 We further propose that enhanced expression of NBC-3 in severe acid stress could play an important role in cell survival by mediating the influx of HCO-3 into the cells. Bicarbonates 148-153 solute carrier family 4 member 7 Homo sapiens 47-52 34219652-9 2021 NBCn1 expression and dependency on Na+,HCO3--cotransport for pHi regulation, measured in biopsies of human primary breast carcinomas, independently predict proliferative activity, lymph node metastasis, and patient survival. Bicarbonates 39-43 solute carrier family 4 member 7 Homo sapiens 0-5 11875256-1 2001 Together, the Na(+)-coupled HCO(3)(-) transporters and the AE family of anion exchangers (i.e., Cl-HCO3 exchangers) comprise the bicarbonate transporter (BT) superfamily. Bicarbonates 99-103 solute carrier family 4 member 7 Homo sapiens 129-152 11875256-1 2001 Together, the Na(+)-coupled HCO(3)(-) transporters and the AE family of anion exchangers (i.e., Cl-HCO3 exchangers) comprise the bicarbonate transporter (BT) superfamily. Bicarbonates 99-103 solute carrier family 4 member 7 Homo sapiens 154-156 10850716-4 2000 When expressed in Xenopus oocytes, NBCn1-B (which encodes 1,218 amino acids) is electroneutral, Na+-dependent and HCO3(-)-dependent, but not Cl(-)-dependent. Bicarbonates 114-118 solute carrier family 4 member 7 Homo sapiens 35-40