PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23506864-4 2013 Functionally, eight of these proteins fall into two major groups: three Cl-HCO3 exchangers (AE1-3) and five Na(+)-coupled HCO3(-) transporters (NBCe1, NBCe2, NBCn1, NBCn2, NDCBE). Bicarbonates 75-79 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 92-95 22580993-2 2012 The AE1 is the most abundant integral protein of red cell membranes and plays a critical role in the carbon dioxide transport system in which carbon dioxide is carried as bicarbonate in the plasma. Bicarbonates 171-182 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 4-7 23640117-9 2013 Autosomal recessive dRTA is associated with mutations in genes ATP6V1B1, ATP6V0A4 and SLC4A1, which encode subunits a4 and B1 of V-ATPase and the AE1 bicarbonate/chloride exchanger respectively. Bicarbonates 168-179 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 104-110 21300752-0 2011 Cytosolic H+ microdomain developed around AE1 during AE1-mediated Cl-/HCO3- exchange. Bicarbonates 70-74 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 42-45 22126643-1 2012 Mutations in the anion exchanger 1 (AE1) gene encoding the erythroid and kidney anion (chloride-bicarbonate) exchanger 1 may result in familial distal renal tubular acidosis (dRTA) in association with membrane defect hemolytic anemia. Bicarbonates 96-107 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 17-34 22126643-1 2012 Mutations in the anion exchanger 1 (AE1) gene encoding the erythroid and kidney anion (chloride-bicarbonate) exchanger 1 may result in familial distal renal tubular acidosis (dRTA) in association with membrane defect hemolytic anemia. Bicarbonates 96-107 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 36-39 21543742-0 2011 An intramolecular transport metabolon: fusion of carbonic anhydrase II to the COOH terminus of the Cl(-)/HCO(3)(-)exchanger, AE1. Bicarbonates 105-110 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 125-128 21543742-1 2011 Anion exchanger 1 (AE1) is the plasma membrane Cl(-)/HCO(3)(-) exchanger of erythrocytes. Bicarbonates 53-58 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-17 21543742-1 2011 Anion exchanger 1 (AE1) is the plasma membrane Cl(-)/HCO(3)(-) exchanger of erythrocytes. Bicarbonates 53-58 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 19-22 21543742-5 2011 When expressed in transfected human embryonic kidney 293 cells, AE1.CAII had a similar Cl(-)/HCO(3)(-) exchange activity to AE1 alone, as assessed by the flux of H(+) equivalents (87 +- 4% vs. AE1) or rate of change of intracellular Cl(-) concentration (93 +- 4% vs. AE1), suggesting that CAII does not activate AE1. Bicarbonates 93-99 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 64-67 21543742-7 2011 Fusion of CAII to AE1 therefore reduces anion transport activity, but this reduction is compensated for during Cl(-)/HCO(3)(-) exchange by the presence of catalytically active CAII. Bicarbonates 117-123 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 18-21 21543742-8 2011 Overexpression of free CAII-V143Y acts in a dominant negative manner to reduce AE1-mediated HCO(3)(-) transport by displacement of endogenous CAII-wild type from its binding site on AE1. Bicarbonates 92-98 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 79-82 21543742-8 2011 Overexpression of free CAII-V143Y acts in a dominant negative manner to reduce AE1-mediated HCO(3)(-) transport by displacement of endogenous CAII-wild type from its binding site on AE1. Bicarbonates 92-98 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 182-185 21543742-10 2011 The bicarbonate transport activity of AE1 was inhibited by CAII-V143Y, whereas the activity of AE1.CAII was unaffected by CAII-V143Y, suggesting impaired transport activity upon displacement of functional CAII from AE1 but not AE1.CAII. Bicarbonates 4-15 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 38-41 21455263-1 2011 The bicarbonate/chloride exchanger 1 (AE1, Band 3) is abundantly expressed in the red blood cell membrane, where it is involved in gas exchange and functions as a major site of cytoskeletal attachment to the erythrocyte membrane. Bicarbonates 4-15 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 38-41 21300752-0 2011 Cytosolic H+ microdomain developed around AE1 during AE1-mediated Cl-/HCO3- exchange. Bicarbonates 70-74 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 53-56 21300752-4 2011 As AE1 drives Cl-/HCO3- exchange, differences in pH, near and remote from AE1, were monitored by confocal microscopy using two pH-sensitive fluorescent proteins: deGFP4 (GFP) and mNectarine (mNect). Bicarbonates 18-22 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 3-6 21300752-7 2011 As the GFP.AE1-mNect.hCNT3 distance increased, mNect.hCNT3 detected the Cl-/HCO3- exchange-associated cytosolic pH change with a time delay and reduced rate of pH change compared to GFP.AE1. Bicarbonates 76-80 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 7-14 21300752-7 2011 As the GFP.AE1-mNect.hCNT3 distance increased, mNect.hCNT3 detected the Cl-/HCO3- exchange-associated cytosolic pH change with a time delay and reduced rate of pH change compared to GFP.AE1. Bicarbonates 76-80 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 182-189 21300752-8 2011 We found that a H+ microdomain 0.3 mum in diameter forms around GFP.AE1 during physiological HCO3- transport. Bicarbonates 93-97 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 64-71 20947140-10 2011 CONCLUSIONS: SLC4A1 associated changes of HCO(3)(-) and pH levels influenced the cellular oxalate levels and urinary oxalate clearance. Bicarbonates 42-48 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 13-19 21170890-6 2010 Dominant and recessive forms of dRTA are also caused by loss-of-function mutations in the basolateral membrane AE1 Cl-/HCO3- exchanger of the type A intercalated cell. Bicarbonates 119-123 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 111-114 20828148-0 2010 Distance measurements within a concatamer of the plasma membrane Cl-/HCO3- exchanger, AE1. Bicarbonates 69-73 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 86-89 20828148-1 2010 AE1, which exists in the erythrocyte plasma membrane as a noncovalent dimer, facilitates transmembrane Cl-/HCO3- exchange. Bicarbonates 107-111 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-3 20828148-3 2010 The concatameric protein (AE1 AE1) was expressed at the plasma membrane at levels similar to that of wild-type AE1 and had Cl-/HCO3- exchange activity indistinguishable from that of wild-type AE1. Bicarbonates 127-131 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 26-29 20828148-3 2010 The concatameric protein (AE1 AE1) was expressed at the plasma membrane at levels similar to that of wild-type AE1 and had Cl-/HCO3- exchange activity indistinguishable from that of wild-type AE1. Bicarbonates 127-131 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 30-33 20828148-3 2010 The concatameric protein (AE1 AE1) was expressed at the plasma membrane at levels similar to that of wild-type AE1 and had Cl-/HCO3- exchange activity indistinguishable from that of wild-type AE1. Bicarbonates 127-131 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 30-33 20828148-3 2010 The concatameric protein (AE1 AE1) was expressed at the plasma membrane at levels similar to that of wild-type AE1 and had Cl-/HCO3- exchange activity indistinguishable from that of wild-type AE1. Bicarbonates 127-131 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 30-33 20346715-1 2010 The bicarbonate/chloride exchanger band 3 (Anion Exchanger 1, AE1) is the most abundant protein in the erythrocyte membrane, it has an important role in gas exchange and functions as a point of attachment for the cytoskeletons maintaining the mechanistic and osmotic properties of the erythrocyte. Bicarbonates 4-15 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 43-60 20346715-1 2010 The bicarbonate/chloride exchanger band 3 (Anion Exchanger 1, AE1) is the most abundant protein in the erythrocyte membrane, it has an important role in gas exchange and functions as a point of attachment for the cytoskeletons maintaining the mechanistic and osmotic properties of the erythrocyte. Bicarbonates 4-15 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 62-65 20132789-1 2010 Anion exchanger 1 (AE1 or band 3) is responsible for Cl(-)-HCO3(-) exchange on erythrocyte membrane. Bicarbonates 59-66 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-17 20132789-1 2010 Anion exchanger 1 (AE1 or band 3) is responsible for Cl(-)-HCO3(-) exchange on erythrocyte membrane. Bicarbonates 59-66 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 19-22 19277700-2 2009 Acid-secretory type-A intercalated cells secrete protons via a luminally expressed V-type H(+)-ATPase and generate new bicarbonate released by basolateral chloride/bicarbonate exchangers including the AE1 anion exchanger. Bicarbonates 119-130 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 201-204 20068363-3 2010 RESULTS: In all affected children, the disease was associated with mutations of the SLC4A1 gene that codes for the bicarbonate/chloride anion-exchanger 1 (AE1, band 3) protein situated in the red cell membrane and the alpha-intercalated (proton-secreting) cell of the renal collecting duct. Bicarbonates 115-126 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 84-90 20068363-3 2010 RESULTS: In all affected children, the disease was associated with mutations of the SLC4A1 gene that codes for the bicarbonate/chloride anion-exchanger 1 (AE1, band 3) protein situated in the red cell membrane and the alpha-intercalated (proton-secreting) cell of the renal collecting duct. Bicarbonates 115-126 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 127-166 19438409-1 2009 AE1 [anion exchanger 1, also known as SLC4A1 (solute carrier family 4, anion exchanger, member 1) and band 3 (erythrocyte membrane protein band 3)] is a major membrane glycoprotein expressed in human erythrocytes where it mediates the exchange of chloride and bicarbonate across the plasma membrane. Bicarbonates 260-271 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-3 19438409-1 2009 AE1 [anion exchanger 1, also known as SLC4A1 (solute carrier family 4, anion exchanger, member 1) and band 3 (erythrocyte membrane protein band 3)] is a major membrane glycoprotein expressed in human erythrocytes where it mediates the exchange of chloride and bicarbonate across the plasma membrane. Bicarbonates 260-271 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 5-22 19438409-1 2009 AE1 [anion exchanger 1, also known as SLC4A1 (solute carrier family 4, anion exchanger, member 1) and band 3 (erythrocyte membrane protein band 3)] is a major membrane glycoprotein expressed in human erythrocytes where it mediates the exchange of chloride and bicarbonate across the plasma membrane. Bicarbonates 260-271 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 38-44 20100494-1 2010 The membrane domain of human erythrocyte anion exchanger 1 (AE1) works as a Cl(-)/HCO(3)(-) antiporter. Bicarbonates 82-88 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 41-58 20100494-1 2010 The membrane domain of human erythrocyte anion exchanger 1 (AE1) works as a Cl(-)/HCO(3)(-) antiporter. Bicarbonates 82-88 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 60-63 19277700-2 2009 Acid-secretory type-A intercalated cells secrete protons via a luminally expressed V-type H(+)-ATPase and generate new bicarbonate released by basolateral chloride/bicarbonate exchangers including the AE1 anion exchanger. Bicarbonates 164-175 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 201-204 17690931-3 2008 Ovalocytosis and dRTA may co-exist in the same patient, since both can originate in mutations of the anion-exchanger 1 (AE1) gene, which codes for band 3, the bicarbonate/chloride exchanger, present in both the red cell membrane and the basolateral membrane of the collecting tubule alpha-intercalated cell. Bicarbonates 159-170 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 101-118 19391452-3 2009 Both can originate in mutations of the anion-exchanger 1 gene (AE1), which codes for band 3, the bicarbonate/chloride exchanger in both the red cell membrane and the basolateral membrane of the collecting tubule alpha-intercalated cell. Bicarbonates 97-108 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 39-56 19391452-3 2009 Both can originate in mutations of the anion-exchanger 1 gene (AE1), which codes for band 3, the bicarbonate/chloride exchanger in both the red cell membrane and the basolateral membrane of the collecting tubule alpha-intercalated cell. Bicarbonates 97-108 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 63-66 17941824-1 2008 The human chloride/bicarbonate AE1 (anion exchanger) is a dimeric glycoprotein expressed in the red blood cell membrane,and expressed as an N-terminal (Delta1-65) truncated form, kAE1(kidney AE1), in the basolateral membrane of alpha-intercalated cells in the distal nephron. Bicarbonates 19-30 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 31-34 17941824-1 2008 The human chloride/bicarbonate AE1 (anion exchanger) is a dimeric glycoprotein expressed in the red blood cell membrane,and expressed as an N-terminal (Delta1-65) truncated form, kAE1(kidney AE1), in the basolateral membrane of alpha-intercalated cells in the distal nephron. Bicarbonates 19-30 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 180-183 17690931-3 2008 Ovalocytosis and dRTA may co-exist in the same patient, since both can originate in mutations of the anion-exchanger 1 (AE1) gene, which codes for band 3, the bicarbonate/chloride exchanger, present in both the red cell membrane and the basolateral membrane of the collecting tubule alpha-intercalated cell. Bicarbonates 159-170 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 120-123 17554061-6 2007 Our results show that the point mutations of hAE1 convert the electroneutral anion exchanger to a cation conductance: the exchangers are no longer able to exchange Cl(-) and HCO(3)(-), whereas they transport Na(+) and K(+) through a conductive mechanism. Bicarbonates 174-180 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 45-49 17317744-9 2007 Although this conductive pathway is not a usual feature of intact mammalian AE1, it shares many properties with the anion-conductive pathways intrinsic to two other Cl-HCO3- exchangers, trout AE1 and mammalian SLC26A7. Bicarbonates 168-172 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 76-79 17533027-1 2007 BACKGROUND: Mutations in the anion exchanger 1 (AE1) gene encoding the erythroid and kidney anion (chloride-bicarbonate) exchanger 1 may result in hereditary distal renal tubular acidosis (dRTA). Bicarbonates 108-119 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 29-46 17533027-1 2007 BACKGROUND: Mutations in the anion exchanger 1 (AE1) gene encoding the erythroid and kidney anion (chloride-bicarbonate) exchanger 1 may result in hereditary distal renal tubular acidosis (dRTA). Bicarbonates 108-119 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 48-51 17317744-9 2007 Although this conductive pathway is not a usual feature of intact mammalian AE1, it shares many properties with the anion-conductive pathways intrinsic to two other Cl-HCO3- exchangers, trout AE1 and mammalian SLC26A7. Bicarbonates 168-172 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 192-195 16038940-2 2006 A mechanism of control of the erythrocyte shape has been previously proposed in which Band 3 (AE1), the protein anion exchanger of Cl(-) and HCO(3)(-), plays a central role. Bicarbonates 141-147 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 94-97 17453414-1 2007 The human anion exchanger 1 (AE1) is the most abundant integral membrane protein in red cells and is responsible for the exchange of Cl(-) for HCO(3)(-). Bicarbonates 143-149 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 10-27 17453414-1 2007 The human anion exchanger 1 (AE1) is the most abundant integral membrane protein in red cells and is responsible for the exchange of Cl(-) for HCO(3)(-). Bicarbonates 143-149 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 29-32 16700540-1 2006 The one-for-one exchange of Cl(-) and HCO(3)(-) ions is catalyzed by human erythrocyte anion exchanger 1 (hAE1) through a ping-pong mechanism whereby the protein exists in two main conformations, with the single anion-binding site exposed at either the cytoplasmic (inner) side (E(i)) or the extracellular side (E(o)), with interconversion between the two states being possible only after anion binding. Bicarbonates 38-44 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 87-104 16700540-1 2006 The one-for-one exchange of Cl(-) and HCO(3)(-) ions is catalyzed by human erythrocyte anion exchanger 1 (hAE1) through a ping-pong mechanism whereby the protein exists in two main conformations, with the single anion-binding site exposed at either the cytoplasmic (inner) side (E(i)) or the extracellular side (E(o)), with interconversion between the two states being possible only after anion binding. Bicarbonates 38-44 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 106-110 16118313-1 2005 The 911 amino acid band 3 (SLC4A1) is the major intrinsic membrane protein of red cells and is the principal Cl-/HCO3- exchanger. Bicarbonates 113-117 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 27-33 16107207-1 2005 Human AE1 (anion exchanger 1) is a membrane glycoprotein found in erythrocytes and as a truncated form (kAE1) in the BLM (basolateral membrane) of a-intercalated cells of the distal nephron, where they carry out electroneutral chloride/bicarbonate exchange. Bicarbonates 236-247 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 6-9 16107207-1 2005 Human AE1 (anion exchanger 1) is a membrane glycoprotein found in erythrocytes and as a truncated form (kAE1) in the BLM (basolateral membrane) of a-intercalated cells of the distal nephron, where they carry out electroneutral chloride/bicarbonate exchange. Bicarbonates 236-247 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 11-28 16227998-0 2005 Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1. Bicarbonates 132-143 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 155-158 15764372-6 2004 AE1 activity was assessed in both Cl-/NO3- exchange assays, which were independent of CA activity, and in Cl-/HCO3- exchange assays. Bicarbonates 110-114 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-3 16096263-1 2005 Anion exchanger 1 (AE1, or Band 3) is an integral membrane glycoprotein found in erythrocytes, responsible for the electroneutral exchange of chloride and bicarbonate ions across the plasma membrane. Bicarbonates 155-166 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-33 15121095-1 2004 The red cell anion exchanger (band 3; AE1) is a multispanning membrane protein that traverses the bilayer up to 14 times and mediates the stilbene-disulfonate-sensitive, electroneutral exchange of chloride and bicarbonate. Bicarbonates 210-221 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 38-41 15499994-2 2004 Physical interactions have been identified between the carbonic anhydrase isoform, CAII, and the erythrocyte membrane Cl- /HCO3(-) anion exchanger, AE1, mediated by an acidic motif in the AE1 C-terminus. Bicarbonates 123-127 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 148-151 15499994-2 2004 Physical interactions have been identified between the carbonic anhydrase isoform, CAII, and the erythrocyte membrane Cl- /HCO3(-) anion exchanger, AE1, mediated by an acidic motif in the AE1 C-terminus. Bicarbonates 123-127 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 188-191 15499994-3 2004 We have found that the presence of CAII attached to AE1 accelerates AE1 HCO3(-) transport activity, as AE1 moves bicarbonate either into or out of the cell. Bicarbonates 113-124 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 52-55 15499994-3 2004 We have found that the presence of CAII attached to AE1 accelerates AE1 HCO3(-) transport activity, as AE1 moves bicarbonate either into or out of the cell. Bicarbonates 113-124 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 68-71 15499994-3 2004 We have found that the presence of CAII attached to AE1 accelerates AE1 HCO3(-) transport activity, as AE1 moves bicarbonate either into or out of the cell. Bicarbonates 113-124 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 68-71 15499994-4 2004 In efflux mode the presence of CAII attached to AE1 will increase the local concentration of bicarbonate at the AE1 transport site. Bicarbonates 93-104 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 48-51 15499994-4 2004 In efflux mode the presence of CAII attached to AE1 will increase the local concentration of bicarbonate at the AE1 transport site. Bicarbonates 93-104 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 112-115 15499994-5 2004 As bicarbonate is transported into the cell by AE1, the presence of CAII on the cytosolic surface accelerates transport by consumption of bicarbonate, thereby maximizing the transmembrane bicarbonate concentration gradient experienced by the AE1 molecule. Bicarbonates 3-14 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 47-50 15499994-5 2004 As bicarbonate is transported into the cell by AE1, the presence of CAII on the cytosolic surface accelerates transport by consumption of bicarbonate, thereby maximizing the transmembrane bicarbonate concentration gradient experienced by the AE1 molecule. Bicarbonates 3-14 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 242-245 15499994-5 2004 As bicarbonate is transported into the cell by AE1, the presence of CAII on the cytosolic surface accelerates transport by consumption of bicarbonate, thereby maximizing the transmembrane bicarbonate concentration gradient experienced by the AE1 molecule. Bicarbonates 138-149 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 47-50 15499994-5 2004 As bicarbonate is transported into the cell by AE1, the presence of CAII on the cytosolic surface accelerates transport by consumption of bicarbonate, thereby maximizing the transmembrane bicarbonate concentration gradient experienced by the AE1 molecule. Bicarbonates 138-149 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 47-50 15044489-1 2004 AE1 facilitates Cl-/HCO3- exchange across the erythrocyte membrane. Bicarbonates 20-24 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-3 15044489-3 2004 These mutants spanning the C-terminal portion of the AE1 membrane domain from Phe806-Cys885 were characterized for functional activity when expressed in human embryonic kidney 293 cells by measurement of changes of intracellular pH associated with bicarbonate transport. Bicarbonates 248-259 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 53-56 15121095-3 2004 Here we demonstrate that the chloride uptake mediated by assemblies separated at EC3 represents the physiological electroneutral Cl(-)/HCO(3)(-) activity associated with intact AE1 protein. Bicarbonates 135-141 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 177-180 14640982-1 2004 AE1 (anion exchanger 1) is a glycoprotein found in the plasma membrane of erythrocytes, where it mediates the electroneutral exchange of chloride and bicarbonate, a process important in CO2 removal from tissues. Bicarbonates 150-161 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-3 14640982-1 2004 AE1 (anion exchanger 1) is a glycoprotein found in the plasma membrane of erythrocytes, where it mediates the electroneutral exchange of chloride and bicarbonate, a process important in CO2 removal from tissues. Bicarbonates 150-161 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 5-22 12911818-1 2003 The human anion exchanger AE1 (Band 3) is an abundant glycoprotein localized in plasma membrane of red cells and is responsible for the electro-neutral exchange of chloride for bicarbonate. Bicarbonates 177-188 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 26-29 14654610-1 2003 OBJECTIVE: The anion exchanger gene (AE1) or band 3 encodes a chloride-bicarbonate (Cl(-)/HCO(3)(-)) exchanger expressed in the erythrocyte and in the renal alpha-intercalated cells involved in urine acidification. Bicarbonates 71-82 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 37-40 14654610-1 2003 OBJECTIVE: The anion exchanger gene (AE1) or band 3 encodes a chloride-bicarbonate (Cl(-)/HCO(3)(-)) exchanger expressed in the erythrocyte and in the renal alpha-intercalated cells involved in urine acidification. Bicarbonates 90-96 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 37-40 12539048-1 2003 Autosomal dominant distal renal tubular acidosis (ddRTA) is caused by mutations in SLC4A1, which encodes the polytopic chloride-bicarbonate exchanger AE1 that is normally expressed at the basolateral surface of alpha-intercalated cells in the distal nephron. Bicarbonates 128-139 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 83-89 12578372-2 2003 Glutamate 681 is thought to be located within the transport channel of band 3 (AE1, the chloride/bicarbonate exchanger), where it acts as a proton donor for the anion/proton cotransport function. Bicarbonates 97-108 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 79-82 12539048-1 2003 Autosomal dominant distal renal tubular acidosis (ddRTA) is caused by mutations in SLC4A1, which encodes the polytopic chloride-bicarbonate exchanger AE1 that is normally expressed at the basolateral surface of alpha-intercalated cells in the distal nephron. Bicarbonates 128-139 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 150-153 12446737-1 2003 Human AE1 performs electroneutral exchange of Cl(-) for HCO(3)(-) across the erythrocyte membrane. Bicarbonates 56-65 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 6-9 11994299-3 2002 To determine whether cell surface-anchored carbonic anhydrase IV (CAIV) interacts with AE proteins to accelerate the bicarbonate transport rate, AE1-mediated bicarbonate transport was monitored in transfected HEK293 cells. Bicarbonates 158-169 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 145-148 11994299-9 2002 We conclude that AE1 and CAIV interact on extracellular loop 4 of AE1, forming the extracellular component of a bicarbonate transport metabolon, which accelerates the rate of AE-mediated bicarbonate transport. Bicarbonates 112-123 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 17-20 11994299-9 2002 We conclude that AE1 and CAIV interact on extracellular loop 4 of AE1, forming the extracellular component of a bicarbonate transport metabolon, which accelerates the rate of AE-mediated bicarbonate transport. Bicarbonates 112-123 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 66-69 11994299-9 2002 We conclude that AE1 and CAIV interact on extracellular loop 4 of AE1, forming the extracellular component of a bicarbonate transport metabolon, which accelerates the rate of AE-mediated bicarbonate transport. Bicarbonates 187-198 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 17-20 11994299-9 2002 We conclude that AE1 and CAIV interact on extracellular loop 4 of AE1, forming the extracellular component of a bicarbonate transport metabolon, which accelerates the rate of AE-mediated bicarbonate transport. Bicarbonates 187-198 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 66-69 12087557-1 2002 Anion exchanger 1 (AE1 or band 3), encoded by the AE1 or SLC4A1 gene, regulates chloride-bicarbonate exchange in erythrocytes and alpha-intercalated cells of the distal nephron. Bicarbonates 89-100 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-17 12087557-1 2002 Anion exchanger 1 (AE1 or band 3), encoded by the AE1 or SLC4A1 gene, regulates chloride-bicarbonate exchange in erythrocytes and alpha-intercalated cells of the distal nephron. Bicarbonates 89-100 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 19-22 12087557-1 2002 Anion exchanger 1 (AE1 or band 3), encoded by the AE1 or SLC4A1 gene, regulates chloride-bicarbonate exchange in erythrocytes and alpha-intercalated cells of the distal nephron. Bicarbonates 89-100 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 50-53 12087557-1 2002 Anion exchanger 1 (AE1 or band 3), encoded by the AE1 or SLC4A1 gene, regulates chloride-bicarbonate exchange in erythrocytes and alpha-intercalated cells of the distal nephron. Bicarbonates 89-100 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 57-63 12081559-2 2002 Both can originate in mutations of the anion-exchanger 1 gene (AE1), which codes for band 3, the bicarbonate/chloride exchanger in both the red cell membrane and the basolateral membrane of the collecting tubule alpha-intercalated cell. Bicarbonates 97-108 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 39-56 12081559-2 2002 Both can originate in mutations of the anion-exchanger 1 gene (AE1), which codes for band 3, the bicarbonate/chloride exchanger in both the red cell membrane and the basolateral membrane of the collecting tubule alpha-intercalated cell. Bicarbonates 97-108 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 63-66 11934582-1 2002 Di-/tri- and especially tetrapeptides incorporating the sequence DADD present in the carboxyterminal region of the bicarbonate/chloride anion exchanger AE1 strongly activate human carbonic anhydrase (CA) isozyme II, whereas they act as more inefficient activators of isozymes I and IV. Bicarbonates 115-126 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 152-155 11160790-6 2001 AE1 contributes to urinary acidification by providing the major exit route for HCO3- across the basolateral membrane. Bicarbonates 79-83 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-3 12027221-6 2002 The AE1 gene encodes eAE1 (band 3), the major intrinsic protein of the erythrocyte, as well as kAE1, the basolateral Cl/HCO3 exchanger of the acid-secreting Type A intercalated cell. Bicarbonates 120-124 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 4-7 11672441-1 2001 The human erythrocyte anion-exchanger isoform 1 (AE1) is a dimeric membrane protein that exchanges chloride for bicarbonate across the erythrocyte plasma membrane. Bicarbonates 112-123 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 49-52 11606574-2 2001 The cytoplasmic carboxyl-terminal domain of AE1, the plasma membrane chloride/bicarbonate exchanger of erythrocytes, contains a binding site for carbonic anhydrase II (CAII). Bicarbonates 78-89 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 44-47 11606574-3 2001 To examine the physiological role of the AE1/CAII interaction, anion exchange activity of transfected HEK293 cells was monitored by following the changes in intracellular pH associated with AE1-mediated bicarbonate transport. Bicarbonates 203-214 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 190-193 11606574-4 2001 AE1-mediated chloride/bicarbonate exchange was reduced 50-60% by inhibition of endogenous carbonic anhydrase with acetazolamide, which indicates that CAII activity is required for full anion transport activity. Bicarbonates 22-33 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-3 11606574-10 2001 The interaction of CAII with AE1 forms a transport metabolon, a membrane protein complex involved in regulation of bicarbonate metabolism and transport. Bicarbonates 115-126 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 29-32 11358366-1 2001 The erythrocyte Cl-/HCO3- anion exchanger (AE1, Band 3) and the enzyme carbonic anhydrase (CA) catalyze interconnected processes involved in bicarbonate metabolism. Bicarbonates 141-152 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 43-54 11063570-1 2000 Human carbonic anhydrase II (CAII) possesses a binding site for an acidic motif (D887ADD) within the carboxyl-terminal region (Ct) of the human erythrocyte chloride/bicarbonate anion exchanger, AE1. Bicarbonates 165-176 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 194-197 11063570-11 2000 The binding of the basic amino-terminal region of CAII to an acidic Ct in AE1 provides a structural basis for linking bicarbonate transport across the cell membrane to intracellular bicarbonate metabolism. Bicarbonates 118-129 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 74-77 11063570-11 2000 The binding of the basic amino-terminal region of CAII to an acidic Ct in AE1 provides a structural basis for linking bicarbonate transport across the cell membrane to intracellular bicarbonate metabolism. Bicarbonates 182-193 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 74-77 11149111-7 2000 Mutation analysis of the AE1 gene coding for the renal Cl-/HCO3(-)-exchanger AE1 displayed a heterozygous Arg589Cys exchange in both patients but not in the healthy family members. Bicarbonates 59-63 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 25-28 11149111-7 2000 Mutation analysis of the AE1 gene coding for the renal Cl-/HCO3(-)-exchanger AE1 displayed a heterozygous Arg589Cys exchange in both patients but not in the healthy family members. Bicarbonates 59-63 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 77-80 10741469-9 2000 Our results indicate that, depending on the nephron segment and corresponding cell types, AE1 and AE2 proteins are differentially involved in the Na+-independent exchange of Cl- for HCO3- at the basolateral membrane of polarized kidney epithelial cells. Bicarbonates 182-186 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 90-93 10820026-0 2000 Identification of the carbonic anhydrase II binding site in the Cl(-)/HCO(3)(-) anion exchanger AE1. Bicarbonates 70-76 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 96-99 10820026-1 2000 The human Cl(-)/HCO(3)(-) anion exchanger (AE1) possesses a binding site within its 33 residue carboxyl-terminal region (Ct) for carbonic anhydrase II (CAII). Bicarbonates 16-21 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 43-46 10491290-7 1999 In addition, an AE1 Cl(-)/HCO(3) was identified in fetal pancreas but was absent from the adult pancreas and cultured ductal epithelial cells from fetal and adult pancreas. Bicarbonates 26-32 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 16-19 11328653-1 2000 The human AE1 anion exchanger gene SLC4A1 encodes the Cl-/HCO3-exchangers of the erythrocyte and the Type Acid-secreting intercalated cell basolateral membrane. Bicarbonates 58-62 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 10-13 11328653-1 2000 The human AE1 anion exchanger gene SLC4A1 encodes the Cl-/HCO3-exchangers of the erythrocyte and the Type Acid-secreting intercalated cell basolateral membrane. Bicarbonates 58-62 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 35-41 10545179-1 1999 AE1, the chloride/bicarbonate anion exchanger of the erythrocyte plasma membrane, is highly sensitive to inhibition by stilbene disulfonate compounds such as DIDS (4,4"-diisothiocyanostilbene-2, 2"-disulfonate) and DNDS (4,4"-dinitrostilbene-2,2"-disulfonate). Bicarbonates 18-29 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-3 9920902-1 1999 AE1 is the chloride/bicarbonate anion exchanger of the erythrocyte plasma membrane. Bicarbonates 20-31 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-3 10352205-1 1999 Southeast Asian ovalocytosis (SAO) is the best-documented disease in which mutation in the anion exchanger-1 (AE1) causes decreased anion (chloride [Cl-]/bicarbonate [HCO3-]) transport. Bicarbonates 154-165 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 91-108 10352205-1 1999 Southeast Asian ovalocytosis (SAO) is the best-documented disease in which mutation in the anion exchanger-1 (AE1) causes decreased anion (chloride [Cl-]/bicarbonate [HCO3-]) transport. Bicarbonates 154-165 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 110-113 10352205-1 1999 Southeast Asian ovalocytosis (SAO) is the best-documented disease in which mutation in the anion exchanger-1 (AE1) causes decreased anion (chloride [Cl-]/bicarbonate [HCO3-]) transport. Bicarbonates 167-172 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 91-108 10352205-1 1999 Southeast Asian ovalocytosis (SAO) is the best-documented disease in which mutation in the anion exchanger-1 (AE1) causes decreased anion (chloride [Cl-]/bicarbonate [HCO3-]) transport. Bicarbonates 167-172 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 110-113 10037758-1 1999 Anion exchanger 1 (AE1) is the chloride/bicarbonate exchange protein of the erythrocyte membrane. Bicarbonates 40-51 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-17 10037758-1 1999 Anion exchanger 1 (AE1) is the chloride/bicarbonate exchange protein of the erythrocyte membrane. Bicarbonates 40-51 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 19-22 9920902-6 1999 Anion exchange activity was assessed by measurement of changes of intracellular pH, which follow transmembrane bicarbonate movement mediated by AE1. Bicarbonates 111-122 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 144-147 9827569-1 1998 The anion exchange protein AE1 is the most abundant membrane protein in human erythrocytes mediating the electroneutral chloride/bicarbonate exchange. Bicarbonates 129-140 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 27-30 10645535-4 1999 As a membrane transporter, AE1 mediates Cl-/HCO3- exchange, thus enhancing the blood capacity for carrying CO2 and for acid-base homeostasis. Bicarbonates 44-48 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 27-30 9712881-1 1998 AE1 protein transports Cl- and HCO3- across the erythrocyte membrane by an electroneutral exchange mechanism. Bicarbonates 31-35 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-3 10353702-1 1998 The anion exchanger genes (AE1-3) encode a family of transport proteins responsible for the electroneutral exchange of bicarbonate and chloride across membranes. Bicarbonates 119-130 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 27-32 9600966-3 1998 Mutations in the chloride-bicarbonate exchanger AE1 have recently been reported in four autosomal dominant dRTA kindreds, three of these altering codon Arg589. Bicarbonates 26-37 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 48-51 9497368-0 1998 Autosomal dominant distal renal tubular acidosis is associated in three families with heterozygosity for the R589H mutation in the AE1 (band 3) Cl-/HCO3- exchanger. Bicarbonates 148-152 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 131-134 9497368-2 1998 Cl-/HCO3- exchange mediated by the AE1 anion exchanger in the basolateral membrane of type A intercalated cells is thought to be an essential component of lumenal H+ secretion by collecting duct intercalated cells. Bicarbonates 4-8 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 35-38 9422766-3 1998 This Cl:HCO3 exchanger, kAE1, is an alternately spliced form of the erythroid anion exchanger (AE1, band 3), but unlike band 3 it does not bind ankyrin. Bicarbonates 8-12 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 95-106 10353703-2 1998 I present a brief summary of recent kinetic studies that provide insight into the mechanism of stilbenedisulfonate-chloride competition in binding to human erythrocyte band 3 (AE1) (B), the chloride-bicarbonate exchanger. Bicarbonates 199-210 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 176-179 7721750-1 1995 AE1 (Band 3), a congruent to 110-kDa integral plasma membrane protein, facilitates the electroneutral movement of Cl- and HCO3- across the erythrocyte membrane and serves as the primary attachment site for the erythrocyte spectrin-actin cytoskeleton. Bicarbonates 122-126 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-3 9326249-0 1997 Band 3 Campinas: a novel splicing mutation in the band 3 gene (AE1) associated with hereditary spherocytosis, hyperactivity of Na+/Li+ countertransport and an abnormal renal bicarbonate handling. Bicarbonates 174-185 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 63-66 8043929-3 1993 Band 3 (AE1) is a member of a family of anion transporters which carry out Cl-/HCO3- exchange. Bicarbonates 79-83 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 8-11 8238316-1 1993 The human erythrocyte anion transport protein (AE1) mediates the rapid, tightly coupled, electroneutral transmembrane exchange of bicarbonate for chloride. Bicarbonates 130-141 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 47-50 8238316-2 1993 AE1 transports a wide range of oxyanions, such as phosphate, sulfate and the physiological substrate bicarbonate. Bicarbonates 101-112 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-3 1911837-6 1991 Bicarbonate and chloride were found to be competitive inhibitors of the AE1 specific 14NO3- line-broadening (94 +/- 6% and 101 +/- 3% inhibition, respectively). Bicarbonates 0-11 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 72-75 1911837-7 1991 Based on the concentration dependence of inhibition and using a model of competitive inhibition, the KD of bicarbonate binding to AE1 was estimated to be 5.4 +/- 1.3 mM. Bicarbonates 107-118 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 130-133 1911837-8 1991 Nitrate is a structural analog of bicarbonate, making the interaction of nitrate with AE1 a good model for the bicarbonate-AE1 interaction. Bicarbonates 34-45 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 86-89 1911837-8 1991 Nitrate is a structural analog of bicarbonate, making the interaction of nitrate with AE1 a good model for the bicarbonate-AE1 interaction. Bicarbonates 34-45 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 123-126 1911837-8 1991 Nitrate is a structural analog of bicarbonate, making the interaction of nitrate with AE1 a good model for the bicarbonate-AE1 interaction. Bicarbonates 111-122 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 86-89 1911837-8 1991 Nitrate is a structural analog of bicarbonate, making the interaction of nitrate with AE1 a good model for the bicarbonate-AE1 interaction. Bicarbonates 111-122 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 123-126 1911837-9 1991 The 14N-NMR nitrate binding assay, along with the 35Cl-NMR binding assay now in use, will provide a powerful tool for studying the structure of the AE1 binding site for both physiologic substrates, bicarbonate and chloride. Bicarbonates 198-209 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 148-151 34175296-1 2021 Band 3 (Anion Exchanger 1, AE1), the predominant protein of erythrocyte membranes, facilitates Cl-/HCO3- exchange and anchors the plasma membrane to the cytoskeleton. Bicarbonates 99-103 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 8-25 34669510-1 2021 The major transmembrane protein of the red blood cell, known as band 3, AE1, and SLC4A1, has two main functions: 1) catalysis of Cl-/HCO3- exchange, one of the steps in CO2 excretion; 2) anchoring the membrane skeleton. Bicarbonates 133-137 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 72-75 34669510-1 2021 The major transmembrane protein of the red blood cell, known as band 3, AE1, and SLC4A1, has two main functions: 1) catalysis of Cl-/HCO3- exchange, one of the steps in CO2 excretion; 2) anchoring the membrane skeleton. Bicarbonates 133-137 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 81-87 34175296-1 2021 Band 3 (Anion Exchanger 1, AE1), the predominant protein of erythrocyte membranes, facilitates Cl-/HCO3- exchange and anchors the plasma membrane to the cytoskeleton. Bicarbonates 99-103 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 27-30 33932403-3 2021 Recently solved outward facing (OF) structures of two SLC4 members (hAE1 and hNBCe1) with different transport modes (Cl /HCO3 exchange vs Na+-CO32 symport) revealed highly-conserved three-dimensional organization of their transmembrane domains. Bicarbonates 121-125 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 68-72 34584093-2 2021 The previously solved structures of the outward facing (OF) conformation for AE1 (SLC4A1) and NBCe1 (SLC4A4) transporters revealed an identical overall fold despite their different transport modes (chloride/bicarbonate exchange versus sodium-carbonate cotransport). Bicarbonates 207-218 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 77-80 34584093-2 2021 The previously solved structures of the outward facing (OF) conformation for AE1 (SLC4A1) and NBCe1 (SLC4A4) transporters revealed an identical overall fold despite their different transport modes (chloride/bicarbonate exchange versus sodium-carbonate cotransport). Bicarbonates 207-218 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 82-88 32632909-1 2020 Mutations in SLC4A1, encoding the chloride-bicarbonate exchanger known as anion exchanger 1, have been reported as the sole genetic cause of autosomal dominant distal renal tubular acidosis (dRTA). Bicarbonates 43-54 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 13-19 32632909-1 2020 Mutations in SLC4A1, encoding the chloride-bicarbonate exchanger known as anion exchanger 1, have been reported as the sole genetic cause of autosomal dominant distal renal tubular acidosis (dRTA). Bicarbonates 43-54 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 74-91 28387307-2 2017 Erythroid and kidney AE1 play a major role in HCO3- and Cl- exchange. Bicarbonates 46-50 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 21-24 31750613-4 2019 In this work, applying scanning flow cytometry, we observed experimentally for the first time the dynamics behind a significant increase of HCO3 - /Cl- transmembrane exchange rate of CDB3 (main anion exchanger, AE1, Band 3, SLC4A1) of human erythrocytes in the presence of nifedipine in blood. Bicarbonates 140-144 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 211-222 31750613-4 2019 In this work, applying scanning flow cytometry, we observed experimentally for the first time the dynamics behind a significant increase of HCO3 - /Cl- transmembrane exchange rate of CDB3 (main anion exchanger, AE1, Band 3, SLC4A1) of human erythrocytes in the presence of nifedipine in blood. Bicarbonates 140-144 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 224-230 31540709-1 2019 Anion exchanger 1 (AE1) is responsible for the exchange of bicarbonate and chloride across the erythrocyte plasma membrane. Bicarbonates 59-70 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-17 31540709-1 2019 Anion exchanger 1 (AE1) is responsible for the exchange of bicarbonate and chloride across the erythrocyte plasma membrane. Bicarbonates 59-70 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 19-22 29167180-2 2017 In both erythrocytes and the basolateral membrane of the collecting-duct alpha-intercalated cells, the role of AE1 is to catalyze a one-for-one exchange of chloride for bicarbonate. Bicarbonates 169-180 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 111-114 28596233-1 2017 Human CO2 respiration requires rapid conversion between CO2 and HCO3- Carbonic anhydrase II facilitates this reversible reaction inside red blood cells, and band 3 [anion exchanger 1 (AE1)] provides a passage for HCO3- flux across the cell membrane. Bicarbonates 64-68 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 184-187 32154456-1 2020 Introduction: Anion exchanger 1 (AE1) (SLC4A1 gene product) is a membrane protein expressed in both kidney and red blood cells (RBCs): it exchanges extracellular bicarbonate (HCO3 -) for intracellular chloride (Cl-) and participates in acid-base homeostasis. Bicarbonates 162-173 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 14-31 32154456-1 2020 Introduction: Anion exchanger 1 (AE1) (SLC4A1 gene product) is a membrane protein expressed in both kidney and red blood cells (RBCs): it exchanges extracellular bicarbonate (HCO3 -) for intracellular chloride (Cl-) and participates in acid-base homeostasis. Bicarbonates 162-173 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 33-36 32154456-1 2020 Introduction: Anion exchanger 1 (AE1) (SLC4A1 gene product) is a membrane protein expressed in both kidney and red blood cells (RBCs): it exchanges extracellular bicarbonate (HCO3 -) for intracellular chloride (Cl-) and participates in acid-base homeostasis. Bicarbonates 162-173 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 39-45 32154456-1 2020 Introduction: Anion exchanger 1 (AE1) (SLC4A1 gene product) is a membrane protein expressed in both kidney and red blood cells (RBCs): it exchanges extracellular bicarbonate (HCO3 -) for intracellular chloride (Cl-) and participates in acid-base homeostasis. Bicarbonates 175-181 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 14-31 32154456-1 2020 Introduction: Anion exchanger 1 (AE1) (SLC4A1 gene product) is a membrane protein expressed in both kidney and red blood cells (RBCs): it exchanges extracellular bicarbonate (HCO3 -) for intracellular chloride (Cl-) and participates in acid-base homeostasis. Bicarbonates 175-181 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 33-36 32154456-1 2020 Introduction: Anion exchanger 1 (AE1) (SLC4A1 gene product) is a membrane protein expressed in both kidney and red blood cells (RBCs): it exchanges extracellular bicarbonate (HCO3 -) for intracellular chloride (Cl-) and participates in acid-base homeostasis. Bicarbonates 175-181 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 39-45 30011272-1 2018 The Band 3 (AE1, SLC4A1) membrane protein is found in red blood cells and in kidney where it functions as an electro-neutral chloride/bicarbonate exchanger. Bicarbonates 134-145 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 12-15 30011272-1 2018 The Band 3 (AE1, SLC4A1) membrane protein is found in red blood cells and in kidney where it functions as an electro-neutral chloride/bicarbonate exchanger. Bicarbonates 134-145 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 17-23 28646128-1 2017 Mutations of the solute carrier family 4 member 1 (SLC4A1) gene encoding kidney anion (chloride/bicarbonate ion) exchanger 1 (kAE1) can cause genetic distal renal tubular acidosis (dRTA). Bicarbonates 96-107 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 51-57 28387307-6 2017 Here, the ability of stomatin to modulate AE1-dependent Cl-/HCO3- exchange was evaluated using stopped-flow methods. Bicarbonates 60-64 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 42-45 26049106-1 2015 Human kidney anion exchanger 1 (kAE1) mediates Cl(-)/HCO3(-) exchanges at the basolateral membrane of the acid-secreting alpha-intercalated cells. Bicarbonates 53-57 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 13-30 28638614-1 2017 Distal renal tubular acidosis caused by missense mutations in kidney isoform of anion exchanger 1 (kAE1/SLC4A1), the basolateral membrane Cl-/HCO3- exchanger of renal alpha-intercalated cells, has been extensively investigated in heterologous expression systems but rarely in human kidneys. Bicarbonates 142-146 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 80-97 28638614-1 2017 Distal renal tubular acidosis caused by missense mutations in kidney isoform of anion exchanger 1 (kAE1/SLC4A1), the basolateral membrane Cl-/HCO3- exchanger of renal alpha-intercalated cells, has been extensively investigated in heterologous expression systems but rarely in human kidneys. Bicarbonates 142-146 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 104-110 26582474-9 2016 Homology modeling revealed that the structure of CD-SLC4A11 is similar to that of the Cl(-)/HCO3(-) exchange protein AE1 (SLC4A1) CD. Bicarbonates 92-96 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 117-120 26582474-9 2016 Homology modeling revealed that the structure of CD-SLC4A11 is similar to that of the Cl(-)/HCO3(-) exchange protein AE1 (SLC4A1) CD. Bicarbonates 92-96 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 52-58 26542571-1 2015 Anion exchanger 1 (AE1), also known as band 3 or SLC4A1, plays a key role in the removal of carbon dioxide from tissues by facilitating the exchange of chloride and bicarbonate across the plasma membrane of erythrocytes. Bicarbonates 165-176 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-17 26542571-1 2015 Anion exchanger 1 (AE1), also known as band 3 or SLC4A1, plays a key role in the removal of carbon dioxide from tissues by facilitating the exchange of chloride and bicarbonate across the plasma membrane of erythrocytes. Bicarbonates 165-176 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 19-22 26542571-1 2015 Anion exchanger 1 (AE1), also known as band 3 or SLC4A1, plays a key role in the removal of carbon dioxide from tissues by facilitating the exchange of chloride and bicarbonate across the plasma membrane of erythrocytes. Bicarbonates 165-176 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 49-55 28509104-1 2015 Autosomal dominant distal renal tubular acidosis (dRTA) is a rare disorder caused by a mutation in the AE1 gene encoding the chloride-bicarbonate (Cl-/HCO3-) anion exchanger 1 (AE1). Bicarbonates 151-155 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 103-106 28509104-1 2015 Autosomal dominant distal renal tubular acidosis (dRTA) is a rare disorder caused by a mutation in the AE1 gene encoding the chloride-bicarbonate (Cl-/HCO3-) anion exchanger 1 (AE1). Bicarbonates 151-155 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 158-175 28509104-1 2015 Autosomal dominant distal renal tubular acidosis (dRTA) is a rare disorder caused by a mutation in the AE1 gene encoding the chloride-bicarbonate (Cl-/HCO3-) anion exchanger 1 (AE1). Bicarbonates 151-155 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 177-180 28045035-1 2017 Anion exchanger 1 (AE1) mediates Cl-/HCO3- exchange in erythrocytes and kidney intercalated cells where it functions to maintain normal bodily acid-base homeostasis. Bicarbonates 37-41 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-17 28045035-1 2017 Anion exchanger 1 (AE1) mediates Cl-/HCO3- exchange in erythrocytes and kidney intercalated cells where it functions to maintain normal bodily acid-base homeostasis. Bicarbonates 37-41 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 19-22 27595783-1 2016 BACKGROUND: Human anion exchanger 1 and 2 (AE1 and AE2) mediate the exchange of Cl(-)/HCO3 (-) across the plasma membrane and regulate intracellular pH (pHi). Bicarbonates 86-90 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 18-41 27595783-1 2016 BACKGROUND: Human anion exchanger 1 and 2 (AE1 and AE2) mediate the exchange of Cl(-)/HCO3 (-) across the plasma membrane and regulate intracellular pH (pHi). Bicarbonates 86-90 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 43-46 23878365-6 2013 Both the CAII and the AE1 fusion proteins are fully functional in tsA201 cells as judged by CA activity and by cellular HCO3(-) permeability (P(HCO3(-))) sensitive to inhibition by 4,4-Diisothiocyano-2,2-stilbenedisulfonic acid. Bicarbonates 120-124 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 22-25 25012180-1 2015 Anion exchanger-1 (AE1) mediates chloride-bicarbonate exchange across the plasma membranes of erythrocytes and, via a slightly shorter transcript, kidney epithelial cells. Bicarbonates 42-53 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-17 25012180-1 2015 Anion exchanger-1 (AE1) mediates chloride-bicarbonate exchange across the plasma membranes of erythrocytes and, via a slightly shorter transcript, kidney epithelial cells. Bicarbonates 42-53 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 19-22 24515290-8 2014 It has become increasingly apparent that the structure of NBCe1 differs in several key features from the SLC4 Cl(-)-HCO3 (-) exchanger AE1 whose structural properties have been well-studied. Bicarbonates 116-120 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 135-138 23864610-6 2013 The data indicate that HS(-) is a very good substrate for AE1; the Cl(-)/HS(-) exchange rate is about one-third as rapid as Cl(-)/HCO3(-) exchange. Bicarbonates 130-134 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 58-61 25669330-7 2015 Bicarbonates are exchanged for intraductal chloride by anion exchanger 1 (AE1) in the ApM. Bicarbonates 0-12 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 74-77 23878365-6 2013 Both the CAII and the AE1 fusion proteins are fully functional in tsA201 cells as judged by CA activity and by cellular HCO3(-) permeability (P(HCO3(-))) sensitive to inhibition by 4,4-Diisothiocyano-2,2-stilbenedisulfonic acid. Bicarbonates 144-148 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 22-25 23878365-11 2013 A functional contribution of the hypothesized CAII-AE1 metabolon to erythroid AE1-mediated HCO3(-) transport was further tested in normal red cells and red cells from CAII-deficient patients that retain substantial CA activity associated with the erythroid CAI protein lacking the proposed AE1-binding sequence. Bicarbonates 91-95 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 51-54 23878365-11 2013 A functional contribution of the hypothesized CAII-AE1 metabolon to erythroid AE1-mediated HCO3(-) transport was further tested in normal red cells and red cells from CAII-deficient patients that retain substantial CA activity associated with the erythroid CAI protein lacking the proposed AE1-binding sequence. Bicarbonates 91-95 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 78-81 23878365-11 2013 A functional contribution of the hypothesized CAII-AE1 metabolon to erythroid AE1-mediated HCO3(-) transport was further tested in normal red cells and red cells from CAII-deficient patients that retain substantial CA activity associated with the erythroid CAI protein lacking the proposed AE1-binding sequence. Bicarbonates 91-95 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 78-81 23842529-1 2013 Anion exchanger 1 (AE1) or band 3 is a membrane protein responsible for the rapid exchange of chloride for bicarbonate across the red blood cell membrane. Bicarbonates 107-118 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 0-17 23842529-1 2013 Anion exchanger 1 (AE1) or band 3 is a membrane protein responsible for the rapid exchange of chloride for bicarbonate across the red blood cell membrane. Bicarbonates 107-118 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 19-22 23842529-5 2013 Measurement of the rapid and specific chloride/bicarbonate exchange by surface expressed AE1 showed that E758K mutant was fully active compared with wild-type (WT) AE1, whereas R730C and G796R mutants were inactive, reinforcing previously reported data on other experimental models. Bicarbonates 47-58 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 89-92 23842529-7 2013 In conclusion, stopped-flow led to measurement of rapid transport kinetics using the natural substrate for AE1 and, conjugated with flow cytometry, allowed a reliable correlation of chloride/bicarbonate exchange to surface expression of AE1, both in recombinant cells and ghosts and therefore a fine comparison of function between different stomatocytosis samples. Bicarbonates 191-202 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 237-240 23846695-1 2013 The anion exchanger 1 (AE1), a member of bicarbonate transporter family SLC4, mediates an electroneutral chloride/bicarbonate exchange in physiological conditions. Bicarbonates 41-52 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 4-21 23846695-1 2013 The anion exchanger 1 (AE1), a member of bicarbonate transporter family SLC4, mediates an electroneutral chloride/bicarbonate exchange in physiological conditions. Bicarbonates 41-52 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 23-26