PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9558296-7 1998 CONCLUSIONS: PACAP-27 dose-dependently stimulates pancreatic secretion of fluid, bicarbonate, and protein in rats. Bicarbonates 81-92 adenylate cyclase activating polypeptide 1 Rattus norvegicus 13-18 14749298-5 2004 It is further shown that secretin and pituitary adenylate cyclase-activating polypeptide (PACAP) function via totally different mechanisms: 1) PACAP works only from the apical side of the epithelium to stimulate chloride and not bicarbonate secretion, while secretin acts on the apical and basolateral sides to stimulate chloride and bicarbonate secretion. Bicarbonates 229-240 adenylate cyclase activating polypeptide 1 Rattus norvegicus 38-88 14749298-5 2004 It is further shown that secretin and pituitary adenylate cyclase-activating polypeptide (PACAP) function via totally different mechanisms: 1) PACAP works only from the apical side of the epithelium to stimulate chloride and not bicarbonate secretion, while secretin acts on the apical and basolateral sides to stimulate chloride and bicarbonate secretion. Bicarbonates 229-240 adenylate cyclase activating polypeptide 1 Rattus norvegicus 90-95 14749298-5 2004 It is further shown that secretin and pituitary adenylate cyclase-activating polypeptide (PACAP) function via totally different mechanisms: 1) PACAP works only from the apical side of the epithelium to stimulate chloride and not bicarbonate secretion, while secretin acts on the apical and basolateral sides to stimulate chloride and bicarbonate secretion. Bicarbonates 229-240 adenylate cyclase activating polypeptide 1 Rattus norvegicus 143-148 14749298-5 2004 It is further shown that secretin and pituitary adenylate cyclase-activating polypeptide (PACAP) function via totally different mechanisms: 1) PACAP works only from the apical side of the epithelium to stimulate chloride and not bicarbonate secretion, while secretin acts on the apical and basolateral sides to stimulate chloride and bicarbonate secretion. Bicarbonates 334-345 adenylate cyclase activating polypeptide 1 Rattus norvegicus 38-88 14749298-5 2004 It is further shown that secretin and pituitary adenylate cyclase-activating polypeptide (PACAP) function via totally different mechanisms: 1) PACAP works only from the apical side of the epithelium to stimulate chloride and not bicarbonate secretion, while secretin acts on the apical and basolateral sides to stimulate chloride and bicarbonate secretion. Bicarbonates 334-345 adenylate cyclase activating polypeptide 1 Rattus norvegicus 90-95 14749298-5 2004 It is further shown that secretin and pituitary adenylate cyclase-activating polypeptide (PACAP) function via totally different mechanisms: 1) PACAP works only from the apical side of the epithelium to stimulate chloride and not bicarbonate secretion, while secretin acts on the apical and basolateral sides to stimulate chloride and bicarbonate secretion. Bicarbonates 334-345 adenylate cyclase activating polypeptide 1 Rattus norvegicus 143-148 9990657-0 1998 Involvement of PACAP in acid-induced HCO3- response in rat duodenums. Bicarbonates 37-41 adenylate cyclase activating polypeptide 1 Rattus norvegicus 15-20 9990657-1 1998 Pituitary adenylate cyclase activating polypeptides (PACAP) stimulate duodenal HCO3- secretion in the rat. Bicarbonates 79-83 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-51 9990657-1 1998 Pituitary adenylate cyclase activating polypeptides (PACAP) stimulate duodenal HCO3- secretion in the rat. Bicarbonates 79-83 adenylate cyclase activating polypeptide 1 Rattus norvegicus 53-58 9990657-2 1998 The present study was performed to determine whether endogenous PACAP is involved in the mechanism of acid-induced HCO3- response in the duodenum, using a PACAP antagonist, PACAP6-27. Bicarbonates 115-119 adenylate cyclase activating polypeptide 1 Rattus norvegicus 64-69 9990657-12 1998 These findings suggest that PACAP may play a role in local modulation of the duodenal mucosal integrity, by mediating the HCO3- secretory response induced by mucosal acidification. Bicarbonates 122-126 adenylate cyclase activating polypeptide 1 Rattus norvegicus 28-33 9714419-6 1998 These results suggest that PACAP-27 increases duodenal HCO3- secretion and this action may be important in maintaining the duodenal mucosal integrity against acid, and VIP affords duodenal protection by both increasing duodenal HCO3- secretion and decreasing acid secretion. Bicarbonates 55-59 adenylate cyclase activating polypeptide 1 Rattus norvegicus 27-32 9714419-6 1998 These results suggest that PACAP-27 increases duodenal HCO3- secretion and this action may be important in maintaining the duodenal mucosal integrity against acid, and VIP affords duodenal protection by both increasing duodenal HCO3- secretion and decreasing acid secretion. Bicarbonates 228-232 adenylate cyclase activating polypeptide 1 Rattus norvegicus 27-32 9403800-0 1997 Stimulatory effect of PACAP on gastroduodenal bicarbonate secretion in rats. Bicarbonates 46-57 adenylate cyclase activating polypeptide 1 Rattus norvegicus 22-27 9403800-3 1997 Intravenous injection of PACAP-27 stimulated HCO3- secretion in a dose-dependent manner in the duodenum but not in the stomach; at 8 nmol/kg PACAP-27 increased the HCO3- secretion to maximal values of four times greater than basal levels, although this peptide had no effect on duodenal HCO3- secretion after intracisternal administration (1 nmol/rat). Bicarbonates 45-49 adenylate cyclase activating polypeptide 1 Rattus norvegicus 25-30 9403800-3 1997 Intravenous injection of PACAP-27 stimulated HCO3- secretion in a dose-dependent manner in the duodenum but not in the stomach; at 8 nmol/kg PACAP-27 increased the HCO3- secretion to maximal values of four times greater than basal levels, although this peptide had no effect on duodenal HCO3- secretion after intracisternal administration (1 nmol/rat). Bicarbonates 164-168 adenylate cyclase activating polypeptide 1 Rattus norvegicus 25-30 9403800-3 1997 Intravenous injection of PACAP-27 stimulated HCO3- secretion in a dose-dependent manner in the duodenum but not in the stomach; at 8 nmol/kg PACAP-27 increased the HCO3- secretion to maximal values of four times greater than basal levels, although this peptide had no effect on duodenal HCO3- secretion after intracisternal administration (1 nmol/rat). Bicarbonates 164-168 adenylate cyclase activating polypeptide 1 Rattus norvegicus 141-146 9403800-3 1997 Intravenous injection of PACAP-27 stimulated HCO3- secretion in a dose-dependent manner in the duodenum but not in the stomach; at 8 nmol/kg PACAP-27 increased the HCO3- secretion to maximal values of four times greater than basal levels, although this peptide had no effect on duodenal HCO3- secretion after intracisternal administration (1 nmol/rat). Bicarbonates 164-168 adenylate cyclase activating polypeptide 1 Rattus norvegicus 25-30 9403800-3 1997 Intravenous injection of PACAP-27 stimulated HCO3- secretion in a dose-dependent manner in the duodenum but not in the stomach; at 8 nmol/kg PACAP-27 increased the HCO3- secretion to maximal values of four times greater than basal levels, although this peptide had no effect on duodenal HCO3- secretion after intracisternal administration (1 nmol/rat). Bicarbonates 164-168 adenylate cyclase activating polypeptide 1 Rattus norvegicus 141-146 9403800-5 1997 The potency of duodenal HCO3- secretory action was in the following order; PACAP-27 > PACAP-38 = VIP, and that of PACAP-27 was about 100-fold greater than that of PGE2. Bicarbonates 24-28 adenylate cyclase activating polypeptide 1 Rattus norvegicus 75-80 9403800-5 1997 The potency of duodenal HCO3- secretory action was in the following order; PACAP-27 > PACAP-38 = VIP, and that of PACAP-27 was about 100-fold greater than that of PGE2. Bicarbonates 24-28 adenylate cyclase activating polypeptide 1 Rattus norvegicus 89-94 9403800-5 1997 The potency of duodenal HCO3- secretory action was in the following order; PACAP-27 > PACAP-38 = VIP, and that of PACAP-27 was about 100-fold greater than that of PGE2. Bicarbonates 24-28 adenylate cyclase activating polypeptide 1 Rattus norvegicus 89-94 9403800-6 1997 The duodenal HCO3- secretory action of PACAP-27 as well as PGE2 was markedly potentiated by prior administration of isobutylmethyl xanthine (10 mg/kg, sc), the inhibitor of phosphodiesterase. Bicarbonates 13-17 adenylate cyclase activating polypeptide 1 Rattus norvegicus 39-44 9124587-0 1997 PACAPs stimulate duodenal bicarbonate secretion at PACAP receptors in the rat. Bicarbonates 26-37 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-5 9124587-3 1997 Intravenous injection of PACAP-27 stimulated HCO(3)- secretion in a dose-dependent manner in the duodenum, but not in the stomach, although this peptide had no effect on duodenal HCO(3)- secretion after intracisternal administration. Bicarbonates 45-51 adenylate cyclase activating polypeptide 1 Rattus norvegicus 25-30 9124587-4 1997 The duodenal HCO(3)- stimulatory action was similarly observed after intravenous administration of PACAP-38 and VIP, and the potency of action was in the following order: PACAP-27 > PACAP-38 = VIP. Bicarbonates 13-19 adenylate cyclase activating polypeptide 1 Rattus norvegicus 99-104 9124587-4 1997 The duodenal HCO(3)- stimulatory action was similarly observed after intravenous administration of PACAP-38 and VIP, and the potency of action was in the following order: PACAP-27 > PACAP-38 = VIP. Bicarbonates 13-19 adenylate cyclase activating polypeptide 1 Rattus norvegicus 171-176 9124587-4 1997 The duodenal HCO(3)- stimulatory action was similarly observed after intravenous administration of PACAP-38 and VIP, and the potency of action was in the following order: PACAP-27 > PACAP-38 = VIP. Bicarbonates 13-19 adenylate cyclase activating polypeptide 1 Rattus norvegicus 171-176 9124587-5 1997 The duodenal HCO(3)- stimulatory action of PACAP-27 was potentiated by pretreatment with 3-isobutyl-1-methylxanthine, similar to that of prostaglandin E2, and was significantly attenuated by PACAP-(6--27) (PACAP antagonist) or Ac-Tyr1,D-Phe2-VIP (VIP antagonist) but was not affected by bilateral vagotomy or prior administration of atropine, verapamil, and indomethacin. Bicarbonates 13-19 adenylate cyclase activating polypeptide 1 Rattus norvegicus 43-48 9124587-5 1997 The duodenal HCO(3)- stimulatory action of PACAP-27 was potentiated by pretreatment with 3-isobutyl-1-methylxanthine, similar to that of prostaglandin E2, and was significantly attenuated by PACAP-(6--27) (PACAP antagonist) or Ac-Tyr1,D-Phe2-VIP (VIP antagonist) but was not affected by bilateral vagotomy or prior administration of atropine, verapamil, and indomethacin. Bicarbonates 13-19 adenylate cyclase activating polypeptide 1 Rattus norvegicus 191-196 9124587-5 1997 The duodenal HCO(3)- stimulatory action of PACAP-27 was potentiated by pretreatment with 3-isobutyl-1-methylxanthine, similar to that of prostaglandin E2, and was significantly attenuated by PACAP-(6--27) (PACAP antagonist) or Ac-Tyr1,D-Phe2-VIP (VIP antagonist) but was not affected by bilateral vagotomy or prior administration of atropine, verapamil, and indomethacin. Bicarbonates 13-19 adenylate cyclase activating polypeptide 1 Rattus norvegicus 191-196