PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12227255-2 2002 NHE3 antiporter has a major role in HCO3- and NaCl reabsorption in the proximal tubule. Bicarbonates 36-40 solute carrier family 9 member A3 Homo sapiens 0-4 9019664-4 1996 NHE3, which is the apical isoform of the proximal tubule and thick ascending limb of Henle, is involved in bicarbonate reabsorption and displays activation during metabolic acidosis. Bicarbonates 107-118 solute carrier family 9 member A3 Homo sapiens 0-4 28271233-3 2017 Increased fluid flow stimulates Na+ and HCO3- absorption in the proximal tubule via stimulation of Na/H-exchanger isoform 3 (NHE3) and H+-ATPase. Bicarbonates 40-44 solute carrier family 9 member A3 Homo sapiens 99-123 35076190-1 2022 BACKGROUND/AIMS: NHE3 (Na+/H+ exchanger3) and SLC26A3 (Cl-/HCO3- exchanger, DRA) are the major components of the intestinal neutral NaCl absorptive process and based on the intestinal segment, contribute to HCO3- absorption and HCO3- secretion. Bicarbonates 207-211 solute carrier family 9 member A3 Homo sapiens 17-21 35076190-1 2022 BACKGROUND/AIMS: NHE3 (Na+/H+ exchanger3) and SLC26A3 (Cl-/HCO3- exchanger, DRA) are the major components of the intestinal neutral NaCl absorptive process and based on the intestinal segment, contribute to HCO3- absorption and HCO3- secretion. Bicarbonates 207-211 solute carrier family 9 member A3 Homo sapiens 23-40 35076190-1 2022 BACKGROUND/AIMS: NHE3 (Na+/H+ exchanger3) and SLC26A3 (Cl-/HCO3- exchanger, DRA) are the major components of the intestinal neutral NaCl absorptive process and based on the intestinal segment, contribute to HCO3- absorption and HCO3- secretion. Bicarbonates 228-232 solute carrier family 9 member A3 Homo sapiens 17-21 35076190-1 2022 BACKGROUND/AIMS: NHE3 (Na+/H+ exchanger3) and SLC26A3 (Cl-/HCO3- exchanger, DRA) are the major components of the intestinal neutral NaCl absorptive process and based on the intestinal segment, contribute to HCO3- absorption and HCO3- secretion. Bicarbonates 228-232 solute carrier family 9 member A3 Homo sapiens 23-40 28271233-3 2017 Increased fluid flow stimulates Na+ and HCO3- absorption in the proximal tubule via stimulation of Na/H-exchanger isoform 3 (NHE3) and H+-ATPase. Bicarbonates 40-44 solute carrier family 9 member A3 Homo sapiens 125-129 26041446-2 2015 Since sodium and bicarbonate reabsorption are coupled, we postulated that the molecules involved in their reabsorption [NHE3 and carbonic anhydrase II (CAII)] might physically and functionally interact. Bicarbonates 17-28 solute carrier family 9 member A3 Homo sapiens 120-124 25131781-6 2014 On the apical domain, Na(+)-H(+) exchanger NHE3 and the vacuolar H(+)-ATPase are two major pathways mediating the apical uptake of HCO3(-)-related species. Bicarbonates 131-138 solute carrier family 9 member A3 Homo sapiens 43-47 25131781-7 2014 Taken together, NHE3 and H(+)-ATPase are responsible for about 80% of HCO3(-) reabsorption in the proximal tubule. Bicarbonates 70-74 solute carrier family 9 member A3 Homo sapiens 16-20 23784542-7 2013 CCh stimulation concomitantly internalized the Na(+/)H(+) exchanger 3 (NHE3) and recruited cystic fibrosis transmembrane conductance regulator (CFTR) to the apical membranes, a process that was important for CFTR-mediated bicarbonate secretion necessary for proper gel-forming mucin unfolding. Bicarbonates 222-233 solute carrier family 9 member A3 Homo sapiens 47-69 23784542-7 2013 CCh stimulation concomitantly internalized the Na(+/)H(+) exchanger 3 (NHE3) and recruited cystic fibrosis transmembrane conductance regulator (CFTR) to the apical membranes, a process that was important for CFTR-mediated bicarbonate secretion necessary for proper gel-forming mucin unfolding. Bicarbonates 222-233 solute carrier family 9 member A3 Homo sapiens 71-75 19538314-2 2009 DRA (downregulated in adenoma) is an intestinal chloride/bicarbonate exchanger that is functionally coupled to CFTR (cystic fibrosis transmembrane regulator) in the upper gastrointestinal tract to mediate chloride and bicarbonate secretion and to NHE3 (Na/H exchanger- isoform 3) in the lower gastrointestinal tract to mediate electroneutral NaCl absorption. Bicarbonates 57-68 solute carrier family 9 member A3 Homo sapiens 247-251 19538314-2 2009 DRA (downregulated in adenoma) is an intestinal chloride/bicarbonate exchanger that is functionally coupled to CFTR (cystic fibrosis transmembrane regulator) in the upper gastrointestinal tract to mediate chloride and bicarbonate secretion and to NHE3 (Na/H exchanger- isoform 3) in the lower gastrointestinal tract to mediate electroneutral NaCl absorption. Bicarbonates 218-229 solute carrier family 9 member A3 Homo sapiens 253-278 22419175-1 2012 The Na(+/)H(+) exchanger isoform 3 (NHE3) is essential for HCO(3)(-) reabsorption in renal proximal tubules. Bicarbonates 59-64 solute carrier family 9 member A3 Homo sapiens 4-34 22419175-1 2012 The Na(+/)H(+) exchanger isoform 3 (NHE3) is essential for HCO(3)(-) reabsorption in renal proximal tubules. Bicarbonates 59-64 solute carrier family 9 member A3 Homo sapiens 36-40 19538314-2 2009 DRA (downregulated in adenoma) is an intestinal chloride/bicarbonate exchanger that is functionally coupled to CFTR (cystic fibrosis transmembrane regulator) in the upper gastrointestinal tract to mediate chloride and bicarbonate secretion and to NHE3 (Na/H exchanger- isoform 3) in the lower gastrointestinal tract to mediate electroneutral NaCl absorption. Bicarbonates 57-68 solute carrier family 9 member A3 Homo sapiens 253-278 19538314-2 2009 DRA (downregulated in adenoma) is an intestinal chloride/bicarbonate exchanger that is functionally coupled to CFTR (cystic fibrosis transmembrane regulator) in the upper gastrointestinal tract to mediate chloride and bicarbonate secretion and to NHE3 (Na/H exchanger- isoform 3) in the lower gastrointestinal tract to mediate electroneutral NaCl absorption. Bicarbonates 218-229 solute carrier family 9 member A3 Homo sapiens 247-251 17913841-1 2007 In mammalian nephrons, most of the Na(+) and HCO(3)(-) is reabsorbed by proximal tubular cells in which the Na(+)/H(+) exchanger 3 (NHE3) is the major player. Bicarbonates 45-51 solute carrier family 9 member A3 Homo sapiens 108-130 17913841-1 2007 In mammalian nephrons, most of the Na(+) and HCO(3)(-) is reabsorbed by proximal tubular cells in which the Na(+)/H(+) exchanger 3 (NHE3) is the major player. Bicarbonates 45-51 solute carrier family 9 member A3 Homo sapiens 132-136 16293618-1 2006 Na+/H+ exchanger 3 (NHE3) plays a pivotal role in transepithelial Na+ and HCO3(-) absorption across a wide range of epithelia in the digestive and renal-genitourinary systems. Bicarbonates 74-78 solute carrier family 9 member A3 Homo sapiens 0-18 17882150-5 2007 NHE3 mediates secretion of the majority of protons involved in bicarbonate reclamation, is involved in ammonium secretion, and provides a source of luminal protons for titrating filtered titratable acids and secreted ammonia to ammonium. Bicarbonates 63-74 solute carrier family 9 member A3 Homo sapiens 0-4 17071327-5 2006 The best-studied isoform for acid-base homeostasis is NHE3, which mediates both HCO(3)(-) absorption and H(+) excretion in the renal tubule. Bicarbonates 80-86 solute carrier family 9 member A3 Homo sapiens 54-58 16293618-1 2006 Na+/H+ exchanger 3 (NHE3) plays a pivotal role in transepithelial Na+ and HCO3(-) absorption across a wide range of epithelia in the digestive and renal-genitourinary systems. Bicarbonates 74-78 solute carrier family 9 member A3 Homo sapiens 20-24 11408268-0 2001 Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement. Bicarbonates 82-93 solute carrier family 9 member A3 Homo sapiens 67-71 12369822-0 2002 The down regulated in adenoma (dra) gene product binds to the second PDZ domain of the NHE3 kinase A regulatory protein (E3KARP), potentially linking intestinal Cl-/HCO3- exchange to Na+/H+ exchange. Bicarbonates 165-169 solute carrier family 9 member A3 Homo sapiens 87-91 12139400-7 2002 The inhibitor sensitivity of Na+-H+ exchange in renal brush-border vesicles and of HCO3- absorption in microperfused tubules suggested that NHE3 is responsible for most, if not all, apical membrane Na+-H+ exchange in the proximal tubule. Bicarbonates 83-87 solute carrier family 9 member A3 Homo sapiens 140-144 11818226-4 2002 NHE-3 is usually expressed in the apical membrane of mammalian epithelial cells where it helps reabsorb Na(+) and HCO(3)(-); it has also been detected in teleost gills. Bicarbonates 114-120 solute carrier family 9 member A3 Homo sapiens 0-5 11875260-3 2001 In pancreatic ducts HCO(3)(-) secretion is mediated by cystic fibrosis transmembrane conductance regulator (CFTR) activated luminal Cl(-)/HCO(3)(-) exchange activity and HCO(3)(-) absorption is achieved by Na(+)-dependent mechanisms including Na(+)/H(+) exchanger 3 (NHE3). Bicarbonates 20-26 solute carrier family 9 member A3 Homo sapiens 243-265 11875260-3 2001 In pancreatic ducts HCO(3)(-) secretion is mediated by cystic fibrosis transmembrane conductance regulator (CFTR) activated luminal Cl(-)/HCO(3)(-) exchange activity and HCO(3)(-) absorption is achieved by Na(+)-dependent mechanisms including Na(+)/H(+) exchanger 3 (NHE3). Bicarbonates 20-26 solute carrier family 9 member A3 Homo sapiens 267-271 11875260-3 2001 In pancreatic ducts HCO(3)(-) secretion is mediated by cystic fibrosis transmembrane conductance regulator (CFTR) activated luminal Cl(-)/HCO(3)(-) exchange activity and HCO(3)(-) absorption is achieved by Na(+)-dependent mechanisms including Na(+)/H(+) exchanger 3 (NHE3). Bicarbonates 20-25 solute carrier family 9 member A3 Homo sapiens 243-265 11875260-3 2001 In pancreatic ducts HCO(3)(-) secretion is mediated by cystic fibrosis transmembrane conductance regulator (CFTR) activated luminal Cl(-)/HCO(3)(-) exchange activity and HCO(3)(-) absorption is achieved by Na(+)-dependent mechanisms including Na(+)/H(+) exchanger 3 (NHE3). Bicarbonates 20-25 solute carrier family 9 member A3 Homo sapiens 267-271