PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20166401-1 2010 Secretin is a polypeptide hormone that stimulates secretion of bicarbonate from the exocrine pancreas and, in healthy human subjects, causes transient pancreatic duct dilation observable sonographically. Bicarbonates 63-74 secretin Homo sapiens 0-8 21525756-8 2010 Secretin is a major stimulator of bicarbonate secretion. Bicarbonates 34-45 secretin Homo sapiens 0-8 16192632-8 2005 High secretin receptor expression in the non-neoplastic ducts reflects the major role of secretin in bicarbonate secretion. Bicarbonates 101-112 secretin Homo sapiens 5-13 19687722-2 2009 Secretin is a polypeptide hormone that has numerous physiological effects, including stimulation of the pancreatic secretion of bicarbonate-rich fluid and transient increase in the tone in the sphincter of Oddi. Bicarbonates 128-139 secretin Homo sapiens 0-8 18280672-3 2008 Once in the circulation, secretin has five well-documented effects that protect the upper intestine from gastric acid: it stimulates secretion of bicarbonate rich exocrine pancreatic juice; it stimulates secretion of alkaline bile; it stimulates secretion of alkaline mucus from the duodenal submucosal glands of Brunner; it inhibits the humoral phase of gastric secretion; and it inhibits gastric motility, thereby delaying gastric emptying. Bicarbonates 146-157 secretin Homo sapiens 25-33 11039470-8 2000 The peak bicarbonate concentration (mean +/- SD) obtained by using biologic porcine secretin and synthetic porcine secretin were 70 +/- 25 mEq/L and 68 +/- 31 mEq/L, respectively (p = 0.58, paired t test; R = 0.964). Bicarbonates 9-20 secretin Homo sapiens 84-92 15767727-6 2005 Pancreatic ductal cells are largely responsible for the amount of bicarbonate and water secretion in response to secretin stimulation. Bicarbonates 66-77 secretin Homo sapiens 113-121 12358245-2 2002 Secretin is a polypeptide hormone that increases the volume and bicarbonate content of pancreatic secretions. Bicarbonates 64-75 secretin Homo sapiens 0-8 12131765-9 2002 In addition, the ratio correlated significantly with the maximal bicarbonate concentration and secretory volume on the secretin test. Bicarbonates 65-76 secretin Homo sapiens 119-127 12709690-1 2003 BACKGROUND: Secretin, a 27 amino acid polypeptide released in response to duodenal luminal acidification, stimulates secretion of water and bicarbonate from pancreatic ductal cells. Bicarbonates 140-151 secretin Homo sapiens 12-20 11039470-8 2000 The peak bicarbonate concentration (mean +/- SD) obtained by using biologic porcine secretin and synthetic porcine secretin were 70 +/- 25 mEq/L and 68 +/- 31 mEq/L, respectively (p = 0.58, paired t test; R = 0.964). Bicarbonates 9-20 secretin Homo sapiens 115-123 10880878-1 2000 Secretin stimulates bicarbonate secretion from pancreatic duct cells, but what influence secretin exerts on intestinal tissues remains to be clarified. Bicarbonates 20-31 secretin Homo sapiens 0-8 11060443-1 2000 Secretin is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Bicarbonates 66-77 secretin Homo sapiens 0-8 8531367-4 1995 Hyposecretion of bicarbonate in secretin test seemed to be characteristic in SS. Bicarbonates 17-28 secretin Homo sapiens 32-40 10537138-1 1999 Secretin is a 27-amino acid long peptide hormone that regulates pancreatic water, bicarbonate, enzymes, and potassium ion secretion. Bicarbonates 82-93 secretin Homo sapiens 0-8 8829188-0 1996 Secretin-induced plasma bicarbonate decrease as a simple indicator of exocrine pancreatic function. Bicarbonates 24-35 secretin Homo sapiens 0-8 8829188-2 1996 A decrease in plasma bicarbonate was observed in persons with normal exocrine pancreatic function as defined by normal bicarbonate and enzyme secretion in the secretin-cerulein test (n = 39). Bicarbonates 21-32 secretin Homo sapiens 159-167 8829188-11 1996 The secretin-induced plasma bicarbonate decrease may therefore be used as a new simple tubeless test to evaluate exocrine pancreatic function. Bicarbonates 28-39 secretin Homo sapiens 4-12 8734352-6 1996 RESULTS: The secretin test was completed in 54 patients, and in 10 (19%) it showed a decreased maximal bicarbonate concentration, corresponding to 4% of the whole study group. Bicarbonates 103-114 secretin Homo sapiens 13-21 10630942-6 2000 Secretin alone decreased salivary flow rate and bicarbonate concentration, whereas secretin supplemented with cerulein not only decreased salivary flow rate, bicarbonate concentration, and bicarbonate output but also increased protein concentration. Bicarbonates 158-169 secretin Homo sapiens 83-91 10630942-6 2000 Secretin alone decreased salivary flow rate and bicarbonate concentration, whereas secretin supplemented with cerulein not only decreased salivary flow rate, bicarbonate concentration, and bicarbonate output but also increased protein concentration. Bicarbonates 158-169 secretin Homo sapiens 83-91 10437774-1 1999 Secretin is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Bicarbonates 52-63 secretin Homo sapiens 0-8 10751901-14 1999 Secretin stimulates the releasing of water, bicarbonate and enteropeptidases whereas cholecystokinin acts on pancreatic enzymes. Bicarbonates 44-55 secretin Homo sapiens 0-8 10069525-6 1999 Secretin significantly (P<0.005-P<0.05) increased volume and bicarbonate output and CCK significantly (P<0.01) increased the output of bilirubin, pancreatic enzymes, bicarbonate and volume, both during normoglycemia and hyperglycemia. Bicarbonates 67-78 secretin Homo sapiens 0-8 9626762-4 1997 Secretin induces a bicarbonate rich choleresis by stimulating the activity of the Cl-/HCO3- exchanger by cAMP and protein kinase A mediated phosphorylation of CFTR regulatory domain. Bicarbonates 19-30 secretin Homo sapiens 0-8 9626762-8 1997 Somatostatin and gastrin inhibit basal and/or secretin-stimulated bicarbonate excretion by down-regulating the secretin receptor and decreasing cAMP intracellular levels induced by secretin. Bicarbonates 66-77 secretin Homo sapiens 46-54 9626762-8 1997 Somatostatin and gastrin inhibit basal and/or secretin-stimulated bicarbonate excretion by down-regulating the secretin receptor and decreasing cAMP intracellular levels induced by secretin. Bicarbonates 66-77 secretin Homo sapiens 111-119 7958697-8 1994 CONCLUSIONS: A negative-feedback regulation of pancreatic secretion of bicarbonate and enzyme occurs in humans and is mediated via both secretin and cholecystokinin. Bicarbonates 71-82 secretin Homo sapiens 136-144 7864894-1 1995 Through binding to high affinity receptors, secretin is the major hormonal stimulant of ductular bicarbonate secretion in the pancreas, contributes toward enzyme secretion from pancreatic acinar cells, and has been implicated as a pancreatic growth factor. Bicarbonates 97-108 secretin Homo sapiens 44-52 7612008-1 1995 Secretin is a gastrointestinal hormone responsible for the regulation of bicarbonate, potassium ion and enzyme secretion from the pancreas. Bicarbonates 73-84 secretin Homo sapiens 0-8 1792500-10 1991 Reabsorption of water and electrolytes in the bile ducts and in the gallbladder, and secretion of bicarbonate by the bile ducts, stimulated by secretin. Bicarbonates 98-109 secretin Homo sapiens 143-151 2083798-7 1990 The pancreaticobiliary secretion of bicarbonate, as judged by plasma secretin concentrations, increased, however, earlier when mucosal bicarbonate secretion had been inhibited than when not (3.7 vs. 3.0 pmol/l at an acid load of 6.0 mmol/h). Bicarbonates 36-47 secretin Homo sapiens 69-77 2210251-11 1990 Secretin caused an increase in bile flow and bicarbonate output. Bicarbonates 45-56 secretin Homo sapiens 0-8 1704124-3 1990 Potentiation (more-than-additive response) was observed between secretin and cerulein for bicarbonate secretion, but not for enzyme secretion. Bicarbonates 90-101 secretin Homo sapiens 64-72 2006391-5 1991 Although secretin did not increase the concentration, bicarbonate output increased threefold during secretin infusion but only twofold during VIP infusion. Bicarbonates 54-65 secretin Homo sapiens 100-108 1981635-16 1990 Both VIP and secretin increased bicarbonate output, whereas only VIP increased the concentration. Bicarbonates 32-43 secretin Homo sapiens 13-21 35195598-1 2022 OBJECTIVES: The objective was to assess if the peak bicarbonate level during secretin stimulation testing (SST) differs between patients with minimal change (or small duct) chronic pancreatitis (CP) versus those with obvious CP (or large duct) versus those without CP. Bicarbonates 52-63 secretin Homo sapiens 77-85 34027905-4 2021 Like in the pancreas, the hormone secretin is a key agonist to activate renal HCO3- secretion. Bicarbonates 78-82 secretin Homo sapiens 34-42 2928730-6 1989 Although secretin (0.01 to 0.18 CU/kg-h intravenously) markedly increased pancreatic bicarbonate secretion, it failed to alter duodenal mucosal bicarbonate output in either the proximal or the distal duodenum. Bicarbonates 85-96 secretin Homo sapiens 9-17 2612013-4 1989 We conclude that (a) measurement of bicarbonate output in 30 min after an appropriate dose of secretin given as a bolus injection yields results that are comparable to those obtained when secretin and pancreozymin are given by constant intravenous infusion in doses to evoke maximal secretory responses; and (b) the yield of hormone tests using duodenal intubation is far from ideal. Bicarbonates 36-47 secretin Homo sapiens 94-102 2663608-5 1989 In all cases with biliary drainage, secretin produced a remarkable choleretic effect with a high concentration of bicarbonate. Bicarbonates 114-125 secretin Homo sapiens 36-44 2446946-4 1988 Increasing doses of either human or porcine secretin produced increasing bicarbonate output (p less than 0.01), whereas trypsin and lipase were not stimulated over basal. Bicarbonates 73-84 secretin Homo sapiens 44-52 2471968-4 1989 Bicarbonate outputs produced by plaunotol correlated well with plasma secretin concentrations (r = 0.727, p less than 0.001). Bicarbonates 0-11 secretin Homo sapiens 70-78 2471968-7 1989 These results indicate that endogenous secretin is released by plaunotol in humans and suggest that the increased pancreatic bicarbonate secretion can be attributed to the increased plasma secretin concentration. Bicarbonates 125-136 secretin Homo sapiens 39-47 2471968-7 1989 These results indicate that endogenous secretin is released by plaunotol in humans and suggest that the increased pancreatic bicarbonate secretion can be attributed to the increased plasma secretin concentration. Bicarbonates 125-136 secretin Homo sapiens 189-197 3197585-4 1988 Pyruvate concentrations were markedly increased by each stimulation, especially by secretin, and the cumulative excretions of pyruvate and bicarbonate after secretin stimulation were significantly correlated among the subjects. Bicarbonates 139-150 secretin Homo sapiens 157-165 2446946-8 1988 When human secretin was infused at postprandial concentrations, significant increases in pancreatic bicarbonate output were observed (p less than 0.05). Bicarbonates 100-111 secretin Homo sapiens 11-19 2889300-9 1987 Secretin might be a protective factor for the gastric mucosa by stimulating mucous and bicarbonate secretion. Bicarbonates 87-98 secretin Homo sapiens 0-8 3362847-1 1988 Potentiating action between secretin and cholecystokinin on exocrine pancreatic secretion of bicarbonate has been well recognized. Bicarbonates 93-104 secretin Homo sapiens 28-36 3362847-8 1988 Since the inhibitory effect of atropine on the secretin-stimulated bicarbonate output was statistically significant, the major inhibitory effect of atropine on the potentiation of pancreatic bicarbonate secretion appears to be its effect on the action of secretin. Bicarbonates 67-78 secretin Homo sapiens 47-55 3423737-2 1987 The release of CCK was found to be unaffected by the changes in osmolality, whereas the plasma levels of secretin were affected in parallel with volume and bicarbonate secretion. Bicarbonates 156-167 secretin Homo sapiens 105-113 3423737-3 1987 An inverse relation was found between fatty acid absorption and release of secretin and bicarbonate secretion but not between fatty acid absorption and release of CCK. Bicarbonates 88-99 secretin Homo sapiens 75-83 3575314-9 1987 Duodenal bicarbonate output/h after secretin also showed a significant correlation with peak fluorescein serum concentration (r = 0.79; p less than 0.001). Bicarbonates 9-20 secretin Homo sapiens 36-44 3562442-4 1986 The correlation between plasma secretin concentrations and bicarbonate outputs was also significant (r = 0.483; p less than 0.01). Bicarbonates 59-70 secretin Homo sapiens 31-39 2445869-4 1986 Furthermore, the bicarbonate secretion and the flow rate elicited by secretin were augmented by CCK, whereas no augmentation was found with regard to the CCK-stimulated enzyme and bile salts output. Bicarbonates 17-28 secretin Homo sapiens 69-77 3562442-5 1986 These results indicate that endogenous secretin is released by Fm100 in humans and suggest strongly that the increased pancreatic bicarbonate secretion is attributable to the increased plasma concentration of secretin. Bicarbonates 130-141 secretin Homo sapiens 39-47 3562442-5 1986 These results indicate that endogenous secretin is released by Fm100 in humans and suggest strongly that the increased pancreatic bicarbonate secretion is attributable to the increased plasma concentration of secretin. Bicarbonates 130-141 secretin Homo sapiens 209-217 3998145-5 1985 Increasing doses of secretin produced increasing bicarbonate output (P less than 0.01), whereas trypsin was not stimulated over basal. Bicarbonates 49-60 secretin Homo sapiens 20-28 4064863-2 1985 One patient had a reduction in the severity of diabetes mellitus, while another showed a progressive increase in the maximum bicarbonate concentration in duodenal juice after the intravenous injection of secretin. Bicarbonates 125-136 secretin Homo sapiens 204-212 3998145-7 1985 Potentiation occurred for bicarbonate secretion between secretin and caerulein, but not for trypsin output. Bicarbonates 26-37 secretin Homo sapiens 56-64 6123268-3 1982 Secretion rate and bicarbonate following secretin, lipase, amylase and secretin rate following pancreozymin were significantly lower in the old than in the young after first and second stimulation. Bicarbonates 19-30 secretin Homo sapiens 41-49 6745726-6 1984 As far as bicarbonate is concerned, the lowest dose of secretin (0.03 CU/kg/h) significantly (p less than 0.001) stimulated bicarbonate output. Bicarbonates 10-21 secretin Homo sapiens 55-63 6745726-6 1984 As far as bicarbonate is concerned, the lowest dose of secretin (0.03 CU/kg/h) significantly (p less than 0.001) stimulated bicarbonate output. Bicarbonates 124-135 secretin Homo sapiens 55-63 6745726-7 1984 The dose of 0.9 CU/kg/h of secretin evoked a bicarbonate output of 526 +/- 49 micromol/min; trebling the dose of secretin did not significantly increase the output of bicarbonate above this value. Bicarbonates 45-56 secretin Homo sapiens 27-35 7091334-2 1982 Secretin given intravenously in graded doses of 0.03, 0.06, and 0.125 clinical units.kg-1.h-1 produced significant increases in pancreatic secretion of bicarbonate in a dose-related manner. Bicarbonates 152-163 secretin Homo sapiens 0-8 7091334-4 1982 Intrajejunal perfusion of HCl at a rate of 3.3 mM/h, producing plasma secretin concentration comparable with that of the postprandial state, resulted in significant increases in the pancreatic secretion of bicarbonate. Bicarbonates 206-217 secretin Homo sapiens 70-78 3969605-2 1985 When administered intravenously to healthy volunteers, terbutaline significantly inhibited secretin-stimulated output of duodenal juice and bicarbonate. Bicarbonates 140-151 secretin Homo sapiens 91-99 6303892-0 1983 Potentiation effect of cholecystokinin-octapeptide on pancreatic bicarbonate secretion stimulated by a physiologic dose of secretin in humans. Bicarbonates 65-76 secretin Homo sapiens 123-131 6303892-1 1983 We studied the potentiation effect of cholecystokinin-octapeptide and secretin on pancreatic secretion of bicarbonate and trypsin in humans. Bicarbonates 106-117 secretin Homo sapiens 70-78 6303892-16 1983 Thus, cholecystokinin-octapeptide in a relatively small dose range potentiated the pancreatic bicarbonate secretion stimulated by a physiologic dose of secretin. Bicarbonates 94-105 secretin Homo sapiens 152-160 6840488-12 1983 These studies indicate that endogenous secretin is released by an agent other than acid and suggest strongly that the increased pancreatic bicarbonate secretion is attributed to the increased plasma concentration of secretin. Bicarbonates 139-150 secretin Homo sapiens 39-47 6840488-12 1983 These studies indicate that endogenous secretin is released by an agent other than acid and suggest strongly that the increased pancreatic bicarbonate secretion is attributed to the increased plasma concentration of secretin. Bicarbonates 139-150 secretin Homo sapiens 216-224 6183160-4 1982 During a background secretin infusion, there was a significant increase of bicarbonate and amylase output (p less than 0.05) during sham feeding. Bicarbonates 75-86 secretin Homo sapiens 20-28 6123268-3 1982 Secretion rate and bicarbonate following secretin, lipase, amylase and secretin rate following pancreozymin were significantly lower in the old than in the young after first and second stimulation. Bicarbonates 19-30 secretin Homo sapiens 71-79 34207-0 1979 Physiological significance of secretin in the pancreatic bicarbonate secretion. Bicarbonates 57-68 secretin Homo sapiens 30-38 6168511-4 1981 However, synthetic secretin evoked a significantly greater volume and amount of bicarbonate after infusion than the natural compound whilst no difference resulted in the other variables. Bicarbonates 80-91 secretin Homo sapiens 19-27 6104568-9 1980 It is concluded that a sensitive, validated secretin radioimmunoassay should be one that is capable of detecting increments of plasma secretin in response to doses of intraduodenal acid at 0.055 mEq/min or lower and intravenous administration of exogenous secretin at 0.03 CU/kg/hr with concomitant stimulation of pancreatic bicarbonate and water secretion. Bicarbonates 325-336 secretin Homo sapiens 44-52 6104568-9 1980 It is concluded that a sensitive, validated secretin radioimmunoassay should be one that is capable of detecting increments of plasma secretin in response to doses of intraduodenal acid at 0.055 mEq/min or lower and intravenous administration of exogenous secretin at 0.03 CU/kg/hr with concomitant stimulation of pancreatic bicarbonate and water secretion. Bicarbonates 325-336 secretin Homo sapiens 134-142 6104568-9 1980 It is concluded that a sensitive, validated secretin radioimmunoassay should be one that is capable of detecting increments of plasma secretin in response to doses of intraduodenal acid at 0.055 mEq/min or lower and intravenous administration of exogenous secretin at 0.03 CU/kg/hr with concomitant stimulation of pancreatic bicarbonate and water secretion. Bicarbonates 325-336 secretin Homo sapiens 134-142 37687-4 1979 Significant positive correlations were obtained between plasma secretin and infused dose of HCl, between pancreatic bicarbonate output and infused dose of HCl and between plasma secretin and pancreatic bicarbonate output. Bicarbonates 202-213 secretin Homo sapiens 178-186 37687-5 1979 The calculated maximal pancreatic bicarbonate output (Vmax) of 30.6 mEq/h and the calculated dose of secretin to elicit half maximal pancreatic bicarbonate output (S50) of 0.2 CU/kg-h following duodenal acidification were comparable to that seen after intravenous infusion of secretin. Bicarbonates 144-155 secretin Homo sapiens 101-109 424692-0 1979 Physiological significance of secretin in the pancreatic bicarbonate secretion. Bicarbonates 57-68 secretin Homo sapiens 30-38 424692-2 1979 Pancreatic bicarbonate response to a physiological increase in plasma secretin concentration. Bicarbonates 11-22 secretin Homo sapiens 70-78 424692-6 1979 All three doses of secretin increased plasma secretin concentration, duodenal bicarbonate concentration, and duodenal bicarbonate output significantly. Bicarbonates 78-89 secretin Homo sapiens 19-27 424692-6 1979 All three doses of secretin increased plasma secretin concentration, duodenal bicarbonate concentration, and duodenal bicarbonate output significantly. Bicarbonates 118-129 secretin Homo sapiens 19-27 424692-8 1979 The increments in median plasma secretin concentration were 1.6, 3.0, and 6.4 pmol x 1(-1) after secretin, 125, 250 and 500 fmol x kg-1, and the corresponding 15-min bicarbonate output 283, 442, and 1435 micromol, respectively. Bicarbonates 166-177 secretin Homo sapiens 32-40 424692-10 1979 It is concluded that the physiological concentrations or secretin influence pancreatic bicarbonate secretion. Bicarbonates 87-98 secretin Homo sapiens 57-65 30676-6 1978 In 7 additional subjects, bolus intravenous injections of 0.005 and 0.01 clinical units kg-1 of porcine secretin resulted in peak delta secretin concentrations of 5.5 and 10.5 pg ml-1, respectively, and were followed by a significant increase of bicarbonate output in the duodenal aspirate. Bicarbonates 246-257 secretin Homo sapiens 104-112 30676-7 1978 These results indicate that secretin is released unevenly and intermittently in the early period after a liquid meal in man, in amounts that seem sufficient for the initiation of a significant bicarbonate response. Bicarbonates 193-204 secretin Homo sapiens 28-36 6946754-6 1981 There was a 92% correlation between a normal or abnormal pancreatic bicarbonate concentration and a normal or abnormal peak/basal PP ratio in response to Boots secretin. Bicarbonates 68-79 secretin Homo sapiens 160-168 6265294-1 1981 In animals, exogenous secretin produces dose--related increases in pancreatic tissue levels of cyclic AMP which are closely correlated with both bicarbonate and cyclic AMP outputs in pancreatic juice. Bicarbonates 145-156 secretin Homo sapiens 22-30 6265294-5 1981 In man, bicarbonate and cyclic AMP concentrations of pure pancreatic juice obtained by endoscopic cannulation of Vater"s papilla are significantly correlated in response to both secretin and VIP. Bicarbonates 8-19 secretin Homo sapiens 178-186 6797043-2 1981 However, it showed a spectrum of activities which resembled those of secretin, including stimulation of pepsin, hepatic bile secretion, and pancreatic bicarbonate secretion. Bicarbonates 151-162 secretin Homo sapiens 69-77 6797043-4 1981 In particular, if the ratio of the stimulation of pepsin secretion to that of pancreatic juice bicarbonate was 1:1 for secretin, it was 4:1 for gastrozymin. Bicarbonates 95-106 secretin Homo sapiens 119-127 6165067-12 1980 The increase in the plasma concentration of secretin after repeated bile infusions, with a corresponding effect on flow rate and bicarbonate secretion, indicates that secretin may be the main factor responsible for the exocrine pancreatic secretion caused by intraduodenal bile infusions. Bicarbonates 129-140 secretin Homo sapiens 44-52 6165067-12 1980 The increase in the plasma concentration of secretin after repeated bile infusions, with a corresponding effect on flow rate and bicarbonate secretion, indicates that secretin may be the main factor responsible for the exocrine pancreatic secretion caused by intraduodenal bile infusions. Bicarbonates 129-140 secretin Homo sapiens 167-175 549430-3 1979 From a basal level of 28 +/- 13 mu mol/5 min, secretin by itself significantly increased pancreatic bicarbonate to 182 +/- 24 mu mol/5 min. Bicarbonates 100-111 secretin Homo sapiens 46-54 103722-2 1978 In the presence of secretin (0.5 CU/kg.h) the infusion of Ca2+ (0.3 mmol/kg.105 min) resulted in an increase in secretion of enzymes by 100-200%, and in that of Ca2+ and Mg2+ by 50-100% without affecting fluid and bicarbonate secretion. Bicarbonates 214-225 secretin Homo sapiens 19-27 725515-3 1978 Secretin (0.6 microgram per kg/h) was found to abolish the net absorption of water, Na+, and HCO3- and strongly reduce the net absorption of K+ and Cl-, whereas neither glucagon (1--20 microgram per kg/h) nor GIP (1--30 microgram per kg/h) was found to significantly influence the concentrating function of the gallbladder. Bicarbonates 93-97 secretin Homo sapiens 0-8 356498-5 1978 Pancreatic bicarbonate and enzyme secretions are stimulated by secretin and CCK-PZ, especially in combination. Bicarbonates 11-22 secretin Homo sapiens 63-71 648803-4 1978 In chronic pancreatitis, secretin releasing response to acidification was markedly impaired, in addition, inhibition of secretin release by bicarbonate was diminished due to a lack of bicarbonate flow from the pancreas. Bicarbonates 140-151 secretin Homo sapiens 120-128 748090-1 1978 When secretin was given by continuous intravenous infusion in the control subjects, the dose of secretin inducing maximal bicarbonate output was found to be around 6.0 CHR U/kg/hr. Bicarbonates 122-133 secretin Homo sapiens 5-13 748090-1 1978 When secretin was given by continuous intravenous infusion in the control subjects, the dose of secretin inducing maximal bicarbonate output was found to be around 6.0 CHR U/kg/hr. Bicarbonates 122-133 secretin Homo sapiens 96-104 675156-2 1978 The flow rate, bicarbonate output, and amylase output in response to secretin was larger during duodenal aspiration than when collecting during endoscopic cannulation. Bicarbonates 15-26 secretin Homo sapiens 69-77 17563-5 1977 It is suggested that plasma motilin levels are decreased by secretin-induced pancreatic bicarbonate juice flow. Bicarbonates 88-99 secretin Homo sapiens 60-68 930532-5 1977 These results are compatible with the concept that endogenous acid being delivered from the stomach to the duodenum does contribute to the release of secretin which in turn may serve as a physiological stimulus for pancreatic bicarbonate secretion. Bicarbonates 226-237 secretin Homo sapiens 150-158 992278-1 1976 The secretion of bicarbonate into the duodenum in response to stepwise increasing doses of secretin (0.078, 0.23, 0.7, and 2.1 U/kg-hr) was investigated in 11 duodenal ulcer patients before and about 1 1/2 years after proximal gastric vagotomy. Bicarbonates 17-28 secretin Homo sapiens 91-99 852751-0 1977 Plasma secretin and pancreatic bicarbonate response to exogenous secretin in man. Bicarbonates 31-42 secretin Homo sapiens 65-73 852751-1 1977 The dose response of duodenal bicarbonate production during synthetic porcine secretin infusions was studied in six healthy volunteers and related to plasma secretin immunoreactivity. Bicarbonates 30-41 secretin Homo sapiens 78-86 852751-4 1977 The secretin plasma level for half maximal bicarbonate response was estimated to be 22 pmol/l. Bicarbonates 43-54 secretin Homo sapiens 4-12 992278-2 1976 After the vagotomy the mean output of bicarbonate in response to the two lowest doses of secretin increased from 2.2 to 3.7 mmoles per 30 min im response to 0.078 U/kg-hr and from 6.6 to 9.8 mmoles per 30 min in response to 0.23 U/kg-hr. Bicarbonates 38-49 secretin Homo sapiens 89-97 992278-3 1976 On the other hand, the output of bicarbonate in response to the highest dose of secretin decreased from 20.3 mmoles per 30 min before to 16.5 mmoles per 30 min after the vagotomy. Bicarbonates 33-44 secretin Homo sapiens 80-88 992278-6 1976 Thus, increased sensitivity of the bicarbonate-producing cells to low doses of secretin and decreased bicarbonate secretory capacity of the pancreas after proximal gastric vagotomy were found. Bicarbonates 35-46 secretin Homo sapiens 79-87 1168364-0 1975 Secretin snuff: evaluation of the action on pentagastrin-stimulated gastric acid secretion and on pancreatic bicarbonate production. Bicarbonates 109-120 secretin Homo sapiens 0-8 1278646-3 1976 Inhibition of acid secretion in normals was approximately the same as in 2 patients with pancreatic exocrine insufficiency who could secrete only small amounts of pancreatic bicarbonate in response to secretin. Bicarbonates 174-185 secretin Homo sapiens 201-209 955498-2 1976 A combination of 0-5 CU/kg-h secretin and 75 ng/kg-h caerulein provided maximal or near-maximal stimulation of the secretion of both bicarbonate and pancreatic enzymes. Bicarbonates 133-144 secretin Homo sapiens 29-37 176080-0 1976 Bicarbonate and cyclic AMP content of pure human pancreatic juice in response to graded doses of synthetic secretin. Bicarbonates 0-11 secretin Homo sapiens 107-115 173628-0 1975 Proceedings: Bicarbonate and cyclic AMP secretion in pure pancreatic juice: dose-response curves to synthetic secretin in man. Bicarbonates 13-24 secretin Homo sapiens 110-118 237865-3 1975 Urinary bicarbonate excretion increased from 55 plus or minus 13 to 395 plus or minus 33 mueq/30 min after secretin injection. Bicarbonates 8-19 secretin Homo sapiens 107-115 237865-6 1975 These observations are compatible with a direct effect of secretin upon the renal tubular reabsorption of water, bicarbonate, and other ions, and could account for the transient alterations in urinary pH occurring in response to a meal. Bicarbonates 113-124 secretin Homo sapiens 58-66 1276208-16 1976 In contrast, vasoactive intestinal polypeptide, which stimulates pancreatic fluid and bicarbonate secretion, showed a competitive inhibition of secretin binding to the plasma membrane preparation. Bicarbonates 86-97 secretin Homo sapiens 144-152 1219183-3 1975 The dose-response relationship between pancreatic bicarbonate production and varying doses of synthetic secretin administered intravenously and in the form of snuff, was good. Bicarbonates 50-61 secretin Homo sapiens 104-112 1168364-1 1975 In an informative qualitative study 75 U (near the range of 1 U/kg) secretin given as a snuff resulted in a weak but significant stimulation of pancreatic bicarbonate output in 8 volunteers studied. Bicarbonates 155-166 secretin Homo sapiens 68-76 4719217-1 1973 Using a triple-lumen tube perfusion technique in normal human subjects secretin (2U/kg/hour intravenously) was shown to reduce the absorption of sodium, potassium, and chloride in the most proximal 30 cm of jejunum but it had no effect on bicarbonate absorption. Bicarbonates 239-250 secretin Homo sapiens 71-79 4760038-0 1973 Maximum bicarbonate response to intravenous infusion of "GIH" secretin in man. Bicarbonates 8-19 secretin Homo sapiens 62-70 4761603-3 1973 Secretin inhibited the acid response induced by pentagastrin by about 60% and simultaneously provoked a pancreatic bicarbonate output sufficient to neutralize about 60% of the gastric acid output to pentagastrin. Bicarbonates 115-126 secretin Homo sapiens 0-8 4716507-2 1973 In groups of patients with chronic pancreatitis and cancer of the pancreas abnormal scans closely parallel the diminished exocrine secretion, especially bicarbonate output, following a submaximal dose of secretin. Bicarbonates 153-164 secretin Homo sapiens 204-212 4719217-3 1973 Absorption of sodium chloride and water was stimulated rather than inhibited by higher bicarbonate concentrations and the effect of secretin was obvious even when this factor was controlled by adjusting the bicarbonate concentrations of the test fluids. Bicarbonates 207-218 secretin Homo sapiens 132-140 5386632-1 1969 Intraduodenal infusion of increasing amounts of hydrochloric acid solution results in a stepwise increase in the volume of pancreatic secretion and output of bicarbonate, reaching about 90% of amounts attained with exogenous secretin infused intravenously in increasing doses. Bicarbonates 158-169 secretin Homo sapiens 225-233 5429870-0 1970 The effect of pure natural secretin on the bicarbonate secretion into the duodenum in man. Bicarbonates 43-54 secretin Homo sapiens 27-35 5350104-1 1969 In a woman with diarrhoea and the Zollinger-Ellison pattern of gastric secretion, the secretion of fluid and bicarbonate into the duodenum in response to secretin was found to be significantly greater than in controls. Bicarbonates 109-120 secretin Homo sapiens 154-162 22687384-2 2012 Secretin (SEC) stimulates pancreas duct cells to secrete bicarbonate-rich fluid. Bicarbonates 57-68 secretin Homo sapiens 0-8 20184461-3 1967 In patients with pathological values of volume or bicarbonate concentration after secretin injection, the decrease in total nitrogen concentration following stimulation was significantly less. Bicarbonates 50-61 secretin Homo sapiens 82-90 33963548-0 2021 The molecular mechanism of CFTR- and secretin-dependent renal bicarbonate excretion. Bicarbonates 62-73 secretin Homo sapiens 37-45 33963548-1 2021 This review summarizes the newly discovered molecular mechanism of secretin-stimulated urine HCO3 - excretion and the role of CFTR in renal HCO3 - excretion. Bicarbonates 93-97 secretin Homo sapiens 67-75 5653882-4 1968 In response to continuous secretin infusion, the preparation secreted for up to 6 hr a juice which was similar to that obtained in vivo, with the exception that the bicarbonate concentration decreased and the chloride concentration increased with time, even when the rate of secretion remained constant.4. Bicarbonates 165-176 secretin Homo sapiens 26-34 26989929-1 2016 Secretin is a hormone that stimulates the exocrine pancreatic secretion of bicarbonate-rich fluid from the acinar cells of the pancreas that accumulates within the pancreatic ductal lumen. Bicarbonates 75-86 secretin Homo sapiens 0-8 25434010-3 2014 Secretin, a hormone that stimulates bicarbonate secretion, was also found to increase hepatic bile flow. Bicarbonates 36-47 secretin Homo sapiens 0-8 21939730-1 2012 Secretin and the secretin receptor have been reported to play an important role in regulating pancreatic water and bicarbonate secretion in mammals; however, little is known about their expression, structure, and biological functions in non-mammalian vertebrates including birds. Bicarbonates 115-126 secretin Homo sapiens 0-8 22194894-1 2011 BACKGROUND & AIMS: Secretin induces bicarbonate-rich hydrocholeresis in healthy individuals, but not in untreated patients with primary biliary cirrhosis (PBC). Bicarbonates 40-51 secretin Homo sapiens 23-31 20300845-13 2010 CONCLUSIONS: The low densities of secretin and CCK cells in IBS-diarrhea patients may cause a functional pancreatic insufficiency as well as inadequate gall emptying, as these hormones stimulate pancreatic bicarbonate and enzyme secretion and CCK stimulates as well gall bladder contraction. Bicarbonates 206-217 secretin Homo sapiens 34-42