PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17158258-2 2007 Compared with CCK-8, CCK-58 is a much stronger stimulant of pancreatic chloride and water secretion, equivalent to maximally effective secretin, but with a chloride-to-bicarbonate ratio characteristic of acinar fluid. Bicarbonates 168-179 cholecystokinin Rattus norvegicus 21-24 7899465-11 1995 ASA, but not SA inhibited the secretin- and CCK-stimulated pancreatic secretion including volume, bicarbonate, and protein in a dose-dependent manner without affecting basal pancreatic secretion. Bicarbonates 98-109 cholecystokinin Rattus norvegicus 44-47 10505751-4 1999 The responses of bicarbonate secretion to intravenous infusion of CCK, acetyl-beta-methylcholine (Ach), and 2-deoxy-D-glucose (2DG), and to intraduodenal infusion of HCl and a liquid meal were examined. Bicarbonates 17-28 cholecystokinin Rattus norvegicus 66-69 8866756-7 1996 When pancreatic exocrine secretion was stimulated by secretin plus CCK-8, KSG-504 suppressed the increases in juice volume and bicarbonate output to the level stimulated by secretin alone. Bicarbonates 127-138 cholecystokinin Rattus norvegicus 67-70 8361960-9 1993 At lower ASA dosages, the bicarbonate and protein concentrations and outputs of secretin-CCK-stimulated rats were higher than the basal values and the levels of rats without hormonal stimulation. Bicarbonates 26-37 cholecystokinin Rattus norvegicus 89-92 7513369-2 1994 Under stimulation by endogenous CCK or exogenous caerulein, protein output was significantly reduced by intravenous drip infusion of 16,16-dimethyl prostaglandin E2 (DMPGE2), and under stimulation by exogenous secretin, volume and bicarbonate output were markedly reduced by DMPGE2. Bicarbonates 231-242 cholecystokinin Rattus norvegicus 32-35 8333544-1 1993 Although the gastrointestinal peptide cholecystokinin (CCK) has been shown to increase bicarbonate and water secretion and potentiate the effects of secretin on pancreatic ducts, CCK receptors have not been identified on pancreatic ductal epithelium. Bicarbonates 87-98 cholecystokinin Rattus norvegicus 38-53 8333544-1 1993 Although the gastrointestinal peptide cholecystokinin (CCK) has been shown to increase bicarbonate and water secretion and potentiate the effects of secretin on pancreatic ducts, CCK receptors have not been identified on pancreatic ductal epithelium. Bicarbonates 87-98 cholecystokinin Rattus norvegicus 55-58 2877434-6 1986 During recirculation, CCK-OP-stimulated bicarbonate and protein secretion was strongly inhibited by somatostatin. Bicarbonates 40-51 cholecystokinin Rattus norvegicus 22-25 1796181-5 1991 CCK appears to be directly responsible for the protein and also water response to duodenal infusion of oleic acid, and to be indirectly involved in bicarbonate stimulation. Bicarbonates 148-159 cholecystokinin Rattus norvegicus 0-3 1689684-5 1990 Potent CCK antagonist, CR 1409 (5 mg/kg.hr) administered intravenously suppressed completely increase in amylase output induced by oleic acid, and partially in juice volume and bicarbonate output. Bicarbonates 177-188 cholecystokinin Rattus norvegicus 7-10 2262122-10 1990 The CCK antagonists entirely suppressed the protein response to the intraduodenal meal, decreased the volume response by 70 percent (p less than 0.01), and the bicarbonate response by 50 percent (p less than 0.05). Bicarbonates 160-171 cholecystokinin Rattus norvegicus 4-7 2480464-2 1989 Intravenous infusion of CCK-8 in three different doses of 0.03, 0.06 and 0.12 micrograms/kg-hr increased pancreatic secretion of volume, bicarbonate, amylase and trypsin outputs dose-dependently. Bicarbonates 137-148 cholecystokinin Rattus norvegicus 24-27 2480464-3 1989 Simultaneous infusion of CCK-8 with secretin in a dose of 0.03 CU/kg-hr produced statistically greater pancreatic secretion of volume, bicarbonate, amylase and trypsin outputs than that by CCK-8 alone, and than the sum by secretin alone and CCK-8 alone in each dose. Bicarbonates 135-146 cholecystokinin Rattus norvegicus 25-28 343601-4 1978 In CCK-treated rats, the maximal protein and bicarbonate outputs in response to cholecystokinin increased proportionately to the increase in pancreatic weight, but maximal bicarbonate and protein outputs in response to secretin were unaltered. Bicarbonates 45-56 cholecystokinin Rattus norvegicus 3-6 343601-4 1978 In CCK-treated rats, the maximal protein and bicarbonate outputs in response to cholecystokinin increased proportionately to the increase in pancreatic weight, but maximal bicarbonate and protein outputs in response to secretin were unaltered. Bicarbonates 45-56 cholecystokinin Rattus norvegicus 80-95 343601-4 1978 In CCK-treated rats, the maximal protein and bicarbonate outputs in response to cholecystokinin increased proportionately to the increase in pancreatic weight, but maximal bicarbonate and protein outputs in response to secretin were unaltered. Bicarbonates 172-183 cholecystokinin Rattus norvegicus 3-6 343601-7 1978 We conclude that 1) the increase in pancreatic weight produced by repeated injections of cholecystokinin was accompanied by proportional increase in functional capacity as reflected by the increased maximal bicarbonate and protein outputs in response to cholecystokinin, and 2) repeated administration of secretin decreased the sensitivity of the pancreas to secretin without altering maximal bicarbonate response. Bicarbonates 207-218 cholecystokinin Rattus norvegicus 89-104 343601-7 1978 We conclude that 1) the increase in pancreatic weight produced by repeated injections of cholecystokinin was accompanied by proportional increase in functional capacity as reflected by the increased maximal bicarbonate and protein outputs in response to cholecystokinin, and 2) repeated administration of secretin decreased the sensitivity of the pancreas to secretin without altering maximal bicarbonate response. Bicarbonates 207-218 cholecystokinin Rattus norvegicus 254-276 343601-7 1978 We conclude that 1) the increase in pancreatic weight produced by repeated injections of cholecystokinin was accompanied by proportional increase in functional capacity as reflected by the increased maximal bicarbonate and protein outputs in response to cholecystokinin, and 2) repeated administration of secretin decreased the sensitivity of the pancreas to secretin without altering maximal bicarbonate response. Bicarbonates 393-404 cholecystokinin Rattus norvegicus 89-104 23499805-0 2013 Cholecystokinin but not ghrelin stimulates mucosal bicarbonate secretion in rat duodenum: independence of feeding status and cholinergic stimuli. Bicarbonates 51-62 cholecystokinin Rattus norvegicus 0-15 1206529-30 1975 In contrast, the rat pancreas responds well to cholecystokinin (CCK) stimulation, yielding a juice with plasma-like HCO-3 concentration. Bicarbonates 116-121 cholecystokinin Rattus norvegicus 47-63 1206529-30 1975 In contrast, the rat pancreas responds well to cholecystokinin (CCK) stimulation, yielding a juice with plasma-like HCO-3 concentration. Bicarbonates 116-121 cholecystokinin Rattus norvegicus 64-67