PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31890056-10 2019 In contrast, HMTA clearly increased cell toxicity in FANCD2-, BRCA1- and BRCA2- deficient cells under acidic conditions. Methenamine 13-17 BRCA1 DNA repair associated Homo sapiens 62-67 31890056-11 2019 Conclusion: Here we show that in vitro experiments showed that at low pH HMTA causes drastic cytotoxicity specifically in cells deficient in the FANC/BRCA pathway. Methenamine 73-77 BRCA1 DNA repair associated Homo sapiens 150-154 31890056-12 2019 These results strongly suggest that HMTA may be an attractive, dual-targeting chemotherapeutic/preventive drug for the selective delivery of formaldehyde to solid tumors and causes cell death in FANC/BRCA-deficient cells without major adverse effects. Methenamine 36-40 BRCA1 DNA repair associated Homo sapiens 200-204