PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12069855-0 2002 Activator protein-1 and CCAAT/enhancer-binding protein mediated GADD153 expression is involved in deoxycholic acid-induced apoptosis. Deoxycholic Acid 98-114 DNA damage inducible transcript 3 Homo sapiens 64-71 12069855-4 2002 In this study, we examined the effect of DCA on the GADD153 (growth arrest- and DNA damage-inducible gene 153) proapoptotic gene and its role in DCA-induced apoptosis in a human colon cancer cell line, HCT116. Deoxycholic Acid 41-44 DNA damage inducible transcript 3 Homo sapiens 52-59 12069855-4 2002 In this study, we examined the effect of DCA on the GADD153 (growth arrest- and DNA damage-inducible gene 153) proapoptotic gene and its role in DCA-induced apoptosis in a human colon cancer cell line, HCT116. Deoxycholic Acid 41-44 DNA damage inducible transcript 3 Homo sapiens 61-109 12069855-5 2002 Our results showed that GADD153 expression was strongly stimulated by DCA and disruption of this with an antisense GADD153 transcript could significantly suppress DCA-induced apoptosis, suggesting GADD153 is essential for DCA induction of apoptosis. Deoxycholic Acid 70-73 DNA damage inducible transcript 3 Homo sapiens 24-31 12069855-5 2002 Our results showed that GADD153 expression was strongly stimulated by DCA and disruption of this with an antisense GADD153 transcript could significantly suppress DCA-induced apoptosis, suggesting GADD153 is essential for DCA induction of apoptosis. Deoxycholic Acid 70-73 DNA damage inducible transcript 3 Homo sapiens 115-122 12069855-5 2002 Our results showed that GADD153 expression was strongly stimulated by DCA and disruption of this with an antisense GADD153 transcript could significantly suppress DCA-induced apoptosis, suggesting GADD153 is essential for DCA induction of apoptosis. Deoxycholic Acid 70-73 DNA damage inducible transcript 3 Homo sapiens 115-122 12069855-5 2002 Our results showed that GADD153 expression was strongly stimulated by DCA and disruption of this with an antisense GADD153 transcript could significantly suppress DCA-induced apoptosis, suggesting GADD153 is essential for DCA induction of apoptosis. Deoxycholic Acid 163-166 DNA damage inducible transcript 3 Homo sapiens 24-31 12069855-5 2002 Our results showed that GADD153 expression was strongly stimulated by DCA and disruption of this with an antisense GADD153 transcript could significantly suppress DCA-induced apoptosis, suggesting GADD153 is essential for DCA induction of apoptosis. Deoxycholic Acid 163-166 DNA damage inducible transcript 3 Homo sapiens 115-122 12069855-5 2002 Our results showed that GADD153 expression was strongly stimulated by DCA and disruption of this with an antisense GADD153 transcript could significantly suppress DCA-induced apoptosis, suggesting GADD153 is essential for DCA induction of apoptosis. Deoxycholic Acid 163-166 DNA damage inducible transcript 3 Homo sapiens 115-122 12069855-5 2002 Our results showed that GADD153 expression was strongly stimulated by DCA and disruption of this with an antisense GADD153 transcript could significantly suppress DCA-induced apoptosis, suggesting GADD153 is essential for DCA induction of apoptosis. Deoxycholic Acid 163-166 DNA damage inducible transcript 3 Homo sapiens 24-31 12069855-5 2002 Our results showed that GADD153 expression was strongly stimulated by DCA and disruption of this with an antisense GADD153 transcript could significantly suppress DCA-induced apoptosis, suggesting GADD153 is essential for DCA induction of apoptosis. Deoxycholic Acid 163-166 DNA damage inducible transcript 3 Homo sapiens 115-122 12069855-5 2002 Our results showed that GADD153 expression was strongly stimulated by DCA and disruption of this with an antisense GADD153 transcript could significantly suppress DCA-induced apoptosis, suggesting GADD153 is essential for DCA induction of apoptosis. Deoxycholic Acid 163-166 DNA damage inducible transcript 3 Homo sapiens 115-122 12069855-6 2002 Further studies were conducted to investigate the upstream regulatory factors that participated in DCA mediated GADD153 expression. Deoxycholic Acid 99-102 DNA damage inducible transcript 3 Homo sapiens 112-119 12069855-7 2002 Activator protein-1 (AP-1) was activated by DCA and an AP-1 regulatory element was identified in the human GADD153 promoter in our previous studies. Deoxycholic Acid 44-47 DNA damage inducible transcript 3 Homo sapiens 107-114 12069855-8 2002 However, inhibition of the AP-1 activation by the dominant negative mutant c-Jun, Tam67, caused only a partial suppression of both DCA-induced GADD153 expression and apoptosis, indicating AP-1 plays an important but not exclusive role in DCA mediated GADD153 pathway. Deoxycholic Acid 131-134 DNA damage inducible transcript 3 Homo sapiens 143-150 12069855-8 2002 However, inhibition of the AP-1 activation by the dominant negative mutant c-Jun, Tam67, caused only a partial suppression of both DCA-induced GADD153 expression and apoptosis, indicating AP-1 plays an important but not exclusive role in DCA mediated GADD153 pathway. Deoxycholic Acid 131-134 DNA damage inducible transcript 3 Homo sapiens 251-258 12069855-8 2002 However, inhibition of the AP-1 activation by the dominant negative mutant c-Jun, Tam67, caused only a partial suppression of both DCA-induced GADD153 expression and apoptosis, indicating AP-1 plays an important but not exclusive role in DCA mediated GADD153 pathway. Deoxycholic Acid 238-241 DNA damage inducible transcript 3 Homo sapiens 251-258 12069855-9 2002 By further promoter analyses, a novel DCA response element, which is located downstream of the AP-1 binding site in the human GADD153 promoter, was determined and identified as C/EBP regulatory element. Deoxycholic Acid 38-41 DNA damage inducible transcript 3 Homo sapiens 126-133 12069855-10 2002 These results suggest that GADD153 expression is critical for DCA-induced apoptosis and that multiple signaling pathways that include AP-1 and C/EBP transcription factors are involved in DCA-induced GADD153 expression. Deoxycholic Acid 62-65 DNA damage inducible transcript 3 Homo sapiens 27-34 12069855-10 2002 These results suggest that GADD153 expression is critical for DCA-induced apoptosis and that multiple signaling pathways that include AP-1 and C/EBP transcription factors are involved in DCA-induced GADD153 expression. Deoxycholic Acid 187-190 DNA damage inducible transcript 3 Homo sapiens 27-34 12069855-10 2002 These results suggest that GADD153 expression is critical for DCA-induced apoptosis and that multiple signaling pathways that include AP-1 and C/EBP transcription factors are involved in DCA-induced GADD153 expression. Deoxycholic Acid 187-190 DNA damage inducible transcript 3 Homo sapiens 199-206 29891454-7 2018 In HTR-8/SVneo cells treated with different doses of DCA (0, 10, 50, and 100 micromol/L), the mRNA expressions of GRP78, CHOP, caspase-3 and caspase-7 were significantly increased in a dose-dependent manner (P<0.05) and the protein levels of GRP78 and CHOP were also increased dose-dependently. Deoxycholic Acid 53-56 DNA damage inducible transcript 3 Homo sapiens 121-125 29891454-7 2018 In HTR-8/SVneo cells treated with different doses of DCA (0, 10, 50, and 100 micromol/L), the mRNA expressions of GRP78, CHOP, caspase-3 and caspase-7 were significantly increased in a dose-dependent manner (P<0.05) and the protein levels of GRP78 and CHOP were also increased dose-dependently. Deoxycholic Acid 53-56 DNA damage inducible transcript 3 Homo sapiens 255-259 27888615-3 2017 Deoxycholic acid (DCA), Chemodeoxycholic acid (CDCA) and Lithocholic acid (LCA) activated the PERK arm of the UPR, via phosphorylation of eIF2alpha and up-regulation of ATF3, CHOP and BiP/GRP78. Deoxycholic Acid 0-16 DNA damage inducible transcript 3 Homo sapiens 175-179 27888615-3 2017 Deoxycholic acid (DCA), Chemodeoxycholic acid (CDCA) and Lithocholic acid (LCA) activated the PERK arm of the UPR, via phosphorylation of eIF2alpha and up-regulation of ATF3, CHOP and BiP/GRP78. Deoxycholic Acid 18-21 DNA damage inducible transcript 3 Homo sapiens 175-179 15316935-7 2005 In further studying GADD153 in particular, the effect of DOC on GADD153 mRNA was prevented by actinomycin-D (Act-D), but not by antioxidants or MAPK inhibitors. Deoxycholic Acid 57-60 DNA damage inducible transcript 3 Homo sapiens 20-27 15316935-7 2005 In further studying GADD153 in particular, the effect of DOC on GADD153 mRNA was prevented by actinomycin-D (Act-D), but not by antioxidants or MAPK inhibitors. Deoxycholic Acid 57-60 DNA damage inducible transcript 3 Homo sapiens 64-71 15316935-9 2005 Induction of GADD153 protein by DOC was prevented by either anisomycin or cycloheximide. Deoxycholic Acid 32-35 DNA damage inducible transcript 3 Homo sapiens 13-20 15316935-10 2005 These findings suggest that DOC-induced upregulation of GADD153 mRNA expression occurred at the level of transcription without involving reactive oxygen species and MAPK signaling, and that the expression of GADD153 protein was due also to translation of pre-existing, and not just newly synthesized, mRNA. Deoxycholic Acid 28-31 DNA damage inducible transcript 3 Homo sapiens 56-63 15316935-10 2005 These findings suggest that DOC-induced upregulation of GADD153 mRNA expression occurred at the level of transcription without involving reactive oxygen species and MAPK signaling, and that the expression of GADD153 protein was due also to translation of pre-existing, and not just newly synthesized, mRNA. Deoxycholic Acid 28-31 DNA damage inducible transcript 3 Homo sapiens 208-215 10748108-3 2000 Promoter deletion analyses revealed that the activator protein-1 (AP-1) transcription factor was crucial for deoxycholic acid (DCA)-mediated GADD153 gene transcription. Deoxycholic Acid 109-125 DNA damage inducible transcript 3 Homo sapiens 141-148 10748108-3 2000 Promoter deletion analyses revealed that the activator protein-1 (AP-1) transcription factor was crucial for deoxycholic acid (DCA)-mediated GADD153 gene transcription. Deoxycholic Acid 127-130 DNA damage inducible transcript 3 Homo sapiens 141-148