PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30442198-3	2018	Purpose of the current study was to observe possible variations in plasma levels of carbamazepine monotherapy and seizures" control in Pakhtun population of Khyber Pakhtunkhwa (KP) in the context of MTHFR (C677T and A1298C) gene polymorphisms.	Carbamazepine	84-97	methylenetetrahydrofolate reductase	Homo sapiens	199-204	
31920364-3	2019	The aim of the study was to investigate the effect of folate metabolizing genes (MTHFR and DHFR) polymorphisms on different parameters of complete blood count in patients who were treated with carbamazepine and valproic acid.	Carbamazepine	193-206	methylenetetrahydrofolate reductase	Homo sapiens	81-86	
30442198-8	2018	RESULTS: Following for 3rd and 6th month of duration of carbamazepine therapy, poor seizure controlled patients were more likely noticed in heterozygous variants (677CT and 1298 AC) of MTHFR gene (P < 0.05).	Carbamazepine	56-69	methylenetetrahydrofolate reductase	Homo sapiens	185-190	
30442198-11	2018	CONCLUSION: Our study suggests that heterozygous variants of MTHFR (C677T and A1298C) gene are associated with poor seizure control in Pakhtun population of KP despite the fact that plasma level of carbamazepine were found within the therapeutic range.	Carbamazepine	198-211	methylenetetrahydrofolate reductase	Homo sapiens	61-66	
11277368-1	2000	The aim of the study was to observe the influence of carbamazepine and valproic acid on plasma total homocysteine and B-vitamin status and the gene-drug interaction with the 677C-->T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene.	Carbamazepine	53-66	methylenetetrahydrofolate reductase	Homo sapiens	202-237	
29062354-9	2017	CONCLUSION: Following six months of carbamazepine of therapy in heterozygous variant genotypes of MTHFR (677CT and 1298AC) and GABRG2 (588CT and 315CT) genes, we observed a significant fall in vitamin B6 levels and hyperhomocysteinemia.	Carbamazepine	36-49	methylenetetrahydrofolate reductase	Homo sapiens	98-103	
26142939-5	2015	This study aimed to investigate the role of MTHFR C677T polymorphism in epileptic patients receiving AEDs as monotherapy (phenytoin, carbamazepine, and sodium valproate) and showing toxicity and non-toxicity, and the impact of AEDs on hyperhomocysteinemia in North Indian population.	Carbamazepine	133-146	methylenetetrahydrofolate reductase	Homo sapiens	44-49	
11277368-1	2000	The aim of the study was to observe the influence of carbamazepine and valproic acid on plasma total homocysteine and B-vitamin status and the gene-drug interaction with the 677C-->T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene.	Carbamazepine	53-66	methylenetetrahydrofolate reductase	Homo sapiens	239-244	
11277368-8	2000	The lowering action of carbamazepine treatment on folate levels seems to be associated with hyperhomocysteinaemia, which seems to be related to the homozygous condition for the MTHFR 677C-->T mutation.	Carbamazepine	23-36	methylenetetrahydrofolate reductase	Homo sapiens	177-182	
10563481-7	1999	Mutation in the MTHFR gene in a mother taking sodium valproate, phenytoin or carbamazepine during pregnancy is associated with fetal anticonvulsant syndrome in her offspring.	Carbamazepine	77-90	methylenetetrahydrofolate reductase	Homo sapiens	16-21	
10459572-7	1999	Multiple logistic regression analysis showed that MTHFR TT genotype was an independent predictor of hyperhomocysteinemia in epileptic patients receiving anticonvulsants (phenytoin and carbamazepine but not valproic acid), suggesting that gene-drug interactions induce hyperhomocysteinemia.	Carbamazepine	184-197	methylenetetrahydrofolate reductase	Homo sapiens	50-55