PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16217052-5 2005 Sex hormone binding globulin was significantly higher in the CBZ and PHT groups than in all other groups. Carbamazepine 61-64 sex hormone binding globulin Homo sapiens 0-28 16981858-7 2006 CBZ medication was associated with increased concentrations of serum sex hormone-binding globulin (SHBG). Carbamazepine 0-3 sex hormone binding globulin Homo sapiens 69-97 16981858-7 2006 CBZ medication was associated with increased concentrations of serum sex hormone-binding globulin (SHBG). Carbamazepine 0-3 sex hormone binding globulin Homo sapiens 99-103 18164216-5 2008 The use of the liver enzyme inducing AEDs phenobarbital, phenytoin and carbamazepine increases serum sex hormone binding globulin (SHBG) concentrations in both men and women with epilepsy. Carbamazepine 71-84 sex hormone binding globulin Homo sapiens 101-129 18164216-5 2008 The use of the liver enzyme inducing AEDs phenobarbital, phenytoin and carbamazepine increases serum sex hormone binding globulin (SHBG) concentrations in both men and women with epilepsy. Carbamazepine 71-84 sex hormone binding globulin Homo sapiens 131-135 19205363-7 2008 Carbamazepine decreased testosterone/sex-hormone binding globulin (SHBG) ratio, whereas its active metabolite--oxcarbazepine--had no effect on androgens. Carbamazepine 0-13 sex hormone binding globulin Homo sapiens 24-65 19205363-7 2008 Carbamazepine decreased testosterone/sex-hormone binding globulin (SHBG) ratio, whereas its active metabolite--oxcarbazepine--had no effect on androgens. Carbamazepine 0-13 sex hormone binding globulin Homo sapiens 67-71 19205363-9 2008 On the other hand, carbamazepine decreased testosterone level but enhanced SHBG concentration. Carbamazepine 19-32 sex hormone binding globulin Homo sapiens 75-79 11502910-7 2001 Serum SHBG levels increased and DHEAS decreased during the first months of CBZ treatment in both sexes. Carbamazepine 75-78 sex hormone binding globulin Homo sapiens 6-10 15679699-8 2005 The CBZ treated patients had significantly lower testosterone/SHBG ratio than the controls. Carbamazepine 4-7 sex hormone binding globulin Homo sapiens 62-66 15679699-13 2005 Long-term CBZ treatment leads to significant lower testosterone/SHBG ratio. Carbamazepine 10-13 sex hormone binding globulin Homo sapiens 64-68 15740176-5 2005 The use of the liver enzyme-inducing AEDs phenobarbital, phenytoin and carbamazepine increases serum sex hormone-binding globulin (SHBG) concentrations in both men and women with epilepsy. Carbamazepine 71-84 sex hormone binding globulin Homo sapiens 101-129 15740176-5 2005 The use of the liver enzyme-inducing AEDs phenobarbital, phenytoin and carbamazepine increases serum sex hormone-binding globulin (SHBG) concentrations in both men and women with epilepsy. Carbamazepine 71-84 sex hormone binding globulin Homo sapiens 131-135 14504307-5 2003 The hepatic enzyme-inducing AEDs phenytoin and carbamazepine (CBZ) have been shown to increase serum levels of sex hormone-binding globulin (SHBG). Carbamazepine 47-60 sex hormone binding globulin Homo sapiens 111-139 14504307-5 2003 The hepatic enzyme-inducing AEDs phenytoin and carbamazepine (CBZ) have been shown to increase serum levels of sex hormone-binding globulin (SHBG). Carbamazepine 47-60 sex hormone binding globulin Homo sapiens 141-145 14504307-5 2003 The hepatic enzyme-inducing AEDs phenytoin and carbamazepine (CBZ) have been shown to increase serum levels of sex hormone-binding globulin (SHBG). Carbamazepine 62-65 sex hormone binding globulin Homo sapiens 111-139 14504307-5 2003 The hepatic enzyme-inducing AEDs phenytoin and carbamazepine (CBZ) have been shown to increase serum levels of sex hormone-binding globulin (SHBG). Carbamazepine 62-65 sex hormone binding globulin Homo sapiens 141-145 14504307-6 2003 This increase leads in time to a diminished estradiol:SHBG ratio and decreased bioactivity of estradiol, which may result in menstrual disorders in some women receiving long-term CBZ treatment. Carbamazepine 179-182 sex hormone binding globulin Homo sapiens 54-58 11502910-11 2001 The use of CBZ, in turn, was associated with increased SHBG concentrations and thus with diminished sex steroid function in both sexes. Carbamazepine 11-14 sex hormone binding globulin Homo sapiens 55-59 30187004-12 2018 Conversely, our results indicate that CBZ might have unfavorable effects on serum levels of TC, LDL, HDL, SHBG, and free testosterone. Carbamazepine 38-41 sex hormone binding globulin Homo sapiens 106-110 11148232-6 2001 Serum levels of dehydroepiandrosterone sulfate were low, and serum concentrations of sex hormone-binding globulin (SHBG) were high in men taking CBZ. Carbamazepine 145-148 sex hormone binding globulin Homo sapiens 85-113 11148232-6 2001 Serum levels of dehydroepiandrosterone sulfate were low, and serum concentrations of sex hormone-binding globulin (SHBG) were high in men taking CBZ. Carbamazepine 145-148 sex hormone binding globulin Homo sapiens 115-119 9952267-5 1999 RESULTS: Men taking carbamazepine (CBZ) only had significantly higher mean sex hormone-binding globulin (SHBG) levels than the control group. Carbamazepine 20-33 sex hormone binding globulin Homo sapiens 75-103 9952267-5 1999 RESULTS: Men taking carbamazepine (CBZ) only had significantly higher mean sex hormone-binding globulin (SHBG) levels than the control group. Carbamazepine 20-33 sex hormone binding globulin Homo sapiens 105-109 9952267-5 1999 RESULTS: Men taking carbamazepine (CBZ) only had significantly higher mean sex hormone-binding globulin (SHBG) levels than the control group. Carbamazepine 35-38 sex hormone binding globulin Homo sapiens 75-103 7555984-3 1995 Serum SHBG levels increased, and serum concentrations of 17 beta-estradiol (estradiol) and estradiol/SHBG ratio decreased during CBZ treatment. Carbamazepine 129-132 sex hormone binding globulin Homo sapiens 6-10 7555984-3 1995 Serum SHBG levels increased, and serum concentrations of 17 beta-estradiol (estradiol) and estradiol/SHBG ratio decreased during CBZ treatment. Carbamazepine 129-132 sex hormone binding globulin Homo sapiens 101-105 7555984-8 1995 Long-term CBZ treatment results in increased serum SHBG levels and decreased estradiol effect, which correlate with the frequency of menstrual disorders in CBZ-treated women with epilepsy. Carbamazepine 10-13 sex hormone binding globulin Homo sapiens 51-55 7555984-8 1995 Long-term CBZ treatment results in increased serum SHBG levels and decreased estradiol effect, which correlate with the frequency of menstrual disorders in CBZ-treated women with epilepsy. Carbamazepine 156-159 sex hormone binding globulin Homo sapiens 51-55 9952267-5 1999 RESULTS: Men taking carbamazepine (CBZ) only had significantly higher mean sex hormone-binding globulin (SHBG) levels than the control group. Carbamazepine 35-38 sex hormone binding globulin Homo sapiens 105-109 7607115-2 1995 Serum sex hormone binding globulin (SHBG) levels increased and free androgen index (FAI) decreased during CBZ treatment, and these changes correlated with duration of CBZ therapy. Carbamazepine 106-109 sex hormone binding globulin Homo sapiens 6-34 7607115-2 1995 Serum sex hormone binding globulin (SHBG) levels increased and free androgen index (FAI) decreased during CBZ treatment, and these changes correlated with duration of CBZ therapy. Carbamazepine 106-109 sex hormone binding globulin Homo sapiens 36-40 7607115-4 1995 CBZ and PHT increase serum SHBG levels, leading to decreased FAI. Carbamazepine 0-3 sex hormone binding globulin Homo sapiens 27-31 2142450-5 1990 However, serum sex hormone binding globulin (SHBG) levels increased and dehydroepiandrosterone sulfate (DHEAS) levels decreased during CBZ treatment. Carbamazepine 135-138 sex hormone binding globulin Homo sapiens 15-43 2142450-5 1990 However, serum sex hormone binding globulin (SHBG) levels increased and dehydroepiandrosterone sulfate (DHEAS) levels decreased during CBZ treatment. Carbamazepine 135-138 sex hormone binding globulin Homo sapiens 45-49 2142450-8 1990 Moreover, patients with long-term CBZ also had high SHBG levels, low serum DHEAS levels, and low FAI values. Carbamazepine 34-37 sex hormone binding globulin Homo sapiens 52-56 3191895-2 1988 No significant differences in the mean T or FT levels were found between the three groups, but the CBZ-treated patients had significantly higher SHBG levels and their FAI values and DHEAS concentrations were lower. Carbamazepine 99-102 sex hormone binding globulin Homo sapiens 145-149 3191895-4 1988 CBZ monotherapy does not significantly change the serum balance of sex hormones; however, CBZ clearly affects the serum levels of SHBG and DHEAS. Carbamazepine 90-93 sex hormone binding globulin Homo sapiens 130-134 6231939-3 1984 Within 7 days of starting CBZ there was a rise in SHBG (P less than 0.05) and a fall in testosterone, free testosterone fraction, DHAS and androstenedione (P less than 0.05). Carbamazepine 26-29 sex hormone binding globulin Homo sapiens 50-54 6231939-5 1984 The rise in SHBG and increased androgen catabolism is most likely to be secondary to induction of hepatic monooxygenase activity by CBZ. Carbamazepine 132-135 sex hormone binding globulin Homo sapiens 12-16 21338669-6 2011 AEDs can induce various hormonal abnormalities; in particular, the use of the liver enzyme inducing AEDs, such as phenobarbital, phenytoin and carbamazepine, which increases serum sex hormone binding globulin (SHBG) concentrations. Carbamazepine 143-156 sex hormone binding globulin Homo sapiens 180-208 21338669-6 2011 AEDs can induce various hormonal abnormalities; in particular, the use of the liver enzyme inducing AEDs, such as phenobarbital, phenytoin and carbamazepine, which increases serum sex hormone binding globulin (SHBG) concentrations. Carbamazepine 143-156 sex hormone binding globulin Homo sapiens 210-214 21204821-4 2011 The use of the liver enzyme-inducing AEDs--such as phenobarbital, phenytoin, and carbamazepine--can increase serum sex hormone-binding globulin concentrations, leading to diminished bioactivity of testosterone (T) and estradiol. Carbamazepine 81-94 sex hormone binding globulin Homo sapiens 115-143