PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27456663-9 2017 However, in the zVAD pretreated cells, necroptotic cell death with a significant increase in expression of RIP1, RIP3, and MLKL genes was observed Conclusion: The novel hybrid benzoxazole-coumarins effectively induce Caspase-3 dependent apoptosis in HN-5 cancer cells, but also could circumvent the blockage of apoptotic cell death by induction of necroptosis. Benzoxazoles 176-187 receptor interacting serine/threonine kinase 1 Homo sapiens 107-111