PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24597901-3	2014	Here we assessed the anti-BACE-1 and behavioral activities of curcuminoids from rhizomes of Curcuma longa (Zingiberaceae), diarylalkyls curcumin (CCN), demethoxycurcumin (DMCCN), and bisdemethoxycurcumin (BDMCCN) against AD Drosophila melanogaster models.	Curcumin	62-70	beta-secretase 1	Homo sapiens	26-32	
32785161-5	2020	A combinatorial library containing more than 3 million structures of curcumin and flavonoid derivatives was generated and screened for drug-likeness and enzymatic inhibitory bioactivities against AChE and BACE-1 through the validated in silico models.	Curcumin	69-77	beta-secretase 1	Homo sapiens	205-211	
32785161-6	2020	A total of 47 substances (two curcumins and 45 flavonoids), with remarkable predicted pIC50 values against AChE and BACE-1 ranging from 4.24-5.11 (AChE) and 4.52-10.27 (BACE-1), were designed.	Curcumin	30-39	beta-secretase 1	Homo sapiens	116-122	
31595422-7	2020	Our results show that curcumin inhibits BACE1 gene expression in SH-SY5Y cells at transcriptional and translational levels.	Curcumin	22-30	beta-secretase 1	Homo sapiens	40-45	
31595422-8	2020	Furthermore, we reveal that nuclear factor kappa B (NFkappaB) signaling is involved in the regulation of curcumin on BACE1.	Curcumin	105-113	beta-secretase 1	Homo sapiens	117-122	
31595422-11	2020	The above results indicate that curcumin reduces BACE1 expression through ERbeta and NFkappaB pathway, providing a novel mechanism for curcumin as a candidate for AD therapy.	Curcumin	32-40	beta-secretase 1	Homo sapiens	49-54	
31595422-11	2020	The above results indicate that curcumin reduces BACE1 expression through ERbeta and NFkappaB pathway, providing a novel mechanism for curcumin as a candidate for AD therapy.	Curcumin	135-143	beta-secretase 1	Homo sapiens	49-54	
29310523-3	2019	Till now only two scaffolds (triazinone and curcumin) derivatives have been reported as BACE-1 and GSK-3beta dual inhibitors.	Curcumin	44-52	beta-secretase 1	Homo sapiens	88-94	
30559668-5	2018	The minor curcumin constituent, bisdemethoxycurcumin (BDC) showed the most potent protective action to decrease levels of NF-kappaB and BACE1, decrease the inflammatory cascade and diminish Abeta aggregates in cells from AD patients.	Curcumin	10-18	beta-secretase 1	Homo sapiens	136-141	
28741112-3	2017	Until now, only two-scaffold triazinone and curcumin have been reported as BACE-1 and GSK-3beta dual inhibitors.	Curcumin	44-52	beta-secretase 1	Homo sapiens	75-81	
18695518-0	2008	Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation.	Curcumin	31-39	beta-secretase 1	Homo sapiens	70-101	
18695518-5	2008	Here, we demonstrate that naturally occurring compounds (-)-epigallocatechin-3-gallate and curcumin suppress beta amyloid-induced BACE-1 upregulation.	Curcumin	91-99	beta-secretase 1	Homo sapiens	130-136	
31595422-0	2020	Curcumin inhibits BACE1 expression through the interaction between ERbeta and NFkappaB signaling pathway in SH-SY5Y cells.	Curcumin	0-8	beta-secretase 1	Homo sapiens	18-23	
28950235-4	2017	Recent studies revealed that only two scaffolds i.e. triazinone and curcumin act as a dual inhibitor against BACE-1 and GSK-3beta.	Curcumin	68-76	beta-secretase 1	Homo sapiens	109-115	
26696252-0	2016	Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3beta Inhibitors.	Curcumin	19-27	beta-secretase 1	Homo sapiens	76-82	
24597901-6	2014	RESULTS: BDMCCN has the strongest inhibitory activity toward BACE-1 with 17 muM IC50, which was 20 and 13 times lower than those of CCN and DMCCN respectively.	Curcumin	12-15	beta-secretase 1	Homo sapiens	61-67	
24360557-0	2014	Synthesis and evaluation of curcumin derivatives toward an inhibitor of beta-site amyloid precursor protein cleaving enzyme 1.	Curcumin	28-36	beta-secretase 1	Homo sapiens	72-125	
24360557-1	2014	To research a new non-peptidyl inhibitor of beta-site amyloid precursor protein cleaving enzyme 1, we focused on the curcumin framework, two phenolic groups combined with an sp2 carbon spacer for low-molecular and high lipophilicity.	Curcumin	117-125	beta-secretase 1	Homo sapiens	44-97