PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25422208-0 2014 Curcumin-loaded PLGA nanoparticles conjugated with anti- P-glycoprotein antibody to overcome multidrug resistance. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 57-71 24814288-10 2014 In addition, cell viability and drug pump-out ability were significantly reduced in the FZD1 inhibitor curcumin-treated and FZD1 shRNA-knockdown MES-SA/Dx5 cells, indicating involvement of PKCdelta in FZD1-modulated ABCB1 expression pathway. Curcumin 103-111 ATP binding cassette subfamily B member 1 Homo sapiens 216-221 25543853-1 2015 Curcumin (CUR) is a phytochemical that inhibits the xenobiotic ABC efflux transporters implicated in cancer multidrug resistance (MDR), such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 and 5 (MRP1 and MRP5). Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 144-158 25543853-1 2015 Curcumin (CUR) is a phytochemical that inhibits the xenobiotic ABC efflux transporters implicated in cancer multidrug resistance (MDR), such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 and 5 (MRP1 and MRP5). Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 160-164 25594233-2 2015 This study aimed at identifying whether curcumin, demethoxycurcumin, and bisdemethoxycurcumin could modulate efflux function of human P-glycoprotein and be used as chemosensitizers in cancer treatments. Curcumin 40-48 ATP binding cassette subfamily B member 1 Homo sapiens 134-148 24247158-2 2014 Our previous study showed that water-soluble PLGA curcumin nanoparticles (Cur-NPs) triggered apoptotic cell death through regulation of the function of MDR1 and the production of reactive oxygen species (ROS) in cisplatin-resistant human oral cancer CAR cells. Curcumin 50-58 ATP binding cassette subfamily B member 1 Homo sapiens 152-156 24229684-0 2013 Reversion effects of curcumin on multidrug resistance of MNNG/HOS human osteosarcoma cells in vitro and in vivo through regulation of P-glycoprotein. Curcumin 21-29 ATP binding cassette subfamily B member 1 Homo sapiens 134-148 24229684-9 2013 Real-time PCR and Western blotting assays demonstrated that curcumin down-regulated P-gp expression of MNNG/HOS/MTX cells. Curcumin 60-68 ATP binding cassette subfamily B member 1 Homo sapiens 84-88 24229684-10 2013 Rh123 transport test showed that curcumin inhibited the transport function of P-gp in vitro. Curcumin 33-41 ATP binding cassette subfamily B member 1 Homo sapiens 78-82 24229684-12 2013 CONCLUSION: Down-regulation of P-gp and inhibition of the function of P-gp efflux pump may contribute to MDR reversion induced by curcumin in vitro and in vivo. Curcumin 130-138 ATP binding cassette subfamily B member 1 Homo sapiens 31-35 24229684-12 2013 CONCLUSION: Down-regulation of P-gp and inhibition of the function of P-gp efflux pump may contribute to MDR reversion induced by curcumin in vitro and in vivo. Curcumin 130-138 ATP binding cassette subfamily B member 1 Homo sapiens 70-74 22725663-0 2012 Effects of curcumin on the pharmacokinetics of talinolol in human with ABCB1 polymorphism. Curcumin 11-19 ATP binding cassette subfamily B member 1 Homo sapiens 71-76 22725663-1 2012 This study was to investigate the effect of concomitantly administered curcumin on the pharmacokinetics of talinolol and association with ABCB1 C3435T genetic polymorphism. Curcumin 71-79 ATP binding cassette subfamily B member 1 Homo sapiens 138-143 22725663-9 2012 The effect of curcumin on talinolol was associated with ABCB1 genotypes (C3435T). Curcumin 14-22 ATP binding cassette subfamily B member 1 Homo sapiens 56-61 23917396-0 2013 Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 96-100 23761708-0 2013 Modulation of multidrug resistance 1 expression and function in retinoblastoma cells by curcumin. Curcumin 88-96 ATP binding cassette subfamily B member 1 Homo sapiens 14-36 23761708-1 2013 OBJECTIVE: To determine the possible interaction of curcumin with P-glycoprotein (P-gp) expression and function by in vitro and in silico studies. Curcumin 52-60 ATP binding cassette subfamily B member 1 Homo sapiens 66-80 23761708-1 2013 OBJECTIVE: To determine the possible interaction of curcumin with P-glycoprotein (P-gp) expression and function by in vitro and in silico studies. Curcumin 52-60 ATP binding cassette subfamily B member 1 Homo sapiens 82-86 23761708-2 2013 MATERIALS AND METHODS: In this study, curcumin was compared for its potential to modulate the expression and function of P-gp in Y79 RB cells by western blot, RT-PCR (reverse transcription polymerase chain reaction) and functional assay. Curcumin 38-46 ATP binding cassette subfamily B member 1 Homo sapiens 121-125 23761708-5 2013 The effect of curcumin on P-gp function was demonstrated by Rhodamine 123 (Rh123) accumulation and efflux study. Curcumin 14-22 ATP binding cassette subfamily B member 1 Homo sapiens 26-30 23761708-8 2013 Moreover, molecular docking studies concurrently infer the binding of curcumin into the substrate binding site of P-gp with a binding energy of -7.66 kcal/mol. Curcumin 70-78 ATP binding cassette subfamily B member 1 Homo sapiens 114-118 23761708-9 2013 CONCLUSION: These findings indicate that curcumin suppresses the MDR1 expression and function, and therefore may be useful as modulators of multidrug resistance in RB tumor. Curcumin 41-49 ATP binding cassette subfamily B member 1 Homo sapiens 65-69 20450049-5 2010 The effect of curcumin on the expression of anti-apoptosis genes (Survivin and BCl-xL) and drug resistance genes (DRG2 and MDR1) was studied by reverse transcription-polymerase chain reaction (RT-PCR). Curcumin 14-22 ATP binding cassette subfamily B member 1 Homo sapiens 123-127 23467256-8 2011 While in the curcumin pretreated groups, the induced P-gp and mdr1 mRNA levels gradually decreased with increasing curcumin concentrations, and the Rh-123 accumulation level was almost recovered close to the control group"s. Curcumin 13-21 ATP binding cassette subfamily B member 1 Homo sapiens 53-57 23467256-8 2011 While in the curcumin pretreated groups, the induced P-gp and mdr1 mRNA levels gradually decreased with increasing curcumin concentrations, and the Rh-123 accumulation level was almost recovered close to the control group"s. Curcumin 13-21 ATP binding cassette subfamily B member 1 Homo sapiens 62-66 23467256-8 2011 While in the curcumin pretreated groups, the induced P-gp and mdr1 mRNA levels gradually decreased with increasing curcumin concentrations, and the Rh-123 accumulation level was almost recovered close to the control group"s. Curcumin 115-123 ATP binding cassette subfamily B member 1 Homo sapiens 53-57 23467256-8 2011 While in the curcumin pretreated groups, the induced P-gp and mdr1 mRNA levels gradually decreased with increasing curcumin concentrations, and the Rh-123 accumulation level was almost recovered close to the control group"s. Curcumin 115-123 ATP binding cassette subfamily B member 1 Homo sapiens 62-66 23467256-10 2011 CONCLUSION: Our present study suggested that curcumin exhibits the novel ability to prevent the up-regulation of P-gp and its mRNA induced by ADM. Curcumin 45-53 ATP binding cassette subfamily B member 1 Homo sapiens 113-117 20450049-6 2010 The expression of MDR1 mRNA was significantly decreased in Sk-hep-1 cells treated with curcumin, while no alterations in the amount of DRG2 and anti-apoptosis genes" mRNA levels were found. Curcumin 87-95 ATP binding cassette subfamily B member 1 Homo sapiens 18-22 20450049-7 2010 These results indicate that curcumin is able to inhibit proliferation and induce apoptosis in Sk-hep-1 cells and it may cause by down-regulating the expression of MDR1 mRNA. Curcumin 28-36 ATP binding cassette subfamily B member 1 Homo sapiens 163-167 20118549-1 2010 The present study was conducted to investigate the functional and transcriptional modulation of P-glycoprotein (MDR-1) by several dietary ingredients (piperine, capsaicin, daidzein, genistein, sesamin, curcumin, taurine) in vinblastine-resistant colon carcinoma LS-180 cells (LS-180V cells). Curcumin 202-210 ATP binding cassette subfamily B member 1 Homo sapiens 112-117 20118549-7 2010 Piperine, genistein and curcumin have been suggested to stimulate P-glycoprotein-mediated efflux without increasing P-glycoprotein expression. Curcumin 24-32 ATP binding cassette subfamily B member 1 Homo sapiens 66-80 20118549-7 2010 Piperine, genistein and curcumin have been suggested to stimulate P-glycoprotein-mediated efflux without increasing P-glycoprotein expression. Curcumin 24-32 ATP binding cassette subfamily B member 1 Homo sapiens 116-130 17121181-0 2006 Inhibitory effect of curcumin on MDR1 gene expression in patient leukemic cells. Curcumin 21-29 ATP binding cassette subfamily B member 1 Homo sapiens 33-37 18414057-7 2008 The expression of MDR-related genes mdr1, gst-pi and topo IIalpha, was altered by sulfinosine and curcumin. Curcumin 98-106 ATP binding cassette subfamily B member 1 Homo sapiens 36-40 18385293-3 2008 Curcumin (from turmeric) at 30 to 60 microM and 6-gingerol (from ginger) at 100 to 500 microM were observed to inhibit P-gp-mediated [(3)H]digoxin transport in L-MDR1 and Caco-2 cells. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 119-123 18385293-3 2008 Curcumin (from turmeric) at 30 to 60 microM and 6-gingerol (from ginger) at 100 to 500 microM were observed to inhibit P-gp-mediated [(3)H]digoxin transport in L-MDR1 and Caco-2 cells. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 162-166 18439772-7 2008 Interestingly, contrary to Curcumas, curcumin treatment inhibited the activity of P-gp with a decrease in P-gp protein and MDR1 mRNA expression levels. Curcumin 37-45 ATP binding cassette subfamily B member 1 Homo sapiens 123-127 16960658-0 2007 Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. Curcumin 175-183 ATP binding cassette subfamily B member 1 Homo sapiens 55-69 16960658-0 2007 Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. Curcumin 175-183 ATP binding cassette subfamily B member 1 Homo sapiens 71-76 16960658-0 2007 Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. Curcumin 175-183 ATP binding cassette subfamily B member 1 Homo sapiens 123-153 17121181-5 2006 The aim of this study was to further investigate the effect of curcumin on MDR1 gene expression in patient leukemic cells. Curcumin 63-71 ATP binding cassette subfamily B member 1 Homo sapiens 75-79 17121181-12 2006 It was found that curcumin reduced MDR1 gene expression in the cells from 33 patients (42%). Curcumin 18-26 ATP binding cassette subfamily B member 1 Homo sapiens 35-39 17121181-13 2006 Curcumin affected the MDR1 gene expression in 5 of 11 relapsed cases (45%), 10 of 26 cases of drug maintenance (38%), 7 of 18 cases of completed treatment (39%), and 11 of 23 cases of new patients (48%). Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 22-26 17121181-15 2006 In summary, curcumin decreased MDR1 mRNA level in patient leukemic cells, especially in high level of MDR1 gene groups. Curcumin 12-20 ATP binding cassette subfamily B member 1 Homo sapiens 31-35 17121181-15 2006 In summary, curcumin decreased MDR1 mRNA level in patient leukemic cells, especially in high level of MDR1 gene groups. Curcumin 12-20 ATP binding cassette subfamily B member 1 Homo sapiens 102-106 34065600-8 2021 Because curcumin inhibits P-glycoprotein (P-gp) in cancer cells and contributes to overcoming multidrug resistance, we showed that curcumin similarly inhibited platelet P-gp activity. Curcumin 8-16 ATP binding cassette subfamily B member 1 Homo sapiens 26-40 16038636-10 2005 P-gp was overexpressed in SGC7901/VCR cells, whereas it was downregulated after a 24-h treatment with curcumin (10 micromol/L). Curcumin 102-110 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 15476675-0 2004 Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder. Curcumin 71-79 ATP binding cassette subfamily B member 1 Homo sapiens 45-59 15476675-0 2004 Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder. Curcumin 71-79 ATP binding cassette subfamily B member 1 Homo sapiens 61-66 15476675-2 2004 Previously [Biochem Pharmacol 2002;64:573-82], we reported that a curcumin mixture could modulate both function and expression of Pgp. Curcumin 66-74 ATP binding cassette subfamily B member 1 Homo sapiens 130-133 15476675-3 2004 This study focuses on the effect of three major curcuminoids--curcumin I, II and III purified from a curcumin mixture--on modulation of Pgp function in a multidrug resistant human cervical carcinoma cell line (KB-V1). Curcumin 48-56 ATP binding cassette subfamily B member 1 Homo sapiens 136-139 15476675-3 2004 This study focuses on the effect of three major curcuminoids--curcumin I, II and III purified from a curcumin mixture--on modulation of Pgp function in a multidrug resistant human cervical carcinoma cell line (KB-V1). Curcumin 62-70 ATP binding cassette subfamily B member 1 Homo sapiens 136-139 11351295-6 2001 The GST inhibitor curcumin also enhanced cytotoxicity in HEp2A cells when the Pgp/MRP efflux barrier had been reversed by verapamil or overcome by high doxorubicin concentrations. Curcumin 18-26 ATP binding cassette subfamily B member 1 Homo sapiens 78-81 34601070-7 2021 RESULTS: The lowest effective CYP3A4 inhibitory concentrations were observed for curcumin (75microM and 100 microM), quercetin (75 and 100 microM) and glycyrrhizic acid (50 microM) while the most effective p-glycoprotein (P-gp) inhibition concentrations were curcumin (10, 15, 25, 50, 75 and 100 microM), sinomenine (50, 75, and 100 microM), quercetin (75 and 100 microM) and naringin (50 microM). Curcumin 259-267 ATP binding cassette subfamily B member 1 Homo sapiens 222-226 34601070-9 2021 CONCLUSION: Incorporation of the drug absorption enhancers (e.g., curcumin and quercetin), at specific concentrations, in dosage forms could improve the bioavailability of the BCS Class III and IV drugs that are substrates of CYP3A4 and p-glycoprotein. Curcumin 66-74 ATP binding cassette subfamily B member 1 Homo sapiens 237-251 15649425-6 2005 These results suggest that dietary phytochemicals, such as capsaicin, curcumin, [6]-gingerol, and resveratrol, have inhibitory effects on P-glycoprotein and potencies to cause drug-food interactions. Curcumin 70-78 ATP binding cassette subfamily B member 1 Homo sapiens 138-152 15476675-8 2004 The inhibitory effect in a concentration-dependent manner of curcuminoids on verapamil-stimulated ATPase activity and photoaffinity labeling of Pgp with the [(125)I]-iodoarylazidoprazosin offered additional support; curcumin I was the most potent modulator. Curcumin 216-226 ATP binding cassette subfamily B member 1 Homo sapiens 144-147 15090070-6 2004 In additional studies we found that commercial grade curcuminoid (approximately 77% curcumin, 17% demethoxycurcumin and 3% bisdemthoxycurcumin) decreased MDR-1 gene expression in a dose dependent manner and had about the same potent inhibitory effect on MDR-1 gene expression as our natural curcuminoid mixtures. Curcumin 53-61 ATP binding cassette subfamily B member 1 Homo sapiens 154-159 15090070-6 2004 In additional studies we found that commercial grade curcuminoid (approximately 77% curcumin, 17% demethoxycurcumin and 3% bisdemthoxycurcumin) decreased MDR-1 gene expression in a dose dependent manner and had about the same potent inhibitory effect on MDR-1 gene expression as our natural curcuminoid mixtures. Curcumin 53-61 ATP binding cassette subfamily B member 1 Homo sapiens 254-259 15090070-8 2004 Treatment of drug resistant KB-V1 cells with curcumin increased their sensitivity to vinblastine, which was consistent with a decreased MDR-1 gene product, a P-glycoprotein, on the cell plasma membrane. Curcumin 45-53 ATP binding cassette subfamily B member 1 Homo sapiens 136-141 15090070-8 2004 Treatment of drug resistant KB-V1 cells with curcumin increased their sensitivity to vinblastine, which was consistent with a decreased MDR-1 gene product, a P-glycoprotein, on the cell plasma membrane. Curcumin 45-53 ATP binding cassette subfamily B member 1 Homo sapiens 158-172 15072439-5 2004 Curcumin, ginsenosides, piperine, some catechins from green tea, and silymarin from milk thistle were found to be inhibitors of Pgp, while some catechins from green tea increased Pgp-mediated drug transport by heterotropic allosteric mechanism, and St. John"s wort induced the intestinal expression of Pgp in vitro and in vivo. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 128-131 15072439-5 2004 Curcumin, ginsenosides, piperine, some catechins from green tea, and silymarin from milk thistle were found to be inhibitors of Pgp, while some catechins from green tea increased Pgp-mediated drug transport by heterotropic allosteric mechanism, and St. John"s wort induced the intestinal expression of Pgp in vitro and in vivo. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 179-182 15072439-5 2004 Curcumin, ginsenosides, piperine, some catechins from green tea, and silymarin from milk thistle were found to be inhibitors of Pgp, while some catechins from green tea increased Pgp-mediated drug transport by heterotropic allosteric mechanism, and St. John"s wort induced the intestinal expression of Pgp in vitro and in vivo. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 179-182 12167476-0 2002 Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells. Curcumin 56-64 ATP binding cassette subfamily B member 1 Homo sapiens 14-28 12167476-3 2002 In this study, curcumin was tested for its potential ability to modulate the expression and function of Pgp in the multidrug-resistant human cervical carcinoma cell line KB-V1. Curcumin 15-23 ATP binding cassette subfamily B member 1 Homo sapiens 104-107 12167476-4 2002 Western blot analysis and reverse transcription-polymerase chain reaction (RT-PCR) showed that treatment with 1, 5, and 10 microM curcumin for up to 72hr was able to significantly lower Pgp expression in KB-V1 cells. Curcumin 130-138 ATP binding cassette subfamily B member 1 Homo sapiens 186-189 12167476-5 2002 Curcumin (1-10 microM) decreased Pgp expression in a concentration-dependent manner and was also found to have the same effect on MDR1 mRNA levels. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 33-36 12167476-5 2002 Curcumin (1-10 microM) decreased Pgp expression in a concentration-dependent manner and was also found to have the same effect on MDR1 mRNA levels. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 130-134 12167476-6 2002 The effect of curcumin on Pgp function was demonstrated by rhodamine 123 (Rh123) accumulation and efflux in Pgp-expressing KB-V1 cells. Curcumin 14-22 ATP binding cassette subfamily B member 1 Homo sapiens 26-29 12167476-6 2002 The effect of curcumin on Pgp function was demonstrated by rhodamine 123 (Rh123) accumulation and efflux in Pgp-expressing KB-V1 cells. Curcumin 14-22 ATP binding cassette subfamily B member 1 Homo sapiens 108-111 12167476-9 2002 In addition, curcumin inhibited verapamil-stimulated ATPase activity and the photoaffinity labeling of Pgp with the prazosin analog [125I]iodoarylazidoprazosin in a concentration-dependent manner, demonstrating that curcumin interacts directly with the transporter. Curcumin 13-21 ATP binding cassette subfamily B member 1 Homo sapiens 103-106 12167476-9 2002 In addition, curcumin inhibited verapamil-stimulated ATPase activity and the photoaffinity labeling of Pgp with the prazosin analog [125I]iodoarylazidoprazosin in a concentration-dependent manner, demonstrating that curcumin interacts directly with the transporter. Curcumin 216-224 ATP binding cassette subfamily B member 1 Homo sapiens 103-106 12167476-10 2002 Thus, curcumin seems to be able to modulate the in vitro expression and function of Pgp in multidrug-resistant human KB-V1 cells. Curcumin 6-14 ATP binding cassette subfamily B member 1 Homo sapiens 84-87 12167476-11 2002 In summary, this study describes the duel modulation of MDR1 expression and Pgp function by the phytochemical curcumin, which may be an attractive new agent for the chemosensitization of cancer cells. Curcumin 110-118 ATP binding cassette subfamily B member 1 Homo sapiens 56-60 12167476-11 2002 In summary, this study describes the duel modulation of MDR1 expression and Pgp function by the phytochemical curcumin, which may be an attractive new agent for the chemosensitization of cancer cells. Curcumin 110-118 ATP binding cassette subfamily B member 1 Homo sapiens 76-79 34829695-4 2021 P-glycoprotein activity was determined in LS180 cells, incubated with 30 or 60 micromol/L of curcumin in the form of seven different formulations or native curcuma extract for 1 h. All formulations inhibited P-glycoprotein activity at both concentrations. Curcumin 93-101 ATP binding cassette subfamily B member 1 Homo sapiens 208-222 34829695-7 2021 In conclusion, curcumin inhibits P-glycoprotein activity independently of its formulation. Curcumin 15-23 ATP binding cassette subfamily B member 1 Homo sapiens 33-47 34065600-8 2021 Because curcumin inhibits P-glycoprotein (P-gp) in cancer cells and contributes to overcoming multidrug resistance, we showed that curcumin similarly inhibited platelet P-gp activity. Curcumin 8-16 ATP binding cassette subfamily B member 1 Homo sapiens 42-46 34065600-8 2021 Because curcumin inhibits P-glycoprotein (P-gp) in cancer cells and contributes to overcoming multidrug resistance, we showed that curcumin similarly inhibited platelet P-gp activity. Curcumin 131-139 ATP binding cassette subfamily B member 1 Homo sapiens 26-40 34065600-8 2021 Because curcumin inhibits P-glycoprotein (P-gp) in cancer cells and contributes to overcoming multidrug resistance, we showed that curcumin similarly inhibited platelet P-gp activity. Curcumin 131-139 ATP binding cassette subfamily B member 1 Homo sapiens 42-46 34065600-8 2021 Because curcumin inhibits P-glycoprotein (P-gp) in cancer cells and contributes to overcoming multidrug resistance, we showed that curcumin similarly inhibited platelet P-gp activity. Curcumin 131-139 ATP binding cassette subfamily B member 1 Homo sapiens 169-173 33488079-0 2021 Enhanced Photothermal-Photodynamic Therapy by Indocyanine Green and Curcumin-Loaded Layered MoS2 Hollow Spheres via Inhibition of P-Glycoprotein. Curcumin 68-76 ATP binding cassette subfamily B member 1 Homo sapiens 130-144 34000577-0 2021 Curcumin reverses doxorubicin resistance in colon cancer cells at the metabolic level. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 18-40 33488079-2 2021 In this study, we have prepared and characterized a kind of novel ICG&Cur@MoS2 (ICG and Cur represent indocyanine green and curcumin, respectively) nanoplatform, which can achieve photothermal-photodynamic therapy and inhibit the P-gp effectively and safely. Curcumin 124-132 ATP binding cassette subfamily B member 1 Homo sapiens 230-234 31991669-3 2020 Curcumin (CURC) is a Pgp inhibitor, but it is poorly soluble and bioavailable. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 21-24 33025506-15 2020 Concentration dependent alleviation of chemoresistance development by curcumin was confirmed and was found to reduce gene level expression of P-glycoprotein and Cox-2. Curcumin 70-78 ATP binding cassette subfamily B member 1 Homo sapiens 142-156 31967866-0 2020 Reversal of P-Glycoprotein-Mediated Multidrug Resistance by Novel Curcumin Analogues in Paclitaxel-resistant Human Breast Cancer Cells. Curcumin 66-74 ATP binding cassette subfamily B member 1 Homo sapiens 12-26 31991669-0 2020 Curcumin-Loaded Solid Lipid Nanoparticles Bypass P-Glycoprotein Mediated Doxorubicin Resistance in Triple Negative Breast Cancer Cells. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 49-63 31991669-3 2020 Curcumin (CURC) is a Pgp inhibitor, but it is poorly soluble and bioavailable. Curcumin 10-14 ATP binding cassette subfamily B member 1 Homo sapiens 21-24 31991669-0 2020 Curcumin-Loaded Solid Lipid Nanoparticles Bypass P-Glycoprotein Mediated Doxorubicin Resistance in Triple Negative Breast Cancer Cells. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 73-95 31991669-5 2020 Both CURC-loaded SLNs were 5-10-fold more effective than free CURC in increasing the intracellular retention and toxicity of doxorubicin in Pgp-expressing triple negative breast cancer (TNBC). Curcumin 5-9 ATP binding cassette subfamily B member 1 Homo sapiens 140-143 31991669-8 2020 These results suggest that the combination therapy, based on CURC-loaded SLNs and doxorubicin, is an effective and safe approach to overcome the Pgp-mediated chemoresistance in TNBC. Curcumin 61-65 ATP binding cassette subfamily B member 1 Homo sapiens 145-148 31628941-0 2020 Inhibition of aldehyde dehydrogenase-1 and p-glycoprotein-mediated multidrug resistance by curcumin and vitamin D3 increases sensitivity to paclitaxel in breast cancer. Curcumin 91-99 ATP binding cassette subfamily B member 1 Homo sapiens 43-57 31628941-4 2020 The present study, therefore, aimed at investigating the effect of both curcumin (CUR) and vitamin D3 (D3) on MDR-1 and ALDH-1 expression and consequently the resistance to PAX both in vitro and in vivo. Curcumin 72-80 ATP binding cassette subfamily B member 1 Homo sapiens 110-115 31628941-4 2020 The present study, therefore, aimed at investigating the effect of both curcumin (CUR) and vitamin D3 (D3) on MDR-1 and ALDH-1 expression and consequently the resistance to PAX both in vitro and in vivo. Curcumin 82-85 ATP binding cassette subfamily B member 1 Homo sapiens 110-115 31897118-0 2020 Curcumin increases the sensitivity of K562/DOX cells to doxorubicin by targeting S100 calcium-binding protein A8 and P-glycoprotein. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 117-131 31897118-6 2020 Western blot analysis revealed that curcumin treatment caused a downregulation of the expression of P-glycoprotein (P-gp) and S100A8 in a dose- and time-dependent manner. Curcumin 36-44 ATP binding cassette subfamily B member 1 Homo sapiens 100-114 31897118-6 2020 Western blot analysis revealed that curcumin treatment caused a downregulation of the expression of P-glycoprotein (P-gp) and S100A8 in a dose- and time-dependent manner. Curcumin 36-44 ATP binding cassette subfamily B member 1 Homo sapiens 116-120 31897118-10 2020 In conclusion, the present study suggested that inhibition of S100A8 expression increased DOX-induced apoptosis, and curcumin acted independently on S100A8 and P-gp to exert its drug resistance reversal effects. Curcumin 117-125 ATP binding cassette subfamily B member 1 Homo sapiens 160-164 30771095-2 2019 However, it is challenging to study curcumin as it exhibits poor aqueous solubility and low permeability and it is a substrate for P-glycoprotein (P-gp). Curcumin 36-44 ATP binding cassette subfamily B member 1 Homo sapiens 131-145 30771095-2 2019 However, it is challenging to study curcumin as it exhibits poor aqueous solubility and low permeability and it is a substrate for P-glycoprotein (P-gp). Curcumin 36-44 ATP binding cassette subfamily B member 1 Homo sapiens 147-151 30484020-0 2019 Curcumin Reverses 5-Fluorouracil Resistance by Promoting Human Colon Cancer HCT-8/5-FU Cell Apoptosis and Down-regulating Heat Shock Protein 27 and P-Glycoprotein. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 148-162 30484020-15 2019 Down-regulation of P-gp and HSP-27 may be the mechanism of curcumin reversing the drug resistance of HCT-8/5-FU to 5-FU. Curcumin 59-67 ATP binding cassette subfamily B member 1 Homo sapiens 19-23 28423731-3 2017 The faster release of curcumin from the folate-conjugated curcumin and paclitaxel-loaded lipid nanoparticles enables sufficient p-glycoprotein inhibition, which allows increased cellular uptake and cytotoxicity of paclitaxel. Curcumin 22-30 ATP binding cassette subfamily B member 1 Homo sapiens 128-142 31190861-1 2019 Purpose: To explore the effect of curcumin and low-frequency and low-intensity ultrasound (LFLIU) on C6 and U87 cell, and whether LFLIU could inhibit multidrug resistance protein 1 (MRP1) by increasing the sensitivity of curcumin via vascular epithelial growth factor (VEGF)/PI3K/Akt signaling pathway targeting. Curcumin 221-229 ATP binding cassette subfamily B member 1 Homo sapiens 182-186 31190861-7 2019 VEGF and MRP1 were highly expressed in C6 and U87 cells, curcumin and LFLIU alone or in combination could decrease the expression of both VEGF and MRP1. Curcumin 57-65 ATP binding cassette subfamily B member 1 Homo sapiens 9-13 31190861-7 2019 VEGF and MRP1 were highly expressed in C6 and U87 cells, curcumin and LFLIU alone or in combination could decrease the expression of both VEGF and MRP1. Curcumin 57-65 ATP binding cassette subfamily B member 1 Homo sapiens 147-151 31190861-9 2019 Conclusion: The synergistic effects, such as a higher inhibition rate, and lower expressions of MRP1 and VEGF, of combined curcumin and LFLIU against glioma was much better than that of a single treatment. Curcumin 123-131 ATP binding cassette subfamily B member 1 Homo sapiens 96-100 28536971-0 2017 Selection of P-Glycoprotein Inhibitor and Formulation of Combinational Nanoformulation Containing Selected Agent Curcumin and DOX for Reversal of Resistance in K562 Cells. Curcumin 113-121 ATP binding cassette subfamily B member 1 Homo sapiens 13-27 28536971-6 2017 RESULTS: P-gp inhibitors such as biochanin-A and curcumin were marked suitable for combination with DOX. Curcumin 49-57 ATP binding cassette subfamily B member 1 Homo sapiens 9-13 31190861-0 2019 The reversal of MRP1 expression induced by low-frequency and low-intensity ultrasound and curcumin mediated by VEGF in brain glioma. Curcumin 90-98 ATP binding cassette subfamily B member 1 Homo sapiens 16-20 28423731-3 2017 The faster release of curcumin from the folate-conjugated curcumin and paclitaxel-loaded lipid nanoparticles enables sufficient p-glycoprotein inhibition, which allows increased cellular uptake and cytotoxicity of paclitaxel. Curcumin 58-66 ATP binding cassette subfamily B member 1 Homo sapiens 128-142 28423731-4 2017 In western blot assay, curcumin can efficiently inhibit the expression of p-glycoprotein, conformed the enhancement of cytotoxicity by paclitaxel. Curcumin 23-31 ATP binding cassette subfamily B member 1 Homo sapiens 74-88 27318188-0 2016 Modulation of P-glycoprotein activity by novel synthetic curcumin derivatives in sensitive and multidrug-resistant T-cell acute lymphoblastic leukemia cell lines. Curcumin 57-65 ATP binding cassette subfamily B member 1 Homo sapiens 14-28 28123572-0 2017 Solid lipid nanoparticles with TPGS and Brij 78: A co-delivery vehicle of curcumin and piperine for reversing P-glycoprotein-mediated multidrug resistance in vitro. Curcumin 74-82 ATP binding cassette subfamily B member 1 Homo sapiens 110-124 27834897-0 2016 Curcumin as a Modulator of P-Glycoprotein in Cancer: Challenges and Perspectives. Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 27-41 27834897-5 2016 Curcumin is a secondary metabolite isolated from the turmeric of Curcuma longa L. which has been associated with several biological activities, particularly P-gp modulatory activity (by inhibiting both P-gp function and expression). Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 157-161 27834897-5 2016 Curcumin is a secondary metabolite isolated from the turmeric of Curcuma longa L. which has been associated with several biological activities, particularly P-gp modulatory activity (by inhibiting both P-gp function and expression). Curcumin 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 202-206 27834897-6 2016 However, curcumin shows extensive metabolism and instability, which has justified the recent and intensive search for analogs of curcumin that maintain the P-gp modulatory activity but have enhanced stability. Curcumin 129-137 ATP binding cassette subfamily B member 1 Homo sapiens 156-160 27834897-7 2016 This review summarizes and compares the effects of curcumin and several curcumin analogs on P-glycoprotein function and expression, emphasizing the potential of these molecules for the possible development of safe and effective inhibitors of P-gp to overcome MDR in human cancer. Curcumin 51-59 ATP binding cassette subfamily B member 1 Homo sapiens 92-106 27834897-7 2016 This review summarizes and compares the effects of curcumin and several curcumin analogs on P-glycoprotein function and expression, emphasizing the potential of these molecules for the possible development of safe and effective inhibitors of P-gp to overcome MDR in human cancer. Curcumin 51-59 ATP binding cassette subfamily B member 1 Homo sapiens 242-246 27834897-7 2016 This review summarizes and compares the effects of curcumin and several curcumin analogs on P-glycoprotein function and expression, emphasizing the potential of these molecules for the possible development of safe and effective inhibitors of P-gp to overcome MDR in human cancer. Curcumin 72-80 ATP binding cassette subfamily B member 1 Homo sapiens 92-106 27834897-7 2016 This review summarizes and compares the effects of curcumin and several curcumin analogs on P-glycoprotein function and expression, emphasizing the potential of these molecules for the possible development of safe and effective inhibitors of P-gp to overcome MDR in human cancer. Curcumin 72-80 ATP binding cassette subfamily B member 1 Homo sapiens 242-246 27152196-5 2016 Moreover, curcumin, an intracellularly cleaved product of PCDA, can effectively down regulate the expression of drug efflux transporters such as P-glycoprotein (P-gp) to increase PTX accumulation within target cancer cells, thereby enhancing PTX induced cytotoxicity and therapeutic efficacy against MCF-7/ADR cells. Curcumin 10-18 ATP binding cassette subfamily B member 1 Homo sapiens 145-159 27313684-0 2016 MiR-593 mediates curcumin-induced radiosensitization of nasopharyngeal carcinoma cells via MDR1. Curcumin 17-25 ATP binding cassette subfamily B member 1 Homo sapiens 91-95 27152196-5 2016 Moreover, curcumin, an intracellularly cleaved product of PCDA, can effectively down regulate the expression of drug efflux transporters such as P-glycoprotein (P-gp) to increase PTX accumulation within target cancer cells, thereby enhancing PTX induced cytotoxicity and therapeutic efficacy against MCF-7/ADR cells. Curcumin 10-18 ATP binding cassette subfamily B member 1 Homo sapiens 161-165 26278546-3 2016 These cells were then exposed to different concentration of cytarabine and curcumin to find out IC50 values and also its effect on MDR genes like MDR1, BCRP, LRP and FLT3 by RT-PCR method. Curcumin 75-83 ATP binding cassette subfamily B member 1 Homo sapiens 146-150