PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11592943-5 2001 Surprisingly, curcumin by itself was a very potent inducer of HO-1. Curcumin 14-22 heme oxygenase 1 Homo sapiens 62-66 11854435-0 2002 Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers. Curcumin 33-41 heme oxygenase 1 Homo sapiens 60-76 11854435-2 2002 Curcumin, a polyphenolic natural compound that possesses anti-tumor and anti-inflammatory properties, has been reported recently to induce potently HO-1 expression in vascular endothelial cells (Free Rad Biol Med 28:1303-1312, 2000). Curcumin 0-8 heme oxygenase 1 Homo sapiens 148-152 11592943-0 2001 Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cells. Curcumin 48-56 heme oxygenase 1 Homo sapiens 13-29 11592943-7 2001 To evaluate the mechanism of curcumin-mediated induction of HO-1, confluent human renal proximal tubule cells were exposed to curcumin (1-8 microM). Curcumin 29-37 heme oxygenase 1 Homo sapiens 60-64 11592943-9 2001 Coincubation of curcumin with actinomycin D completely blocked the upregulation of HO-1 mRNA. Curcumin 16-24 heme oxygenase 1 Homo sapiens 83-87 11592943-10 2001 Blockade of nuclear factor-kappaB (NF-kappaB) with an IkappaBalpha phosphorylation inhibitor attenuated curcumin-mediated induction of HO-1 mRNA and protein. Curcumin 104-112 heme oxygenase 1 Homo sapiens 135-139 11592943-11 2001 These data demonstrate that curcumin induces HO-1 mRNA and protein in renal proximal tubule cells. Curcumin 28-36 heme oxygenase 1 Homo sapiens 45-49 11592943-12 2001 HO-1 induction by curcumin is mediated, at least in part, via transcriptional mechanisms and involves the NF-kappaB pathway. Curcumin 18-26 heme oxygenase 1 Homo sapiens 0-4 9530200-8 1998 Inhibition of the AP-1 transcription factor with curcumin decreased the cytokine induction of HO-1 mRNA, suggesting the involvement of this transcription factor in cytokine signaling of HO-1. Curcumin 49-57 heme oxygenase 1 Homo sapiens 94-98 9530200-8 1998 Inhibition of the AP-1 transcription factor with curcumin decreased the cytokine induction of HO-1 mRNA, suggesting the involvement of this transcription factor in cytokine signaling of HO-1. Curcumin 49-57 heme oxygenase 1 Homo sapiens 186-190 34153850-6 2021 In addition, curcumin pretreatment significantly increased the expression of nuclear Nrf2, and the productions of superoxide dismutase 1 and heme oxygenase-1, which were the target anti-oxidative enzymes of the Keap1/Nrf2/ARE pathway. Curcumin 13-21 heme oxygenase 1 Homo sapiens 141-157 35189631-10 2022 Furthermore, curcumin positively regulated the expression of Nrf2, HO-1, and SOD1 mRNAs in cells treated with 0.1 and 0.5 muM doxazosin. Curcumin 13-21 heme oxygenase 1 Homo sapiens 67-71 35015114-3 2022 RESULTS: In experimental models, curcumin showed its pleiotropic effects in retinal diseases like diabetic retinopathy by increasing anti-oxidant enzymes, upregulating HO-1, nrf2 and reducing or inhibiting inflammatory mediators, growth factors and by inhibiting proliferation and migration of retinal endothelial cells in a dose-dependent manner in HRPC, HREC and ARPE-19 cells. Curcumin 33-41 heme oxygenase 1 Homo sapiens 168-172 35015114-4 2022 In age-related macular degeneration, curcumin acts by reducing ROS and inhibiting apoptosis inducing proteins and cellular inflammatory genes and upregulating HO-1, thioredoxin and NQO1. Curcumin 37-45 heme oxygenase 1 Homo sapiens 159-163 35361044-0 2022 Curcumin analog, GO-Y078, induces HO-1 transactivation-mediated apoptotic cell death of oral cancer cells by triggering MAPK pathways and AP-1 DNA-binding activity. Curcumin 0-8 heme oxygenase 1 Homo sapiens 34-38 33980059-0 2021 Curcumin Can Activate the Nrf2/HO-1 Signaling Pathway and Scavenge Free Radicals in Spinal Cord Injury Treatment. Curcumin 0-8 heme oxygenase 1 Homo sapiens 31-35 33980059-6 2021 In this review, we analyze the role of curcumin in activating Nrf2/HO-1 and scavenging free radicals to repair SCI. Curcumin 39-47 heme oxygenase 1 Homo sapiens 67-71 33875681-3 2021 Here, we observed that curcumin induced the expression of genes downstream of Nrf2 such as HO-1, NQO1, and GST-mu1 in neuronal cells, and increased the level of Nrf2 protein. Curcumin 23-31 heme oxygenase 1 Homo sapiens 91-95 32500379-9 2020 Therapies with anti-viral properties that raise HO-1 include certain anesthetics (sevoflurane or isoflurane), hemin, estrogen, statins, curcumin, resveratrol, and melatonin. Curcumin 136-144 heme oxygenase 1 Homo sapiens 48-52 33096358-10 2021 The present study further enriches and perfects the mechanism theory of HgCl2 toxicity and suggest that the CYP450 signaling and Nrf2/HO-1 pathway is important in shedding light on curcumin"s hepatoprotective effects in HgCl2 toxicity. Curcumin 181-189 heme oxygenase 1 Homo sapiens 134-138 32623920-6 2020 We further showed that H2O2-induced oxidative stress was reduced by curcumin via the Nrf2/HO-1 pathway in human neuroblastoma cells. Curcumin 68-76 heme oxygenase 1 Homo sapiens 90-94 33217990-6 2020 Curcumin quenches free radicals, induces antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase), and upregulates antioxidative protein markers-Nrf2 and HO-1 that lead to the suppression of cellular oxidative stress. Curcumin 0-8 heme oxygenase 1 Homo sapiens 174-178 33294119-0 2020 Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells. Curcumin 57-65 heme oxygenase 1 Homo sapiens 74-78 33294119-7 2020 Curcumin upregulates a variety of ferroptosis target genes related to redox regulation, especially heme oxygenase-1 (HO-1). Curcumin 0-8 heme oxygenase 1 Homo sapiens 99-115 33294119-7 2020 Curcumin upregulates a variety of ferroptosis target genes related to redox regulation, especially heme oxygenase-1 (HO-1). Curcumin 0-8 heme oxygenase 1 Homo sapiens 117-121 33294119-9 2020 Therefore, these data demonstrate that curcumin triggers the molecular and cytological characteristics of ferroptosis in breast cancer cells, and HO-1 promotes curcumin-induced ferroptosis. Curcumin 160-168 heme oxygenase 1 Homo sapiens 146-150 31983246-10 2020 Tq + Cur treatment increased the expressions of phosphorylated Akt, Nrf2 and HO-1 proteins while decreasing the levels of cleaved caspase 3 and NFkB in kidney homogenates. Curcumin 5-8 heme oxygenase 1 Homo sapiens 77-81 31983246-11 2020 In summary, Tq + Cur had protective effects on cisplatin-induced nephrotoxicity and renal injury, which could be mediated by up-regulation of survival signals like Akt, Nrf2/HO-1, and attenuation of KIM-1, NFkB. Curcumin 17-20 heme oxygenase 1 Homo sapiens 174-178 32891672-8 2020 Furthermore, we observed that neuroprotective effects of curcumin and riluzole are mediated through Nrf2/HO-1 signaling. Curcumin 57-65 heme oxygenase 1 Homo sapiens 105-109 33096358-0 2021 Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway. Curcumin 0-8 heme oxygenase 1 Homo sapiens 110-114 33096358-7 2021 Furthermore, curcumin significantly increased the nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) and consequently upregulated the expression of heme oxygenase 1 (HO-1) under HgCl2 treatment. Curcumin 13-21 heme oxygenase 1 Homo sapiens 164-180 33096358-7 2021 Furthermore, curcumin significantly increased the nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) and consequently upregulated the expression of heme oxygenase 1 (HO-1) under HgCl2 treatment. Curcumin 13-21 heme oxygenase 1 Homo sapiens 182-186 33096358-8 2021 Meanwhile, inhibition of HO-1 by zinc protoporphyria could abolish the cytoprotective effects of curcumin in HgCl2-treated L02 hepatocytes. Curcumin 97-105 heme oxygenase 1 Homo sapiens 25-29 33096358-9 2021 In conclusion, our data identify that curcumin could enhance Nrf2-mediated HO-1 to upregulate antioxidant ability, which might be associate with CYP450 signaling to suppress liver damage induced by HgCl2. Curcumin 38-46 heme oxygenase 1 Homo sapiens 75-79 31983246-0 2020 Thymoquinone and Curcumin combination protects cisplatin-induced Kidney Injury, Nephrotoxicity by attenuating NFkB, KIM-1 and ameliorating Nrf2/HO-1 signaling. Curcumin 17-25 heme oxygenase 1 Homo sapiens 144-148 31972171-2 2020 Treatment of mouse epidermal JB-6 cells with curcumin resulted in the induction of HO-1 expression, and this was abrogated in cells transiently transfected with Nrf2 siRNA. Curcumin 45-53 heme oxygenase 1 Homo sapiens 83-87 32124251-6 2020 Pathway analysis demonstrated that the ROS/Nrf2/HO-1-SOD2-NQO-1-GCLC signaling axis is a key axis through which curcumin activates the Nrf2/ARE pathway in TMJ inflammatory chondrocytes. Curcumin 112-120 heme oxygenase 1 Homo sapiens 48-57 32228565-0 2020 Activation of the Nrf2/HO-1 pathway by curcumin inhibits oxidative stress in human nasal fibroblasts exposed to urban particulate matter. Curcumin 39-47 heme oxygenase 1 Homo sapiens 23-27 32228565-10 2020 Nrf2 production was also promoted to increase the expression of HO-1 and SOD2 by curcumin. Curcumin 81-89 heme oxygenase 1 Homo sapiens 64-68 30770549-0 2019 Curcumin prevents high glucose damage in retinal pigment epithelial cells through ERK1/2-mediated activation of the Nrf2/HO-1 pathway. Curcumin 0-8 heme oxygenase 1 Homo sapiens 121-125 31817533-0 2019 Dietary Curcumin Supplementation Increases Antioxidant Capacity, Upregulates Nrf2 and Hmox1 Levels in the Liver of Piglet Model with Intrauterine Growth Retardation. Curcumin 8-16 heme oxygenase 1 Homo sapiens 86-91 31817533-8 2019 Dietary curcumin supplementation increased body-weight gain, feed intake, activities of antioxidant enzymes, and the expressions of nuclear factor, erythroid 2-like 2 (Nrf2) and heme oxygenase-1 (Hmox1) proteins in the liver of weaned piglets with IUGR. Curcumin 8-16 heme oxygenase 1 Homo sapiens 178-194 31817533-8 2019 Dietary curcumin supplementation increased body-weight gain, feed intake, activities of antioxidant enzymes, and the expressions of nuclear factor, erythroid 2-like 2 (Nrf2) and heme oxygenase-1 (Hmox1) proteins in the liver of weaned piglets with IUGR. Curcumin 8-16 heme oxygenase 1 Homo sapiens 196-201 31817533-10 2019 Curcumin could efficiently improve the growth, increase hepatic antioxidant capacity, and upregulate Nrf2 and Hmox1 levels in the liver of IUGR weaned piglets. Curcumin 0-8 heme oxygenase 1 Homo sapiens 110-115 31577640-5 2019 Mechanistic studies have revealed superoxide dismutase, heme oxygenase-1 and nuclear factor erythroid 2-related factor 2 as emerging targets for the beneficial effects of curcumin on the vasculature. Curcumin 171-179 heme oxygenase 1 Homo sapiens 56-120 31656916-7 2019 Furthermore, resveratrol and curcumin decreased the content of m6A and decreased the enrichment of m6A on the transcripts of tight junction proteins and on heme oxygenase-1 in the intestine. Curcumin 29-37 heme oxygenase 1 Homo sapiens 156-172 30770549-5 2019 Further, curcumin was able to induce HO-1 expression via Nrf2 activation and counteracts the damage elicited by HG. Curcumin 9-17 heme oxygenase 1 Homo sapiens 37-41 30770549-6 2019 The present study demonstrated that curcumin provides protection against HG-induced damage in RPE cells through the activation of Nrf2/HO-1 signaling that involves the ERK pathway, suggesting that curcumin may have therapeutic value in the treatment of diabetic retinopathy. Curcumin 36-44 heme oxygenase 1 Homo sapiens 135-139 30770549-6 2019 The present study demonstrated that curcumin provides protection against HG-induced damage in RPE cells through the activation of Nrf2/HO-1 signaling that involves the ERK pathway, suggesting that curcumin may have therapeutic value in the treatment of diabetic retinopathy. Curcumin 197-205 heme oxygenase 1 Homo sapiens 135-139 30327711-12 2018 Treatment of cultured human artery endothelial cells with curcumin induced the HO-1 expression through the activation of nuclear factor-E2-related factor 2 (Nrf2) and an antioxidant responsive element via the p38 MAPK signalling pathway. Curcumin 58-66 heme oxygenase 1 Homo sapiens 79-83 30840308-10 2019 Moreover, curcumin also decreased the expression of HIF-1alpha downstream genes, VEGF, HMOX1, ROS and PDGF. Curcumin 10-18 heme oxygenase 1 Homo sapiens 87-92 30881359-7 2019 Previously we have reported that both carnosol and curcumin can regulate the maturation and function of human DC through upregulation of the immunomodulatory enzyme, Heme Oxygenase-1 (HO-1). Curcumin 51-59 heme oxygenase 1 Homo sapiens 166-182 30881359-7 2019 Previously we have reported that both carnosol and curcumin can regulate the maturation and function of human DC through upregulation of the immunomodulatory enzyme, Heme Oxygenase-1 (HO-1). Curcumin 51-59 heme oxygenase 1 Homo sapiens 184-188 30881359-10 2019 This study therefore describes a novel relationship between metabolic signaling via AMPK and HO-1 induction by carnosol and curcumin in human DC, and characterizes the effects of these polyphenols on DC immunometabolism for the first time. Curcumin 124-132 heme oxygenase 1 Homo sapiens 93-97 30143976-0 2018 Curcumin confers hepatoprotection against AFB1-induced toxicity via activating autophagy and ameliorating inflammation involving Nrf2/HO-1 signaling pathway. Curcumin 0-8 heme oxygenase 1 Homo sapiens 134-138 30143976-9 2018 Moreover, curcumin treatment significantly (p < 0.05) elevated AFB1-induced decrease in Nrf2 and HO-1 mRNA and protein expression level. Curcumin 10-18 heme oxygenase 1 Homo sapiens 100-104 29980703-3 2018 The plant-derived polyphenols, carnosol and curcumin, have been identified as candidate HO-1 inducers however there has been little investigation into their effects on human immune cells. Curcumin 44-52 heme oxygenase 1 Homo sapiens 88-92 30218018-6 2018 We validated genes belonging to these pathways, such as HSPA5, SEC61B, G6PD, HMOX1 and PDE3B to be cooperatively modulated by the OPCs-curcumin combination. Curcumin 135-143 heme oxygenase 1 Homo sapiens 77-82 27375190-0 2016 Curcumin attenuates quinocetone induced apoptosis and inflammation via the opposite modulation of Nrf2/HO-1 and NF-kB pathway in human hepatocyte L02 cells. Curcumin 0-8 heme oxygenase 1 Homo sapiens 103-107 29626606-6 2018 Moreover, curcumin markedly enhanced the translocation of Nrf2 from the cytoplasm to the nucleus, proved by the results of western blot and immunofluorescence, subsequently increased the expression of downstream factors such as heme oxygenase 1 (HO1) and NAD(P)H: quinone oxidoreductase 1 (NQO1) and prevented the decline of antioxidant enzyme activities. Curcumin 10-18 heme oxygenase 1 Homo sapiens 228-244 29626606-6 2018 Moreover, curcumin markedly enhanced the translocation of Nrf2 from the cytoplasm to the nucleus, proved by the results of western blot and immunofluorescence, subsequently increased the expression of downstream factors such as heme oxygenase 1 (HO1) and NAD(P)H: quinone oxidoreductase 1 (NQO1) and prevented the decline of antioxidant enzyme activities. Curcumin 10-18 heme oxygenase 1 Homo sapiens 246-249 29191105-3 2018 Curcumin dose-dependently inhibited TCDD-induced expression of phase I enzyme cytochrome P450 1A1 (CYP1A1) and phase II enzymes NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase 1 (HO-1) but not tert-butyl hydroquinone-induced NQO1 and HO-1, suggesting that curcumin inhibited only AhR pathway, but not Nrf2 one directly. Curcumin 0-8 heme oxygenase 1 Homo sapiens 172-188 29191105-3 2018 Curcumin dose-dependently inhibited TCDD-induced expression of phase I enzyme cytochrome P450 1A1 (CYP1A1) and phase II enzymes NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase 1 (HO-1) but not tert-butyl hydroquinone-induced NQO1 and HO-1, suggesting that curcumin inhibited only AhR pathway, but not Nrf2 one directly. Curcumin 0-8 heme oxygenase 1 Homo sapiens 190-194 29191105-3 2018 Curcumin dose-dependently inhibited TCDD-induced expression of phase I enzyme cytochrome P450 1A1 (CYP1A1) and phase II enzymes NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase 1 (HO-1) but not tert-butyl hydroquinone-induced NQO1 and HO-1, suggesting that curcumin inhibited only AhR pathway, but not Nrf2 one directly. Curcumin 0-8 heme oxygenase 1 Homo sapiens 245-249 29436680-0 2018 Curcumin increases cholesterol efflux via heme oxygenase-1-mediated ABCA1 and SR-BI expression in macrophages. Curcumin 0-8 heme oxygenase 1 Homo sapiens 42-58 29436680-9 2018 Additionally, curcumin significantly upregulated HO-1 expression. Curcumin 14-22 heme oxygenase 1 Homo sapiens 49-53 29436680-12 2018 HO-1 small interfering (si)RNA partly abolished the increased SR-BI and ABCA1 expression induced by curcumin. Curcumin 100-108 heme oxygenase 1 Homo sapiens 0-4 29436680-14 2018 Nrf2 siRNA successfully inhibited the curcumin-induced HO-1 expression. Curcumin 38-46 heme oxygenase 1 Homo sapiens 55-59 29436680-16 2018 Overall, these data indicated that curcumin activates the Nrf2-ARE signaling pathway and upregulates HO-1 expression, which mediates SR-BI and ABCA1 expression and thereby increases cholesterol efflux. Curcumin 35-43 heme oxygenase 1 Homo sapiens 101-105 29560114-9 2018 Intriguingly, we observed that treatment with anti-tumoral epigenetic drugs like LBH-589 (Panobinostat) and Curcumin induced the expression of linc-PINT and HMOX1 in ALL. Curcumin 108-116 heme oxygenase 1 Homo sapiens 157-162 27996348-7 2017 Moreover, compared with the control, FZD exposure activated the protein and mRNA expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1), which were further activated by curcumin treatment. Curcumin 214-222 heme oxygenase 1 Homo sapiens 157-173 27996348-7 2017 Moreover, compared with the control, FZD exposure activated the protein and mRNA expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1), which were further activated by curcumin treatment. Curcumin 214-222 heme oxygenase 1 Homo sapiens 175-179 27996348-8 2017 These results reveal that curcumin could prevent FZD induced cytotoxicity and S phase arrest, which may involve the activation of Nrf2/HO-1 pathway and the inhibition of p38 MAPK pathway and ER stress. Curcumin 26-34 heme oxygenase 1 Homo sapiens 135-139 28228072-8 2017 Dietary curcumin supplementation can also increase antioxidant activity through the induction of heme oxygenase-1, a scavenger of free radicals, and by reduction of reactive oxygen species and Nox-2. Curcumin 8-16 heme oxygenase 1 Homo sapiens 97-113 28412905-10 2017 The regulation of HO-1/CO expression has been achieved either by genetic overexpression of HO-1 cDNA or pharmacological induction with drugs including curcumin and resveratrol. Curcumin 151-159 heme oxygenase 1 Homo sapiens 18-25 28412905-10 2017 The regulation of HO-1/CO expression has been achieved either by genetic overexpression of HO-1 cDNA or pharmacological induction with drugs including curcumin and resveratrol. Curcumin 151-159 heme oxygenase 1 Homo sapiens 18-22 29751106-6 2018 Curcumin significantly induced HMOX1 in single cell type models and co-cultures. Curcumin 0-8 heme oxygenase 1 Homo sapiens 31-36 28618991-11 2018 In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1). Curcumin 40-48 heme oxygenase 1 Homo sapiens 239-255 28618991-11 2018 In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1). Curcumin 40-48 heme oxygenase 1 Homo sapiens 257-261 29158871-4 2017 Starting from curcumin and caffeic acid phenethyl ester (CAPE), two known HO-1 inducers, the molecules were chemically modified by acylation with 4-bromo-butanoyl chloride and 2-chloro-propanoyl chloride, respectively, and then treated in the dark with AgNO3 to obtain the nitrate derivatives VP10/12 and VP10/39. Curcumin 14-22 heme oxygenase 1 Homo sapiens 74-78 27375190-8 2016 These results indicate that curcumin could effectively inhibit QCT induced apoptosis and inflammatory response in L02 cells, which may involve the activation of Nrf2/HO-1 and inhibition of NF-kB pathway. Curcumin 28-36 heme oxygenase 1 Homo sapiens 166-170 27375190-6 2016 Meanwhile, curcumin pretreatment markedly down-regulated the expression of nuclear factor -kB (NF-kB) and iNOS mRNAs, but up-regulated the expressions of Nrf2 and HO-1 mRNAs, compared to the QCT alone group. Curcumin 11-19 heme oxygenase 1 Homo sapiens 163-167 27375190-7 2016 Zinc protoporphyrin IX, a HO-1 inhibitor, markedly partly abolished the cytoprotective effect of curcumin against QCT-induced caspase activation, NF-kB mRNA expression. Curcumin 97-105 heme oxygenase 1 Homo sapiens 26-30 26691217-9 2016 Induction of CUGBP2 expression by curcumin resulted in the downregulation of HO-1 and COX-2 and strongly sensitized tumor cells to GEM treatment. Curcumin 34-42 heme oxygenase 1 Homo sapiens 77-81 26071936-4 2015 We previously demonstrated that curcumin increased reactive oxygen species (ROS) formation and apoptosis in dermal fibroblasts, which could be prevented by pre-induction of the cytoprotective enzyme heme oxygenase (HO)-1. Curcumin 32-40 heme oxygenase 1 Homo sapiens 199-220 26456836-11 2015 Curcumin also inhibited superoxide anion-induced leukocyte recruitment in the peritoneal cavity and in the paw skin inhibited myeloperoxidase activity, oxidative stress, IL-1beta and TNF-alpha production and NF-kappaB activation as well as enhanced IL-10 production, and HO-1 and Nrf2 mRNA expression. Curcumin 0-8 heme oxygenase 1 Homo sapiens 271-275 25891083-13 2015 CONCLUSION: Curcumin inhibits appoptosin-induced apoptosis in SH-SY5Y cells by upregulating the expression of HO-1, reducing the production of intracellular heme and ROS, and preventing the DeltaPsim loss. Curcumin 12-20 heme oxygenase 1 Homo sapiens 110-114 25891083-0 2015 Curcumin inhibits appoptosin-induced apoptosis via upregulating heme oxygenase-1 expression in SH-SY5Y cells. Curcumin 0-8 heme oxygenase 1 Homo sapiens 64-80 24830678-7 2014 We compared curcumin with hemin, an agonist of heme oxygenase-1 (HO-1), which significantly affects only one KEGG pathway, porphyrin and chlorophyll metabolism (adjusted p = 1.5x10-5). Curcumin 12-20 heme oxygenase 1 Homo sapiens 47-63 25136316-7 2014 In addition, curcumin with its versatile activities modulated the expression of many oxidative stress-regulating genes such as PDGF, VEGF, IGFBP-2, HO1, SOD2, and GPX1. Curcumin 13-21 heme oxygenase 1 Homo sapiens 148-151 24830678-7 2014 We compared curcumin with hemin, an agonist of heme oxygenase-1 (HO-1), which significantly affects only one KEGG pathway, porphyrin and chlorophyll metabolism (adjusted p = 1.5x10-5). Curcumin 12-20 heme oxygenase 1 Homo sapiens 65-69 24830678-10 2014 Selective inhibition of HO-1 completely blocked the action of hemin but not that of curcumin, suggesting simultaneous multi-pathway intervention by curcumin. Curcumin 148-156 heme oxygenase 1 Homo sapiens 24-28 22922731-0 2012 Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. Curcumin 0-8 heme oxygenase 1 Homo sapiens 50-66 24101950-0 2013 Therapeutic roles of heme oxygenase-1 in metabolic diseases: curcumin and resveratrol analogues as possible inducers of heme oxygenase-1. Curcumin 61-69 heme oxygenase 1 Homo sapiens 120-136 24592391-0 2014 Human pharmacokinetics of high dose oral curcumin and its effect on heme oxygenase-1 expression in healthy male subjects. Curcumin 41-49 heme oxygenase 1 Homo sapiens 68-84 24592391-3 2014 We investigated the inducibility of HO-1 by orally administered curcumin in healthy male subjects and its correlation with the GT length polymorphism. Curcumin 64-72 heme oxygenase 1 Homo sapiens 36-40 23977989-0 2013 Curcumin ameliorates TNF-alpha-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells. Curcumin 0-8 heme oxygenase 1 Homo sapiens 112-128 23977989-3 2013 Curcumin induced expression of heme oxygenase-1 (HO-1) in the human keratinocyte cell line HaCaT. Curcumin 0-8 heme oxygenase 1 Homo sapiens 31-47 23977989-3 2013 Curcumin induced expression of heme oxygenase-1 (HO-1) in the human keratinocyte cell line HaCaT. Curcumin 0-8 heme oxygenase 1 Homo sapiens 49-53 23977989-5 2013 Curcumin suppressed TNF-alpha- induced ICAM-1 expression and subsequent monocyte adhesion, which were reversed by the addition of tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, or HO-1 knockdown using siRNA. Curcumin 0-8 heme oxygenase 1 Homo sapiens 184-188 23977989-5 2013 Curcumin suppressed TNF-alpha- induced ICAM-1 expression and subsequent monocyte adhesion, which were reversed by the addition of tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, or HO-1 knockdown using siRNA. Curcumin 0-8 heme oxygenase 1 Homo sapiens 193-197 23977989-7 2013 These results suggest that curcumin may exert its anti-inflammatory activity by suppressing the TNF-alpha-induced ICAM-1 expression and subsequent monocyte adhesion via expression of HO-1 in the keratinocytes. Curcumin 27-35 heme oxygenase 1 Homo sapiens 183-187 24191253-0 2013 Antidiabetic potential of the heme oxygenase-1 inducer curcumin analogues. Curcumin 55-63 heme oxygenase 1 Homo sapiens 30-46 22922731-5 2012 Under the same conditions, curcumin also dose-dependently induced heme oxygenase-1 with the highest induction at 24 h. Hemin, a heme oxygenase-1 inducer, also inhibited HCV protein expression in a dose-dependent manner. Curcumin 27-35 heme oxygenase 1 Homo sapiens 66-82 22922731-5 2012 Under the same conditions, curcumin also dose-dependently induced heme oxygenase-1 with the highest induction at 24 h. Hemin, a heme oxygenase-1 inducer, also inhibited HCV protein expression in a dose-dependent manner. Curcumin 27-35 heme oxygenase 1 Homo sapiens 128-144 22922731-6 2012 The knockdown of heme oxygenase-1 partially reversed the curcumin-inhibited HCV protein expression. Curcumin 57-65 heme oxygenase 1 Homo sapiens 17-33 22922731-7 2012 In addition to the heme oxygenase-1 induction, signaling molecule activities of AKT, extracellular signal-regulated kinases (ERK) and nuclear factor-kappaB (NF-kappaB) were inhibited by curcumin. Curcumin 186-194 heme oxygenase 1 Homo sapiens 19-35 22922731-10 2012 In summary, curcumin inhibited HCV replication by heme oxygenase-1 induction and AKT pathway inhibition. Curcumin 12-20 heme oxygenase 1 Homo sapiens 50-66 22539869-0 2012 Curcumin protects retinal pigment epithelial cells against oxidative stress via induction of heme oxygenase-1 expression and reduction of reactive oxygen. Curcumin 0-8 heme oxygenase 1 Homo sapiens 93-109 22392462-0 2012 Curcumin ameliorates hydrogen peroxide-induced epithelial barrier disruption by upregulating heme oxygenase-1 expression in human intestinal epithelial cells. Curcumin 0-8 heme oxygenase 1 Homo sapiens 93-109 22392462-2 2012 Heme oxygenase-1 (HO-1), which can be induced by curcumin (Cur), provides protection against various forms of oxidative stress. Curcumin 49-57 heme oxygenase 1 Homo sapiens 0-16 22392462-2 2012 Heme oxygenase-1 (HO-1), which can be induced by curcumin (Cur), provides protection against various forms of oxidative stress. Curcumin 49-57 heme oxygenase 1 Homo sapiens 18-22 25774181-2 2012 Graded concentration and time course experiments demonstrate that curcumin significantly upregulates phosphatidylinositol 3-kinase (PI3K), Akt, nuclear factor E2-related factor-2 (Nrf2), heme oxygenase 1 and ferritin expression, and that it significantly downregulates heme oxygenase 2, reactive oxygen species and amyloid-beta 40/42 expression. Curcumin 66-74 heme oxygenase 1 Homo sapiens 187-203 25774181-4 2012 The results indicate that the cytoprotection conferred by curcumin on APPswe transfected SH-SY5Y cells is mediated by its ability to regulate the balance between heme oxygenase 1 and 2 via the PI3K/Akt/Nrf2 intracellular signaling pathway. Curcumin 58-66 heme oxygenase 1 Homo sapiens 162-184 22539869-1 2012 PURPOSE: To determine whether curcumin induces expression of the defensive enzyme heme oxygenase-1 (HO-1) and protects cells against oxidative stress in cultured human retinal pigment epithelial cells. Curcumin 30-38 heme oxygenase 1 Homo sapiens 82-98 22539869-1 2012 PURPOSE: To determine whether curcumin induces expression of the defensive enzyme heme oxygenase-1 (HO-1) and protects cells against oxidative stress in cultured human retinal pigment epithelial cells. Curcumin 30-38 heme oxygenase 1 Homo sapiens 100-104 22539869-5 2012 To confirm the protective role of HO-1 in oxidative stress, small interfering RNA (siRNA) against HO-1 or inhibitor of HO-1 was treated with curcumin in retinal pigment epithelium cells. Curcumin 141-149 heme oxygenase 1 Homo sapiens 98-123 22539869-10 2012 Curcumin"s effect on the reduction of ROS was mediated by the increase in HO-1 expression. Curcumin 0-8 heme oxygenase 1 Homo sapiens 74-78 22539869-11 2012 CONCLUSIONS: Curcumin upregulated the oxidative stress defense enzyme HO-1 and may protect human retinal pigment epithelial cells against oxidative stress by reducing ROS levels. Curcumin 13-21 heme oxygenase 1 Homo sapiens 70-74 21499987-3 2011 Data from our and other laboratories have previously demonstrated that curcumin, the yellow pigment of curry, strongly induces heme-oxygenase-1 (HO-1) expression and activity in different brain cells via the activation of heterodimers of NF-E2-related factors 2 (Nrf2)/antioxidant responsive element (ARE) pathway. Curcumin 71-79 heme oxygenase 1 Homo sapiens 127-143 21380847-6 2011 Furthermore, our results show that the hormetic effects of low levels of curcumin are achieved by virtue of it being a hormetin in terms of the induction of stress response pathways, including Nrf2 and HO-1 in human cells. Curcumin 73-81 heme oxygenase 1 Homo sapiens 202-206 21499987-3 2011 Data from our and other laboratories have previously demonstrated that curcumin, the yellow pigment of curry, strongly induces heme-oxygenase-1 (HO-1) expression and activity in different brain cells via the activation of heterodimers of NF-E2-related factors 2 (Nrf2)/antioxidant responsive element (ARE) pathway. Curcumin 71-79 heme oxygenase 1 Homo sapiens 145-149 20938987-0 2011 Curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: relevance for anti-aging intervention. Curcumin 0-8 heme oxygenase 1 Homo sapiens 17-33 20938987-2 2011 METHODS AND RESULTS: Early passage young human skin fibroblasts treated with low doses of curcumin (below 20 muM) showed a time- and concentration-dependent induction of heme oxygenase-1 (HO-1), followed by compensatory increase in glutathione-S-transferase activity, GSH levels and GSH/GSSG ratio. Curcumin 90-98 heme oxygenase 1 Homo sapiens 170-186 20938987-2 2011 METHODS AND RESULTS: Early passage young human skin fibroblasts treated with low doses of curcumin (below 20 muM) showed a time- and concentration-dependent induction of heme oxygenase-1 (HO-1), followed by compensatory increase in glutathione-S-transferase activity, GSH levels and GSH/GSSG ratio. Curcumin 90-98 heme oxygenase 1 Homo sapiens 188-192 20938987-5 2011 The use of the antioxidant N-acetyl cysteine prevented the induction of HO-1 by curcumin. Curcumin 80-88 heme oxygenase 1 Homo sapiens 72-76 20938987-6 2011 Pharmacological inhibition of phosphatidylinositol 3-kinase, but not other kinases, significantly prevented curcumin-induced HO-1 levels, which was corroborated by the induction of phospho-Akt levels by curcumin. Curcumin 108-116 heme oxygenase 1 Homo sapiens 125-129 20938987-7 2011 Late passage senescent cells already had higher HO-1 levels, and further induction of HO-1 by curcumin was considerably impaired. Curcumin 94-102 heme oxygenase 1 Homo sapiens 86-90 20430097-1 2010 We have identified a novel anti-inflammatory signaling pathway that leads to the expression of heme oxygenase-1 (HO-1) in response to bisdemethoxycurcumin (BDMC), an analog of curcumin. Curcumin 146-154 heme oxygenase 1 Homo sapiens 95-111 20430097-1 2010 We have identified a novel anti-inflammatory signaling pathway that leads to the expression of heme oxygenase-1 (HO-1) in response to bisdemethoxycurcumin (BDMC), an analog of curcumin. Curcumin 146-154 heme oxygenase 1 Homo sapiens 113-117 19344704-4 2009 Whereas the expression of glutathione peroxidase (GPx), catalase, Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and heme oxygenase-1 (HO-1) increased with curcumin concentration and also with increase in time of incubation, the expression of Mn- superoxide dismutase (Mn-SOD) showed concentration dependant repression upon treatment with curcumin. Curcumin 148-156 heme oxygenase 1 Homo sapiens 109-125 19344704-4 2009 Whereas the expression of glutathione peroxidase (GPx), catalase, Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and heme oxygenase-1 (HO-1) increased with curcumin concentration and also with increase in time of incubation, the expression of Mn- superoxide dismutase (Mn-SOD) showed concentration dependant repression upon treatment with curcumin. Curcumin 148-156 heme oxygenase 1 Homo sapiens 127-131 18357586-0 2008 Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes. Curcumin 58-66 heme oxygenase 1 Homo sapiens 0-16 19177192-0 2009 Dimethoxycurcumin, a Synthetic Curcumin Analogue, Induces Heme Oxygenase-1 Expression through Nrf2 Activation in RAW264.7 Macrophages. Curcumin 31-39 heme oxygenase 1 Homo sapiens 58-74 19177192-2 2009 The aim of this study was to investigate whether dimethoxycurcumin [1,7-bis(4,3-dimethoxyphenyl)-1,6-heptadiene-3,5-dione], a synthetic curcumin analogue with higher metabolic stability over curcumin, could induce HO-1 expression to the same extent as curcumin in RAW264.7 macrophages. Curcumin 58-66 heme oxygenase 1 Homo sapiens 214-218 19177192-3 2009 Dimethoxycurcumin and curcumin, but not tetrahydrocurcumin, induced HO-1 expression and Nrf2 nuclear translocation, suggesting that the unsaturated nature of the diarylheptanoid chain of the compounds are crucial for HO-1 expression and Nrf2 activation. Curcumin 9-17 heme oxygenase 1 Homo sapiens 68-72 19177192-3 2009 Dimethoxycurcumin and curcumin, but not tetrahydrocurcumin, induced HO-1 expression and Nrf2 nuclear translocation, suggesting that the unsaturated nature of the diarylheptanoid chain of the compounds are crucial for HO-1 expression and Nrf2 activation. Curcumin 9-17 heme oxygenase 1 Homo sapiens 217-221 19177192-5 2009 In comparison, dimethoxycurcumin and curcumin had about the same effect on HO-1 expression, suggesting that dimethoxycurcumin retains the HO-1-inducing activity of its parent compound curcumin in RAW264.7 macrophages. Curcumin 24-32 heme oxygenase 1 Homo sapiens 75-79 19177192-5 2009 In comparison, dimethoxycurcumin and curcumin had about the same effect on HO-1 expression, suggesting that dimethoxycurcumin retains the HO-1-inducing activity of its parent compound curcumin in RAW264.7 macrophages. Curcumin 37-45 heme oxygenase 1 Homo sapiens 75-79 18357586-4 2008 Further, Curcumin inhibited LPS-induced IL-1 and IL-6 secretion and blockage of HO-1 expression/activity by HO-1 siRNA or HO-1 inhibitor, SnPP reversed the inhibitory effects of Curcumin on cytokines secretion. Curcumin 178-186 heme oxygenase 1 Homo sapiens 80-84 18357586-4 2008 Further, Curcumin inhibited LPS-induced IL-1 and IL-6 secretion and blockage of HO-1 expression/activity by HO-1 siRNA or HO-1 inhibitor, SnPP reversed the inhibitory effects of Curcumin on cytokines secretion. Curcumin 178-186 heme oxygenase 1 Homo sapiens 108-112 18357586-4 2008 Further, Curcumin inhibited LPS-induced IL-1 and IL-6 secretion and blockage of HO-1 expression/activity by HO-1 siRNA or HO-1 inhibitor, SnPP reversed the inhibitory effects of Curcumin on cytokines secretion. Curcumin 178-186 heme oxygenase 1 Homo sapiens 108-112 18357586-5 2008 HO-1 over-expression produced the same inhibitory effects of Curcumin on IL-1 secretion. Curcumin 61-69 heme oxygenase 1 Homo sapiens 0-4 18357586-6 2008 Collectively, our results suggest that Curcumin inhibits cytokines secretion within LPS-stimulated monocytes through a mechanism that involves the action of HO-1. Curcumin 39-47 heme oxygenase 1 Homo sapiens 157-161 18357586-1 2008 Curcumin, a polyphenolic compound derived from plant, regulates heme oxygenase (HO-1) expression within certain cell types; however, the Curcumin-mediated signal transduction in the regulation of HO-1 expression within human monocytes/macrophages is unclear. Curcumin 0-8 heme oxygenase 1 Homo sapiens 80-84 18357586-1 2008 Curcumin, a polyphenolic compound derived from plant, regulates heme oxygenase (HO-1) expression within certain cell types; however, the Curcumin-mediated signal transduction in the regulation of HO-1 expression within human monocytes/macrophages is unclear. Curcumin 0-8 heme oxygenase 1 Homo sapiens 196-200 18357586-1 2008 Curcumin, a polyphenolic compound derived from plant, regulates heme oxygenase (HO-1) expression within certain cell types; however, the Curcumin-mediated signal transduction in the regulation of HO-1 expression within human monocytes/macrophages is unclear. Curcumin 137-145 heme oxygenase 1 Homo sapiens 80-84 18357586-1 2008 Curcumin, a polyphenolic compound derived from plant, regulates heme oxygenase (HO-1) expression within certain cell types; however, the Curcumin-mediated signal transduction in the regulation of HO-1 expression within human monocytes/macrophages is unclear. Curcumin 137-145 heme oxygenase 1 Homo sapiens 196-200 18357586-2 2008 Herein, we show that Curcumin dose dependently induced HO-1 expression and HO-1 activity through the activation of PKCalpha, PKCdelta/ERK1/2, p38alpha, and PI3-kinase. Curcumin 21-29 heme oxygenase 1 Homo sapiens 55-59 18357586-2 2008 Herein, we show that Curcumin dose dependently induced HO-1 expression and HO-1 activity through the activation of PKCalpha, PKCdelta/ERK1/2, p38alpha, and PI3-kinase. Curcumin 21-29 heme oxygenase 1 Homo sapiens 75-79 18357586-3 2008 In addition, H2O2 release is essential for Curcumin-mediated ERK1/2 and p38 phosphorylation and HO-1 expression. Curcumin 43-51 heme oxygenase 1 Homo sapiens 96-100 17603281-7 2007 In human aortic smooth muscle cells (HASMCs), curcumin also inhibited growth triggered by TNF-alpha and increased p21(WAF1/CIP1) expression via HO-1-dependent manner. Curcumin 46-54 heme oxygenase 1 Homo sapiens 144-148 16495813-5 2006 Pretreatment with curcumin protected hepatocytes in a model of oxidative injury and this protection was mediated through HO-1. Curcumin 18-26 heme oxygenase 1 Homo sapiens 121-125 17464175-1 2007 Curcumin is a polyphenolic compound possessing interesting anti-inflammatory and antioxidant properties and has the ability to induce the defensive protein heme oxygenase-1 (HO-1). Curcumin 0-8 heme oxygenase 1 Homo sapiens 156-172 17464175-1 2007 Curcumin is a polyphenolic compound possessing interesting anti-inflammatory and antioxidant properties and has the ability to induce the defensive protein heme oxygenase-1 (HO-1). Curcumin 0-8 heme oxygenase 1 Homo sapiens 174-178 17464175-5 2007 In additional experiments, an inhibitor of heme oxygenase activity (tin protoporphyrin IX, 10 microM) or siRNA for HO-1 were used to investigate the participation of HO-1 as a mediator of curcumin-induced effects. Curcumin 188-196 heme oxygenase 1 Homo sapiens 166-170 17464175-6 2007 Treatment with curcumin produced a marked induction of cardiac HO-1 in normothermic condition but cells were less responsive to the polyphenolic compound at low temperature. Curcumin 15-23 heme oxygenase 1 Homo sapiens 63-67 17464175-8 2007 Thus, curcumin added to Celsior preservation solution effectively prevents the damage caused by cold-storage; this effect involves the protective enzyme HO-1 but also other not yet identified mechanisms. Curcumin 6-14 heme oxygenase 1 Homo sapiens 153-157 16460683-4 2006 Curcumin increased HO-1 and glutamyl cysteine ligase modulator (GCLM) expression and stimulated Nrf2 binding to the ARE. Curcumin 0-8 heme oxygenase 1 Homo sapiens 19-23 16460683-5 2006 Curcumin also rapidly stimulated PKC phosphorylation and Ro-31-8220, a pan-PKC inhibitor, decreased curcumin-induced GCLM and HO-1 mRNA expression and ARE binding. Curcumin 0-8 heme oxygenase 1 Homo sapiens 126-130 16460683-5 2006 Curcumin also rapidly stimulated PKC phosphorylation and Ro-31-8220, a pan-PKC inhibitor, decreased curcumin-induced GCLM and HO-1 mRNA expression and ARE binding. Curcumin 100-108 heme oxygenase 1 Homo sapiens 126-130 16460683-6 2006 Rottlerin (a PKC delta inhibitor) and PKC delta antisense oligonucleotides significantly inhibited curcumin-induced GCLM and HO-1 mRNA expression and ARE binding. Curcumin 99-107 heme oxygenase 1 Homo sapiens 125-129 17569214-1 2007 Curcumin possesses anti-inflammatory activity and is a potent inhibitor of reactive-oxygen-generating enzymes such as lipoxygenase/cyclooxygenase, xanthine dehydrogenase/oxidase, and inducible nitric oxide synthase (iNOS); it is an effective inducer of heme oxygenase-1. Curcumin 0-8 heme oxygenase 1 Homo sapiens 253-269 17143561-0 2007 Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition. Curcumin 0-8 heme oxygenase 1 Homo sapiens 17-33 17143561-1 2007 Curcumin is a naturally occurring compound which is known to induce heme oxygenase 1 (HO-1), although the underlying mechanism has not been fully elucidated. Curcumin 0-8 heme oxygenase 1 Homo sapiens 68-84 17143561-1 2007 Curcumin is a naturally occurring compound which is known to induce heme oxygenase 1 (HO-1), although the underlying mechanism has not been fully elucidated. Curcumin 0-8 heme oxygenase 1 Homo sapiens 86-90 17143561-2 2007 This study investigates in detail the mechanism of HO-1 induction by curcumin in human hepatoma cells. Curcumin 69-77 heme oxygenase 1 Homo sapiens 51-55 17143561-4 2007 Curcumin was found to induce HO-1 at doses of 10 to 25 microM. Curcumin 0-8 heme oxygenase 1 Homo sapiens 29-33 17143561-6 2007 This was reinforced by the finding that pretreatment with the antioxidants N-acetylcysteine, vitamin E and catalase prevented HO-1 induction by curcumin. Curcumin 144-152 heme oxygenase 1 Homo sapiens 126-130 17143561-10 2007 A panel of kinase inhibitors was used to examine the contribution of MAP kinases to the induction of HO-1 by curcumin. Curcumin 109-117 heme oxygenase 1 Homo sapiens 101-105 17143561-13 2007 In conclusion, curcumin treatment results in ROS generation, activation of Nrf2 and MAP kinases and the inhibition of phosphatase activity in hepatocytes, and when curcumin is not administered in toxic doses, these multiple pathways converge to induce HO-1. Curcumin 15-23 heme oxygenase 1 Homo sapiens 252-256 16953118-1 2006 Recently, it has been reported that curcumin, which is known as a potent antioxidant, acts as a non- stressful and non-cytotoxic inducer of the cytoprotective heme oxygenase (HO)-1. Curcumin 36-44 heme oxygenase 1 Homo sapiens 159-180 16495813-4 2006 This study investigates in detail the effect of curcumin on the stress-response in human hepatocytes, in particular its effect on heme oxygenase 1 (HO-1) and its cytoprotective effect. Curcumin 48-56 heme oxygenase 1 Homo sapiens 130-146 16495813-4 2006 This study investigates in detail the effect of curcumin on the stress-response in human hepatocytes, in particular its effect on heme oxygenase 1 (HO-1) and its cytoprotective effect. Curcumin 48-56 heme oxygenase 1 Homo sapiens 148-152 16495813-6 2006 In a model of cold preservation injury, curcumin pretreatment resulted in elevation of HO-1 throughout the cold storage and rewarming period, and was cytoprotective against oxidative injury. Curcumin 40-48 heme oxygenase 1 Homo sapiens 87-91 16495813-7 2006 This is the first study to demonstrate that curcumin induces HO-1 in human hepatocytes, and that the protective effects of curcumin pretreatment may have clinical potential in hepatic transplantation. Curcumin 44-52 heme oxygenase 1 Homo sapiens 61-65 12927811-0 2003 Changes in temperature modulate heme oxygenase-1 induction by curcumin in renal epithelial cells. Curcumin 62-70 heme oxygenase 1 Homo sapiens 32-48 15356994-3 2004 Curcumin possesses anti-inflammatory activity and is a potent inhibitor of reactive oxygen-generating enzymes such as lipoxygenase/cyclooxygenase, xanthine dehydrogenase/oxidase and inducible nitric oxide synthase; and an effective inducer of heme oxygenase-1. Curcumin 0-8 heme oxygenase 1 Homo sapiens 243-259 12570874-0 2003 Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Curcumin 0-8 heme oxygenase 1 Homo sapiens 23-39 12570874-4 2003 Recently, the natural antioxidants curcumin and caffeic acid phenethyl ester (CAPE) have been identified as potent inducers of haem oxygenase-1 (HO-1), a redox-sensitive inducible protein that provides protection against various forms of stress. Curcumin 35-43 heme oxygenase 1 Homo sapiens 127-143 12570874-4 2003 Recently, the natural antioxidants curcumin and caffeic acid phenethyl ester (CAPE) have been identified as potent inducers of haem oxygenase-1 (HO-1), a redox-sensitive inducible protein that provides protection against various forms of stress. Curcumin 35-43 heme oxygenase 1 Homo sapiens 145-149 12570874-7 2003 From several lines of investigation we also report that curcumin (and, by inference, CAPE) stimulates ho-1 gene activity by promoting inactivation of the Nrf2-Keap1 complex, leading to increased Nrf2 binding to the resident ho-1 AREs. Curcumin 56-64 heme oxygenase 1 Homo sapiens 102-106 12570874-7 2003 From several lines of investigation we also report that curcumin (and, by inference, CAPE) stimulates ho-1 gene activity by promoting inactivation of the Nrf2-Keap1 complex, leading to increased Nrf2 binding to the resident ho-1 AREs. Curcumin 56-64 heme oxygenase 1 Homo sapiens 224-228 12570874-8 2003 Moreover, using antibodies and specific inhibitors of the mitogen-activated protein kinase (MAPK) pathways, we provide data implicating p38 MAPK in curcumin-mediated ho-1 induction. Curcumin 148-156 heme oxygenase 1 Homo sapiens 166-170 12570874-9 2003 Taken together, these results demonstrate that induction of HO-1 by curcumin and CAPE requires the activation of the Nrf2/ARE pathway. Curcumin 68-76 heme oxygenase 1 Homo sapiens 60-64