PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18460899-6 2008 We also found that levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and inducible nitric oxide synthase (iNOS) in the mdx mice were decreased by curcumin administration. Curcumin 177-185 interleukin 1 beta Mus musculus 70-88 21349269-9 2011 On the other hand, curcumin, either alone or combined with bone marrow transplantation, blunted the pancreatic lipid-peroxidation, up-regulated activities of the antioxidant enzymes, and suppressed serum levels of TNF-alpha and IL-1beta. Curcumin 19-27 interleukin 1 beta Mus musculus 228-236 20950131-9 2011 Protein concentration of IL-1beta, IL-6 (section 3), and CCL2 was increased (P < 0.05) and curcumin reduced this response for IL-1beta (section 2) and CCL2 (P < 0.05). Curcumin 94-102 interleukin 1 beta Mus musculus 129-137 20132469-4 2010 The protective effect of curcumin was associated with a significant attenuation in the acute pericontusional expression of interleukin-1beta, a pro-inflammatory cytokine, after injury. Curcumin 25-33 interleukin 1 beta Mus musculus 123-140 20132469-6 2010 Notably, curcumin blocked IL-1beta-induced aquaporin-4 expression in cultured astrocytes, an effect mediated, at least in part, by reduced activation of the p50 and p65 subunits of nuclear factor kappaB. Curcumin 9-17 interleukin 1 beta Mus musculus 26-34 20188213-8 2010 The results showed that compared with untreated CIA mice, curcumin-treated mice downregulated clinical arthritis score, the proliferation of splenic T cells, expression levels of TNF-alpha and IL-1beta in the ankle joint, and expression levels of IgG2a in serum. Curcumin 58-66 interleukin 1 beta Mus musculus 193-201 19121625-3 2009 The incubation of RAW264.7 cells with curcumin dose-dependently inhibited the stimulatory responses of macrophage triggered by lipopolysaccharide; the enhanced secretion of inflammatory cytokines such as TNF-alpha and IL-1beta and the up-regulated expression of surface antigens like CD14 and CD40. Curcumin 38-46 interleukin 1 beta Mus musculus 218-226 18417733-4 2008 In both the acute (LPS) and chronic inflammation (Tg2576), TC and curcumin similarly reduced interleukin-1beta. Curcumin 66-74 interleukin 1 beta Mus musculus 93-110 18460899-6 2008 We also found that levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and inducible nitric oxide synthase (iNOS) in the mdx mice were decreased by curcumin administration. Curcumin 177-185 interleukin 1 beta Mus musculus 90-98 14728887-12 2003 Yet curcumin could significantly decrease collagen type IV and III in the supernatant of cultured mesangial cells induced by LPS (20.5 +/- 1.00, P < 0.05 and 20.5 +/- 4.12 ng/ml, P < 0.05) and down-regulated the mRNA expression of IL-1 beta and MCP-1 in mesangial cells induced by LPS (P < 0.01). Curcumin 4-12 interleukin 1 beta Mus musculus 237-246 18849645-9 2008 RESULTS: Curcumin dose-dependently inhibited TNF-alpha and IL-1beta gene expression and protein synthesis in RAW264.7 cells stimulated with P. gingivalis LPS. Curcumin 9-17 interleukin 1 beta Mus musculus 59-67 16779518-7 2006 Curcumin-treated mice also exhibited relative decreases in aortic tissue activator protein-1 and nuclear factor kappaB DNA binding activities and significantly lower aortic tissue concentrations of interleukin-1beta (IL-1beta), IL-6, monocyte chemoattractant protein-1, and matrix metalloproteinase-9 (all p < 0.05). Curcumin 0-8 interleukin 1 beta Mus musculus 198-215 16779518-7 2006 Curcumin-treated mice also exhibited relative decreases in aortic tissue activator protein-1 and nuclear factor kappaB DNA binding activities and significantly lower aortic tissue concentrations of interleukin-1beta (IL-1beta), IL-6, monocyte chemoattractant protein-1, and matrix metalloproteinase-9 (all p < 0.05). Curcumin 0-8 interleukin 1 beta Mus musculus 217-225 15604057-7 2004 CONCLUSIONS: Curcumin could modulate the expressions of IL-1beta and IL-10 mRNA in murine model of IBD, which suggests the potential of curcumin as a targeted therapeutic agent for IBD. Curcumin 13-21 interleukin 1 beta Mus musculus 56-64 15604057-7 2004 CONCLUSIONS: Curcumin could modulate the expressions of IL-1beta and IL-10 mRNA in murine model of IBD, which suggests the potential of curcumin as a targeted therapeutic agent for IBD. Curcumin 136-144 interleukin 1 beta Mus musculus 56-64 28669709-0 2017 A mechanistic insight into curcumin modulation of the IL-1beta secretion and NLRP3 S-glutathionylation induced by needle-like cationic cellulose nanocrystals in myeloid cells. Curcumin 27-35 interleukin 1 beta Mus musculus 54-62 31856816-7 2019 However, this effect was lower than 4 mug/mL of curcumin, which inhibited NO, IL-1beta and TNF-alpha production by 89.50 +- 5.00%, 78.80 +- 6.20% and 87.30 +- 4.00%, respectively. Curcumin 48-56 interleukin 1 beta Mus musculus 78-86 31762728-13 2019 Curcumin also attenuated inflammation by inhibiting the IkappaBalpha-NF-kappaB pathway, which reduced the production of TNF, IL-1beta, and IL-6. Curcumin 0-8 interleukin 1 beta Mus musculus 125-133 30599909-7 2019 RESULTS: Our results showed that Curcumin markedly reduced the mRNA expression and secretion of IL-1beta, IL-6, TNFalpha and MCP-1 in LPS stimulated RAW264.7 cell and the supernatant. Curcumin 33-41 interleukin 1 beta Mus musculus 96-104 29549176-0 2018 Curcumin Suppresses IL-1beta Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome. Curcumin 0-8 interleukin 1 beta Mus musculus 20-28 29549176-4 2018 We report that curcumin inhibited caspase-1 activation and IL-1beta secretion through suppressing LPS priming and the inflammasome activation pathway in mouse bone marrow-derived macrophages. Curcumin 15-23 interleukin 1 beta Mus musculus 59-67 29549176-8 2018 Importantly, in vivo data show that curcumin attenuated IL-1beta secretion and prevented high-fat diet-induced insulin resistance in wide-type C57BL/6 mice but not in Nlrp3-deficient mice. Curcumin 36-44 interleukin 1 beta Mus musculus 56-64 29445415-0 2018 Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1beta. Curcumin 0-8 interleukin 1 beta Mus musculus 101-118 29224353-4 2018 Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels. Curcumin 0-8 interleukin 1 beta Mus musculus 29-46 29224353-4 2018 Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels. Curcumin 0-8 interleukin 1 beta Mus musculus 48-56 29224353-4 2018 Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels. Curcumin 0-8 interleukin 1 beta Mus musculus 257-265 11606625-7 2001 Low and high doses of curcumin significantly lowered oxidized proteins and interleukin-1beta, a proinflammatory cytokine elevated in the brains of these mice. Curcumin 22-30 interleukin 1 beta Mus musculus 75-92 31788011-12 2019 In addition, the mRNA expression of hepatic tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) as well as the plasma levels of TNF-alpha and IL-1beta were also lowered by curcumin treatment. Curcumin 194-202 interleukin 1 beta Mus musculus 89-106 31788011-12 2019 In addition, the mRNA expression of hepatic tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) as well as the plasma levels of TNF-alpha and IL-1beta were also lowered by curcumin treatment. Curcumin 194-202 interleukin 1 beta Mus musculus 164-172 31455356-7 2019 RESULTS: Curcumin treatment markedly inhibited the degradation of IkappaBalpha, the activation of NF-kappaB signaling pathway, and the expression levels of the NF-kappaB downstream inflammatory genes such as IL-1beta, IL-6, TNF-alpha, COX-2, and PGE2 in the MSU-stimulated THP-1-derived macrophages. Curcumin 9-17 interleukin 1 beta Mus musculus 208-216 30599892-9 2019 The mRNA expression levels of M1 macrophage-related inflammatory factors IL-6, iNOS and IL-1beta were markedly elevated in the spleens of asthmatic mice, but significantly decreased after the 8-week treatment with curcumin. Curcumin 214-222 interleukin 1 beta Mus musculus 88-96 30396035-0 2018 Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1beta production. Curcumin 0-8 interleukin 1 beta Mus musculus 88-96 30396035-3 2018 OBJECTIVE: The present study was to investigate the protective effects of curcumin on dextran sulfate sodium (DSS)-induced colitis through inhibiting NLRP3 inflammasome activation and IL-1beta production. Curcumin 74-82 interleukin 1 beta Mus musculus 184-192 30396035-4 2018 METHODS: LPS-primed macrophages were treated with curcumin prior to DSS triggering NLRP3 inflammasome activation, IL-1beta secretion and ASC oligomerization were observed. Curcumin 50-58 interleukin 1 beta Mus musculus 114-122 30396035-9 2018 RESULTS: NLRP3 inflammasome activation was dramatically inhibited by curcumin in DSS-stimulated macrophages, as evidenced by decreased IL-1beta secretion, less caspase-1 activation and ASC specks. Curcumin 69-77 interleukin 1 beta Mus musculus 135-143 30396035-12 2018 Meanwhile, curcumin significantly decreased the expression of multiple inflammatory cytokines (including mature IL-1beta, IL-6, MCP-1), MPO activity, caspase-1 activity as well as histopathological damage. Curcumin 11-19 interleukin 1 beta Mus musculus 112-120 29802156-13 2018 In vitro, curcumin treatment improved IL-1beta induced autophagy inhibition, cell viability decrease, and apoptosis. Curcumin 10-18 interleukin 1 beta Mus musculus 38-46 28941865-10 2017 RESULTS: The experiment showed that curcumin markedly inhibited SCI-induced production of inflammatory mediators, including TNF-alpha, IL-1beta, IL-6 (ELISA assay) and nitrite oxide (Griess method) in a concentration-dependent manner. Curcumin 36-44 interleukin 1 beta Mus musculus 135-143 28669709-2 2017 In this study we demonstrated that curcumin, a naturally occurring polyphenolic compound isolated from Curcuma longa (Zingiberaceae), was able to suppress, at least in part, this immunological response, as observed by diminished IL-1beta secretion in CNC-AEMA2-stimulated macrophages primed with LPS. Curcumin 35-43 interleukin 1 beta Mus musculus 229-237 28669709-5 2017 We hypothesize that curcumin may also affect S-glutathionylation of key proteins involved in the NLRP3 inflammasome/IL-1beta pathway, and therefore impact their protein-protein interactions. Curcumin 20-28 interleukin 1 beta Mus musculus 116-124 28669709-8 2017 Taking together, our results suggest that, at least in part, the anti-inflammatory activity of curcumin is associated with changes in S-glutathionylation of key NLRP3 inflammasome components, and perhaps resulting in sustained complex assembly and suppression of IL-1beta secretion. Curcumin 95-103 interleukin 1 beta Mus musculus 263-271 28595079-6 2017 Furthermore, curcumin markedly decreased NAD(P)H oxidase subunits (p67phox, p47phox, p22phox), nitrotyrosine and CYP2E1 renal protein expression as well as reduced pro-inflammatory cytokine expression (TNFalpha, IL-1beta, IFNgamma). Curcumin 13-21 interleukin 1 beta Mus musculus 212-220 28194406-7 2017 Additionally, curcumin treatment was associated with significant reductions in mature interleukin-1beta, cleaved caspase-1, and NLRP3 protein levels in the renal cortices of db/db mice as well as in HK-2 cells exposed to high glucose concentration. Curcumin 14-22 interleukin 1 beta Mus musculus 86-103 28110063-6 2017 In addition, curcumin treatment markedly reduced the hepatic protein expression of oxidative stress, pro-inflammatory cytokines, and chemokines including interferon (IFN) gamma, interleukin-1beta and IFNgamma-inducible protein 10, in NASH mice. Curcumin 13-21 interleukin 1 beta Mus musculus 178-195 27817102-8 2017 Moreover, increased placental TNF-alpha, IL-1beta, and IL-6 expressions in LPS-treated group were significantly suppressed after curcumin administration. Curcumin 129-137 interleukin 1 beta Mus musculus 41-49 27446282-9 2016 In the present study, curcumin demonstrated marked suppression of the LPS-induced expression of MyD88, NF-kappaB, caspase-3, inducible nitric oxide synthase, tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 in the microglia. Curcumin 22-30 interleukin 1 beta Mus musculus 187-209 26250869-7 2015 Furthermore, administration of curcumin significantly reduced peritoneal IL-1beta and HMGB-1 concentration induced by LPS and improved the survival of mice suffering from lethal endotoxic shock. Curcumin 31-39 interleukin 1 beta Mus musculus 73-81 27260322-9 2016 RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta. Curcumin 14-22 interleukin 1 beta Mus musculus 121-129 27260322-9 2016 RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta. Curcumin 14-22 interleukin 1 beta Mus musculus 324-332 27260322-9 2016 RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta. Curcumin 55-63 interleukin 1 beta Mus musculus 121-129 27260322-9 2016 RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta. Curcumin 55-63 interleukin 1 beta Mus musculus 324-332 26796031-1 2016 BACKGROUND: The aim of this study was to evaluate the effects of photodynamic therapy with curcumin (PDT) comparatively to 5% sodium hypochlorite (NaOCl) and saline solution on cell viability and cytokine (IL-1beta and IL-6) production by mouse fibroblasts. Curcumin 91-99 interleukin 1 beta Mus musculus 206-214 26507910-6 2015 In addition, curcumin suppressed the production of inflammatory cytokines, such as TNF-alpha, IL-1beta, IL-6 and IL-8. Curcumin 13-21 interleukin 1 beta Mus musculus 94-102 26250869-3 2015 Here, we sought to investigate the role and mechanism of curcumin on the inhibition of mature IL-1beta production via the regulation of NLRP3 inflammasome. Curcumin 57-65 interleukin 1 beta Mus musculus 94-102 26250869-4 2015 METHODS AND RESULTS: Curcumin dramatically inhibited the production of mature IL-1beta in LPS-primed macrophages triggered by multiple NLRP3 inflammasome activators, and also reduced the level of cleaved caspase-1 as measured by western blot and ELISA. Curcumin 21-29 interleukin 1 beta Mus musculus 78-86 23825622-0 2013 Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice. Curcumin 0-8 interleukin 1 beta Mus musculus 78-86 25739561-17 2015 Curcumin blocked lipopolysaccharide-upregulated expression of tumour necrosis factor-alpha, IL-1beta, and IL-6. Curcumin 0-8 interleukin 1 beta Mus musculus 92-100 25131506-8 2014 Moreover, pre-treatment with curcumin attenuated LPS-induced microglial activation and overproduction of pro-inflammatory cytokine (interleukin-1beta and tumor necrosis factor-alpha), as well as the levels of inducible nitric oxide synthase and cyclooxygenase-2 mRNA in the hippocampus and prefrontal cortex (PFC). Curcumin 29-37 interleukin 1 beta Mus musculus 132-181 24508537-6 2014 The results showed that curcumin attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), and the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in a dose-dependent manner. Curcumin 24-32 interleukin 1 beta Mus musculus 211-228 24508537-6 2014 The results showed that curcumin attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), and the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in a dose-dependent manner. Curcumin 24-32 interleukin 1 beta Mus musculus 230-238 25998196-16 2015 Moreover, nuclear factor-kappaB activation, concentrations of the inflammatory cytokines tumour necrosis factor-alpha and interleukin-1beta and oxidative stress were increased in the skeletal muscle from DM mice and inhibited in DM+Curcumin mice. Curcumin 232-240 interleukin 1 beta Mus musculus 122-139 25890744-0 2015 Anti-inflammatory activity of curcumin-loaded solid lipid nanoparticles in IL-1beta transgenic mice subjected to the lipopolysaccharide-induced sepsis. Curcumin 30-38 interleukin 1 beta Mus musculus 75-83 24645646-11 2014 We also found that EMF exposure significantly increased the secretion of pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-1beta) and the production of NO; however, these increases were efficiently chilled by the addition of curcumin to the culture medium. Curcumin 226-234 interleukin 1 beta Mus musculus 121-129 24316441-4 2014 Curcumin treatment greatly reduced the astrogliosis in SCI mice and significantly decreased the expression of IL-1beta and NO, as well as the number of Iba1(+) inflammatory cells at the lesion site. Curcumin 0-8 interleukin 1 beta Mus musculus 110-118 23888334-3 2013 A2 also showed a stronger inhibitory effect than curcumin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in NF-kappaB activation and IL-1beta expression as well as in aldose reductase activity. Curcumin 49-57 interleukin 1 beta Mus musculus 150-158 23888334-5 2013 In vivo studies indicated that A2 was more potent than curcumin for inhibiting TPA-induced ear edema and TPA-induced increases in IL-1beta. Curcumin 55-63 interleukin 1 beta Mus musculus 130-138 23825622-8 2013 We inferred that curcumin was capable of impacting the IL-23/IL-17A axis by inhibiting IL-1beta/IL-6 and then indirectly down-regulating IL-17A/IL-22 production. Curcumin 17-25 interleukin 1 beta Mus musculus 87-95 23825622-6 2013 Real-time PCR showed that mRNA levels of IL-17A, IL-17F, IL-22, IL-1beta, IL-6 and TNF-alpha cytokines were decreased significantly by curcumin in ear skin, an effect similar to that of clobetasol. Curcumin 135-143 interleukin 1 beta Mus musculus 64-72 22729592-6 2013 Curcumin supplementation increased plasma concentrations of angiogenic factors angiogenin (p < 0.05), basic fibroblast growth factor (p < 0.05) and vascular endothelial growth factor (p < 0.05), as well as inflammatory cytokines interleukin-1beta (p < 0.05) and monocyte chemotactic protein-1 (p < 0.05), compared to the controls. Curcumin 0-8 interleukin 1 beta Mus musculus 238-255 22948514-7 2013 In addition, curcumin inhibited intrahepatic expression of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 protein. Curcumin 13-21 interleukin 1 beta Mus musculus 100-122