PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32934683-6 2020 Combined rAd-p53 and curcumin treatment resulted in higher p53 (P<0.01) and p21 (P<0.01) expression compared with rAd-p53 or curcumin were added alone, suggesting an additive effect on TP53 expression. Curcumin 21-29 H3 histone pseudogene 16 Homo sapiens 76-79 33046993-8 2020 Our results showed that curcumin induced ROS accumulation, apoptosis, autophagy, cell cycle arrest, and cellular senescence accompanied by upregulation of p53 and p21 proteins in SiHa cells. Curcumin 24-32 H3 histone pseudogene 16 Homo sapiens 163-166 30717973-7 2019 Moreover, we found that curcumin could regulate XIST/miR-106b-5p/P21 axis in RCC cells. Curcumin 24-32 H3 histone pseudogene 16 Homo sapiens 65-68 31752145-4 2019 In cancer cells, CN induced apoptosis and cell cycle arrest at G2/M phase through a p53-mediated mechanism, where p53 was activated, p21 and pro-apoptotic proteins Bid and Bak were upregulated, and PARP was cleaved. Curcumin 17-19 H3 histone pseudogene 16 Homo sapiens 133-136 31752145-5 2019 In non-transformed human mammary epithelial cells MCF10A, CN at 50 microM had no cytotoxicity and p53 was not activated, but curcumin at 12.5 microM activated p53 and p21 and inhibited MCF10A cell growth. Curcumin 125-133 H3 histone pseudogene 16 Homo sapiens 167-170 30116377-7 2018 In conclusion, curcumin inhibited the proliferation of breast cancer cells and induced G2/M phase cell cycle arrest and apoptosis, which may be associated with the decrease of CDC25 and CDC2 and increase of P21 protein levels, as well as inhibition of the phosphorylation of Akt/mTOR and induction of the mitochondrial apoptotic pathway. Curcumin 15-23 H3 histone pseudogene 16 Homo sapiens 207-210 30116377-5 2018 In-depth study of its mechanism of action revealed that curcumin induced cell cycle arrest at the G2/M phase and decreased the expression of the CDC25 and CDC2 proteins, while increasing the expression of P21. Curcumin 56-64 H3 histone pseudogene 16 Homo sapiens 205-208 27280688-5 2016 At the molecular and cellular level, curcumin can blunt epithelial-to-mesenchymal transition and affect many targets that are involved in melanoma initiation and progression (e.g., BCl2, MAPKS, p21 and some microRNAs). Curcumin 37-45 H3 histone pseudogene 16 Homo sapiens 194-197 28496336-0 2017 Curcumin exerts its antitumor activity through regulation of miR-7/Skp2/p21 in nasopharyngeal carcinoma cells. Curcumin 0-8 H3 histone pseudogene 16 Homo sapiens 72-75 28926094-10 2018 Additionally, curcumin activated the P53 signaling pathway by up-regulating P53 and P21, which also inhibited PI3K pathway through down-regulating PI3K, p-Akt, and p-mTOR. Curcumin 14-22 H3 histone pseudogene 16 Homo sapiens 84-87 27564099-7 2016 In addition, when 253J-Bv cells were co-treated with curcumin and cisplatin, p53 and p21 expression levels were markedly increased when compared to controls. Curcumin 53-61 H3 histone pseudogene 16 Homo sapiens 85-88 27564099-9 2016 Moreover, pretreatment with U0126 suppressed curcumin and cisplatin-induced upregulation of p53, p21, and p-STAT3 and downregulation of survival proteins in both cells. Curcumin 45-53 H3 histone pseudogene 16 Homo sapiens 97-100 27432244-5 2016 Curcumin induced G1 phase arrest through downregulating the expression of cyclin D3 and cyclin-dependent kinase (CDK)2/6 and upregulating the expression of CDK inhibitor proteins p21 and p27. Curcumin 0-8 H3 histone pseudogene 16 Homo sapiens 179-182 27725901-7 2016 The molecular basis of curcumin-mediated cell growth inhibition we identified is that curcumin significantly suppressed Skp2 expression and subsequently induced p21 expression. Curcumin 23-31 H3 histone pseudogene 16 Homo sapiens 161-164 27725901-7 2016 The molecular basis of curcumin-mediated cell growth inhibition we identified is that curcumin significantly suppressed Skp2 expression and subsequently induced p21 expression. Curcumin 86-94 H3 histone pseudogene 16 Homo sapiens 161-164 27482284-7 2016 All of the studies indicated that curcumin decreased glioblastoma cell viability through various pathways (i.e. decrease in prosurvival proteins such as nuclear factor kappaB, activator protein 1, and phosphoinositide 3 kinase, and upregulation of apoptotic pathways like p21, p53, and executor caspase 3). Curcumin 34-42 H3 histone pseudogene 16 Homo sapiens 272-275 26531053-0 2016 Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines. Curcumin 0-8 H3 histone pseudogene 16 Homo sapiens 88-91 26985469-0 2016 Retraction notice to "Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines" [Biochem. Curcumin 22-30 H3 histone pseudogene 16 Homo sapiens 166-169 25441423-5 2015 The protein expressions of p21 were significantly increased by the co-treatment of EGCG and curcumin, whereas it was not changed by the treatment with each individual compound. Curcumin 92-100 H3 histone pseudogene 16 Homo sapiens 27-30 26166196-8 2015 The findings revealed that curcumin significantly decreased cell proliferation, which was associated with increased expression of the p21/CIP1 and p27/KIP1 cyclin-dependent kinase inhibitors, and inhibited expression of cyclin D1. Curcumin 27-35 H3 histone pseudogene 16 Homo sapiens 134-137 26498137-9 2015 In addition, curcumin was found to cause the induction of p21, a cyclin-dependent kinase inhibitor, and reduction of X-linked inhibitor of apoptosis protein (XIAP), an anti-apoptotic molecule, in parental H460 cells as well as chemoresistant cells, H460/CisR and H460/TR. Curcumin 13-21 H3 histone pseudogene 16 Homo sapiens 58-61 25441423-7 2015 These results suggest that the enhanced inhibitory effect of EGCG on PC3 cell proliferation by curcumin was mediated by the synergic up-regulation of p21-induced growth arrest and followed cell growth arrest. Curcumin 95-103 H3 histone pseudogene 16 Homo sapiens 150-153 25786122-7 2015 Expression of downstream effectors of TGF-beta signaling pathway, cyclinD1, p21 and Pin1, was inhibited along with the down regulation of key mesenchymal markers (Snail and Slug) upon curcumin and emodin treatment. Curcumin 184-192 H3 histone pseudogene 16 Homo sapiens 76-79 25583641-7 2015 Further, the expression of two important cell cycle inhibitory proteins, p21 and p53, in the curcumin- and culture medium-treated cells without curcumin was evaluated by intracellular flow cytometry. Curcumin 93-101 H3 histone pseudogene 16 Homo sapiens 73-76 25583641-10 2015 Flow cytometry analysis showed a twofold increase in the expression of both p21 and p53 in curcumin-treated cells as compared to the medium-treated cells, suggesting that curcumin inhibits EPC growth by mainly inhibiting the G1 to S phase transition in the cell cycle. Curcumin 91-99 H3 histone pseudogene 16 Homo sapiens 76-79 25583641-10 2015 Flow cytometry analysis showed a twofold increase in the expression of both p21 and p53 in curcumin-treated cells as compared to the medium-treated cells, suggesting that curcumin inhibits EPC growth by mainly inhibiting the G1 to S phase transition in the cell cycle. Curcumin 171-179 H3 histone pseudogene 16 Homo sapiens 76-79 22273506-6 2012 The histone acetyltransferase (HAT) inhibitor curcumin was able to abrogate microgravity-induced p21 mRNA expression, whereas expression was enhanced by a histone deacetylase (HDAC) inhibitor. Curcumin 46-54 H3 histone pseudogene 16 Homo sapiens 97-100 26235577-6 2015 Results showed that pretreatment with curcumin significantly attenuated the H2O2-induced HUVECs" premature senescence, which was evidenced by a decreased percentage of senescence-associated beta-galactosidase positive cells, improved cell division and decreased expression of senescence-associated protein p21 (all p<0.05). Curcumin 38-46 H3 histone pseudogene 16 Homo sapiens 306-309 25530715-8 2014 RESULTS: We demonstrated MCF-7 and MDA-MB-231 cells exhibited differential responses to curcumin by WST-1 and clonogenic assay (MDA-MB-231 cells was sensitive, and MCF-7 cells was resistant), which were found to be related to the differential curcumin-mediated regulation of SKP2-Cip/Kips (p21 and p27 but not p57) signaling. Curcumin 88-96 H3 histone pseudogene 16 Homo sapiens 290-293 22290509-6 2013 The decreased cell viability observed in SkBr3 cells when curcumin was combined with TSA led to a G0/G1 cell cycle arrest and increased p21 and p27, and decreased Cyclin D1 protein expression. Curcumin 58-66 H3 histone pseudogene 16 Homo sapiens 136-139 23152782-11 2012 Western blot analysis suggested that pretreatment with Ki-67-7 sensitized bladder cancer cells to curcumin-mediated apoptosis and cell cycle arrest by p53- and p21-independent mechanisms. Curcumin 98-106 H3 histone pseudogene 16 Homo sapiens 160-163 20596601-10 2010 In the core signaling pathways of glioblastoma, curcumin either significantly influences the p53 pathway by enhancing p53 and p21 and suppressing cdc2 or significantly inhibits the RB pathway by enhancing CDKN2A/p16 and suppressing phosphorylated RB. Curcumin 48-56 H3 histone pseudogene 16 Homo sapiens 126-129 22101335-0 2011 Curcumin induces Apaf-1-dependent, p21-mediated caspase activation and apoptosis. Curcumin 0-8 H3 histone pseudogene 16 Homo sapiens 35-38 22101335-10 2011 Importantly, p21-deficiency resulted in reduced expression of Apaf-1 during curcumin treatment, indicating a requirement of p21 in Apaf-1 dependent caspase activation and apoptosis. Curcumin 76-84 H3 histone pseudogene 16 Homo sapiens 13-16 22101335-11 2011 Together, our findings demonstrate that Apaf-1, Bax, and p21 as novel potential targets for curcumin or curcumin-based anticancer agents. Curcumin 92-100 H3 histone pseudogene 16 Homo sapiens 57-60 22101335-11 2011 Together, our findings demonstrate that Apaf-1, Bax, and p21 as novel potential targets for curcumin or curcumin-based anticancer agents. Curcumin 104-112 H3 histone pseudogene 16 Homo sapiens 57-60 21036715-4 2010 RESULTS: Curcumin significantly caused radiation induced expression of p21 and Bax, and reduced BclXl, Mcl1 with only marginal Bcl2 modulation. Curcumin 9-17 H3 histone pseudogene 16 Homo sapiens 71-74 21311680-6 2010 Expression of several genes, cyclin A, p21, and p27, which has been shown to be regulated in E2F4-dependent manner and involved in the cell cycle progression was also affected by curcumin. Curcumin 179-187 H3 histone pseudogene 16 Homo sapiens 39-42 21311680-7 2010 Moreover, decreased (cyclin A) and increased (p21 and p27) expression of these E2F4 downstream genes by curcumin was restored by pretreatment of cells with NAC and E2F4 overexpression which is induced by doxycycline. Curcumin 104-112 H3 histone pseudogene 16 Homo sapiens 46-49 20055131-0 2009 [Effect of p21-targeted shRNA on curcumin-induced apoptosis of human hepatoma Huh7 cells]. Curcumin 33-41 H3 histone pseudogene 16 Homo sapiens 11-14 20055131-1 2009 In the present study, shRNA plasmid of pSi-p21 targeting p21 mRNA was constructed and the effect of p21 shRNA on curcumin-induced apoptosis of human hepatoma Huh7 cells was investigated. Curcumin 113-121 H3 histone pseudogene 16 Homo sapiens 57-60 20055131-1 2009 In the present study, shRNA plasmid of pSi-p21 targeting p21 mRNA was constructed and the effect of p21 shRNA on curcumin-induced apoptosis of human hepatoma Huh7 cells was investigated. Curcumin 113-121 H3 histone pseudogene 16 Homo sapiens 57-60 20055131-2 2009 The effect of curcumin on the expression of p21 mRNA and protein and the silence efficiency of pSi-p21 were detected with RT-PCR and Western blotting. Curcumin 14-22 H3 histone pseudogene 16 Homo sapiens 44-47 20055131-3 2009 The effect of pSi-p21 on curcumin-induced apoptosis of Huh7 cells was evaluated with DAPI staining. Curcumin 25-33 H3 histone pseudogene 16 Homo sapiens 18-21 20055131-4 2009 The results showed that curcumin significantly upregulated p21 mRNA and protein expression, which was knocked down by pSi-p21 of Huh7 cells. Curcumin 24-32 H3 histone pseudogene 16 Homo sapiens 59-62 20055131-4 2009 The results showed that curcumin significantly upregulated p21 mRNA and protein expression, which was knocked down by pSi-p21 of Huh7 cells. Curcumin 24-32 H3 histone pseudogene 16 Homo sapiens 122-125 20055131-5 2009 DAPI staining results showed that pSi-p21 significantly decreased curcumin-induced apoptosis of Huh7 cells. Curcumin 66-74 H3 histone pseudogene 16 Homo sapiens 38-41 20055131-6 2009 The data suggested that curcumin induced apoptosis of Huh7 cells via upregulation of p21 expression. Curcumin 24-32 H3 histone pseudogene 16 Homo sapiens 85-88 19288022-9 2009 Our results show that one molecular mechanism of curcumin inhibits the proliferation of MDA-MB-231 cells either through up-regulating p21 expression and then inducing apoptosis, or through up-regulating the Bax to Bcl-2 ratio and then inducing apoptosis. Curcumin 49-57 H3 histone pseudogene 16 Homo sapiens 134-137 19288022-8 2009 Curcumin increased the protein expressions of p21 and Bax, but decreased the protein expression of p53 and Bcl-2 in MDA-MB-231 cells. Curcumin 0-8 H3 histone pseudogene 16 Homo sapiens 46-49 17201158-6 2006 Curcumin also promoted the expression of Bax, cytochrome C, p53 and p21 but inhibited the expression of Bcl-2. Curcumin 0-8 H3 histone pseudogene 16 Homo sapiens 68-71 18384098-4 2008 Curcumin can also activate apoptosis, down-regulate cell survival gene products, and up-regulate p53, p21, and p27. Curcumin 0-8 H3 histone pseudogene 16 Homo sapiens 102-105 18423603-0 2008 Curcumin induces apoptosis in HCT-116 human colon cancer cells in a p21-independent manner. Curcumin 0-8 H3 histone pseudogene 16 Homo sapiens 68-71 18423603-3 2008 Several studies report that curcumin inhibits cancer cell proliferation and induces apoptosis in cancer cells through p21-mediated cell cycle arrest. Curcumin 28-36 H3 histone pseudogene 16 Homo sapiens 118-121 18423603-5 2008 In this study, we determined whether curcumin-induced cytotoxicity in cultures of HCT-116 human colon cancer cells was dependent on p21 status. Curcumin 37-45 H3 histone pseudogene 16 Homo sapiens 132-135 18423603-7 2008 Moreover, an equivalent cytotoxic effect by curcumin was observed in both p21(+/+) and p21(-/-)HCT-116 cells, indicating that curcumin-induced cytotoxicity was p21-independent. Curcumin 44-52 H3 histone pseudogene 16 Homo sapiens 74-77 18423603-7 2008 Moreover, an equivalent cytotoxic effect by curcumin was observed in both p21(+/+) and p21(-/-)HCT-116 cells, indicating that curcumin-induced cytotoxicity was p21-independent. Curcumin 44-52 H3 histone pseudogene 16 Homo sapiens 87-90 18423603-7 2008 Moreover, an equivalent cytotoxic effect by curcumin was observed in both p21(+/+) and p21(-/-)HCT-116 cells, indicating that curcumin-induced cytotoxicity was p21-independent. Curcumin 44-52 H3 histone pseudogene 16 Homo sapiens 87-90 18423603-9 2008 Western blot analysis showed that cell death in curcumin-treated cultures of p21(+/+) and p21(-/-) HCT-116 cells was associated with a reduction in pro-caspase-3 and PARP-1 cleavage, which are indicative of apoptosis. Curcumin 48-56 H3 histone pseudogene 16 Homo sapiens 77-80 18423603-9 2008 Western blot analysis showed that cell death in curcumin-treated cultures of p21(+/+) and p21(-/-) HCT-116 cells was associated with a reduction in pro-caspase-3 and PARP-1 cleavage, which are indicative of apoptosis. Curcumin 48-56 H3 histone pseudogene 16 Homo sapiens 90-93 12466962-4 2002 Results showed that curcumin treatment causes p53- and p21-independent G(2)/M phase arrest and apoptosis in HCT-116(p53(+/+)), HCT-116(p53(-/-)) and HCT-116(p21(-/-)) cell lines. Curcumin 20-28 H3 histone pseudogene 16 Homo sapiens 55-58 12466962-4 2002 Results showed that curcumin treatment causes p53- and p21-independent G(2)/M phase arrest and apoptosis in HCT-116(p53(+/+)), HCT-116(p53(-/-)) and HCT-116(p21(-/-)) cell lines. Curcumin 20-28 H3 histone pseudogene 16 Homo sapiens 157-160 33649826-7 2021 It was also demonstrated that curcumin regulated the cell cycle- and apoptosis-related proteins (cyclin D1, p21, Bcl2, cleaved-caspase-3 and cleaved-PARP), leading to cell cycle arrest and apoptosis in both ML-2 and OCI-AML5 cells. Curcumin 30-38 H3 histone pseudogene 16 Homo sapiens 108-111 33486250-6 2021 Here we investigated how curcumin affects the p53-p21 pathway in fluoride toxicity. Curcumin 25-33 H3 histone pseudogene 16 Homo sapiens 50-53 33486250-13 2021 However, curcumin itself significantly increased Ac-p53 and upregulated p21 protein levels to suppress cell proliferation in a dose-dependent manner. Curcumin 9-17 H3 histone pseudogene 16 Homo sapiens 72-75 33486250-14 2021 Curcumin suppressed fluoride-induced phosphorylation of p21 and increased p21 levels within the nuclear fraction. Curcumin 0-8 H3 histone pseudogene 16 Homo sapiens 56-59 33486250-14 2021 Curcumin suppressed fluoride-induced phosphorylation of p21 and increased p21 levels within the nuclear fraction. Curcumin 0-8 H3 histone pseudogene 16 Homo sapiens 74-77 33486250-16 2021 These results suggest that curcumin-induced Ac-p53 and p21 led to cell cycle arrest, while curcumin attenuated fluoride-mediated apoptosis via activation of Akt and suppressed fluoride-mediated DNA damage. Curcumin 27-35 H3 histone pseudogene 16 Homo sapiens 55-58