PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24896104-9 2014 miR-125a-5p inhibited the expression of tumour protein 53 (TP53), and curcumin treatment up-regulated the expression of TP53. Curcumin 70-78 tumor protein p53 Homo sapiens 120-124 24896104-10 2014 Taken together, these results indicate that curcumin exerted inhibitory effects on NPC by inhibiting the expression of miR-125a-5p and, subsequently, enhancing the expression of TP53. Curcumin 44-52 tumor protein p53 Homo sapiens 178-182 25172633-10 2014 Between 2 and 4 h following curcumin treatment, p53 levels increased with maximum levels reached by 8 h. Thus, curcumin homing to the nucleolus induces redistribution of p14(ARF) to the nucleoplasm where interaction with MDM2 leads to stabilization of p53, with subsequent initiation of apoptosis. Curcumin 28-36 tumor protein p53 Homo sapiens 48-51 25172633-10 2014 Between 2 and 4 h following curcumin treatment, p53 levels increased with maximum levels reached by 8 h. Thus, curcumin homing to the nucleolus induces redistribution of p14(ARF) to the nucleoplasm where interaction with MDM2 leads to stabilization of p53, with subsequent initiation of apoptosis. Curcumin 28-36 tumor protein p53 Homo sapiens 252-255 25172633-10 2014 Between 2 and 4 h following curcumin treatment, p53 levels increased with maximum levels reached by 8 h. Thus, curcumin homing to the nucleolus induces redistribution of p14(ARF) to the nucleoplasm where interaction with MDM2 leads to stabilization of p53, with subsequent initiation of apoptosis. Curcumin 111-119 tumor protein p53 Homo sapiens 48-51 25172633-10 2014 Between 2 and 4 h following curcumin treatment, p53 levels increased with maximum levels reached by 8 h. Thus, curcumin homing to the nucleolus induces redistribution of p14(ARF) to the nucleoplasm where interaction with MDM2 leads to stabilization of p53, with subsequent initiation of apoptosis. Curcumin 111-119 tumor protein p53 Homo sapiens 252-255 25070648-5 2014 Furthermore, western blot analysis revealed that curcumin induced p53 and p21(WAF1/CIP1) expression with a concomitant decrease in proliferating cell nuclear antigen protein levels (P<0.05). Curcumin 49-57 tumor protein p53 Homo sapiens 66-69 25070648-6 2014 Curcumin effectively inhibited primary hRPE cell proliferation, which may be mediated by the p53 pathway. Curcumin 0-8 tumor protein p53 Homo sapiens 93-96 24604218-10 2014 Immunoblotting revealed the Bid and Bcl-2 proteins to be downregulated, and truncated-Bid, Bax and p53 proteins to be upregulated by curcumin and EF-24. Curcumin 133-141 tumor protein p53 Homo sapiens 99-102 24831732-0 2014 Curcumin modulates miR-19/PTEN/AKT/p53 axis to suppress bisphenol A-induced MCF-7 breast cancer cell proliferation. Curcumin 0-8 tumor protein p53 Homo sapiens 35-38 24831732-8 2014 These results suggest for the first time that curcumin modulates miR-19/PTEN/AKT/p53 axis to exhibit its protective effects against BPA-associated breast cancer promotion. Curcumin 46-54 tumor protein p53 Homo sapiens 81-84 24806432-0 2014 Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin. Curcumin 173-181 tumor protein p53 Homo sapiens 97-100 24806432-4 2014 To further explore the potential mechanism, we showed that curcumin increased the phosphorylation of ERK1/2 but not p38 MAPK in a time-dependent manner, and induced protein expression of the tumor suppressors FOXO3a and p53 in a dose-dependent manner, which were not observed in the presence of PD98059, an inhibitor of ERK1/2. Curcumin 59-67 tumor protein p53 Homo sapiens 220-223 24806432-5 2014 Furthermore, silencing of FOXO3a and p53 genes by siRNAs overcame the inhibitory effect of curcumin on cell proliferation. Curcumin 91-99 tumor protein p53 Homo sapiens 37-40 24806432-6 2014 Silencing or blockade of p53 using siRNA or chemical inhibitor abrogated the effect of curcumin on expression of FOXO3a protein; silencing or overexpression of FOXO3a had no further effect on curcumin-induced p53 protein expression. Curcumin 87-95 tumor protein p53 Homo sapiens 25-28 24806432-8 2014 Together, our studies show that curcumin inhibits growth and induces apoptosis of NPC cells through ERK1/2-mediated increase in the protein expression and interaction of p53 and FOXO3a. Curcumin 32-40 tumor protein p53 Homo sapiens 170-173 24806432-9 2014 p53 is upstream of FOXO3a, which form a regulatory loop that mediates the effect of curcumin. Curcumin 84-92 tumor protein p53 Homo sapiens 0-3 24664296-7 2014 Moreover, the level of activated p53 and PARP-1 were significantly induced by BaP, whereas this induction was markedly reduced after curcumin and VE co-treatment. Curcumin 133-141 tumor protein p53 Homo sapiens 33-36 24743574-15 2014 Taken together, combined treatment with NVP-BEZ235 and curcumin induces apoptosis through p53-dependent Bcl-2 mRNA down-regulation at the transcriptional level and Mcl-1 protein down-regulation at the post-transcriptional level. Curcumin 55-63 tumor protein p53 Homo sapiens 90-93 24743574-0 2014 Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability. Curcumin 0-8 tumor protein p53 Homo sapiens 157-160 24743574-11 2014 Combined treatment with NVP-BEZ235 and curcumin reduced Bcl-2 expression in wild-type p53 HCT116 human colon carcinoma cells but not p53-null HCT116 cells. Curcumin 39-47 tumor protein p53 Homo sapiens 86-89 22290509-11 2013 We conclude that p53 independent apoptosis induced by combining curcumin and TSA involves JNK activation. Curcumin 64-72 tumor protein p53 Homo sapiens 17-20 23686430-0 2013 Curcumin induces apoptosis in human colorectal carcinoma (HCT-15) cells by regulating expression of Prp4 and p53. Curcumin 0-8 tumor protein p53 Homo sapiens 109-112 23686430-6 2013 Western blot analysis revealed that curcumin treatment activated caspase-3 and decreased expression of p53 and Prp4B in a time-dependent manner. Curcumin 36-44 tumor protein p53 Homo sapiens 103-106 24606473-4 2014 Curcumin inhibited HDACs, HPV expression and differentially increased acetylation and up-regulation of p53 in SiHa and SiHaR, leading to cell cycle arrest at G1-S phase. Curcumin 0-8 tumor protein p53 Homo sapiens 103-106 23946688-0 2013 Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells. Curcumin 48-56 tumor protein p53 Homo sapiens 7-10 23946688-3 2013 The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis. Curcumin 192-200 tumor protein p53 Homo sapiens 56-59 23946688-3 2013 The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis. Curcumin 192-200 tumor protein p53 Homo sapiens 173-176 23946688-6 2013 We confirmed the suppressive effect of curcumin on Notch1 transcription by performing a Notch1 promoter-driven reporter assay and identified a putative p53-binding site in the Notch1 promoter by EMSA and chromatin immunoprecipitation analysis. Curcumin 39-47 tumor protein p53 Homo sapiens 152-155 23946688-8 2013 Moreover, curcumin-induced apoptosis was further enhanced by the knockdown of Notch1 or mutant p53, but it was decreased by the overexpression of active Notch1. Curcumin 10-18 tumor protein p53 Homo sapiens 95-98 23946688-9 2013 Taken together, our results demonstrate, for the first time, that Notch1 is a transcriptional target of mutant p53 in breast cancer cells and suggest that the targeting of mutant p53 and/or Notch1 may be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to curcumin. Curcumin 296-304 tumor protein p53 Homo sapiens 111-114 23946688-9 2013 Taken together, our results demonstrate, for the first time, that Notch1 is a transcriptional target of mutant p53 in breast cancer cells and suggest that the targeting of mutant p53 and/or Notch1 may be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to curcumin. Curcumin 296-304 tumor protein p53 Homo sapiens 179-182 23874455-4 2013 Pharmacologic targeting of STAT3 expression in cervical cancer cell lines either by STAT3-specific siRNA or blocking its tyrosine phosphorylation by AG490 or curcumin led to dose-dependent accumulation of p53 and pRb in cervical cancer cells. Curcumin 158-166 tumor protein p53 Homo sapiens 205-208 23486648-6 2013 We showed that curcumin-treated Jurkat cells and resting T cells showed neither DNA lesions nor did they activate key proteins in the DDR signalling pathway, such as phospho-ATM and phospho-p53. Curcumin 15-23 tumor protein p53 Homo sapiens 190-193 22628241-8 2013 Furthermore, western blotting analysis indicated that curcumin induced the release of cytochrome c, a significant increase of Bax and p53 and a marked reduction of Bcl-2 and survivin in LoVo cells. Curcumin 54-62 tumor protein p53 Homo sapiens 134-137 23356739-0 2013 Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells. Curcumin 37-45 tumor protein p53 Homo sapiens 61-64 23356739-4 2013 In this study we assessed the effects of the phytocompounds garcinol and curcumin on histone and p53 modification in cancer cells, focussing on the breast tumour cell line MCF7. Curcumin 73-81 tumor protein p53 Homo sapiens 97-100 23117293-7 2013 Pre-treatment with curcumin at a low concentration of 2 micromol/l increased IR-induced G2/M arrest in the cell cycle and increased the expression of cyclin-dependent kinase inhibitors, p21cip1 and p53. Curcumin 19-27 tumor protein p53 Homo sapiens 198-201 22765290-3 2012 In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53. Curcumin 96-104 tumor protein p53 Homo sapiens 357-360 22910273-3 2012 We explored synergistic efficacy of a low dose of curcumin (CCM) and a low dose of paclitaxel (PTX) in HBTSC and human glioblastoma LN18 (p53 mutant and PTEN proficient) and U138MG (p53 mutant and PTEN mutant) cells. Curcumin 50-58 tumor protein p53 Homo sapiens 138-141 23351311-0 2012 Genistein abrogates G2 arrest induced by curcumin in p53 deficient T47D cells. Curcumin 41-49 tumor protein p53 Homo sapiens 53-56 23351311-10 2012 RESULTS: In this study curcumin induced G2 arrest on p53 deficient T47D cells at the concentration of 10 muM. Curcumin 23-31 tumor protein p53 Homo sapiens 53-56 21134073-6 2011 Combined treatment of isoflavones and curcumin additively suppressed cellular proliferation and induced phosphorylation of ATM, histone H2AX, Chk2 and p53. Curcumin 38-46 tumor protein p53 Homo sapiens 151-154 22522053-8 2012 In addition, p53 involved in curcumin-mediated Fas, FasL, and DR5 expression and cell apoptosis in chondrosarcoma cells. Curcumin 29-37 tumor protein p53 Homo sapiens 13-16 22298641-1 2012 Curcumin can induce p53-independent apoptosis. Curcumin 0-8 tumor protein p53 Homo sapiens 20-23 22298641-3 2012 Here, we show that curcumin-induced apoptosis in a panel of tumor cells with mutant p53. Curcumin 19-27 tumor protein p53 Homo sapiens 84-87 22298641-10 2012 The results suggest that curcumin induction of ROS activates MAPKs, at least partially by inhibiting PP2A and PP5, thereby leading to p53-independent apoptosis in tumor cells. Curcumin 25-33 tumor protein p53 Homo sapiens 134-137 22227273-12 2012 These results were also supported by our therapeutic study, where curcumin induced apoptosis both by p53 dependent and independent manner, while celecoxib followed only p53 independent pathway. Curcumin 66-74 tumor protein p53 Homo sapiens 101-104 22013068-0 2011 Curcumin enhances the efficacy of chemotherapy by tailoring p65NFkappaB-p300 cross-talk in favor of p53-p300 in breast cancer. Curcumin 0-8 tumor protein p53 Homo sapiens 100-103 20839263-5 2011 Curcumin in combination with oxaliplatin was able to decrease proliferative capacity of oxaliplatin-resistant p53 wildtype and p53(-/-) cell lines more effectively than oxaliplatin alone. Curcumin 0-8 tumor protein p53 Homo sapiens 110-113 20839263-5 2011 Curcumin in combination with oxaliplatin was able to decrease proliferative capacity of oxaliplatin-resistant p53 wildtype and p53(-/-) cell lines more effectively than oxaliplatin alone. Curcumin 0-8 tumor protein p53 Homo sapiens 127-130 21167259-0 2011 Curcumin I protects the dopaminergic cell line SH-SY5Y from 6-hydroxydopamine-induced neurotoxicity through attenuation of p53-mediated apoptosis. Curcumin 0-10 tumor protein p53 Homo sapiens 123-126 21167259-9 2011 Taken together, these findings indicate that curcumin I protects dopaminergic neurons from 6-OHDA-induced toxicity via the reduction of ROS production, and subsequent attenuation of p53 phosphorylation and reduction of the Bax/Bcl-2 ratio. Curcumin 45-55 tumor protein p53 Homo sapiens 182-185 22179573-3 2012 The resulting pyr-dba functioned as the enone analogs of curcumin and efficiently inhibited the activation of NF-kappaB and the growth of colorectal carcinoma HCT116 p53+/+ cells as well as the HIV-1 IN-LEDGF/p75 interaction. Curcumin 57-65 tumor protein p53 Homo sapiens 166-169 23152782-11 2012 Western blot analysis suggested that pretreatment with Ki-67-7 sensitized bladder cancer cells to curcumin-mediated apoptosis and cell cycle arrest by p53- and p21-independent mechanisms. Curcumin 98-106 tumor protein p53 Homo sapiens 151-154 21314329-0 2011 Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Curcumin 87-95 tumor protein p53 Homo sapiens 16-19 21314329-3 2011 The results showed that curcumin administration increased body weight, decreased serum TNF-alpha levels, increased apoptotic tumor cells, enhanced expression of p53 molecule in tumor tissue, and modulated tumor cell apoptotic pathway. Curcumin 24-32 tumor protein p53 Homo sapiens 161-164 21314329-4 2011 We conclude that the curcumin treatment improves the general health of patients with colorectal cancer via the mechanism of increased p53 molecule expression in tumor cells and consequently speeds up tumor cell apoptosis. Curcumin 21-29 tumor protein p53 Homo sapiens 134-137 21386967-5 2011 Direct or indirect activation of TP53 pathway with 5-aza-2"-deoxycitidine, Curcumin or Nutlin-3 induced an increase in apoptosis of ALL cells. Curcumin 75-83 tumor protein p53 Homo sapiens 33-37 20472336-0 2010 Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells. Curcumin 0-8 tumor protein p53 Homo sapiens 48-51 20472336-3 2010 Curcumin killed wild-type p53 HCT-116 cells and mutant p53 HT-29 cells in a dose- and time-dependent manner. Curcumin 0-8 tumor protein p53 Homo sapiens 26-29 20472336-3 2010 Curcumin killed wild-type p53 HCT-116 cells and mutant p53 HT-29 cells in a dose- and time-dependent manner. Curcumin 0-8 tumor protein p53 Homo sapiens 55-58 20472336-5 2010 Similar results were obtained when the cytotoxic effect of curcumin was assessed in wild-type p53 HCT-116 cells after siRNA-mediated p53 knockdown. Curcumin 59-67 tumor protein p53 Homo sapiens 94-97 20472336-5 2010 Similar results were obtained when the cytotoxic effect of curcumin was assessed in wild-type p53 HCT-116 cells after siRNA-mediated p53 knockdown. Curcumin 59-67 tumor protein p53 Homo sapiens 133-136 20472336-6 2010 Chromatin condensation, poly (ADP-ribose) polymerase-1 cleavage and reduced pro-caspase-3 levels in curcumin-treated p53(+/+) and p53(-/-) HCT-116 cells suggested that curcumin caused apoptosis. Curcumin 100-108 tumor protein p53 Homo sapiens 117-120 20472336-7 2010 In addition, exposure to curcumin resulted in superoxide anion production and phosphorylation of oxidative stress proteins in p53(+/+) and p53(-/-) HCT-116 cells. Curcumin 25-33 tumor protein p53 Homo sapiens 126-129 20472336-7 2010 In addition, exposure to curcumin resulted in superoxide anion production and phosphorylation of oxidative stress proteins in p53(+/+) and p53(-/-) HCT-116 cells. Curcumin 25-33 tumor protein p53 Homo sapiens 139-142 21036715-0 2010 Curcumin-altered p53-response genes regulate radiosensitivity in p53-mutant Ewing"s sarcoma cells. Curcumin 0-8 tumor protein p53 Homo sapiens 17-20 21036715-0 2010 Curcumin-altered p53-response genes regulate radiosensitivity in p53-mutant Ewing"s sarcoma cells. Curcumin 0-8 tumor protein p53 Homo sapiens 65-68 21036715-1 2010 AIM: Curcumin has been demonstrated to have antitumor effects including radiosensitization by modulating many molecular targets including p53. Curcumin 5-13 tumor protein p53 Homo sapiens 138-141 21036715-2 2010 Herein, we investigated the radiosensitizing effect of curcumin in p53 mutant Ewing"s sarcoma (ES) cells. Curcumin 55-63 tumor protein p53 Homo sapiens 67-70 21036715-8 2010 CONCLUSION: These results suggest that curcumin potentially radiosensitizes p53-mutant ES cells by regulating IR-modulated p53-response genes. Curcumin 39-47 tumor protein p53 Homo sapiens 76-79 21036715-8 2010 CONCLUSION: These results suggest that curcumin potentially radiosensitizes p53-mutant ES cells by regulating IR-modulated p53-response genes. Curcumin 39-47 tumor protein p53 Homo sapiens 123-126 21036715-9 2010 However, the curcumin-associated p53-independent regulation of downstream targets remains to be explored. Curcumin 13-21 tumor protein p53 Homo sapiens 33-36 20686221-6 2010 In our study curcumin increased the expression of GADD45 and 153 in a p53-independent manner. Curcumin 13-21 tumor protein p53 Homo sapiens 70-73 20138829-5 2010 In this study we found that curcumin induces apoptotic cell death in MCF-7 cells, as assessed by MTT assay, DNA ladder formation, PARP cleavage, p53 and Bax induction. Curcumin 28-36 tumor protein p53 Homo sapiens 145-148 20596601-10 2010 In the core signaling pathways of glioblastoma, curcumin either significantly influences the p53 pathway by enhancing p53 and p21 and suppressing cdc2 or significantly inhibits the RB pathway by enhancing CDKN2A/p16 and suppressing phosphorylated RB. Curcumin 48-56 tumor protein p53 Homo sapiens 93-96 20596601-10 2010 In the core signaling pathways of glioblastoma, curcumin either significantly influences the p53 pathway by enhancing p53 and p21 and suppressing cdc2 or significantly inhibits the RB pathway by enhancing CDKN2A/p16 and suppressing phosphorylated RB. Curcumin 48-56 tumor protein p53 Homo sapiens 118-121 19944674-7 2010 Curcumin inhibited cell growth, induced apoptosis and upregulated maspin gene expression in MCF-7 cells and these findings were further correlated with the upregulation of p53 protein and downregulation of Bcl-2, suggesting maspin mediated apoptosis in MCF-7 cells. Curcumin 0-8 tumor protein p53 Homo sapiens 172-175 19676105-10 2010 We conclude that p53-independent curcumin-induced apoptosis in ovarian carcinoma cells involves p38 MAPK activation, ablation of prosurvival Akt signaling, and reduced expression of the antiapoptotic proteins Bcl-2 and survivin. Curcumin 33-41 tumor protein p53 Homo sapiens 17-20 19020741-5 2008 We also observed that curcumin induces p53 phosphorylation (Ser 15) and both compound C and SB203580 pretreatment inhibit p53 phosphorylation. Curcumin 22-30 tumor protein p53 Homo sapiens 39-42 19693275-4 2009 Curcumin predominantly induced mitochondria-mediated ROS formation and stimulated the expression of the redox-sensitive pro-apoptotic factor p53. Curcumin 0-8 tumor protein p53 Homo sapiens 141-144 19676105-0 2010 Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling. Curcumin 0-8 tumor protein p53 Homo sapiens 57-60 19676105-3 2010 In this study we show that curcumin exhibited time- and dose-dependent cytotoxicity against monolayer cultures of ovarian carcinoma cell lines with differing p53 status (wild-type p53: HEY, OVCA429; mutant p53: OCC1; null p53: SKOV3). Curcumin 27-35 tumor protein p53 Homo sapiens 158-161 19676105-3 2010 In this study we show that curcumin exhibited time- and dose-dependent cytotoxicity against monolayer cultures of ovarian carcinoma cell lines with differing p53 status (wild-type p53: HEY, OVCA429; mutant p53: OCC1; null p53: SKOV3). Curcumin 27-35 tumor protein p53 Homo sapiens 180-183 19676105-3 2010 In this study we show that curcumin exhibited time- and dose-dependent cytotoxicity against monolayer cultures of ovarian carcinoma cell lines with differing p53 status (wild-type p53: HEY, OVCA429; mutant p53: OCC1; null p53: SKOV3). Curcumin 27-35 tumor protein p53 Homo sapiens 180-183 19676105-3 2010 In this study we show that curcumin exhibited time- and dose-dependent cytotoxicity against monolayer cultures of ovarian carcinoma cell lines with differing p53 status (wild-type p53: HEY, OVCA429; mutant p53: OCC1; null p53: SKOV3). Curcumin 27-35 tumor protein p53 Homo sapiens 180-183 19580791-8 2009 A subsequent p53/p21(CIP1/WAF1)-dependent inhibition of G1 to S transition is triggered by Curcumin and DAC as a consequence of the mitotic slippage, preventing post-mitotic cells from re-entering the cell cycle. Curcumin 91-99 tumor protein p53 Homo sapiens 13-16 19288022-8 2009 Curcumin increased the protein expressions of p21 and Bax, but decreased the protein expression of p53 and Bcl-2 in MDA-MB-231 cells. Curcumin 0-8 tumor protein p53 Homo sapiens 99-102 19838927-4 2009 Indeed, the combination of curcumin and resveratrol was found to be more effective in inhibiting growth of p53-positive (wt) and p53-negative colon cancer HCT-116 cells in vitro and in vivo in SCID xenografts of colon cancer HCT-116 (wt) cells than either agent alone. Curcumin 27-35 tumor protein p53 Homo sapiens 107-110 19838927-4 2009 Indeed, the combination of curcumin and resveratrol was found to be more effective in inhibiting growth of p53-positive (wt) and p53-negative colon cancer HCT-116 cells in vitro and in vivo in SCID xenografts of colon cancer HCT-116 (wt) cells than either agent alone. Curcumin 27-35 tumor protein p53 Homo sapiens 129-132 17594054-0 2007 Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma. Curcumin 0-8 tumor protein p53 Homo sapiens 45-48 18646516-9 2008 When AP-1 activities were inhibited by curcumin, overexpression of p53 induced by B(a)P was not markedly changed. Curcumin 39-47 tumor protein p53 Homo sapiens 67-70 18384098-4 2008 Curcumin can also activate apoptosis, down-regulate cell survival gene products, and up-regulate p53, p21, and p27. Curcumin 0-8 tumor protein p53 Homo sapiens 97-100 18414057-11 2008 Our results show that sulfinosine and curcumin overcome MDR in non-small cell lung carcinoma cell line (NSCLC), especially in combination despite the presence of a mutated p53 gene. Curcumin 38-46 tumor protein p53 Homo sapiens 172-175 18370854-4 2008 The potentially adverse sequelae of curcumin"s effects on proapoptotic genes, particularly p53, represent a cause for current debate. Curcumin 36-44 tumor protein p53 Homo sapiens 91-94 18316600-9 2008 Our results indicate that ERK and JNK MAPK/Elk-1/Egr-1 signal cascade is required for p53-independent transcriptional activation of p21(Waf1/Cip1) in response to curcumin in U-87MG human glioblastoma cells. Curcumin 162-170 tumor protein p53 Homo sapiens 86-89 17879958-4 2008 We show that curcumin, an important inhibitor of CSN-associated kinases, can downregulate not only CSN5 but also MDM2, which results in p53 stabilization. Curcumin 13-21 tumor protein p53 Homo sapiens 136-139 17594054-12 2007 The results demonstrate that curcumin exerts inhibitory action on glioma cell growth and proliferation via induction of cell cycle arrest instead of induction of apoptosis in a p53-dependent manner, and ING4 possibly is in part involved in the signal pathways. Curcumin 29-37 tumor protein p53 Homo sapiens 177-180 17332930-11 2007 Overexpression of constitutively active AKT inhibited curcumin-induced p53 translocation to mitochondria, and Smac release to cytoplasm, whereas inhibition of AKT by dominant negative AKT enhanced curcumin-induced p53 translocation to mitochondria and Smac release. Curcumin 54-62 tumor protein p53 Homo sapiens 71-74 17332930-0 2007 Involvement of Bcl-2 family members, phosphatidylinositol 3"-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer. Curcumin 97-105 tumor protein p53 Homo sapiens 90-93 17596214-6 2007 Curcumin reduced cell survival in a p53- and caspase-independent manner, an effect correlated with the inhibition of AP-1 and NFkappaB signaling pathways via prevention of constitutive JNK and Akt activation. Curcumin 0-8 tumor protein p53 Homo sapiens 36-39 17240359-6 2007 We found that curcumin enhanced the expression of tumor cyclin-dependent kinase (CDK) inhibitors p21 and p27 as well as tumor suppressor protein p53 but suppressed the expression of retinoblastoma protein. Curcumin 14-22 tumor protein p53 Homo sapiens 145-148 17332930-4 2007 Curcumin downregulated the expression of Bcl-2, and Bcl-XL and upregulated the expression of p53, Bax, Bak, PUMA, Noxa, and Bim. Curcumin 0-8 tumor protein p53 Homo sapiens 93-96 17332930-11 2007 Overexpression of constitutively active AKT inhibited curcumin-induced p53 translocation to mitochondria, and Smac release to cytoplasm, whereas inhibition of AKT by dominant negative AKT enhanced curcumin-induced p53 translocation to mitochondria and Smac release. Curcumin 54-62 tumor protein p53 Homo sapiens 214-217 17332930-5 2007 Curcumin upregulated the expression of p53 as well as its phosphorylation at serine 15, and acetylation in a concentration-dependent manner. Curcumin 0-8 tumor protein p53 Homo sapiens 39-42 17332930-7 2007 Treatment of LNCaP cells with curcumin resulted in translocation of Bax and p53 to mitochondria, production of reactive oxygen species, drop in mitochondrial membrane potential, release of mitochondrial proteins (cytochrome c, Smac/DIABLO and Omi/HtrA2), activation of caspase-3 and induction of apoptosis. Curcumin 30-38 tumor protein p53 Homo sapiens 76-79 17332930-12 2007 Our study establishes a role for AKT in modulating the direct action of p53 on the caspase-dependent mitochondrial death pathway and suggests that these important biological molecules interact at the level of the mitochondria to influence curcumin sensitivity. Curcumin 239-247 tumor protein p53 Homo sapiens 72-75 16787365-5 2006 In addition to inducing p300 degradation curcumin inhibited the acetyltransferase activity of purified p300 as assessed using either histone H3 or p53 as substrate. Curcumin 41-49 tumor protein p53 Homo sapiens 147-150 17218783-5 2007 Curcumin induced G(2)/M phase cell-cycle arrest in CR cells by enhancing the p53 phosphorylation and apoptosis through the activation of caspase-3 followed by PARP degradation. Curcumin 0-8 tumor protein p53 Homo sapiens 77-80 17201158-6 2006 Curcumin also promoted the expression of Bax, cytochrome C, p53 and p21 but inhibited the expression of Bcl-2. Curcumin 0-8 tumor protein p53 Homo sapiens 60-63 16376585-5 2006 A decrease in expression of Bcl-2, Bcl-X(L) and pro-caspase-3 was observed after exposure to 40 microM curcumin, while the levels of p53 and Bax were increased in the curcumin-treated cells. Curcumin 103-111 tumor protein p53 Homo sapiens 133-136 16376585-5 2006 A decrease in expression of Bcl-2, Bcl-X(L) and pro-caspase-3 was observed after exposure to 40 microM curcumin, while the levels of p53 and Bax were increased in the curcumin-treated cells. Curcumin 167-175 tumor protein p53 Homo sapiens 133-136 17332326-4 2007 In a human prostate cancer cell lines PC3 (p53(null)), curcumin reduced MDM2 protein and mRNA in a dose- and time-dependent manner, and enhanced the expression of the tumor suppressor p21(Waf1/CIP1). Curcumin 55-63 tumor protein p53 Homo sapiens 43-46 17569210-4 2007 Curcumin decreased the expression of antiapoptotic members of the Bcl-2 family and elevated the expression of p53, Bax, procaspases 3, 8, and 9. Curcumin 0-8 tumor protein p53 Homo sapiens 110-113 16302093-0 2005 Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expression. Curcumin 0-8 tumor protein p53 Homo sapiens 79-82 16302093-5 2005 The colon adenocarcinoma cells were treated with curcumin (0-75 microM) for 0-24 h. We observed that p53 was highly expressed in HT-29 cells and curcumin could up-regulate the serine phosphorylation of p53 in a time- and concentration-dependent manner. Curcumin 49-57 tumor protein p53 Homo sapiens 101-104 16302093-5 2005 The colon adenocarcinoma cells were treated with curcumin (0-75 microM) for 0-24 h. We observed that p53 was highly expressed in HT-29 cells and curcumin could up-regulate the serine phosphorylation of p53 in a time- and concentration-dependent manner. Curcumin 49-57 tumor protein p53 Homo sapiens 202-205 16302093-5 2005 The colon adenocarcinoma cells were treated with curcumin (0-75 microM) for 0-24 h. We observed that p53 was highly expressed in HT-29 cells and curcumin could up-regulate the serine phosphorylation of p53 in a time- and concentration-dependent manner. Curcumin 145-153 tumor protein p53 Homo sapiens 101-104 16302093-5 2005 The colon adenocarcinoma cells were treated with curcumin (0-75 microM) for 0-24 h. We observed that p53 was highly expressed in HT-29 cells and curcumin could up-regulate the serine phosphorylation of p53 in a time- and concentration-dependent manner. Curcumin 145-153 tumor protein p53 Homo sapiens 202-205 16302093-8 2005 These data suggest a possible underlying molecular mechanism whereby curcumin could induce the apoptosis signaling pathway in human HT-29 colon adenocarcinoma cells by p53 activation and by the regulation of apoptosis-related proteins. Curcumin 69-77 tumor protein p53 Homo sapiens 168-171 16468334-0 2005 [Effects of curcumin on the acetylation of histone H3, P53 and the proliferation of NB4 cells]. Curcumin 12-20 tumor protein p53 Homo sapiens 55-58 16468334-1 2005 OBJECTIVE: To investigate the effects of curcumin on the acetylation of histone H3, P53 and the proliferation of NB4 cells. Curcumin 41-49 tumor protein p53 Homo sapiens 84-87 16468334-7 2005 CONCLUSION: Curcumin functions as a deacetylase inhibitor,which could increase the level of acetylated histone H3, enhance the expression and activity of tumor suppressor P53, and inhibit the proliferation of NB4 cells. Curcumin 12-20 tumor protein p53 Homo sapiens 171-174 15738001-0 2005 Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner. Curcumin 0-8 tumor protein p53 Homo sapiens 111-114 16083495-1 2005 BACKGROUND: Inhibition of the COP9 signalosome (CSN) associated kinases CK2 and PKD by curcumin causes stabilization of the tumor suppressor p53. Curcumin 87-95 tumor protein p53 Homo sapiens 141-144 15738001-3 2005 In our search toward delineating the molecular mechanisms behind such differential activities of curcumin, we found that it selectively increases p53 expression at G(2) phase of carcinoma cells and releases cytochrome c from mitochondria, which is an essential requirement for apoptosis. Curcumin 97-105 tumor protein p53 Homo sapiens 146-149 15738001-4 2005 Further experiments using p53-null as well as dominant-negative and wild-type p53-transfected cells have established that curcumin induces apoptosis in carcinoma cells via a p53-dependent pathway. Curcumin 122-130 tumor protein p53 Homo sapiens 26-29 15738001-4 2005 Further experiments using p53-null as well as dominant-negative and wild-type p53-transfected cells have established that curcumin induces apoptosis in carcinoma cells via a p53-dependent pathway. Curcumin 122-130 tumor protein p53 Homo sapiens 78-81 15738001-4 2005 Further experiments using p53-null as well as dominant-negative and wild-type p53-transfected cells have established that curcumin induces apoptosis in carcinoma cells via a p53-dependent pathway. Curcumin 122-130 tumor protein p53 Homo sapiens 78-81 15809436-0 2005 Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin. Curcumin 122-130 tumor protein p53 Homo sapiens 73-76 15383533-5 2004 Furthermore, curcumin could also inhibit the p300-mediated acetylation of p53 in vivo. Curcumin 13-21 tumor protein p53 Homo sapiens 74-77 15809436-3 2005 Here, we show that curcumin, a natural phenolic compound found in the spice turmeric, induced ubiquitin-independent degradation of WT p53 and inhibited p53-induced apoptosis in normal thymocytes and myeloid leukemic cells. Curcumin 19-27 tumor protein p53 Homo sapiens 134-137 15809436-3 2005 Here, we show that curcumin, a natural phenolic compound found in the spice turmeric, induced ubiquitin-independent degradation of WT p53 and inhibited p53-induced apoptosis in normal thymocytes and myeloid leukemic cells. Curcumin 19-27 tumor protein p53 Homo sapiens 152-155 15809436-4 2005 Like dicoumarol, curcumin inhibited the activity of recombinant NQO1 in vitro, inhibited the activity of endogenous cellular NQO1 in vivo, and dissociated NQO1-WT p53 complexes. Curcumin 17-25 tumor protein p53 Homo sapiens 163-166 15809436-7 2005 The results indicate that curcumin induces p53 degradation and inhibits p53-induced apoptosis by an NQO1-dependent pathway. Curcumin 26-34 tumor protein p53 Homo sapiens 43-46 15809436-7 2005 The results indicate that curcumin induces p53 degradation and inhibits p53-induced apoptosis by an NQO1-dependent pathway. Curcumin 26-34 tumor protein p53 Homo sapiens 72-75 15179184-4 2004 Curcumin induced melanoma cell apoptosis and cell cycle arrest, which is associated with the downregulation of NFkappaB activation, iNOS and DNA-dependent protein kinase catalytic subunit expression, and upregulation of p53, p21(Cip1), p27(Kip1) and checkpoint kinase 2. Curcumin 0-8 tumor protein p53 Homo sapiens 220-223 15090465-0 2004 Curcumin impairs tumor suppressor p53 function in colon cancer cells. Curcumin 0-8 tumor protein p53 Homo sapiens 34-37 15090465-5 2004 In compounds other than curcumin this same electrophilic moiety is associated with inactivation of the tumor suppressor, p53. Curcumin 24-32 tumor protein p53 Homo sapiens 121-124 15142674-8 2004 A decrease in expression of p53, bcl-2, and bcl-X(L) was observed after 12 h exposure of 40 microM curcumin. Curcumin 99-107 tumor protein p53 Homo sapiens 28-31 15161054-0 2004 Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma. Curcumin 0-8 tumor protein p53 Homo sapiens 86-89 15140256-14 2004 In addition, curcumin affected expression of metallothionein genes, tubulin genes, p53 and other genes involved in colon carcinogenesis. Curcumin 13-21 tumor protein p53 Homo sapiens 83-86 12408761-3 2002 The effect of curcumin on the expression of c-myc, bcl-2, mutant-type p53 and Fas protein and mRNA was studied by flow cytometry (FCM) and reverse transcription-polymerase chain reaction (RT-PCR). Curcumin 14-22 tumor protein p53 Homo sapiens 70-73 12118335-0 2002 Curcumin inhibits cell cycle progression of immortalized human umbilical vein endothelial (ECV304) cells by up-regulating cyclin-dependent kinase inhibitor, p21WAF1/CIP1, p27KIP1 and p53. Curcumin 0-8 tumor protein p53 Homo sapiens 183-186 12118335-3 2002 Curcumin was found to induce G0/G1 and/or G2/M phase cell cycle arrest, up-regulate CDKIs, p21WAF1/CIP1, p27KIP1, and p53, and slightly down-regulate cyclin B1 and cdc2 in ECV304 cells. Curcumin 0-8 tumor protein p53 Homo sapiens 118-121 15161054-7 2004 CONCLUSION: Observations suggest that the cytotoxicity, cell cycle arrest and apoptosis induced by curcumin and resveratrol in NB cells may be mediated via functionally activated p53 and merit further study. Curcumin 99-107 tumor protein p53 Homo sapiens 179-182 12466962-4 2002 Results showed that curcumin treatment causes p53- and p21-independent G(2)/M phase arrest and apoptosis in HCT-116(p53(+/+)), HCT-116(p53(-/-)) and HCT-116(p21(-/-)) cell lines. Curcumin 20-28 tumor protein p53 Homo sapiens 46-49 12466962-4 2002 Results showed that curcumin treatment causes p53- and p21-independent G(2)/M phase arrest and apoptosis in HCT-116(p53(+/+)), HCT-116(p53(-/-)) and HCT-116(p21(-/-)) cell lines. Curcumin 20-28 tumor protein p53 Homo sapiens 116-119 12466962-4 2002 Results showed that curcumin treatment causes p53- and p21-independent G(2)/M phase arrest and apoptosis in HCT-116(p53(+/+)), HCT-116(p53(-/-)) and HCT-116(p21(-/-)) cell lines. Curcumin 20-28 tumor protein p53 Homo sapiens 116-119 12130688-6 2002 Shikoccin (a diterpene), dibenzylideneacetone, and curcumin fit the pharmacophore hypothesis, inhibit cellular isopeptidases, and cause cell death independently of p53 in isogenic pairs of RKO and HCT 116 cells with differential p53 status. Curcumin 51-59 tumor protein p53 Homo sapiens 164-167 12130688-6 2002 Shikoccin (a diterpene), dibenzylideneacetone, and curcumin fit the pharmacophore hypothesis, inhibit cellular isopeptidases, and cause cell death independently of p53 in isogenic pairs of RKO and HCT 116 cells with differential p53 status. Curcumin 51-59 tumor protein p53 Homo sapiens 229-232 12408761-8 2002 The expression of c-myc, bcl-2, mutant-type p53 protein and mRNA was decreased sharply in CA46 cells treated with curcumin, while Fas protein and mRNA was increased. Curcumin 114-122 tumor protein p53 Homo sapiens 44-47 12408761-9 2002 CONCLUSION: Curcumin is able to inhibit the proliferation of CA46 cells and induce the cell apoptosis by down-regulating the expression of c-myc, bcl-2, mutant-type p53 and up-regulating the expression of Fas. Curcumin 12-20 tumor protein p53 Homo sapiens 165-168 10445426-6 1999 Curcumin treatment caused a reduction in the expression of Ki67, PCNA, and p53 mRNAs in breast cancer cells. Curcumin 0-8 tumor protein p53 Homo sapiens 75-78 11852106-0 2002 Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. Curcumin 0-8 tumor protein p53 Homo sapiens 64-67 11852106-2 2002 From quantitative image analysis data showing an increase in the percentage of cells with a sub-G0/G1 DNA content, we demonstrated curcumin-induced apoptosis in the breast cancer cell line MCF-7, in which expression of wild-type p53 could be induced. Curcumin 131-139 tumor protein p53 Homo sapiens 229-232 11852106-4 2002 Further experiments using p53-null MDAH041 cell as well as low and high p53-expressing TR9-7 cell, in which p53 expression is under tight control of tetracycline, established that curcumin induced apoptosis in tumor cells via a p53-dependent pathway in which Bax is the downstream effector of p53. Curcumin 180-188 tumor protein p53 Homo sapiens 26-29 11852106-4 2002 Further experiments using p53-null MDAH041 cell as well as low and high p53-expressing TR9-7 cell, in which p53 expression is under tight control of tetracycline, established that curcumin induced apoptosis in tumor cells via a p53-dependent pathway in which Bax is the downstream effector of p53. Curcumin 180-188 tumor protein p53 Homo sapiens 72-75 11852106-4 2002 Further experiments using p53-null MDAH041 cell as well as low and high p53-expressing TR9-7 cell, in which p53 expression is under tight control of tetracycline, established that curcumin induced apoptosis in tumor cells via a p53-dependent pathway in which Bax is the downstream effector of p53. Curcumin 180-188 tumor protein p53 Homo sapiens 72-75 11852106-4 2002 Further experiments using p53-null MDAH041 cell as well as low and high p53-expressing TR9-7 cell, in which p53 expression is under tight control of tetracycline, established that curcumin induced apoptosis in tumor cells via a p53-dependent pathway in which Bax is the downstream effector of p53. Curcumin 180-188 tumor protein p53 Homo sapiens 72-75 11852106-4 2002 Further experiments using p53-null MDAH041 cell as well as low and high p53-expressing TR9-7 cell, in which p53 expression is under tight control of tetracycline, established that curcumin induced apoptosis in tumor cells via a p53-dependent pathway in which Bax is the downstream effector of p53. Curcumin 180-188 tumor protein p53 Homo sapiens 72-75 10527691-0 1999 Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53. Curcumin 0-8 tumor protein p53 Homo sapiens 126-129 10527691-5 1999 Furthermore, curcumin downregulated the expression of survival genes egr-1, c-myc, and bcl-X(L) as well as the tumor suppressor gene p53 in B cells. Curcumin 13-21 tumor protein p53 Homo sapiens 133-136 11716543-2 2001 We found that curcumin caused cell death in eight melanoma cell lines, four with wild-type and four with mutant p53. Curcumin 14-22 tumor protein p53 Homo sapiens 112-115 11716543-10 2001 Since melanoma cells with mutant p53 are strongly resistant to conventional chemotherapy, curcumin may overcome the chemoresistance of these cells and provide potential new avenues for treatment. Curcumin 90-98 tumor protein p53 Homo sapiens 33-36 11285227-7 2001 Curcumin, a CSN kinase inhibitor, blocks E6-dependent p53 degradation in reticulocyte lysates. Curcumin 0-8 tumor protein p53 Homo sapiens 54-57 8989916-0 1996 Induction of HSP70 gene expression by modulation of Ca(+2) ion and cellular p53 protein by curcumin in colorectal carcinoma cells. Curcumin 91-99 tumor protein p53 Homo sapiens 76-79 9764849-0 1998 Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells. Curcumin 0-8 tumor protein p53 Homo sapiens 19-22 9764849-3 1998 In our study, consistent with the occurrence of DNA fragmentation, nuclear p53 protein initially increased at 12 h and peaked at 48 h after curcumin treatment. Curcumin 140-148 tumor protein p53 Homo sapiens 75-78 9215611-9 1997 Curcumin-induced cell death was neither due to apoptosis nor to any significant change in the expression of apoptosis-related genes, including Bcl-2, p53, cyclin B and transglutaminase. Curcumin 0-8 tumor protein p53 Homo sapiens 150-153 9764849-4 1998 Prior treatment of cells with cycloheximide or actinomycin D abolished the p53 increase and apoptosis induced by curcumin, suggesting that either de novo p53 protein synthesis or some proteins synthesis for stabilization of p53 is required for apoptosis. Curcumin 113-121 tumor protein p53 Homo sapiens 75-78 9764849-4 1998 Prior treatment of cells with cycloheximide or actinomycin D abolished the p53 increase and apoptosis induced by curcumin, suggesting that either de novo p53 protein synthesis or some proteins synthesis for stabilization of p53 is required for apoptosis. Curcumin 113-121 tumor protein p53 Homo sapiens 154-157 9764849-4 1998 Prior treatment of cells with cycloheximide or actinomycin D abolished the p53 increase and apoptosis induced by curcumin, suggesting that either de novo p53 protein synthesis or some proteins synthesis for stabilization of p53 is required for apoptosis. Curcumin 113-121 tumor protein p53 Homo sapiens 154-157 9764849-5 1998 In electrophoretic mobility gel-shift assays, nuclear extracts of cells treated with curcumin displayed distinct patterns of binding between p53 and its consensus binding site. Curcumin 85-93 tumor protein p53 Homo sapiens 141-144 9764849-6 1998 Supportive of these findings, p53 downstream targets, including p21(CIP1/WAF1) and Gadd45, could be induced to localize on the nucleus by curcumin with similar p53 kinetics. Curcumin 138-146 tumor protein p53 Homo sapiens 30-33 9764849-6 1998 Supportive of these findings, p53 downstream targets, including p21(CIP1/WAF1) and Gadd45, could be induced to localize on the nucleus by curcumin with similar p53 kinetics. Curcumin 138-146 tumor protein p53 Homo sapiens 160-163 9764849-10 1998 Finally, treatment of cells with p53 antisense oligonucleotide could effectively prevent curcumin-induced intracellular p53 protein increase and apoptosis, but sense p53 oligonucleotide could not. Curcumin 89-97 tumor protein p53 Homo sapiens 33-36 9764849-10 1998 Finally, treatment of cells with p53 antisense oligonucleotide could effectively prevent curcumin-induced intracellular p53 protein increase and apoptosis, but sense p53 oligonucleotide could not. Curcumin 89-97 tumor protein p53 Homo sapiens 120-123 9764849-10 1998 Finally, treatment of cells with p53 antisense oligonucleotide could effectively prevent curcumin-induced intracellular p53 protein increase and apoptosis, but sense p53 oligonucleotide could not. Curcumin 89-97 tumor protein p53 Homo sapiens 120-123 9764849-11 1998 Thus, our data suggest that the p53-associated signaling pathway is critically involved in curcumin-mediated apoptotic cell death. Curcumin 91-99 tumor protein p53 Homo sapiens 32-35 8989916-5 1996 The reduction of p53 gene expression was accompanied by the induction of HSP70 gene expression in the curcumin-treated cells. Curcumin 102-110 tumor protein p53 Homo sapiens 17-20 8989916-6 1996 These findings suggest that curcumin may induce the expression of the HSP70 gene through the initial depletion of intracellular Ca(+2), followed by the suppression of p53 gene function in the target cells. Curcumin 28-36 tumor protein p53 Homo sapiens 167-170 33809462-8 2021 This review discusses curcumin"s anticancer mechanism through modulation of Rb, p53, MAPK, P13K/Akt, JAK/STAT, Shh, and NF-kappaB pathways, which are commonly involved and dysregulated in preclinical and clinical GBM models. Curcumin 22-30 tumor protein p53 Homo sapiens 80-83 34331475-0 2021 Curcumin induced G2/M cycle arrest in SK-N-SH neuroblastoma cells through the ROS-mediated p53 signaling pathway. Curcumin 0-8 tumor protein p53 Homo sapiens 91-94 34896432-9 2022 Furthermore, curcumin was found that it could not only reduce the mRNA and protein levels of mitophagy (PINK1, Parkin, LC3, p62) and pro-apoptotic genes (p53, Bax, Caspase-3, Cytc), but also increased the levels of anti-apoptotic genes (Bcl-2). Curcumin 13-21 tumor protein p53 Homo sapiens 154-157 34331475-6 2021 Furthermore, curcumin promoted the overproduction of intracellular ROS and apoptosis induced by activating p53 and Bcl-2 signal pathways. Curcumin 13-21 tumor protein p53 Homo sapiens 107-110 34298639-6 2021 The current review has highlighted the anticancer activity of curcumin in hormone-independent breast cancer via focusing on its impact on key signaling pathways including the PI3K/Akt/mTOR pathway, JAK/STAT pathway, MAPK pathway, NF-kB pathway, p53 pathway, and Wnt/beta-catenin, as well as apoptotic and cell cycle pathways. Curcumin 62-70 tumor protein p53 Homo sapiens 245-248 34577580-6 2021 Our network and pathway analyses implicated the four targets of AKT1, RELA, MAPK1, and TP53 that could be involved in the inhibitory effects of curcumin on influenza. Curcumin 144-152 tumor protein p53 Homo sapiens 87-91 33857585-0 2021 Anti-Proliferative and Apoptotic Effect of Gemini Curcumin in p53-Wild Type and p53-Mutant Colorectal Cancer Cell Lines. Curcumin 50-58 tumor protein p53 Homo sapiens 62-65 34195018-16 2021 The expression of apoptosis regulatory genes assessed by PCR revealed an upregulation of p53 by ME, accompanied by downregulation of Bcl-2 and high expression of Bax after treatment with curcumin. Curcumin 187-195 tumor protein p53 Homo sapiens 89-92 35487055-9 2022 Generally, both cell lines treated with the combination of Curcumin and As2O3 displayed decreased angiogenesis genes (VEGFA and VEGFC), apoptosis genes (BAX and Bcl2), and prostate cancer marker (KLK2), the zinc-finger protein (SNAIL); and an increase in expression (P < 0.05) of cell-cell adhesion molecule (E-cadherin) and tumor suppressor gene (P53) genes. Curcumin 59-67 tumor protein p53 Homo sapiens 348-351 33857585-0 2021 Anti-Proliferative and Apoptotic Effect of Gemini Curcumin in p53-Wild Type and p53-Mutant Colorectal Cancer Cell Lines. Curcumin 50-58 tumor protein p53 Homo sapiens 80-83 33278547-5 2021 RESULTS: Our results showed that the Curcumin binds p53Y220C with Kd = 3.169 +- 0.257 muM and it increases the DNA binding affinity of the mutant by 4-fold with Kd = 851.29 +- 186.27 nM. Curcumin 37-45 tumor protein p53 Homo sapiens 52-55 33937075-11 2021 Curcumin-mediated covalent binding of MYC to TRRAP reduces the protein amounts of both interaction partners but does not downregulate TP53, so that the growth-arresting effect of wild type TP53 could prevail. Curcumin 0-8 tumor protein p53 Homo sapiens 189-193 33278547-7 2021 By caspase and Annexin V assays, we could demonstrate Curcumin at 3 muM to 8 muM concentration could initiate p53 mediated apoptosis in BxPC-3 cell lines. Curcumin 54-62 tumor protein p53 Homo sapiens 110-113 32420759-11 2021 Combination of quercetin and curcumin was effective on genes that were particularly related to p53, NF-kappaB and TGF-alpha pathways. Curcumin 29-37 tumor protein p53 Homo sapiens 95-98 33486250-5 2021 We hypothesized that curcumin attenuates fluoride toxicity through modulation of Ac-p53. Curcumin 21-29 tumor protein p53 Homo sapiens 84-87 33486250-6 2021 Here we investigated how curcumin affects the p53-p21 pathway in fluoride toxicity. Curcumin 25-33 tumor protein p53 Homo sapiens 46-49 33486250-13 2021 However, curcumin itself significantly increased Ac-p53 and upregulated p21 protein levels to suppress cell proliferation in a dose-dependent manner. Curcumin 9-17 tumor protein p53 Homo sapiens 52-55 33486250-16 2021 These results suggest that curcumin-induced Ac-p53 and p21 led to cell cycle arrest, while curcumin attenuated fluoride-mediated apoptosis via activation of Akt and suppressed fluoride-mediated DNA damage. Curcumin 27-35 tumor protein p53 Homo sapiens 47-50 33320772-0 2021 Influence of common dietary supplements (curcumin, andrographolide, and d-limonene) on the radiobiological responses of p53-competent colonic cancer epithelial cells. Curcumin 41-49 tumor protein p53 Homo sapiens 120-123 33320772-1 2021 PURPOSE: The main goal of the research was to determine whether commercially available common dietary phytochemical supplements (curcumin, andrographolide, and d-limonene) have radiomodulatory effects on p53-competent human colonic epithelial cells. Curcumin 129-137 tumor protein p53 Homo sapiens 204-207 32864863-0 2021 Curcumin induced apoptosis is mediated through oxidative stress in mutated p53 and wild type p53 colon adenocarcinoma cell lines. Curcumin 0-8 tumor protein p53 Homo sapiens 75-78 32864863-0 2021 Curcumin induced apoptosis is mediated through oxidative stress in mutated p53 and wild type p53 colon adenocarcinoma cell lines. Curcumin 0-8 tumor protein p53 Homo sapiens 93-96 32864863-3 2021 This study evaluates the role of p53 in curcumin mediated ROS generation and cell death. Curcumin 40-48 tumor protein p53 Homo sapiens 33-36 32864863-9 2021 Our results indicate that curcumin induces ROS mediated cell death in colon adenocarcinoma cell lines and may be mediated via p53. Curcumin 26-34 tumor protein p53 Homo sapiens 126-129 33046993-8 2020 Our results showed that curcumin induced ROS accumulation, apoptosis, autophagy, cell cycle arrest, and cellular senescence accompanied by upregulation of p53 and p21 proteins in SiHa cells. Curcumin 24-32 tumor protein p53 Homo sapiens 155-158 32934683-8 2020 These results indicated that the combination of rAd-p53 with curcumin synergistically potentiates apoptosis and inhibit EMT compared with either rAd-p53 or curcumin treatment alone via the regulation of TP53 regulation. Curcumin 61-69 tumor protein p53 Homo sapiens 203-207 32934683-8 2020 These results indicated that the combination of rAd-p53 with curcumin synergistically potentiates apoptosis and inhibit EMT compared with either rAd-p53 or curcumin treatment alone via the regulation of TP53 regulation. Curcumin 156-164 tumor protein p53 Homo sapiens 203-207 32934683-6 2020 Combined rAd-p53 and curcumin treatment resulted in higher p53 (P<0.01) and p21 (P<0.01) expression compared with rAd-p53 or curcumin were added alone, suggesting an additive effect on TP53 expression. Curcumin 21-29 tumor protein p53 Homo sapiens 59-62 32934683-6 2020 Combined rAd-p53 and curcumin treatment resulted in higher p53 (P<0.01) and p21 (P<0.01) expression compared with rAd-p53 or curcumin were added alone, suggesting an additive effect on TP53 expression. Curcumin 21-29 tumor protein p53 Homo sapiens 59-62 32934683-6 2020 Combined rAd-p53 and curcumin treatment resulted in higher p53 (P<0.01) and p21 (P<0.01) expression compared with rAd-p53 or curcumin were added alone, suggesting an additive effect on TP53 expression. Curcumin 21-29 tumor protein p53 Homo sapiens 185-189 32934683-6 2020 Combined rAd-p53 and curcumin treatment resulted in higher p53 (P<0.01) and p21 (P<0.01) expression compared with rAd-p53 or curcumin were added alone, suggesting an additive effect on TP53 expression. Curcumin 125-133 tumor protein p53 Homo sapiens 13-16 32141677-2 2020 Curcumin is considered to play a role in the regulation of T-lymphocytes function in the lymphoid tissue of the large intestine, apoptosis of the human papilloma and the activity of the 26S proteasome, and p53 level. Curcumin 0-8 tumor protein p53 Homo sapiens 206-209 32445778-9 2020 Further, we found that curcumin promoted the PTEN and p53 expression, as the tumor suppressor genes. Curcumin 23-31 tumor protein p53 Homo sapiens 54-57 32605658-6 2020 RESULTS: We found that the curcumin compound induced a certain degree of cell death in all tested cancer cell lines, independently of the p53 status. Curcumin 27-35 tumor protein p53 Homo sapiens 138-141 32774710-0 2020 Downregulation of LINC01021 by curcumin analog Da0324 inhibits gastric cancer progression through activation of P53. Curcumin 31-39 tumor protein p53 Homo sapiens 112-115 32657624-10 2021 Curcumin induces apoptosis in Pre B- ALL and T- ALL cells by decreased NF-kB levels, increased p53 levels, PARP-1 cleavage. Curcumin 0-8 tumor protein p53 Homo sapiens 95-98 32605658-8 2020 Pharmacologic or genetic NRF2 inhibition further increased the curcumin-induced cell death in both mutp53- and wtp53-carrying cancer cell lines while it did not increase cell death in p53 null cells, suggesting a cytoprotective role for NRF2 and a critical role for functional p53 to achieve an efficient cancer cell response to therapy. Curcumin 63-71 tumor protein p53 Homo sapiens 102-105 32605658-8 2020 Pharmacologic or genetic NRF2 inhibition further increased the curcumin-induced cell death in both mutp53- and wtp53-carrying cancer cell lines while it did not increase cell death in p53 null cells, suggesting a cytoprotective role for NRF2 and a critical role for functional p53 to achieve an efficient cancer cell response to therapy. Curcumin 63-71 tumor protein p53 Homo sapiens 113-116 32617134-8 2020 Further, curcumin-induced DNA demethylation of hGCCs was mediated by the damaged DNA repair-p53-p21/GADD45A-cyclin/CDK-Rb/E2F-DNMT1 axis. Curcumin 9-17 tumor protein p53 Homo sapiens 92-95 29974318-2 2018 In the present study, we investigated the preventive effects of curcumin against AFB1-induced apoptosis through the molecular regulation of p53, caspase-3, Bax, caspase-9, Bcl-2 and cytochrome-C associated with mitochondrial pathway. Curcumin 64-72 tumor protein p53 Homo sapiens 140-143 31526948-0 2020 Curcumin stabilizes p53 by interaction with NAD(P)H:quinone oxidoreductase 1 in tumor-derived cell lines. Curcumin 0-8 tumor protein p53 Homo sapiens 20-23 31526948-1 2020 Curcumin is a natural phytochemical with potent anti-neoplastic properties including modulation of p53. Curcumin 0-8 tumor protein p53 Homo sapiens 99-102 31526948-3 2020 The purpose of this study was to describe a mechanism by which curcumin restores p53 levels in human cancer cell lines. Curcumin 63-71 tumor protein p53 Homo sapiens 81-84 31526948-5 2020 Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin. Curcumin 20-28 tumor protein p53 Homo sapiens 56-59 31526948-5 2020 Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin. Curcumin 20-28 tumor protein p53 Homo sapiens 94-97 31526948-5 2020 Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin. Curcumin 20-28 tumor protein p53 Homo sapiens 94-97 31526948-5 2020 Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin. Curcumin 174-182 tumor protein p53 Homo sapiens 56-59 31526948-5 2020 Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin. Curcumin 174-182 tumor protein p53 Homo sapiens 94-97 31526948-5 2020 Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin. Curcumin 174-182 tumor protein p53 Homo sapiens 94-97 31526948-6 2020 Interestingly, the cell viability assay after treatment with curcumin showed that the cytotoxic activity was selectively higher in cervical cancer cells contained wild type p53 but not in breast cancer cells contained mutated p53. Curcumin 61-69 tumor protein p53 Homo sapiens 173-176 31526948-6 2020 Interestingly, the cell viability assay after treatment with curcumin showed that the cytotoxic activity was selectively higher in cervical cancer cells contained wild type p53 but not in breast cancer cells contained mutated p53. Curcumin 61-69 tumor protein p53 Homo sapiens 226-229 31526948-7 2020 The cytotoxic effect of curcumin in cervical cancer cells was related to the complex p53-NQO1 that avoids the interaction between p53 and its negative regulator ubiquitin ligase E6-associated protein (E6AP). Curcumin 24-32 tumor protein p53 Homo sapiens 85-88 31526948-7 2020 The cytotoxic effect of curcumin in cervical cancer cells was related to the complex p53-NQO1 that avoids the interaction between p53 and its negative regulator ubiquitin ligase E6-associated protein (E6AP). Curcumin 24-32 tumor protein p53 Homo sapiens 130-133 31752145-0 2019 Curcumin Nicotinate Selectively Induces Cancer Cell Apoptosis and Cycle Arrest through a P53-Mediated Mechanism. Curcumin 0-19 tumor protein p53 Homo sapiens 89-92 31752145-4 2019 In cancer cells, CN induced apoptosis and cell cycle arrest at G2/M phase through a p53-mediated mechanism, where p53 was activated, p21 and pro-apoptotic proteins Bid and Bak were upregulated, and PARP was cleaved. Curcumin 17-19 tumor protein p53 Homo sapiens 84-87 31752145-4 2019 In cancer cells, CN induced apoptosis and cell cycle arrest at G2/M phase through a p53-mediated mechanism, where p53 was activated, p21 and pro-apoptotic proteins Bid and Bak were upregulated, and PARP was cleaved. Curcumin 17-19 tumor protein p53 Homo sapiens 114-117 31752145-5 2019 In non-transformed human mammary epithelial cells MCF10A, CN at 50 microM had no cytotoxicity and p53 was not activated, but curcumin at 12.5 microM activated p53 and p21 and inhibited MCF10A cell growth. Curcumin 125-133 tumor protein p53 Homo sapiens 159-162 31752145-6 2019 These data suggest that CN inhibits cell growth and proliferation through p53-mediated apoptosis and cell cycle arrest with cancer cell selectivity. Curcumin 24-26 tumor protein p53 Homo sapiens 74-77 31236854-0 2019 MicroRNA-1246 regulates the radio-sensitizing effect of curcumin in bladder cancer cells via activating P53. Curcumin 56-64 tumor protein p53 Homo sapiens 104-107 31236854-12 2019 CONCLUSION: miR-1246 is involved in the anti-cancer effects of curcumin and irradiation through targeting the inhibition of p53 gene translation in bladder cancer cells. Curcumin 63-71 tumor protein p53 Homo sapiens 124-127 30483727-5 2019 Curcumin targets numerous signaling pathways associated with cancer therapy, including pathways mediated by p53, Ras, phosphatidylinositol-3-kinase, protein kinase B, Wnt-beta catenin and mammalian target of rapamycin. Curcumin 0-8 tumor protein p53 Homo sapiens 108-111 32605658-0 2020 A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status. Curcumin 16-24 tumor protein p53 Homo sapiens 122-125 31526948-9 2020 Collectively, our findings showed that curcumin is necessary to promote the protein interaction of NQO1 with p53, therefore, it increases the half-life of p53, and permits the cytotoxic effect of curcumin in cancer cells containing wild type p53. Curcumin 39-47 tumor protein p53 Homo sapiens 109-112 31526948-9 2020 Collectively, our findings showed that curcumin is necessary to promote the protein interaction of NQO1 with p53, therefore, it increases the half-life of p53, and permits the cytotoxic effect of curcumin in cancer cells containing wild type p53. Curcumin 39-47 tumor protein p53 Homo sapiens 155-158 31526948-9 2020 Collectively, our findings showed that curcumin is necessary to promote the protein interaction of NQO1 with p53, therefore, it increases the half-life of p53, and permits the cytotoxic effect of curcumin in cancer cells containing wild type p53. Curcumin 39-47 tumor protein p53 Homo sapiens 155-158 31526948-9 2020 Collectively, our findings showed that curcumin is necessary to promote the protein interaction of NQO1 with p53, therefore, it increases the half-life of p53, and permits the cytotoxic effect of curcumin in cancer cells containing wild type p53. Curcumin 196-204 tumor protein p53 Homo sapiens 109-112 31526948-10 2020 Our findings suggest that the use of curcumin may reactivate the p53 pathway in cancer cells with p53 wild-type. Curcumin 37-45 tumor protein p53 Homo sapiens 65-68 31526948-10 2020 Our findings suggest that the use of curcumin may reactivate the p53 pathway in cancer cells with p53 wild-type. Curcumin 37-45 tumor protein p53 Homo sapiens 98-101 31798724-2 2019 The aim of this study was to determine how curcumin (CRM) used as an adjuvant supports the apoptotic process induced by a single chemical agent treatment (cisplatin-CisPT) on two head and neck squamous cell carcinoma cell lines (FaDu and PE/CA-PJ49) and the involvement of ERK1/2 and/or p53 activation in this process. Curcumin 43-51 tumor protein p53 Homo sapiens 287-290 31798724-2 2019 The aim of this study was to determine how curcumin (CRM) used as an adjuvant supports the apoptotic process induced by a single chemical agent treatment (cisplatin-CisPT) on two head and neck squamous cell carcinoma cell lines (FaDu and PE/CA-PJ49) and the involvement of ERK1/2 and/or p53 activation in this process. Curcumin 53-56 tumor protein p53 Homo sapiens 287-290 31798724-4 2019 CRM induced an increase of p53 protein phosphorylation in both cell lines. Curcumin 0-3 tumor protein p53 Homo sapiens 27-30 31798724-8 2019 Our data suggest that p53 phosphorylation in the apoptotic process induced by CRM treatment might require the involvement of ERK1/2. Curcumin 78-81 tumor protein p53 Homo sapiens 22-25 31798724-10 2019 Moreover, in both tumor cell lines our results support the involvement of p53 phosphorylation-ERK1/2 activation-dependent in the apoptosis induced by combined treatments (CisPt and CRM). Curcumin 181-184 tumor protein p53 Homo sapiens 74-77 31018701-0 2019 Curcumin induces p53-independent inactivation of Nrf2 during oxidative stress-induced apoptosis. Curcumin 0-8 tumor protein p53 Homo sapiens 17-20 31018701-6 2019 Interestingly, at early times of exposure to a proapoptotic dose of curcumin (15 muM), we observed nuclear accumulation of Nrf2 and the expression of Nrf2 target genes, whereas at late exposure times we found a reduction of total and nuclear protein levels of Nrf2 as well as downregulation of Nrf2 target genes in the absence of p53 activation. Curcumin 68-76 tumor protein p53 Homo sapiens 330-333 30623450-9 2019 Curcumin can also upregulate the expression and activity of p53 that inhibits tumor cell proliferation and increases apoptosis. Curcumin 0-8 tumor protein p53 Homo sapiens 60-63 30935902-6 2019 The inhibitory effect of curcumin, piperine and vitamin E on cell proliferation involves different markers, and in particular inhibits beta-catenin, cyclinD1 and p53, making them candidates for a possible use in alternative therapies although further studies are needed. Curcumin 25-33 tumor protein p53 Homo sapiens 162-165 31223280-7 2019 The anticancer effects of curcumin are mainly mediated through its regulation of multiple cellular signaling pathways, including Wnt/beta-catenin, PI3K/Akt, JAK/STAT, MAPK, p53 and NF-kB signaling pathways. Curcumin 26-34 tumor protein p53 Homo sapiens 173-176 30143976-7 2018 Intriguingly, dietary curcumin supplementation modulated autophagy through the activation of beclin-1, ATG5, Dynein, LC3a, LC3b-I/II and downregulation of p53 & mTOR expression level. Curcumin 22-30 tumor protein p53 Homo sapiens 155-158 30568488-0 2018 Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action. Curcumin 8-16 tumor protein p53 Homo sapiens 31-34 30568488-11 2018 This review summarizes the effects of curcumin as a regulator of p53 in BC and the key molecular mechanisms of this regulation. Curcumin 38-46 tumor protein p53 Homo sapiens 65-68 29966255-0 2018 The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1. Curcumin 4-12 tumor protein p53 Homo sapiens 119-122 29966255-8 2018 These results suggest that CH-5 has potentially higher anticancer activity than curcumin, which is associated with the expression of apoptosis-associated genes regulated by the transcription factors Sp1 and p53. Curcumin 80-88 tumor protein p53 Homo sapiens 207-210 29110611-13 2017 Further study showed curcumin induced cell cycle arrest by activating G2 checkpoint through p53 pathway. Curcumin 21-29 tumor protein p53 Homo sapiens 92-95 28926094-0 2018 Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling. Curcumin 0-8 tumor protein p53 Homo sapiens 105-108 28926094-1 2018 In this study, we aimed to investigate the effects of curcumin on cell activities of gastric cancer (GC), and the connection between curcumin and P53, as well as, PI3K signaling. Curcumin 133-141 tumor protein p53 Homo sapiens 146-149 28926094-4 2018 Western blot assay was also employed to detect impacts of curcumin on tophosphatidylinositol-3 kinase (PI3K) and P53 signaling pathways-related proteins. Curcumin 58-66 tumor protein p53 Homo sapiens 113-116 28926094-8 2018 Western blot results showed that curcumin activated P53 signaling pathway and inhibited PI3K signaling pathway. Curcumin 33-41 tumor protein p53 Homo sapiens 52-55 28926094-10 2018 Additionally, curcumin activated the P53 signaling pathway by up-regulating P53 and P21, which also inhibited PI3K pathway through down-regulating PI3K, p-Akt, and p-mTOR. Curcumin 14-22 tumor protein p53 Homo sapiens 37-40 28926094-10 2018 Additionally, curcumin activated the P53 signaling pathway by up-regulating P53 and P21, which also inhibited PI3K pathway through down-regulating PI3K, p-Akt, and p-mTOR. Curcumin 14-22 tumor protein p53 Homo sapiens 76-79 27819521-4 2018 Moreover, we found that combination treatment of miR-326 and curcumin caused significant inhibition of the SHH/GLI1 pathway in glioma cells compared with either treatment alone, independent of p53 status. Curcumin 61-69 tumor protein p53 Homo sapiens 193-196 29673545-0 2018 Curcumin induces apoptosis and cell cycle arrest via the activation of reactive oxygen species-independent mitochondrial apoptotic pathway in Smad4 and p53 mutated colon adenocarcinoma HT29 cells. Curcumin 0-8 tumor protein p53 Homo sapiens 152-155 29673545-12 2018 In conclusion, our data provide the first evidence that curcumin induces ROS independent apoptosis and cell cycle arrest in colon cancer cells that carry mutation on Smad4 and p53. Curcumin 56-64 tumor protein p53 Homo sapiens 176-179 29223572-0 2018 Curcumin ameliorates the in vitro efficacy of carfilzomib in human multiple myeloma U266 cells targeting p53 and NF-kappaB pathways. Curcumin 0-8 tumor protein p53 Homo sapiens 105-108 29223572-8 2018 Our results confirmed the induction of p53/p21 axis and G0/G1 cell cycle arrest in anticancer activities of both drugs, an effect more pronounced for the CFZ-curcumin tested combinations. Curcumin 158-166 tumor protein p53 Homo sapiens 39-42 28902433-14 2018 Curcumin also regulated the BLM and IL-17A mediated changes in p53-PAI-1 expression. Curcumin 0-8 tumor protein p53 Homo sapiens 63-66 28902433-15 2018 Curcumin has the ability to regulate inflammatory cytokines during BLM-induced injury and their effect on p53-PAI-1 expression. Curcumin 0-8 tumor protein p53 Homo sapiens 106-109 29333130-3 2017 Here, curcumin, flavokawain B, and alpinetin were docked against the crystal structure of R273H mutant p53 in silico. Curcumin 6-14 tumor protein p53 Homo sapiens 103-106 29333130-4 2017 Consequently, all the compounds bind to the cavity of R273H mutant p53 with a dissociation constant estimated to have 36.57, 70.77, and 75.11 microM for curcumin, flavokawain B, and alpinetin, respectively. Curcumin 153-161 tumor protein p53 Homo sapiens 67-70 29382728-0 2018 The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53. Curcumin 4-12 tumor protein p53 Homo sapiens 80-83 29382728-0 2018 The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53. Curcumin 4-12 tumor protein p53 Homo sapiens 129-132 29382728-5 2018 Here, we report on the effects of a curcumin analog, HO-3867, on p53 activity in cancer cells from different origins. Curcumin 36-44 tumor protein p53 Homo sapiens 65-68 28902433-0 2018 Curcumin alleviates IL-17A-mediated p53-PAI-1 expression in bleomycin-induced alveolar basal epithelial cells. Curcumin 0-8 tumor protein p53 Homo sapiens 36-39 28870897-6 2017 Detailed analyses revealed that the mTORC1 and p53 signaling pathways are main targets of curcumin. Curcumin 90-98 tumor protein p53 Homo sapiens 47-50 27989010-0 2017 Effect of curcumin on the expression of p53, transforming growth factor-beta, and inducible nitric oxide synthase in oral submucous fibrosis: A pilot study. Curcumin 10-18 tumor protein p53 Homo sapiens 40-43 27989010-6 2017 After therapy with curcumin, a decrease in the expression of p53, TGF-beta, and iNOS was seen in 25%, 32.1%, and 32.1% of the samples, respectively; however, the difference in pretreatment and post-treatment expressions was not found to be statistically significant. Curcumin 19-27 tumor protein p53 Homo sapiens 61-64 27989010-7 2017 CONCLUSION: The present finding suggest that curcumin could have an effect on the expression of p53, iNOS, and TGF-beta in OSMF, and thus, could prove to be an effective chemopreventive agent for its management. Curcumin 45-53 tumor protein p53 Homo sapiens 96-99 28539160-3 2017 Jab1 stimulated phosphorylation of p53 at T155 was inhibited by curcumin, an inhibitor of COP9 signalosome (CSN)-associated kinases. Curcumin 64-72 tumor protein p53 Homo sapiens 35-38 28684422-0 2017 WITHDRAWN: Curcumin shifts RAS-induced pro-proliferative MEK/ERK-signaling toward pro-apoptotic p38MAPK/JNK1-signaling, triggering p53 activation and apoptosis. Curcumin 11-19 tumor protein p53 Homo sapiens 131-134 28575972-4 2017 After irradiation, the obtained curcumin loaded micelle showed a better transfection, and the p53 protein expression in Hela cells was higher. Curcumin 32-40 tumor protein p53 Homo sapiens 94-97 28575972-5 2017 The apoptosis assay showed that the complex could induce a more significant apoptosis to Hela cells than that of curcumin or p53 used alone, and the curcumin loaded micelle inducing apoptosis was best after irradiation. Curcumin 149-157 tumor protein p53 Homo sapiens 125-128 28881600-0 2017 Curcumin induces G2/M cell cycle arrest and apoptosis of head and neck squamous cell carcinoma in vitro and in vivo through ATM/Chk2/p53-dependent pathway. Curcumin 0-8 tumor protein p53 Homo sapiens 133-136 27657825-12 2016 The apoptosis related protein p53 expression was increased, and apoptosis suppressor Bcl-2 was inhibited in DU-145 after curcumin treatment. Curcumin 121-129 tumor protein p53 Homo sapiens 30-33 28152473-0 2017 Combination of arabinogalactan and curcumin induces apoptosis in breast cancer cells in vitro and inhibits tumor growth via overexpression of p53 level in vivo. Curcumin 35-43 tumor protein p53 Homo sapiens 142-145 28199187-8 2017 Interestingly, the combined treatment with curcumin and docetaxel modulates the expression of RTKs, PI3K, phospho-AKT, NF-kappa B, p53, and COX-2. Curcumin 43-51 tumor protein p53 Homo sapiens 131-134 27604683-0 2017 Antiproliferative and Apoptotic Effect of Dendrosomal Curcumin Nanoformulation in P53 Mutant and Wide-Type Cancer Cell Lines. Curcumin 54-62 tumor protein p53 Homo sapiens 82-85 28769986-0 2017 Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway. Curcumin 0-8 tumor protein p53 Homo sapiens 17-20 28769986-2 2017 This study explored the mechanism by which curcumin induces p53-null hepatoma cell apoptosis. Curcumin 43-51 tumor protein p53 Homo sapiens 60-63 28105222-10 2016 Furthermore, while curcumin induced cell apoptosis and enhanced the expression ratio of Bax/Bcl-2, which are downstream molecules of p53, ectopic expression of H19 inhibited curcumin-induced cell apoptosis. Curcumin 19-27 tumor protein p53 Homo sapiens 133-136 27779649-5 2016 Results indicated that curcumin combined with paclitaxel decreased c-Ha-Ras, Rho-A, p53 and Bcl-xL gene expression in comparison to control and substances alone in MCF-7 cell line. Curcumin 23-31 tumor protein p53 Homo sapiens 84-87 27779649-11 2016 Curcumin alone and combined with paclitaxel increased p53, Bid, caspase-3, caspase-8 and Bax gene expression in MDA-MB-231, whereas Bcl-xL decreased such expression in MDA-MB-231 cells. Curcumin 0-8 tumor protein p53 Homo sapiens 54-57 28105206-0 2016 Curcumin enhances temsirolimus-induced apoptosis in human renal carcinoma cells through upregulation of YAP/p53. Curcumin 0-8 tumor protein p53 Homo sapiens 108-111 28105206-5 2016 Co-treatment with temsirolimus and curcumin led to the activation of cleaved poly ADP-ribose polymerase and caspase 3, upregulation of p53 expression and nuclear translocation, and downregulation of B-cell lymphoma 2 protein expression. Curcumin 35-43 tumor protein p53 Homo sapiens 135-138 28105206-6 2016 Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells. Curcumin 13-21 tumor protein p53 Homo sapiens 198-201 28105206-6 2016 Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells. Curcumin 13-21 tumor protein p53 Homo sapiens 321-324 28105206-6 2016 Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells. Curcumin 159-167 tumor protein p53 Homo sapiens 198-201 28105206-6 2016 Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells. Curcumin 159-167 tumor protein p53 Homo sapiens 321-324 28105206-6 2016 Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells. Curcumin 159-167 tumor protein p53 Homo sapiens 198-201 28105206-6 2016 Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells. Curcumin 159-167 tumor protein p53 Homo sapiens 321-324 28105206-7 2016 In conclusion, the present results indicate that combined curcumin and temsirolimus treatment has a synergistic effect on apoptosis in human RCC cells, through the activation of p53. Curcumin 58-66 tumor protein p53 Homo sapiens 178-181 28105206-8 2016 Mechanistically, YAP is essential in the induction of p53 expression by curcumin. Curcumin 72-80 tumor protein p53 Homo sapiens 54-57 28105222-1 2016 Curcumin, a major phytochemical in turmeric, inhibits the proliferation of many types of solid cancer cells by enhancing p53 expression. Curcumin 0-8 tumor protein p53 Homo sapiens 121-124 28096969-9 2016 CONCLUSION: The findings of the current study suggest that our combination strategy, which merges two detached gene (p53) and drug (curcumin) delivery systems into an integrated platform, may represent huge potential as a novel and efficient modality for glioblastoma treatment. Curcumin 132-140 tumor protein p53 Homo sapiens 117-120 27564099-9 2016 Moreover, pretreatment with U0126 suppressed curcumin and cisplatin-induced upregulation of p53, p21, and p-STAT3 and downregulation of survival proteins in both cells. Curcumin 45-53 tumor protein p53 Homo sapiens 92-95 27626169-0 2016 The putative oncotarget CSN5 controls a transcription-uncorrelated p53-mediated autophagy implicated in cancer cell survival under curcumin treatment. Curcumin 131-139 tumor protein p53 Homo sapiens 67-70 27626169-2 2016 The COP9 signalosome (CSN) component CSN5, a known specific target for curcumin, can control p53 stability by increasing its degradation through ubiquitin system. Curcumin 71-79 tumor protein p53 Homo sapiens 93-96 27626169-3 2016 But the correlation of CSN5-controlled p53 to anticancer therapeutic effect of curcumin is currently unknown. Curcumin 79-87 tumor protein p53 Homo sapiens 39-42 27626169-4 2016 Here we showed that CSN5-controlled p53 was transcriptional inactive and responsible for autophagy in human normal BJ cells and cancer HepG2 cells under curcumin treatment. Curcumin 153-161 tumor protein p53 Homo sapiens 36-39 27626169-5 2016 Of note, CSN5-initiated cellular autophagy by curcumin treatment was abolished in p53-null HCT116p53-/- cancer cells, which could be rescued by reconstitution with wild-type p53 or transcription inactive p53 mutant p53R273H. Curcumin 46-54 tumor protein p53 Homo sapiens 82-85 27626169-5 2016 Of note, CSN5-initiated cellular autophagy by curcumin treatment was abolished in p53-null HCT116p53-/- cancer cells, which could be rescued by reconstitution with wild-type p53 or transcription inactive p53 mutant p53R273H. Curcumin 46-54 tumor protein p53 Homo sapiens 97-100 27626169-5 2016 Of note, CSN5-initiated cellular autophagy by curcumin treatment was abolished in p53-null HCT116p53-/- cancer cells, which could be rescued by reconstitution with wild-type p53 or transcription inactive p53 mutant p53R273H. Curcumin 46-54 tumor protein p53 Homo sapiens 97-100 27626169-6 2016 Furthermore, CSN5-controlled p53 conferred a pro-survival autophagy in diverse cancer cells response to curcumin. Curcumin 104-112 tumor protein p53 Homo sapiens 29-32 27626169-7 2016 Genetic p53 deletion, as well as autophagy pharmacological inhibition by chloroquine, significantly enhanced the therapeutic effect of curcumin on cancer cells in vitro and in vivo, but not normal cells. Curcumin 135-143 tumor protein p53 Homo sapiens 8-11 27626169-9 2016 The p53 expression state is a useful biomarker for predicting the anticancer therapeutic effect of curcumin. Curcumin 99-107 tumor protein p53 Homo sapiens 4-7 28105222-7 2016 The protein expression of p53, B-cell lymphoma (Bcl)-2, Bcl-2-associated X protein (Bax) and c-Myc in curcumin-treated cells was detected by western blotting. Curcumin 102-110 tumor protein p53 Homo sapiens 26-29 27404761-6 2016 The cells treated with 50microM of curcumin, 30.91microM (NEC-1), 20.70microM (NEC-2) and 16.86microM (NEC-3) showed enhanced activation of p53 and elevated bax/Bcl2 expression (NEC-3), increased cytochrome-c in cytosol (NEC-2) confirming the enhanced cytotoxicity. Curcumin 35-43 tumor protein p53 Homo sapiens 140-143 27564099-7 2016 In addition, when 253J-Bv cells were co-treated with curcumin and cisplatin, p53 and p21 expression levels were markedly increased when compared to controls. Curcumin 53-61 tumor protein p53 Homo sapiens 77-80 27556439-7 2016 Curcumin pre-treatment consistently and markedly down-regulated the mRNA expression levels of p53, Bax, caspase-9 and -3 and up-regulated the mRNA expression level of Bcl-2. Curcumin 0-8 tumor protein p53 Homo sapiens 94-97 27468716-4 2016 In particular, extensive studies have demonstrated that curcumin targets numerous therapeutically important cancer signaling pathways such as p53, Ras, PI3K, AKT, Wnt-beta catenin, mTOR and so on. Curcumin 56-64 tumor protein p53 Homo sapiens 142-145 27261574-0 2016 Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells. Curcumin 0-8 tumor protein p53 Homo sapiens 77-80 27261574-5 2016 Besides this, Curcumin and Ellagic acid also restore p53, induce ROS formation and DNA damage. Curcumin 14-22 tumor protein p53 Homo sapiens 53-56 27283735-3 2016 Curcumin is known to activate 20S proteasome and promotes the degradation of intrinsically unfolded p53 tumor suppressor protein. Curcumin 0-8 tumor protein p53 Homo sapiens 100-103 27482284-7 2016 All of the studies indicated that curcumin decreased glioblastoma cell viability through various pathways (i.e. decrease in prosurvival proteins such as nuclear factor kappaB, activator protein 1, and phosphoinositide 3 kinase, and upregulation of apoptotic pathways like p21, p53, and executor caspase 3). Curcumin 34-42 tumor protein p53 Homo sapiens 277-280 26036622-0 2015 Curcumin Inhibits Invasiveness and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Through Reducing Matrix Metalloproteinase 2, 9 and Modulating p53-E-Cadherin Pathway. Curcumin 0-8 tumor protein p53 Homo sapiens 163-166 27228201-9 2016 Finally, we have shown that the inclusion complex of alpha-CD and curcumin (CCC) preferentially enters into the human lung cancer cell (A549) as compared to the normal lung fibroblast cell (WI38), causes apoptotic death, activates tumor suppressor protein (p53) and cyclin-dependent kinase inhibitor 1 (p21), and inhibits 3D spheroid growth of cancer cell. Curcumin 66-74 tumor protein p53 Homo sapiens 257-260 27082017-7 2016 Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB. Curcumin 23-31 tumor protein p53 Homo sapiens 220-223 26496980-8 2015 Numerous pathways, including p53, c-Jun N-terminal kinases (JNK), Akt and extracellular signal-regulated kinases (ERK)1/2 pathways were markedly altered following treatment of THP-1 cells with curcumin and naringenin. Curcumin 193-201 tumor protein p53 Homo sapiens 29-32 26496980-9 2015 These results indicated that naringenin may enhance curcumin-induced apoptosis through inhibiting the Akt and ERK pathways, and promoting the JNK and p53 pathways. Curcumin 52-60 tumor protein p53 Homo sapiens 150-153 26460892-0 2015 Curcumin induces p53-independent necrosis in H1299 cells via a mitochondria-associated pathway. Curcumin 0-8 tumor protein p53 Homo sapiens 17-20 26460892-1 2015 Curcumin has been shown to have various therapeutic and/or adjuvant therapeutic effects on human cancers, as it inhibits cancer cell proliferation and induces apoptosis through p53-dependent molecular pathways. Curcumin 0-8 tumor protein p53 Homo sapiens 177-180 26460892-2 2015 However, numerous cancer cell types bear a mutant p53 gene, and whether curcumin has any therapeutic effects on p53-deficient/mutant cancer cells has remained elusive. Curcumin 72-80 tumor protein p53 Homo sapiens 112-115 26460892-7 2015 In conclusion, the present study suggested that curcumin-induced necrotic cell death was mediated via a p53-independent molecular pathway, which was associated with Bax and Bak translocation, caspase activation and cytochrome c release. Curcumin 48-56 tumor protein p53 Homo sapiens 104-107 26974552-0 2016 Correction: Curcumin Significantly Enhances Dual PI3K/Akt and mTOR Inhibitor NVP-BEZ235-Induced Apoptosis in Human Renal Carcinoma Caki Cells through Down-Regulation of p53-Dependent Bcl-2 Expression and Inhibition of Mcl-1 Protein Stability. Curcumin 12-20 tumor protein p53 Homo sapiens 169-172 26490992-0 2016 Curcumin induces apoptosis in p53-null Hep3B cells through a TAp73/DNp73-dependent pathway. Curcumin 0-8 tumor protein p53 Homo sapiens 30-33 27457236-3 2016 At the molecular level, inhibition of NF-kB, Akt/PI3K, and MAPK pathways and enhancement of p53 are among the most important anticancer alterations induced by curcumin. Curcumin 159-167 tumor protein p53 Homo sapiens 92-95 26036622-5 2015 RESULTS: Our data showed that curcumin treatment not only decreased the expression of MMP-2 and MMP-9 to inhibit invasiveness in oral cancer but also modulated the expression of EMT markers, such as Snail, Twist, and E-cadherin, and induced p53 expression that is crucial to EMT repression. Curcumin 30-38 tumor protein p53 Homo sapiens 241-244 26472972-9 2015 Curcumin and citral generated ROS and activated p53 and poly (ADP-ribose) polymerase-1 mediated apoptotic pathways. Curcumin 0-8 tumor protein p53 Homo sapiens 48-51 26124332-7 2015 Curcumin also increased phosphorylation of p53 and Histone H2A.X (S140) in the nuclei of NCI-H460 cells. Curcumin 0-8 tumor protein p53 Homo sapiens 43-46 25910231-4 2015 Treatment of cells with curcumin induced both p53 and the related protein p73 in head and neck and lung cancer cell lines. Curcumin 24-32 tumor protein p53 Homo sapiens 46-49 25583641-7 2015 Further, the expression of two important cell cycle inhibitory proteins, p21 and p53, in the curcumin- and culture medium-treated cells without curcumin was evaluated by intracellular flow cytometry. Curcumin 93-101 tumor protein p53 Homo sapiens 81-84 25583641-10 2015 Flow cytometry analysis showed a twofold increase in the expression of both p21 and p53 in curcumin-treated cells as compared to the medium-treated cells, suggesting that curcumin inhibits EPC growth by mainly inhibiting the G1 to S phase transition in the cell cycle. Curcumin 91-99 tumor protein p53 Homo sapiens 84-87 25583641-10 2015 Flow cytometry analysis showed a twofold increase in the expression of both p21 and p53 in curcumin-treated cells as compared to the medium-treated cells, suggesting that curcumin inhibits EPC growth by mainly inhibiting the G1 to S phase transition in the cell cycle. Curcumin 171-179 tumor protein p53 Homo sapiens 84-87 25444916-8 2015 Conditional knockdown of p53 by tetracycline inducible expression system significantly abrogated curcumin-induced miR-192-5p/215 upregulation in the p53 wild-type H460, A427 and A549 cells. Curcumin 97-105 tumor protein p53 Homo sapiens 149-152 25780454-0 2015 Curcumin improves the paclitaxel-induced apoptosis of HPV-positive human cervical cancer cells via the NF-kappaB-p53-caspase-3 pathway. Curcumin 0-8 tumor protein p53 Homo sapiens 113-116 25780454-8 2015 The expression levels of p53 protein and cleaved caspase-3 were increased significantly in the curcumin plus paclitaxel-treated HeLa and CaSki cells compared with those in the cells treated with paclitaxel alone (P<0.01). Curcumin 95-103 tumor protein p53 Homo sapiens 25-28 25780454-10 2015 This suggests that the combined effect of curcumin and paclitaxel was associated with the NF-kappaB-p53-caspase-3 pathway. Curcumin 42-50 tumor protein p53 Homo sapiens 100-103 25780454-11 2015 In conclusion, curcumin has the ability to improve the paclitaxel-induced apoptosis of HPV-positive human cervical cancer cell lines via the NF-kappaB-p53-caspase-3 pathway. Curcumin 15-23 tumor protein p53 Homo sapiens 151-154 25789029-0 2015 A preliminary study of the effect of curcumin on the expression of p53 protein in a human multiple myeloma cell line. Curcumin 37-45 tumor protein p53 Homo sapiens 67-70 25789029-5 2015 The expression of p53 protein in the MM RPMI 8226 cells following treatment with curcumin was detected by western blotting and ELISA. Curcumin 81-89 tumor protein p53 Homo sapiens 18-21 25789029-7 2015 In the MM RPMI 8226 cells treated with curcumin, the expression of the p53 and Bax genes was upregulated, while the expression of the MDM2 gene was downregulated. Curcumin 39-47 tumor protein p53 Homo sapiens 71-74 25789029-8 2015 p53 protein expression was higher in the curcumin experimental group compared with the control group. Curcumin 41-49 tumor protein p53 Homo sapiens 0-3 25789029-10 2015 In the MM RPMI 8226 cells treated with curcumin, p53 protein levels were upregulated, which suggested that curcumin may promote the apoptosis of MM cells by upregulating p53 protein expression. Curcumin 39-47 tumor protein p53 Homo sapiens 49-52 25789029-10 2015 In the MM RPMI 8226 cells treated with curcumin, p53 protein levels were upregulated, which suggested that curcumin may promote the apoptosis of MM cells by upregulating p53 protein expression. Curcumin 39-47 tumor protein p53 Homo sapiens 170-173 25789029-10 2015 In the MM RPMI 8226 cells treated with curcumin, p53 protein levels were upregulated, which suggested that curcumin may promote the apoptosis of MM cells by upregulating p53 protein expression. Curcumin 107-115 tumor protein p53 Homo sapiens 49-52 25789029-10 2015 In the MM RPMI 8226 cells treated with curcumin, p53 protein levels were upregulated, which suggested that curcumin may promote the apoptosis of MM cells by upregulating p53 protein expression. Curcumin 107-115 tumor protein p53 Homo sapiens 170-173 25444916-0 2015 Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancer. Curcumin 0-8 tumor protein p53 Homo sapiens 46-49 25444916-7 2015 Curcumin also promoted miR-192-5p/215 expressions in A549 cells (p53 wild type) but not in H1299 cells (p53-null). Curcumin 0-8 tumor protein p53 Homo sapiens 65-68 25444916-8 2015 Conditional knockdown of p53 by tetracycline inducible expression system significantly abrogated curcumin-induced miR-192-5p/215 upregulation in the p53 wild-type H460, A427 and A549 cells. Curcumin 97-105 tumor protein p53 Homo sapiens 25-28 25444916-9 2015 Conversely, ectopic expression of exogenous wild-type but not R273H mutant p53 in the p53-null H1299 cells enabled miR-192-5p/215 response to curcumin treatment. Curcumin 142-150 tumor protein p53 Homo sapiens 75-78 25444916-9 2015 Conversely, ectopic expression of exogenous wild-type but not R273H mutant p53 in the p53-null H1299 cells enabled miR-192-5p/215 response to curcumin treatment. Curcumin 142-150 tumor protein p53 Homo sapiens 86-89 25444916-12 2015 Taken together, this study highlights that the proapoptotic effects of curcumin depend on miR-192-5p/215 induction and the p53-miR-192-5p/215-XIAP pathway is an important therapeutic target for non-small cell lung cancer. Curcumin 71-79 tumor protein p53 Homo sapiens 123-126 25262359-11 2015 Curcumin treatment also altered the expressions of apoptosis associated proteins NF-kappaB, p38 and p53. Curcumin 0-8 tumor protein p53 Homo sapiens 100-103