PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15118344-5 2004 Pretreatment of curcumin, an inhibitor of c-jun N-terminal kinase (JNK), dose-dependently suppressed the induction of Mn-SOD mRNA by YS 51, but not by 2"-amino-3"-methoxyflavone (PD98059) and 4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)imidazol (SB203580), inhibitors of mitogen-activated protein kinase. Curcumin 16-24 superoxide dismutase 2 Homo sapiens 118-124 19344704-4 2009 Whereas the expression of glutathione peroxidase (GPx), catalase, Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and heme oxygenase-1 (HO-1) increased with curcumin concentration and also with increase in time of incubation, the expression of Mn- superoxide dismutase (Mn-SOD) showed concentration dependant repression upon treatment with curcumin. Curcumin 148-156 superoxide dismutase 2 Homo sapiens 235-259 19344704-4 2009 Whereas the expression of glutathione peroxidase (GPx), catalase, Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and heme oxygenase-1 (HO-1) increased with curcumin concentration and also with increase in time of incubation, the expression of Mn- superoxide dismutase (Mn-SOD) showed concentration dependant repression upon treatment with curcumin. Curcumin 148-156 superoxide dismutase 2 Homo sapiens 261-267 14531733-9 2004 This was further supported by the observation that curcumin suppressed both the DNA-binding activity of NF-kappaB and the induction of MnSOD mRNA in cells cultivated under metal-depleted conditions. Curcumin 51-59 superoxide dismutase 2 Homo sapiens 135-140 32814232-10 2020 Punicalagin and curcumin also altered antioxidant (SOD2 and catalase) mRNA expression in placenta, VAT and SAT, with minimal effect on hydrogen peroxide concentrations in tissue lysates. Curcumin 16-24 superoxide dismutase 2 Homo sapiens 51-55 33435886-0 2021 Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin. Curcumin 106-114 superoxide dismutase 2 Homo sapiens 68-72 33435886-9 2021 Curcumin treatment ameliorated peripheral blood cells generation, enhanced SIRT3 activity, decreased SOD2 acetylation, inhibited mROS production, and suppressed iron loading-induced autophagy. Curcumin 0-8 superoxide dismutase 2 Homo sapiens 101-105 33435886-10 2021 CONCLUSIONS: Our results suggest that curcumin exerts a protective effect on bone marrow by reducing mROS-stimulated autophagic cell death in a manner dependent on the SIRT3/SOD2 pathway. Curcumin 38-46 superoxide dismutase 2 Homo sapiens 174-178 32228565-5 2020 We evaluated the effects of UPM and/or curcumin on the expression of phosphorylated ERK, Nrf2, HO-1, and SOD2 in fibroblasts by Western blotting. Curcumin 39-47 superoxide dismutase 2 Homo sapiens 105-109 32228565-10 2020 Nrf2 production was also promoted to increase the expression of HO-1 and SOD2 by curcumin. Curcumin 81-89 superoxide dismutase 2 Homo sapiens 73-77 29460119-6 2018 Our data demonstrated that Curcumin inhibited TNF-alpha-induced astrocytes migration, decreased MCP-1 expression, and up-regulated SOD2 expression in TNF-alpha-induced astrocytes in vitro. Curcumin 27-35 superoxide dismutase 2 Homo sapiens 131-135 29245915-7 2017 Curcumin and sildenafil exposure reduced the expression of MCL-1, BCL-XL, thioredoxin and superoxide dismutase 2 (SOD2) in an eIF2alpha-dependent fashion. Curcumin 0-8 superoxide dismutase 2 Homo sapiens 90-112 29245915-7 2017 Curcumin and sildenafil exposure reduced the expression of MCL-1, BCL-XL, thioredoxin and superoxide dismutase 2 (SOD2) in an eIF2alpha-dependent fashion. Curcumin 0-8 superoxide dismutase 2 Homo sapiens 114-118 29245915-8 2017 Curcumin and sildenafil interacted in a greater than additive fashion to increase the levels of reactive oxygen species; knock down of thioredoxin or SOD2 enhanced killing and over-expression of thioredoxin or SOD2 suppressed killing. Curcumin 0-8 superoxide dismutase 2 Homo sapiens 210-214 25499851-7 2015 MnSOD-mediated cisplatin resistance can be overcome by a Bcl-2 antagonist (ABT-199) or IKKbeta inhibitor (curcumin) in cells and xenograft tumors. Curcumin 106-114 superoxide dismutase 2 Homo sapiens 0-5 25499851-10 2015 Therefore, we suggest that ABT-199 or curcumin may be potentially useful to improve tumor regression and chemotherapeutic response in patients with MnSOD/Bcl-2-positive tumors. Curcumin 38-46 superoxide dismutase 2 Homo sapiens 148-153 21750867-6 2011 Curcumin enhanced manganese superoxide dismutase (MnSOD) protein expression in the MCF-10F and Alpha3 cell lines. Curcumin 0-8 superoxide dismutase 2 Homo sapiens 18-48 21750867-6 2011 Curcumin enhanced manganese superoxide dismutase (MnSOD) protein expression in the MCF-10F and Alpha3 cell lines. Curcumin 0-8 superoxide dismutase 2 Homo sapiens 50-55 25445048-7 2015 Curcumin increased superoxide dimutase-2 (SOD2) transcription and activity by AMPK/PGC-1alpha axis. Curcumin 0-8 superoxide dismutase 2 Homo sapiens 42-46 25445048-9 2015 These results demonstrated the promotion effect of curcumin on PGC-1alpha expression through AMPK pathway, which led to the increases in PPARgamma activity and in SOD-2 transcription and activity. Curcumin 51-59 superoxide dismutase 2 Homo sapiens 163-168 25136316-7 2014 In addition, curcumin with its versatile activities modulated the expression of many oxidative stress-regulating genes such as PDGF, VEGF, IGFBP-2, HO1, SOD2, and GPX1. Curcumin 13-21 superoxide dismutase 2 Homo sapiens 153-157