PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22179005-0 2011 Curcumin blocks Kv11.1 (erg) potassium current and slows proliferation in the infant acute monocytic leukemia cell line THP-1. Curcumin 0-8 GLI family zinc finger 2 Homo sapiens 120-125 26102194-0 2015 Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells. Curcumin 0-8 GLI family zinc finger 2 Homo sapiens 111-116 26102194-3 2015 In this study, results showed that curcumin dramatically increased the expression of ATP-binding cassette transporter 1 (ABCA1), promoted cholesterol efflux from THP-1 macrophage-derived foam cells, and reduced cellular cholesterol levels. Curcumin 35-43 GLI family zinc finger 2 Homo sapiens 162-167 26102194-6 2015 Thus, curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through activating AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells. Curcumin 6-14 GLI family zinc finger 2 Homo sapiens 128-133 24725345-1 2014 We have previously shown that curcumin (CUR) may increase lipid accumulation in cultured human acute monocytic leukaemia cell line THP-1 monocytes/macrophages, but that tetrahydrocurcumin (THC), an in vivo metabolite of CUR, has no such effect. Curcumin 30-38 GLI family zinc finger 2 Homo sapiens 131-136 23977989-0 2013 Curcumin ameliorates TNF-alpha-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells. Curcumin 0-8 GLI family zinc finger 2 Homo sapiens 72-77 29242172-3 2018 In this study, we have investigated whether curcumin regulates metabolic changes in cholesterol metabolism via LXRalpha in THP-1 human macrophages, the cells implicated in atheroma plaques formation. Curcumin 44-52 GLI family zinc finger 2 Homo sapiens 123-128 29242172-7 2018 Curcumin treatment inhibited cell migration and was also able to promote reverse cholesterol transport in THP-1 cells. Curcumin 0-8 GLI family zinc finger 2 Homo sapiens 106-111 26248410-0 2015 [Effects of hydroxyl acetylated curcumin induced sonodynamic therapy on viability, apoptosis and necrosis of THP-1 macrophages]. Curcumin 32-40 GLI family zinc finger 2 Homo sapiens 109-114 23509769-0 2013 The sonodynamic effect of curcumin on THP-1 cell-derived macrophages. Curcumin 26-34 GLI family zinc finger 2 Homo sapiens 38-43 23509769-4 2013 THP-1-derived macrophages were incubated with curcumin at a concentration of 40.7 mumol/L for 2 h and then exposed to pulse ultrasound irradiation (2 W/cm(2) with 0.86 MHz) for 5-15 min. Curcumin 46-54 GLI family zinc finger 2 Homo sapiens 0-5 23509769-8 2013 These findings support that curcumin had sonodynamic effect on THP-1-derived macrophages and that curcumin SDT could be a promising treatment for atherosclerosis. Curcumin 28-36 GLI family zinc finger 2 Homo sapiens 63-68 22179005-6 2011 Curcumin was rapidly internalized by THP-1 cells and possibly exerts potential growth inhibitory activity by interacting with intracellular epitopes of the ion channel. Curcumin 0-8 GLI family zinc finger 2 Homo sapiens 37-42 15569263-6 2004 Curcumin abrogated Abeta1-40-induced expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in both peripheral blood monocytes and THP-1 cells. Curcumin 0-8 GLI family zinc finger 2 Homo sapiens 168-173 15569263-0 2004 Curcumin, the active constituent of turmeric, inhibits amyloid peptide-induced cytochemokine gene expression and CCR5-mediated chemotaxis of THP-1 monocytes by modulating early growth response-1 transcription factor. Curcumin 0-8 GLI family zinc finger 2 Homo sapiens 141-146 15569263-5 2004 We show that curcumin (12.5-25 microm) suppresses the activation of Egr-1 DNA-binding activity in THP-1 monocytic cells. Curcumin 13-21 GLI family zinc finger 2 Homo sapiens 98-103 15569263-8 2004 We observed that curcumin inhibited Abeta1-40-induced expression of CCR5 but not of CCR2b in THP-1 cells. Curcumin 17-25 GLI family zinc finger 2 Homo sapiens 93-98 15569263-10 2004 Finally, curcumin inhibited chemotaxis of THP-1 monocytes in response to chemoattractant. Curcumin 9-17 GLI family zinc finger 2 Homo sapiens 42-47 33952798-0 2021 Curcumin promotes cholesterol efflux by regulating ABCA1 expression through miR-125a-5p/SIRT6 axis in THP-1 macrophage to prevent atherosclerosis. Curcumin 0-8 GLI family zinc finger 2 Homo sapiens 102-107 33952798-1 2021 OBJECTIVE: To seek out the effect of curcumin on cholesterol efflux in THP-1 macrophages and clarify its specific mechanism. Curcumin 37-45 GLI family zinc finger 2 Homo sapiens 71-76 33952798-8 2021 RESULTS: The optimal dosage of curcumin could reduce foam cell formation and intracellular lipid content, and promote cholesterol efflux in THP-1 macrophages. Curcumin 31-39 GLI family zinc finger 2 Homo sapiens 140-145 32912630-4 2020 Using a fluorinated-derivative of curcumin (designated Shiga-Y6), we showed significant inhibition of TXNIP mRNA and protein expression, and induction of TRX mRNA and protein in ARPE-19 retinal pigment epithelial cells and THP-1-derived macrophages, while the non-fluorinated structural equivalent (Shiga-Y52) and native curcumin did not show these same effects. Curcumin 34-42 GLI family zinc finger 2 Homo sapiens 223-228 31455356-7 2019 RESULTS: Curcumin treatment markedly inhibited the degradation of IkappaBalpha, the activation of NF-kappaB signaling pathway, and the expression levels of the NF-kappaB downstream inflammatory genes such as IL-1beta, IL-6, TNF-alpha, COX-2, and PGE2 in the MSU-stimulated THP-1-derived macrophages. Curcumin 9-17 GLI family zinc finger 2 Homo sapiens 273-278 32899726-0 2020 Chlorogenic Acid Potentiates the Anti-Inflammatory Activity of Curcumin in LPS-Stimulated THP-1 Cells. Curcumin 63-71 GLI family zinc finger 2 Homo sapiens 90-95 32899726-4 2020 In this study, the anti-inflammatory potential of curcumin in combination with chlorogenic acid (CGA), was investigated using human THP-1 macrophages stimulated with lipopolysaccharide (LPS). Curcumin 50-58 GLI family zinc finger 2 Homo sapiens 132-137 32899726-10 2020 Overall, co-administration with CGA improved the inflammation-lowering effects of curcumin in THP-1 cells. Curcumin 82-90 GLI family zinc finger 2 Homo sapiens 94-99 31455356-8 2019 Curcumin administration protected THP-1 and RAW264.7 cells from MSU induced mitochondrial damage through preventing mitochondrial membrane potential reduction, decreasing mitochondria ROS, and then inhibited the activity of NLRP3 inflammasome. Curcumin 0-8 GLI family zinc finger 2 Homo sapiens 34-39