PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26442630-7	2016	Interestingly, ATM/ATR activation by curcumin induced phosphorylation of Chk2 (Thr68) followed by that of Cdc25C (Ser216) and Cdc2 (Tyr15), and Cyclin B1 accumulation.	Curcumin	37-45	checkpoint kinase 2	Homo sapiens	73-77	
15179184-4	2004	Curcumin induced melanoma cell apoptosis and cell cycle arrest, which is associated with the downregulation of NFkappaB activation, iNOS and DNA-dependent protein kinase catalytic subunit expression, and upregulation of p53, p21(Cip1), p27(Kip1) and checkpoint kinase 2.	Curcumin	0-8	checkpoint kinase 2	Homo sapiens	250-269	
28881600-0	2017	Curcumin induces G2/M cell cycle arrest and apoptosis of head and neck squamous cell carcinoma in vitro and in vivo through ATM/Chk2/p53-dependent pathway.	Curcumin	0-8	checkpoint kinase 2	Homo sapiens	128-132	
26442630-9	2016	These results collectively show that curcumin treatment induced the DNA damage response via triggering an ATM-activated Chk2-Cdc25C-Cdc2 signaling pathway.	Curcumin	37-45	checkpoint kinase 2	Homo sapiens	120-124	
21134073-6	2011	Combined treatment of isoflavones and curcumin additively suppressed cellular proliferation and induced phosphorylation of ATM, histone H2AX, Chk2 and p53.	Curcumin	38-46	checkpoint kinase 2	Homo sapiens	142-146	
26299580-6	2015	Our data demonstrating that anticancer activity of curcumin is linked to the activation of the ATM/CHK2 pathway and the inhibition of nuclear factor-kappaB.	Curcumin	51-59	checkpoint kinase 2	Homo sapiens	99-103