PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26302188-6	2015	We further found that curcumin interfered with the transforming growth factor-beta (TGF-beta) signaling by reducing the expression of TGF-beta receptor I and inhibiting the expression and phosphorylation of Smad2 and Smad3.	Curcumin	22-30	SMAD family member 3	Homo sapiens	217-222	
26826337-8	2016	Further evidence showed that curcumin decreased TGF-beta1-mediated phosphorylation of Smad2 and Smad3.	Curcumin	29-37	SMAD family member 3	Homo sapiens	96-101	
20160437-6	2010	Curcumin suppressed not only TGF-beta(1)-induced Smad2 phosphorylation in a dose- and time-dependent manner, but also the nuclear accumulation of receptor-regulated Smads (R-Smad), Smad2 and Smad3.	Curcumin	0-8	SMAD family member 3	Homo sapiens	191-196	
34324434-0	2021	Curcumin in combination with homoharringtonine suppresses lymphoma cell growth by inhibiting the TGF-beta/Smad3 signaling pathway.	Curcumin	0-8	SMAD family member 3	Homo sapiens	106-111	
35093937-0	2022	Correction for: Curcumin in combination with homoharringtonine suppresses lymphoma cell growth by inhibiting the TGF-beta/Smad3 signaling pathway.	Curcumin	16-24	SMAD family member 3	Homo sapiens	122-127	
32724322-8	2020	Meanwhile, the curcumin treatment can downregulate miR-21 expression, upregulate TIMP3 expression, and inhibit the TGF-beta1/smad3 signaling pathway.	Curcumin	15-23	SMAD family member 3	Homo sapiens	125-130	
32724322-11	2020	Interestingly, the effect of miR-21 inhibition on cell proliferation, apoptosis, and TGF-beta1/smad3 signaling pathway in HepG2 and HCCLM3 cells exposed to curcumin was attenuated by TIMP3 silencing.	Curcumin	156-164	SMAD family member 3	Homo sapiens	95-100	
32724322-12	2020	Conclusion: Taken together, the present study suggests that miR-21 is involved in the anticancer activities of curcumin through targeting TIMP3, and the mechanism possibly refers to the inhibition of TGF-beta1/smad3 signaling pathway.	Curcumin	111-119	SMAD family member 3	Homo sapiens	210-215	
29578200-10	2017	Results: EGCG and curcumin at 10 muM concentration reversed EMT, inhibited proliferation and migration through Smad-3 phosphorylation, when induced by TGF-beta1 in ARPE-19 cells.	Curcumin	18-26	SMAD family member 3	Homo sapiens	111-117	
23609161-0	2013	Curcumin inhibits TGFbeta1-induced CCN2 via Src, JNK, and Smad3 in gingiva.	Curcumin	0-8	SMAD family member 3	Homo sapiens	58-63	
23609161-8	2013	We further found that curcumin significantly abrogated the TGFbeta1-induced CCN2 in HGFs by inhibiting the phosphorylations of Src, JNK, and Smad3.	Curcumin	22-30	SMAD family member 3	Homo sapiens	141-146